Browsing by Author "Kaderli, Aysel Aydın"

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12.201 Hastanın koroner risk faktörleri ve koroner anjiografi sonuçları
(Uludağ Üniversitesi, 2014-12-18) Günay, Şeyda; Serdar, Osman Akın; Özyılmaz, Sinem Özbay; Dereli, Seçkin; Aydınlar, Ali; Güllülü, Sümeyye; Yeşilbursa, Dilek; Baran, İbrahim; Özdemir, Bülent; Kaderli, Aysel Aydın; Şentürk, Tunay; Sağ, Saim; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.
Giriş: Koroner arter hastalığı (KAH) Türkiye’de önemli bir sağlık problemi olup erişkin ölüm nedenleri arasında ilk sırada yer almaktadır. Çalışmamızın amacı merkezimizde koroner anjiyografi ile değerlendirilmiş olgularda koroner risk faktörlerinin prevalansını belirlemek, risk faktörleri ile KAH yaygınlığı ve topografik olarak damar tutulumu arasındaki ilişkiyi araştırmaktır. Metod: Bu çalışmaya 1993 ve 2012 yılları arasında elektif şartlarda koroner anjiyografisi yapılmış 12.201 hasta alındı. Retrospektif olarak hastaların dosyaları incelenerek anjiyografi sonuçları ve risk faktörleri saptandı. Risk faktörlerinin KAH yaygınlığı (non-kritik, 1 damar, 2 damar, ≥3 damar hastalığı) ve kritik koroner lezyon yerleşim yeriyle ilişkisi araştırıldı. Bulgular: Çalışmaya 8085 erkek, 4116 kadın hasta alındı. KAH yaygınlığı 80 yaş altında erkeklerde daha fazla iken ≥80 yaş grubunda cinsiyetler arasında anlamlı bir fark saptanmadı. ≥3 damar tutulumu diyabetik hastalarda daha fazla iken, hipertansiyon ve hiperlipidemi KAH yaygınlığı ile ilişkisizdi. ≥80 yaş grubunda kritik koroner yerleşimi açısından cinsiyetler arası anlamlı fark saptanmazken, 80 yaş altında kritik koroner lezyon yerleşimi tüm koronerlerde kadınlara göre erkeklerde daha fazlaydı. Sonuç: Türk hastalarda KAH riskini doğru değerlendirmek için kullanılan skorlama sistemlerinde yaş ve cinsiyetten bağımsız olarak diyabet varlığı diğer risk faktörlerine göre daha ağırlıklı bir değere sahip olmalıdır.
Akromegali hastalarında IGF-1 ve büyüme hormonu ile santral aort basıncı ve augmentasyon indeksi arasındaki ilişkinin değerlendirilmesi
(Uludağ Üniversitesi, 2016) Dereli, Seçkin; Kaderli, Aysel Aydın; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.
Akromegali aşırı miktarda büyüme hormonu (GH) ve insülin benzeri büyüme faktörü (IGF-1) salınımı ile karakterize bir sendromdur. Akromegalik hastalar arasında kardiyovasküler hastalıkların yüksek prevalansı bildirildikçe, GH ve IGF-1 ile kardiyovasküler sistem arasındaki ilişki daha fazla ilgi çekmeye başlamıştır. Bu hastalarda endotel disfonksiyonuna işaret eden güçlü kanıtlar vardır. Son zamanlarda arteriyel sertlik ve ilişkili endotelyal disfonksiyonu öngörmede augmentasyon indeksi (AIX) ve santral aort basıncı (SAB) gibi yeni parametreler kullanılmaktadır. Çalışmamızda tedavi ile kontrol altına alınan ve alınamayan akromegali hastalarında non-invaziv olarak ölçülen kardiyovasküler risk belirteçleri, büyüme hormonu ve IGF-1 parametreleri arasındaki ilişkiyi değerlendirmeyi amaçladık. Çalışmaya 53 akromegalili hasta ve 20 kontrol grubu dahil edildi. Hastalar 21'i aktif akromegali (AA), 32'si tedavi ile kontrol edilmiş akromegali (KA) olmak üzere iki gruba ayrıldı. İki grubun serumlarında açlık plazma glukozu, kan lipitleri, GH, IGF-1, HgbA1c değerleri ölçüldü ve hastalardan hemogram çalışıldı. Boy ve kiloya göre vücut kitle indeksi hesaplanıldı. Arteriyel sertlik invaziv olmayan CardioScope II Arteriograf cihazı ile değerlendirildi. Arteriyel sertlik parametreleri akromegali hastalarında kontrol grubuna göre daha yüksek