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Publication The niplette for the nonsurgical correction of inverted nipples(Churchill Livingstone, 1995-03-01) Özcan, Mesut; Kahveci, Ramazan; ÖZCAN, MESUT; KAHVECİ, RAMAZAN; Uudağ Üniversitesi/Tıp Fakültesi.; 0000-0001-8861-0417; AAG-4626-2019Publication Yazar tespit edilemedi -- Evaluation of dna damage using the comet assay in children on long-term benzathine penicillin for secondary prophylaxis of rheumatic fever(Blackwell Publishing Asia, 2001-06-01) Dündaröz, R; Ulucan, H; Denli, M; Karapinar, K; Aydin, HI; Baltaci, V; 0000-0002-2261-9811; 0000-0001-7994-4394; AHD-1839-2022; AAU-3018-2020Backround: Benzathine penicillin is the most widely used antibiotic in the prophylaxis of children with rheumatic fever. The aim of the present study was to evaluate the DNA damage in children receiving one dose of 1.2 million units benzathine penicillin every 4 weeks over a long period to prevent recurrences of rheumatic fever.Methods: Thirty-five children with confirmed rheumatic fever under benzathine penicillin prophylaxis were enrolled in the study and 35 healthy children with similar ages and socioeconomic backgrounds served as controls. To detect any DNA damage, the comet assay was performed on circulating lymphocytes from the study subjects.Results: Damaged (limited and extensive migration) cells in children on prophylactic therapy were higher than those in controls (P<0.001).Conclusions: It has been suggested that differences in the comet scores were induced by the administration of benzathine penicillin over a long period of time and further investigations are needed to confirm this toxic effect.Publication Investigation of apc mutations of a patient with fap and her family members by heterodublex analyses(Nature Publishing Group, 2002-05-01) Menigatti, M; Benatti, P; Pedroni, M; Scarselli, A; Borghi, F; Sala, E; Yerci, O; de Leon, MP; TUNCA, BERRİN; Çeçener, Gülşah; YILMAZLAR, AHMET TUNCAY; ÇEÇENER, GÜLŞAH; Yılmazlar, Tuncay; Zorluoglu, A; EGELİ, ÜNAL; Yerci, Ömer; YERCİ, ÖMER; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Medikal Biyoloji ve Genetik Anabilim Dalı.; 0000-0002-1619-6680; 0000-0002-3820-424X; 0000-0001-7904-883X; AAH-1420-2021; ABI-6078-2020Publication Outcome is worse in male compared to female de novo aml patients and can be improved with the use of granulocyte colony stimulating factor(g-csf) during induction.: Results of a randomized multicentric trial(Turkish leukemia study group (tlg95-002).(Amer Soc Hematology, 2002-11-16) Beksaç, M; Özcan, M; Dündar, S; Bayık, M; Paydaş, S. A; Büyükaşık, Y; İlhan, O; Gürman, G; Uysal, A; Akan, H; Akcağlayan, E; Özdemir, O; Tunalı, Ahmet; Ali Rıza, Yıldız; Özkalemkaş, Fahir; ÖZKALEMKAŞ, FAHİR; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; AAG-8495-2021Publication Emotional stress and aging(Medimond Publishing Co, 2003-01-01) Park, AJ; Tokullugil, H. A; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; Park, AJSenescence is that phase of the life span that is associated with an increasing probability of dying. A fundamental feature of senescence is "the diminished ability to maintain homeostasis".Stress is any real (physical.) or imagined (psychological and/or emotional) threatening situation, in which cellular hoincostasis is disturbed. In humans, mental or physical tension or strain, urgency, pressure, anxiety are conditions associated with stress. Physical or psychological stressors produce responses via the same cascade. Acute stress responses (the first wave) are immediate motor and cognitive responses. Chronic or prolonged stress responses (the second wave) are more delayed neuroendocrine responses. In humans, glucocorticoids (GCs); mainly cortisol increase to stress levels in the second wave, which is particularly responsible from the neuroendocrine effects.GCs have two types of receptors: Type I, mineralocorticoid receptor (MR, high affinity-low capacity) and Type II, glucocorticoid receptor (GR, low affinity-high capacity). MRs may play a role in regulating circadian changes in corticosteroid production. They regulate stress responses by negative feedback inhibition (NFBI) of the HPA-axis under physiological or basal conditions. Whereas, GRs become occupied during chronic stress and when there is excess release of GCs.The deleterious effects of GCs in the nervous system mainly are; disruption of learning, memory and plasticity (and cognition), inhibition of dentate neurogenesis, atrophy of the