Browsing by Author "Aslan, Diler"

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A multicenter nationwide reference intervals study for common biochemical analytes in turkey using abbott analyzers
(Walter De Gruyter Gmbh, 2014-12-01) Ichihara, Kiyoshi; Aslan, Diler; Aybek, Hulya; Ari, Zeki; Taneli, Fatma; Coker, Canan; Akan, Pinar; Şişman, Ali Riza; Bahçeci, Onur; Sezgin, Nurzen; Demir, Meltem; Yücel, Gultekin; Akbas, Halide; Özdem, Sebahat; Polat, Gürbüz; Erbağci, Ayse Binnur; Örkmez, Mustafa; Mete, Nuriye; Evliyaoglu, Osman; Kıyıcı, Aysel; Vatansev, Hüsamettin; Ozturk, Bahadir; Yucel, Dogan; Kayaalp, Damla; Dogan, Kubra; Pinar, Asli; Gurbilek, Mehmet; Çetinkaya, Çiğdem Damla; Akın, Okhan; Serdar, Muhittin; Kurt, Ismail; Erdinç, Selda; Kadiceşme, Özgur; Ilhan, Necip; Atali, Dilek Sadak; Bakan, Ebubekir; Polat, Harun; Noyan, Tevfik; Can, Murat; Bedir, Abdulkerim; Okuyucu, Ali; Değer, Orhan; Agaç, Suret; Ademoğlu, Evin; Kaya, Aysem; Nogay, Turkan; Eren, Nezaket; Gunes, Yeliz; Kawano, Reo; Tezcan, Sehavet; Demirpençe, Özlem; Değirmen, Elif; Özarda, Yesim; ÖZARDA, YEŞİM; Dirican, Melahat; DİRİCAN, MELEHAT; Tuncer, Gül Özlem; Aykuş, Mehmet; Özmen, Sevda Ünalli; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; KYR-0994-2024; AAL-8873-2021
Background: A nationwide multicenter study was organized to establish reference intervals (RIs) in the Turkish population for 25 commonly tested biochemical analytes and to explore sources of variation in reference values, including regionality.Methods: Blood samples were collected nationwide in 28 laboratories from the seven regions (>= 400 samples/region, 3066 in all). The sera were collectively analyzed in Uludag University in Bursa using Abbott reagents and analyzer. Reference materials were used for standardization of test results. After secondary exclusion using the latent abnormal values exclusion method, RIs were derived by a parametric method employing the modified Box-Cox formula and compared with the RIs by the non-parametric method. Three-level nested ANOVA was used to evaluate variations among sexes, ages and regions. Associations between test results and age, body mass index (BMI) and region were determined by multiple regression analysis (MRA).Results: By ANOVA, differences of reference values among seven regions were significant in none of the 25 analytes. Significant sex-related and age-related differences were observed for 10 and seven analytes, respectively. MRA revealed BMI-related changes in results for uric acid, glucose, triglycerides, high-density lipoprotein (HDL)-cholesterol, alanine aminotransferase, and.-glutamyltransferase. Their RIs were thus derived by applying stricter criteria excluding individuals with BMI >28 kg/m(2). Ranges of RIs by non-parametric method were wider than those by parametric method especially for those analytes affected by BMI.Conclusions: With the lack of regional differences and the well-standardized status of test results, the RIs derived from this nationwide study can be used for the entire Turkish population.