saptandı. Augmentasyon indeksi; AA grubunda ortalama %98, KA grubunda %92 ve kontrol grubunda %79.5 bulunarak gruplar arasında istatiksel açıdan anlamlı olarak farklı saptandı (p<0.05). Santral aort basıncı ise en yüksek AA grubunda izlendi ve KA grubunda kontrol grubuna göre anlamlı derecede farklı saptandı (p<0.05). Akromegaliklerde kontrol grubuna göre GH, IGF-1, plazma glukozu, trombosit ölçümleri anlamlı derecede yüksek saptandı. Hem AA hem KA hastalarında regresyon analizi sonucunda HgbA1c ve trombosit sayısı ile arteryel sertlik parametreleri arasında güçlü korelasyon izlendi fakat bu ilişki IGF-1 ve GH düzelerinde izlenmedi. Kontrol grubunda ise açlık kan şekeri, HgbA1c ve trombosit seviyesi ile augmentasyon indeksi ilişkili saptandı. Tedavi alan ve almayan akromegali hastalarındaki arteriyel akromegali hastalarındaki değerlendirildiği çalışmamız sonucunda; hem AA grubunda hem de KA grubunda arteryel sertliğin göstergesi olan AIX ve santral kan basıncının kontrol grubuna göre anlamlı olarak daha yüksek olduğunu saptadık. Sonuçlar akromegalili hastalarda tedavi ile artmış arteryel sertliğin bazal değerlere gerilemediğine gösterilmiştir.
Aortic distensibility and coronary artery bypass graft patency
(Bmc, 2009-03-26) Özdemir, Levent; Özdemir, Bülent; Biçer, Murat; Baran, İbrahim; Kaderli, Aysel Aydın; Şentürk, Tunay; Emül, Ali; Yetgin, Zeynel Abidin; Güllülü, Sümeyye; Aydınlar, Ali; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kalp Damar Cerrahisi Anabilim Dalı.; 0000-0002-8974-8837; C-1517-2017; ABC-2231-2020; AAI-6632-2021; 7004168959; 6507770944; 35572557400; 7801322152; 8342098300; 23967725800; 26436271200; 57204660708; 6603131517
Background: Aortic distensibility is an elasticity index of the aorta, and reflects aortic stiffness. Coronary artery disease has been found to be substantially associated with increased aortic stiffness. In this study we aimed to retrospectively analyze the association of angiographically determined aortic distensibility with the patency rates of coronary bypass grafts Methods: The study was conducted in the Cardiology department of the Applied Research Centre for Health of Uludag University. The coronary angiograms of 53 consecutive coronary bypass patients were analysed retrospectively. Aortic distensibility was calculated using the formula: 2 x (change in aortic diameter)/(diastolic aortic diameter) x (change in aortic pressure). The number of stenosed and patent bypass grafts and the patient characteristics like age, risk factors were noted. Results: There were 44 male (83%) and 9 female (17%) cases. Eighteen cases had only one saphenous vein grafting. The number of cases with two, three and four saphenous grafting were 18, 11 and 1; respectively. In the control angiograms the number of cases with one, two, three and four saphenous vein graft obstruction were 15 (31.3%), 7 (14.6%), 1 (2.1%) and 1 (2.1%) respectively. The aortic distensibility did not differ in cases with and without saphenous graft occlusion (p > 0.05). Also left internal mammary artery (LIMA) graft patency was not related to the distensibility of the aorta (p > 0.05). We also evaluated the data for cut-off values of 50 and 70 mmHg of pulse pressure and did not see any significant difference between the groups in terms of saphenous or LIMA grafts. Conclusion: In this study we failed to show association of angiographically determined aortic distensibility with coronary bypass graft patency in consecutive 53 patients with coronary artery bypass graft surgery (CABG).
