Browsing by Author "Chung, Soon Soup"

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    Effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis
    (Türk Travma ve Acil Cerrahi Derneği, 2018-09) Chung, Soon Soup; Altınel, Yüksel; Okay, Güven; Uğraş, Nesrin; Işık, Ahmet Fatih; Öztürk, Ersin; Özgüç, Halil; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Kliniği.; Uludağ Üniversitesi/Tekstil Mühendisliği Fakültesi/Tekstil Bölümü.; AAL-9231-2020; AAH-2716-2021; 26657125600; 57204588493; 55386535600; 56217319800; 35070171400; 6603867989
    BACKGROUND: We evaluated the feasibility of chitosan-coated sutures for intestinal anastomosis strength through wound-healing effect. METHODS: Vicryl and PDS sutures were coated with 2% chitosan. While laparotomy was applied to the first group, chitosan was applied in the peritoneal cavity in the second group. Then the following materials were applied to colon anastomosis, in order: Vicryl, PDS, chitosan-coated Vicryl, and chitosan-coated PDS sutures. On the 7th and 14th days, eight rats from each group were euthanized. RESULTS: The adhesion scores of chitosan and control groups were lower than the suture groups. The vascularization of Vicryl-chitosan was lower than PDS-chitosan on the 14th day (p=0.038). Fibroblast cells and vascularization of anastomosis with chitosan-coated Vicryl were lower than Vicryl and chitosan-coated PDS on the 14th day (p<0.05). The tensile strength of Vicryl-chitosan increased more than Vicryl in vitro (p<0.05) on the 14th and 7th days, but there was no difference in vivo. The tensile strength of PDS-chitosan decreased more than PDS on the 7th day in vivo (p<0.05). CONCLUSION: The chitosan-coating effect on the adhesion and reinforcement of anastomosis in some parts of Vicryl in vitro and PDS in vivo was slightly improved.