neuronal processes, endangerment of hippocampal neurones and neurotoxicity. GC exposure (i.e. basal concentrations) begin to increase somewhat linearly from late middle ages. "The feed-forward cascade" can partly explain the reason of this increase. Hippocampus is a negative feedback mediator of GC secretion. This is accomplished via hippocampal inhibitory projections to CRH neurones in the hypothalamus. Thus, hippocampal damage and down regulation of hippocampal GRs cause transient GC hypersecretion. Therefore, rising of basal levels of GCs and hippocampal neurone loss occur. So, impaired feedback mechanisms at the level of GRs contribute to "the hyperactivation of the HPA axis" with age. As a result clinically common findings of aging in humans at present can be summarised as following (note that, there are individual variations):1- Decline in cognitive vitality and learning and memory disorders2- Laboratory findings (without an existence of other medical comorbidities): a) Increase in the basal levels of HPA axis hormones: GCs (mainly cortisol), ACTH and CRH and b) Resistance to suppression tests.3- MRI (magnetic resonance imaging): Hippocampal atrophy and volume loss4- Histological findings (Practically not possible, only in biopsy specimens or in post-mortem analysis): Dendritic atrophy, Tau protein inclusions, and. neurone loss.So it can be concluded taht, "if we are sorry or make stress because of aging we must be aware of the danger that we may enhance the aging processes more".Publication Technology management in textile mills through optimization(Technical Univ Crete, 2003-01-01) Rusu, C; İskender, M. A.; Becerir, B.; BECERİR, BEHÇET; Bursa Uludağ Üniversitesi/Mühendislik Fakültesi/Tekstil Mühendisliği Bölümü.; Rusu, C; 0000-0002-2655-2773; AAH-1445-2021Decision - making is an important part of technology management in the textile industry because of the quickly changing consumer demands. Optimization can be considered as one of the major quantitative tools in decision - making. Many problems are associated in the design, operation and productivity of textile mills under the force of increasing competition. These can be resolved only by applying optimization procedures. Optimization can take place at many levels and in many procedures in a textile company from the material supply to the delivery of the goods to the customer. Optimization problems can be found in management, in operations or in equipment A coordination of these levels is necessary for the technological management in the mill.Publication Effect of some postharvest treatments and controlled atmosphere (ca) storage on basic quality criteria of peaches and nectarines(International Society Horticultural Science, 2003-01-01) Verlinden, B.E.; Nicolai, B.M.; DeBaerdemaeker, J.; Akbudak, B; Eriş, A; Bursa Uludağ Üniversitesi/Ziraat Fakültesi.; Verlinden, BE; Nicolai, BM; DeBaerdemaeker, JThe peach (Flavorcrest and Red Top) and nectarine (Fantasia and Fairlane) cultivars used in this study were stored in normal (NA) and controlled atmosphere (CA) conditions [(CO2%:O-2%) 3:3, 5:2, 10:2] consisting of 0+/-0.5degreesC temperature and 90+/-5% relative humidity in three years. Peaches and nectarines were subjected to some treatments (fungicide solution, low O-2 and intermittent warming treatment) either before or during storage. Physical and chemical changes (weight loss, respiration rate, fruit flesh firmness, titratable acidity, total sugar, overall appearance) were recorded at 15-day intervals during 45 day storage and after 10 day shelf life at the end of the storage. The results show that fruits of cv. Flavorcrest were stored more successfully in 5:2, fruits of cv. Red Top in 5:2 and partially 10:2, and fruits of cvs. Fantasia and Fairlane in 10:2 atmosphere combinations, compared with other treatments.Publication Competitive strategies of fruit and vegetable processing industry inTurkey(International Society Horticultural Science, 2003-01-01) Tijskens, LMM; Vollebregt, HM; Çetin, Bahattin; Turhan, S; TURHAN, ŞULE; İrkin, Rehan; Bursa Uludağ Üniversitesi/Ziraat Fakültesi/Tarım Ekonomisi Bölümü.; Tijskens, LMM; Vollebregt, HM; 0000-0002-6838-2215; P-6789-2019; AAG-8086-2021Fruit and vegetable processing industry is very important for Turkey regarding both the internal and the external market. A review of Turkish agricultural history shows that dramatic changes have occurred in fruit and vegetable industry. It seems evident that changes will continue for the