Association of epicardial adipose tissue thickness by echocardiography and heart rate recovery in metabolic syndrome
(Elsevier, 2013-10-29) Böyük, Ferit; Özdemir, Bülent; Sağ, Saim; Şentürk, Tunay; Kaderli, Aysel Aydın; Güllülü, Sümeyye; Aydınlar, Ali; Böyük, Ferit; ÖZDEMİR, BÜLENT; Sağ, Saim; ŞENTÜRK, TUNAY; Kaderli, Aysel Aydın; GÜLLÜLÜ, NAZMİYE SÜMEYYE; AYDINLAR, ALİ; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Bölümü; C-1517-2017; AAI-6632-2021; AAW-9185-2020; JIX-2728-2023; JHE-3353-2023; CXL-7581-2022; JGR-6552-2023
Catheter-directed ultrasound-accelerated thrombolysis may be life-saving in patients with massive pulmonary embolism after failed systemic thrombolysis
(Springer, 2016-10) Sağ, Saim; Nas, Ömer Fatih; Kaderli, Aysel Aydın; Özdemir, Bülent; Baran, İbrahim; Erdoğan, Cüneyt; Güllülü, Sümeyye; Hakyemez, Bahattin; Aydınlar, Ali; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; 0000-0001-8404-8252; 0000-0002-3425-0740; 0000-0002-8974-8837; AAW-9185-2020; AAG-8561-2021; AAI-2318-2021; AAI-6632-2021; 12140008100; 51864050100; 7801322152; 7004168959; 35572557400; 8293835700; 57204660708; 6602527239; 6603131517
The treatment options for high risk acute pulmonary embolism (PE) patients with failed systemic thrombolytic treatment (STT) is limited. The clinical use of catheter directed thrombolysis with the EkoSonic Endovascular System (EKOS) in this population has not been evaluated before. Catheter directed thrombolysis is an effective treatment modality for high risk PE patients with failed STT. Thirteen consecutive patients with failed STT were included in the study. EKOS catheters were placed and tissue plasminogen activator (t-PA) in combination with unfractionated heparin were given. Clinical and echocardiographic properties of the patients were collected before EKOS, at the end of EKOS and during the follow-up visit 6 months after discharge. The duration of EKOS treatment was 21.8 +/- 3.8 h and the total dose of tPA was 31.2 +/- 15.3 mg. One patient who presented with cardiac arrest died and the clinical status of the remaining subjects improved significantly. Any hemorrhagic complication was not observed. EKOS resulted in significant improvement of right ventricular functions and decrease of systolic pulmonary artery pressure. During a follow-up period of 6 months none of the patients died or suffered recurrent PE. In addition, echocardiographic parameters or right ventricular function significantly got better compared to in-hospital measurements. EKOS is an effective treatment modality for high risk PE patients with failed STT and can be applied with very low hemorrhagic complications.
The comparison of depression and anxiety levels determined by self rating scales in patients with acute coronary syndrome, patients with stable coronary artery disease and patients without coronary artery disease
(Elsevier, 2011-03) Yetgin, Zeynel Abidin; Şentürk, Tünay; Kaderli, Aysel Aydın; Sivrioğlu, Yusuf; Yeşilbursa, D.; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı.; C-1517-2017
Coronary artery anomalies in patients with syndrome X
(Türk Kardiyoloji Derneği, 2009-02) Akgüllü, Çağdaş; Yılmaz, Yusuf; Yücel, Enver; Kaderli, Aysel Aydın; Kumbay, Ethem; Aydınlar, Ali; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0002-8974-8837; 0000-0003-4518-5283; AAI-6632-2021; K-6651-2012; 23967699200; 22936014300; 35207289300; 7801322152; 6507775316; 26645541900
Cardiac syndrome X (CSX) is characterized by typical angina, abnormal exercise test results, and no critical coronary stenosis (1). Coronary artery anomalies (CAAs) are a group of congenital disorders resulting in a highly variable clinical phenotype (2). There is a growing interest in the incidence of these anomalies and in their role in the manifestations of ischemic heart disease (3). To our knowledge, however, the role of structural cardiovascular abnormalities in the pathogenesis of syndrome X remains unclear. In the present study, we sought to investigate the presence and frequency of CAAs in patients with CSX. We reviewed the records of 50 patients with CSX who had undergone exercise electrocardiogram test and coronary angiography at the Uluda¤ University Cardiovascular Laboratories between 2003 and 2005. The following variables were collected: time of 1-mm ST depression, onset of angina, maximum ST segment shift, number of leads (derivations) with ST depression observed at peak exercise, and exercise duration in multiples of resting O2 consumption (METS). All patients underwent coronary angiography using the standard Judkins technique.
