Browsing by Author "Uğras, Nesrin"

Now showing 1 - 3 of 3

Evaluation of cystic lesions of the pancreas based on clinicopathologic parameters
(Carbone Editore, 2015-01-01) Atalay, Fatma Öz; Uğras, Nesrin; Aytaç, Berna; Yerci, Ömer; ÖZ ATALAY, FATMA; UĞRAŞ, NESRİN; AYTAÇ VURUŞKAN, BERNA; YERCİ, ÖMER; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; AAH-9746-2021; AAH-2716-2021; JHC-4482-2023; EGD-8703-2022
Aims: To identify demographic, histopathologic and immunohistochentical features of pancreatic cystic lesions, which could assist diagnosis of neoplastic ones.Materials and methods: Sixty-seven cystic lesions from pancreatic resections between 2001 and 2013 were studied. Patient demographics and cyst location and size were recorded. Forty-sir specimens with adjacent non-lesional parenchyma were evaluated for pancreatic intraepithelial neoplasia (PanIN). Neoplastic cysts were immunohistochemically tested for ki67, p53, and progesterone receptor. Ten high-power fields were examined to determine ki67 proliferative index (PI; average percentage of nuclear staining) and p53 status (<1% stained nuclei indicating negative). Presence/absence of progesterone receptor (PR)-positive nuclei in pericystic stromal cells Was recorded.Results: Eighteen (26.9%) of the 67 lesions were non-neoplastic and 49 (73.1%) were neoplastic. Serous cystadenomas (SCAs) were most common (n=23: 34.3%), and 59 (88%) of the patients were women. Mean ages for the mucinous cystic neoplasm (MCN) and SCA subgroups were 46.7 and 64.6 years, respectively, and these lesions tended to be in the pancreatic tail and head, respectively. ki67 PI was higher for non-invasive MCNs with high-grade dysplasia than low-grade dysplasia (20% vs. 4-6%, respectively). No neoplasms were p53-positive. Only MCNs were PR-positive. SCA was the lesion most frequently associated with PanIN.Conclusion: Age of patient and the location of cyst are distinctive features in neoplastic pancreatic cysts. Diameter of the cyst gives an idea about the malignancy potential of the lesions. In MCNs. considering the increased risk of multiple foci of varying degrees of dysplasia, ki67 proliferative index is useful as well as the adequate sampling of the cyst for the accurate diagnosis of these foci, particularly when the presence or degree of it cannot he adequately assessed in hematoxylin and eosin (HE)-stained sections.
Malignant glomus tumor with oncocytic features: An unusual presentation of dysphagia
(Wiley, 2015-07-01) Uğras, Nesrin; Yerci, Ömer, I.; Yalçınkaya, Ulviye; Gülcü, Barış; Öztürk, Ersin; Yıldırım, Çınar; Çavuşoğlu, İlkin; UĞRAŞ, NESRİN; YERCİ, ÖMER; YALÇINKAYA, ÜLVİYE; Gülcü, Barış; Öztürk, Ersin; Yıldırım, Çınar; Çavuşoğlu, İlkin; Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Gastroenteroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.; 0000-0002-9600-9418; AAH-8924-2021; AAH-2716-2021; JIO-2609-2023; JII-0241-2023; JGW-0566-2023; GCS-6830-2022; JIV-8745-2023
Glomus tumors in the gastrointestinal tract are unusual, as the previous series in the literature have been mainly limited to the stomach. Less than 10 cases of esophageal glomus tumors have been described in the literature. Oncocytic glomus tumors are a recently identified, rare variant of the glomus tumor. We report a 47-year-old female who presented with an approximately 3-month history of dysphagia and weight loss. Upper gastrointestinal endoscopy showed a black-purple, hypervascular, protruding lesion measuring approximately 65mm at the 37th cm of the esophagus. The patient underwent an Ivor Lewis operation via open thoracotomy. The resected specimen had a protuberant, ulcerated mass measuring 80x35mm in the posterior wall of the esophagus. Based on the histopathological, immunohistochemical and electron microscope findings, the final diagnosis was a malignant glomus tumor with oncocytic features. To our knowledge, this is the first report of a malignant glomus tumor with oncocytic features in an esophageal location.
Perforation of the small intestine caused by enteropathy-associated t cell lymphoma
(Aves, 2018-09-01) Kabul, Selva; KABUL, SELVA; Uğras, Nesrin; UĞRAŞ, NESRİN; Yerci, Ömer; YERCİ, ÖMER; Öztürk, Ersin; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; AAH-2716-2021; CAF-3650-2022
Enteropathy-associated T cell lymphoma is a rare lymphoma specific to the gastrointestinal system, arising from intraepithelial T lymphocytes, that is often associated with celiac disease. We report a 53-year-old female patient with no previous disease who presented with severe abdominal pain. Physical examination revealed diffuse abdominal tenderness and abdominal guarding and the patient underwent emergency surgery with a diagnosis of acute abdomen. During the operation, a 20-cm mass was found located on Treitz ligament, invading the duodenum and pancreatic head and perforating the jejunum. Histologically, medium-sized monomorphic atypical lymphocyte infiltration with dark nucleus and narrow cytoplasm was seen in the layers of mucosa, submucosa, muscular wall, and serosa of the duodenum. The final pathological diagnosis was "enteropathy-associated T cell lymphoma type 2" based on immunohistochemical and serological findings. Based on the World Health Organization 2008 criteria, enteropathy-associated T cell lymphoma has two subtypes. Type 1 enteropathy-associated T cell lymphoma is associated with celiac disease and has HLA DQ2 and HLA DQ8 genotype. Enteropathy-associated T cell lymphoma 2 enteropathy-associated T cell lymphoma seldom occurs and is not associated with celiac disease.