Educational programme: Genetics and statistics, quality control and accreditation in clinical laboratories
(Wiley, 2009-03) Aslan, Diler; Güner, Gül; İnal, Tamer Cevat; Rousseau, Francois; Demirel, Gülderen Yenikkaya; İlçöl, Yeşim Özarda; Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Bölümü.; AAL-8873-2021
Rate of T alleles and TT genotype at MTHFR 677C->T locus or C alleles and CC genotype at MTHFR 1298A->C locus among healthy subjects in Turkey: Impact on homocysteine and folic acid status and reference intervals
(Wiley, 2009-12) Sucu, Derya Kaynak; Aslan, Diler; İlçöl, Yeşim Özarda; Hızlı, Banu Zafer; Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; AAL-8873-2021; 35741320500; 14019332100
Methylenetetrahydrofolate reductase (MTHFR) is important for folate and homocysteine (Hcy) metabolism. MTHFR 677C->T and 1298A->C MTHFR are two most common mutations which can affect. folate and total homocysteine (tHcy) status This study was designed to determine the rate of,MTHFR 677C->T and 1298A->C mutations. and their Influence Oil serum folate, Hcy and vitamin B12 Status and the reference intervals in 402 healthy Turkish adults. The rate of MTHFR 677C->T or 1298A->C mutations was 50 7% or 54 7%. respectively. The MTHFR 677C->T mutation-specific reference intervals for serum folate and tHcy were characterized by marked shifts in their upper limits In homozygote subjects for MTHFR 677C->T serum folate concentration was lower and serum tHcy concentration was higher than those in the wild genotype. all subjects had lower serum folate and 54% of the subjects had higher tHcy concentration,; than the cutoff Values of <= 10 nmol/L and >= 12 mu mol/L, respectively. Serum vitamin 1312 status was similar in all genotypes Serum tHcy concentrations were inversely correlated with serum folate and vitamin B12 concentrations in all genotypes These data show that the rate of MTHFR 677C->T and 1298A->C mutations is very high in Turks and serum folate and tHcy status are impaired by these mutations.
Serum levels and reference intervals of leptin, adiponectin and resistin in healthy adults in north-west Turkey
(Walter de Gruyter, 2011-05) Aslan, Diler; Eroz, E.; Özarda, Yeşim; Güneş, Yeliz; Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; AAL-8873-2021
The omega-3 index in the Turkish population
(Wiley, 2008-06) Aslan, Diler; Ilcol, Yeşim Özarda; Eröz, Esma; AAL-8873-2021; ETY-5351-2022
Use of total patient data for indirect estimation of reference intervals for 40 clinical chemical analytes in Turkey
(De Gruyter, 2006) Aslan, Diler; İlçol, Yeşim Özarda; Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Merkez Laboratuvarı.; AAL-8873-2021; 14018130800
In the present study we used patient data to calculate laboratory-specific indirect reference intervals. These values were compared with reference intervals obtained for a healthy group according to recommendations of the International Federation of Clinical Chemistry and Laboratory Medicine and manufacturer suggestions. Laboratory results ( 422,919 records) from all subjects of 18-45 years of age over a 1-year period were retrieved from our laboratory information system and indirect reference intervals for 40 common analytes were estimated using a modified Bhattacharya procedure. Indirect reference intervals for most of the biochemical analytes were comparable, with small differences in lower [alkaline phosphatase (ALP) ( male), alanine aminotransferase ( ALT), creatine kinase, iron ( male), total iron-binding capacity, folic acid, calcium ( female), lactate dehydrogenase (LDH), lipoprotein ( a) [Lp(a)], thyroid-stimulating hormone (TSH), total triiodothyronine ( T-3), direct bilirubin, apolipoprotein A-I ( apoA-I), glucose, homocysteine, total cholesterol, ferritin, total protein, ceruloplasmin, sodium, blood urea nitrogen (BUN) and uric acid ( female)] and/or upper limits [albumin, ALP ( male), amylase, apoA-I, creatine kinase-MB (CK-MB), total iron-binding capacity, phosphorus, glucose, total cholesterol, g-glutamyltransferase (g-GT), magnesium, total protein, high-density lipoprotein cholesterol (HDL-C), total T-3, ALP ( male), ALT, aspartate aminotransferase (AST) ( male), direct bilirubin ( male), creatine kinase, iron, folic acid ( female), Lp( a), uric acid and triglycerides], to the reference intervals determined for healthy subjects in our laboratory. The indirect reference intervals, with the exception of a few parameters ( creatinine, direct total bilirubin, calcium, BUN and potassium), were not similar to the reference intervals suggested by the manufacturers. We conclude that laboratory-specific reference intervals can be determined from stored data with a relatively easy and inexpensive method. Indirect reference intervals derived from stored data may be particularly suitable for the evaluation of results for the presenting population.