Coronary risk factors and coronary angiography results of 12.201 patients
(Elsevier, 2015-07-01) Günay, Şeyda; Serdar, Osman Akın; Özyılmaz, Sinem; Dereli, Seçkin; Aydınlar, Ali; Baran, İbrahim; Özdemir, Burhan; Yeşilbursa, Dilek; Güllülü, Sumeyye; Kaderli, Aysel Aydın; Şentürk, Tunay; GÜNAY POLATKAN, ŞEYDA; SERDAR, OSMAN AKIN; Özyılmaz, Sinem; Dereli, Seçkin; AYDINLAR, ALİ; Baran, İbrahim; Özdemir, Burhan; YEŞİLBURSA, DİLEK; GÜLLÜLÜ, NAZMİYE SÜMEYYE; Kaderli, Aysel Aydın; ŞENTÜRK, TUNAY; Uludağ Üniversitesi; 0000-0003-1744-8883; 0000-0003-0090-3835; 0000-0002-8974-8837; 0000-0003-4829-8400; 0000-0003-0012-345X; AAI-5350-2021; AAI-6632-2021; AAG-8709-2020; AAB-5861-2021; AAJ-3962-2020; C-1517-2017; AAF-5116-2019; CDA-1396-2022; FRF-3343-2022
Diffuse involvement of the heart and great vessels in primary cardiac lymphoma
(Oxford Univ, 2010-01) Kaderli, Aysel Aydın; Baran, İbrahim; Aydın, Özlem; Biçer, Murat; Akpınar, Tayyar; Özkalemkaş, Fahir; Yeşilbursa, Dilek; Güllülü, Sümeyye; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kalp ve Damar Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nükleer Tıp Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; ABC-2231-2020; AAG-8495-2021; 7801322152; 37012019200; 57197050271; 6507770944; 37011914700; 6601912387; 36658194500; 57204660708
Primary cardiac lymphoma (PCL) is an extremely rare disorder. In this report, a 57-year-old male with diffuse large B-cell lymphoma involving the heart and great vessels is presented. Trans-thoracic echocardiography was the first modality used to establish the diagnosis. Fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) showed diffuse increased metabolic activity of the heart walls and hypermetabolic lesions occupying cardiac chambers in some areas. The patient underwent systemic chemotherapy, and after 13 days, a marked regression of the tumour mass was evident based on echocardiographic examination. After completing six R-CHOP chemotherapy treatments, PET imaging was planned to control the residual mass, but the patient was intubated due to pneumonia that developed after the sixth chemotherapy session and subsequently died due to sepsis.
