Browsing by Author "Aydoĝan, Kenan"

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Chandrakala SFCR The value of spectrophotometric intracutaneous analysis in the noninvasive diagnosis of nonmelanoma skin cancers
(Wiley, 2013-06-18) Hacıoǧlu, Şenay; Sarıcaoğlu, Hayriye; Başkan, Emel Bülbül; Uner, S. I.; Aydoĝan, Kenan; Tunalı, Şükran; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Anabilim Dalı.; 0000-0002-0193-1128; AAH-6216-2021; 36196495300; 6603722836; 6602518817; 55914302400; 9739755800; 7004191748
Background. Spectrophotometric intracutaneous analysis (SIAscopy) is a recently introduced, noninvasive, rapid and practical method for monitoring pigmented lesions, which calculates the amount of collagen, melanin and haemoglobin deep in the papillary dermis. Aim. To evaluate the value of SIAscopy in the diagnosis of nonmelanoma skin cancers (NMSC). Methods. In total, 80 lesions of 76 patients were clinically evaluated by the first investigator, and the data recorded. Eight months after the clinical evaluation, all lesions were evaluated again by the same investigator, using images (SIAgraphs) obtained by the SIAscope. All SIAgraphs were also evaluated by a second investigator, and all dermatoscopic images by a third, independently of each other. All diagnoses were compared with histopathological diagnoses. Results. The clinical diagnosis was calculated to have a sensitivity of 79% and specificity of 84%. The SIAscopic diagnoses of the first and second investigators had a sensitivity of 55% and 93%, and a specificity of 88% and 53%, respectively, while the dermatoscopic diagnoses of the third investigator had a sensitivity of 86% and specificity of 80%. There was no statistical accordance between the first and second investigators according to the accuracy of SIAscopic diagnoses (P<0.01). The area under the curve for the receiver operator characteristic was 0.82 for clinical diagnosis, 0.73 and 0.80 for the SIAscopic evaluation of the first and the second investigators, respectively, and 0.87 for the dermatoscopic evaluation of the third investigator. Conclusions. Our findings show that dermatoscopic findings are more valuable than SIAscopic and clinical findings for the noninvasive diagnosis of NMSC. We consider that SIAscopy makes no substantial contribution towards the differential diagnosis of NMSC.
Pediatric morphea (localized scleroderma) - Epidemiological, clinical and laboratory findings of 14 cases
(Türk Dermatoloji Veneroloji Derneği, 2011-09) İzol, Belçin; Sarıcaoğlu, Hayriye; Başkan, Emel Bülbül; Toka, Sevil Ovalı; Adım, Şaduman Balaban; Aydoĝan, Kenan; Tunali, Şükran; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/ Deri ve Zührevi Hastalıkları Anabilim Dalı.; 0000-0002-0144-3263; AAH-1388-2021; AAH-6216-2021; 36514794600; 6603722836; 6602518817; 51663995200; 15730076300; 9739755800; 7004191748
Background and Design: Morphea is an inflammatory skin disease seen more frequently than systemic sclerosis in pediatric patients. Important functional deficiencies and cosmetic deformities may develop especially due to linear morphea. Patients may have accompanying extracutaneous involvement, family history of rheumatologic diseases and abnormalities in laboratory parameters like positive ANA and RF. It is important to evaluate pediatric patients accordingly and to carry out further examinations. Data about pediatric morphea in Turkish population could not be found in the literature. We aimed to evaluate epidemiological, clinical and laboratory findings, to compare the data with those in the literature and to propose a model for Turkish pediatric morphea which can be supported by future multicenter national studies. Materials and Methods: Fourteen pediatric morphea patients, 3 males and 11 females under the ageof 18, followed up at Uludag University, Medical Faculty, Dermatovenereology Department between 2000-2010 were enrolled in the study. Inclusion criterion was age under 18 years at diagnosis. Epidemiological, clinical and laboratory findings were analyzed retrospectively. Results: Only 3 patients were males. The mean age at disease onset was 9.5 years. The mean duration of disease was 21 months. Most frequent type was linear morphea. Two patients had contracture, one had shortness in the left lower extremity, and 4 patients had livedo reticularis. Raynaud's phenomenon was positive in one case. Trauma and sunburn were the trigger factors detected. Behcets disease was reported in the father of one patient. One case was RF positive. Five patients had positive ANA in titers of 1/100, while a patient with generalised morphea had significantly higher titer (1/1000). Antihistone antibodies were positive in one patient and 2 cases were Lyme IgM positive. Conclusion: Early diagnosis and therapy are important since childhood morphea can cause cosmetic deformities. Patients should be evaluated for accompanying systemic symptoms and, extracutaneous involvement should be investigated when the disease is suspected.