Effect of percutaneous transluminal coronary angioplasty on QT dispersion and heart rate variability parameters
(Clinics Cardive Publ Pty, 2009) Aydınlar, Ali; Şentürk, Tunay; Özdemir, Bülent; Kaderli, Aysel Aydın; Aydın, Özlem; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0002-8974-8837; AAI-6632-2021; C-1517-2017; 6603131517; 8342098300; 7004168959; 7801322152; 57197050271
Background: The aim of the study was to analyse parameters reflecting the sympathovagal control of ventricular depolarisation and repolarisation [heart rate variability (HRV) and QT interval dispersion (QTd)] in patients undergoing elective percutaneous transluminal coronary angioplasty (PTCA), and determine whether HRV correlates with QT dispersion parameters. Methods: The study consisted of 26 consecutive patients (16 men, 10 women) with single-vessel coronary artery disease (CAD) who underwent elective coronary angioplasty. HRV analyses of all subjects were obtained with the time-and frequency-domain methods. For frequency-domain analysis, low-frequency HRV (LF), high-frequency HRV (HF) and the LF: HF ratio were measured. For time-domain analysis, standard deviations of the normal-to-normal QRS intervals (SDNN) and square roots of the mean squared differences of successive N-N intervals (rMSSD) were obtained. QT intervals were also corrected for heart rate using the Bazett's formula, and the corrected QT interval dispersion (QTcd) was then calculated. All measurements (HRV parameters and QTcd) were made before and immediately after PTCA. Results: QTcd was significantly decreased after PTCA (52.2 +/- 3.5 vs 42 +/- 3.9 ms). SDNN (94.1 +/- 22 vs 123.9 +/- 35.2 ms), rMSSD (43.7 +/- 20.1 vs 73.4 +/- 14.5 ms) and HF (51.1 +/- 48.8 vs 64.2 +/- 28.6 ms(2)) were significantly higher after PTCA, whereas LF (142 +/- 41.5 vs 157.2 +/- 25.9 ms(2)) and the ratio of LF: HF (3.3 +/- 1.9 vs 2.1 +/- 1.2) were significantly decreased after PTCA. We observed a significant negative correlation after PTCA between QTcd and LF (r = -0.87, p = 0.01) and between QTcd and the ratio of LF: HF (r = -056, p < 0.05). Conclusion: Among the patients with CAD undergoing PTCA, QTcd significantly decreased after PTCA, and negatively correlated with LF, the parameter reflecting the sympathetic system.
Effect of rosiglitazone, metformin and medical nutrition treatment on arterial stiffness, serum MMP-9 and MCP-1 levels in drug naive type 2 diabetic patients
(Elsevier, 2009-10) Duran, Cevdet; Kıyıcı, Sinem; Ersoy, Canan; Kaderli, Aysel Aydın; Fazlıoğlu, Murat; Budak, Ferah; Gül, Özen Öz; Sığırlı, Deniz; Baran, İbrahim; Tuncel, Ercan; Ertürk, Erdinç; İmamoğlu, Sazi; Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; AAJ-6536-2021; AAA-7472-2021; F-4657-2014; AAI-1005-2021; 12753880400; 6701485882; 7801322152; 23988764000; 6701913697; 26040787100; 24482063400; 35572557400; 7006929833; 7005488796; 6602297533
The aim of the study was to evaluate the long-term effect of rosiglitazone and metformin monotherapy with medical nutrition treatment (MNT) and of MNT alone on arterial stiffness, serum monocyte chemoattractant protein (MCP)-1 and matrix metalloproteinase (MMP)-9 in drug naive patients with type 2 diabetes mellitus. Fifty type 2 diabetic patients were randomized to receive rosiglitazone 4 mg/day (n = 19) or metformin 850 mg/day (n = 16) with MNT or MNT alone (n = 15), for 52 weeks. Arterial stiffness was assessed by using large and small artery elasticity index (SAEI and LAEI, respectively). SAEI, LAEI, serum MCP-1 and MMP-9 levels were measured at baseline and following 52 weeks of treatment. SAEI was improved only in the rosiglitazone group, and the difference was still statistically significant when the three groups were compared (p = 0.024). There were no differences in LAEI in inter- and intragroup comparisons at the end of the study. Serum MMP-9 levels were decreased in the metformin (-13.5 +/- 34.8%, p = 0.02) and rosiglitazone (-27.2 +/- 51.0%, p = 0.023) groups compared with baseline values, whereas no significant change was seen in serum MCP-1 levels. These results suggest that rosightazone monotherapy has favorable effects on arterial stiffness compared with metformin monotherapy independent of glycemic control.
Effects of carvedilol on left ventricular functions and 24-hour blood pressure profile of dipper and non-dipper hypertensive patients
(Springer, 2007-11) Şentürk, Tunay; Kaderli, Aysel Aydın; Özdabakoğlu, Osman; Özdemir, Bülent; Baran, İbrahim; Güllülü, Sümeyye; Yeşilbursa, Dilek; Aydınlar, Ali; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0002-8974-8837; AAI-6632-2021; C-1517-2017
Endothelin antagonists may be a treatment option for cardiac syndrome x, or not ?
(Elsevier, 2013-10-29) Günay, Şeyda; Baran, İbrahim; Aydınlar, Ali; Serdar, Osman Akın; Güllülü, Sümeyye; Yeşilbursa, Dilek; Özdemir, Bülent; Kaderli, Aysel Aydın; Şentürk, Tünay; Sağ, Saim; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0001-8404-8252; 0000-0002-8974-8837; 0000-0003-0012-345X; AAW-9185-2020; AAF-5116-2019; AAI-6632-2021; AAI-5350-2021; C-1517-2017
Evaluation of left ventricular function with pulsed wave tissue doppler echocardiography in patients with subclinical hyperthyroidism
(Elsevier Ireland, 2010-04) Aydın, Özlem; Güllülü, Sümeyye; Şentürk, Tunay; Kaderli, Aysel Aydın; Özdemir, Bülent; Baran, İbrahim; Aktaş, Özlem; Aydınlar, Ali; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0002-8974-8837; C-1517-2017; AAI-6632-2021
Increased tei index in patients with early grade pulmonary sarkoidosis
(Elsevier, 2010-04) Kaderli, Aysel Aydın; Güllülü, Sümeyye; Coşkun, Funda; Uzaslan, Esra; Yılmaz, Dilber; Şentürk, Tunay; Özdemir, Bülent; Aydınlar, Ali; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; 0000-0002-8974-8837; 0000-0003-3604-8826; AAI-6632-2021; C-1517-2017; AAD-1271-2019
Mitral valve thrombosis and infective endocarditis in a patient with prothrombin mutation
(Taylor & Francis, 2006) Güllülü, Sümeyye; Kaderli, Aysel Aydın; Özdemir, Bülent; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 57204660708; 7801322152; 7004168959
This report deals with a 25-year-old female patient, who was admitted to a medical centre with complaints of fatigue and arthralgia. A non-homogeneous mass originating from the posterior papillary muscle and reaching the posterior and anterior cusps of the mitral valve was evident on the patient's echocardiogram. Her intractable fever, despite adequate antibiotic therapy, led us to consult with the cardiac surgeons. A mitral valve replacement was performed on the 8(th) day of admission. The pathological examination of the mitral valve and the vegetative lesion revealed the presence of organized thrombus and infective endocarditis. The patient had a history of oral contraceptive use for one year and at genetic examination we detected a heterozygous prothrombin mutation (G20210A). The association of infective endocarditis with native mitral valvular thrombosis in a case with prothrombin mutation and history of oral contraceptive use encouraged us to share our experience with our colleagues.
Myocardial performance is impaired in patients with branch retinal vein occlusion
(Sage Publications, 2015-02-01) Kaderli, Berkant; Kaderli, Aysel Aydın; Güllülü, Sümeyye; İnan, Ümit Ubeyt; Şentürk, Tunay; Aydınlar, Ali; Yücel, Ahmet Ali; Avcı, Remzi; Kaderli, Berkant; GÜLLÜLÜ, NAZMİYE SÜMEYYE; ŞENTÜRK, TUNAY; AYDINLAR, ALİ; YÜCEL, AHMET ALİ; Kaderli, Aysel Aydın; Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; AAI-6632-2021; C-1517-2017; FDM-9757-2022; CXL-7581-2022; EXG-3181-2022; JYV-1141-2024
Objective To investigate whether the Tei index, which is an indicator of global myocardial function and an independent predictor of cardiac death, is increased in patients with branch retinal vein occlusion (BRVO).Methods The Tei index was used to evaluate myocardial performance, in addition to conventional echocardiographic evaluation of myocardial structural and functional changes, in patients with BRVO, patients with hypertension and healthy controls.Results Out of 36 patients with BRVO (18 female, 18 male; 17 hypertensive, 19 normotensive), 29 patients with hypertension (15 female, 14 male) and 28 healthy controls (15 female, 13 male), there were no significant between-group differences in age and sex. The mitral A wave was higher and mitral E/A ratio, mitral E wave and ejection time were lower, in patients with BRVO than in healthy controls. Mean Tei index was significantly higher in the BRVO group than in patients with hypertension or healthy controls. Compared with healthy controls, the Tei index was significantly higher in hypertensive and normotensive patients with BRVO.Conclusion Myocardial performance is decreased in patients with BRVO, independent of whether or not they have hypertension.
Paraoxonase 1 enzyme activity in metabolic syndrome patients without coronary artery disease
(Elsevier, 2011-03) Yücel, Elif Özata; Aydınlar, Ali; Kaderli, Aysel Aydın; Şentürk, Tünay; Günay, Şeyda; Özdemir, Bülent; Baran, İbrahim; Güllülü, Sümeyye; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0003-0012-345X; 0000-0002-8974-8837; AAI-5350-2021; C-1517-2017; AAI-6632-2021
Post-discharge heart failure monitoring program in Turkey: Hit-PoinT
(Kare Yayıncılık, 2016-02-19) Çavuşoğlu, Yüksel; Zoghi, Mehdi; Eren, Mehmet; Bozcali, Evin; Kozdağ, Güliz; Alicik, Güray; Soylu, Korhan; Sarı, İbrahim; Berilgen, Rida; Temizhan, Ahmet; Gencer, Erkan; Orhan, Ahmet Lütfü; Polat, Veli; Aktoz, Meryem; Zengin, Halit; Aksoy, Mehmet; Selçuk, Mehmet Timur; Ergene, Oktay; Soran, Özlem; Şentürk, Tunay; Kaderli, Aysel Aydın; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; C-1517-2017; 8342098300; 7801322152
Objective: The aim of this study was to assess the efficacy and feasibility of an enhanced heart failure (HF) education with a 6-month telephone follow- up program in post-discharge ambulatory HF patients. Methods: The Hit-Point trial was a multicenter, randomized, controlled trial of enhanced HF education with a 6-month telephone follow-up program (EHFP) vs routine care (RC) in patients with HF and reduced ejection fraction. A total of 248 patients from 10 centers in various geographical areas were randomized: 125 to EHFP and 123 to RC. Education included information on adherence to treatment, symptom recognition, diet and fluid intake, weight monitoring, activity and exercise training. Patients were contacted by telephone after 1, 3, and 6 months. The primary study endpoint was cardiovascular death. Results: Although all-cause mortality didn't differ between the EHFP and RC groups (p=NS), the percentage of cardiovascular deaths in the EHFP group was significantly lower than in the RC group at the 6-month follow up (5.6% vs. 8.9%, p=0.04). The median number of emergency room visits was one and the median number of all cause hospitalizations and heart failure hospitalizations were zero. Twenty-tree percent of the EHFP group and 35% of the RC group had more than a median number of emergency room visits (p=0.05). There was no significant difference regarding the median number of all-cause or heart failure hospitalizations. At baseline, 60% of patients in EHFP and 61% in RC were in NYHA Class III or IV, while at the 6-month follow up only 12% in EHFP and 32% in RC were in NYHA Class III or IV (p=0.001). Conclusion: These results demonstrate the potential clinical benefits of an enhanced HF education and follow up program led by a cardiologist in reducing cardiovascular deaths and number of emergency room visits with an improvement in functional capacity at 6 months in post-discharge ambulatory HF patients.
Postoperative regression of clubbing at an unexpected rate in a patient with aortic and mitral valve replacement due to infective endocarditis
(Springer, 2009-09) Özdemir, Bülent; Şentürk, Tunay; Kaderli, Aysel Aydın; Keçebaş, Mesut; Güllülü, Sümeyye; Baran, İbrahim; Özdabakoğlu, Osman; Aydınlar, Ali; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0002-8974-8837; C-1517-2017; AAI-6632-2021; 7004168959; 8342098300; 7801322152; 36198369900; 57204660708; 35572557400; 25221805700; 6603131517
Pulmonary diseases such as malignancies, empyema, bronchiectasis, digestive tract malignancies, inflammatory bowel diseases, cyanotic congenital heart diseases and infective endocarditis can cause clubbing. We present a 63-year-old female patient with infective endocarditis, who had clubbing that resolved very rapidly after cardiac surgery due to rupture of the mitral papillary muscle. She had persistent fever and in her echocardiographic examination rupture of the papillary muscle of the anterior mitral valve and significant aortic regurgitation was noted. She was scheduled for emergency operation and had debridement and replacement of the mitral and the aortic valves. During the follow-up, she had complaints of pain in the distal parts of the fingers. The convex shape of the nails changed and basal portions were apparently thinner and paler than the previous thickened and discoloured, hyperkeratotic nails. This newly growing tissue rapidly replaced the old thick nails in 3 days.