coming years. Especially developments of South Marmara Regions fruit and vegetable processing industry provide a good example for the agri-food sector.Today, consumer preferences drive markets. Reshape of the international agricultural trade is required due to, mainly, the globalisation of the markets. This will give growers more competition and the issues of marketing, international trade, environmental protection and government policies will be important factors for them.The aim of this study it to examine the current situation of Turkish fruit and vegetable processing industry and highlight some points for the competitiveness of the industry. SWOT analysis was applied regarding the product quality, consumption, production, imports, exports and structure of market competition and distribution aspects.Publication Correlation of behavioral and psychological symptoms of alzheimer's disease with caregiver burden, depression and anxiety levels(Cambridge Univ Press, 2003-01-01) Sivrioğlu, Y.; Taneli, B.; Sarandöl, A.; SİVRİOĞLU, ENVER YUSUF; Taneli, Baha; SARANDÖL, ASLI; Uludağ Üniversitesi/Tıp Fakültesi.; DTC-7187-2022; DZC-3645-2022; JKB-3005-2023Publication Determination of some biochemical parameters in the seminal plasma of german shepherd dogs(Scientific Technical Research Council Turkey, 2003-01-01) Polat, Ü; Mustafa Kemal; SOYLU, MUSTAFA KEMAL; Kil, F.; Günay, G.; GÜNAY, ÜLGEN; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Dölerme ve Suni Tohumlama Anabilim Dalı.; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Biyokimya Anabilim Dalı.; ACB-3704-2022In this study, we aimed to determine the levels of some biochemical parameters in the seminal plasma of German Shepherd dogs. Seven German Shepherd dogs were used as materials. A total of 35 ejaculates, five from each dog, were collected. The seminal plasma of each ejaculate was separated by centrifugation at 5000 rpm for 10 min. Biochemical analyses of the seminal plasma were performed. In conclusion, the average concentrations of total protein, calcium, phosphorus, magnesium, sodium and potassium were 3.75 +/- 0.21 g/dl, 3.22 +/- 0.32 mg/dl, 2.49 +/- 0.25 mg/dl, 4.50 +/- 0.37 mg/dl, 137.25 +/- 1.98 mEq/l and 12.25 +/- 0.69 mEq/l, respectively.Publication Physical and biochemical changes during controlled atmosphere (CA) storage of cv. Granny Smith(International Society Horticultural Science, 2003-01-01) Özer, Mecid Hakan; Akbudak, Bülent; Verlinden, BE; Nicolai, BM; DeBaerdemaeker, J; Ertürk Ümran; ÖZER, MECİD HAKAN; ERTÜRK, ÜMRAN; Akbudak, Bülent; Uludağ Üniversitesi; Verlinden, BE; Nicolai, BM; DeBaerdemaeker, J; AAH-4101-2021; AAG-7343-2021; EJP-0187-2022In order to determine the possibility of controlled atmosphere (CA) storage of apple (Malus communis L. cv. Granny Smith), two trials were carried out with the fruits taken from the same place during the successive two years. Following the harvest, fruits were transported to the cold storage and then they were stored in plastic cells of 120-L volume in which the inner atmosphere could be controlled. Having completed the precooling treatment, the fruit cv. Granny Smith were stored at 0+/-0.5degreesC and 90-95% relative humidity (RH) storage conditions under different CA combinations [(CO2%:O-2%) 0:21; normal atmosphere (NA)-control, 3:1, 3:1.5, 3:2 and 3:2.5]. After the storage period, they were kept at 20+/-2degreesC and 60-65% RH for 5 days so as to determine their shelf life. Some physical and biochemical analyses such as weight loss (%), respiration rate (Mg CO2/kg h), titratable acidity (TA) (%), pH, water soluble solids (WSS) (%), fruit flesh firmness (FFF) (lb), pectin esterase (PE) activity (ml/h), fruit skin colour (L, a, b) were conducted on samples which were taken at certain intervals during storage and shelf life periods. As a result, all CA applications were found better compared with the control application in cv. Granny Smith stored for 210+5 days. Among CA applications, 3:1.5 combination was determined to be better than the others.Publication Tachyphylaxis and the sequential use of nerve blocks(Lippincott Williams & Wilkins, 2003-04-01) Karacalar, Serap; Karacalar, Ahmet; Şahin, Süner; Türker, G; TÜRKER, YUNUS GÜRKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji Anabilim Dalı.; 0000-0002-3019-581X; AAI-6642-2021Publication Blood, slaughter and carcass characteristics of male turkeys following quantitative feed restriction between 8 to 16 weeks of age(Indian Veterinary Journal, 2003-05-01) Gündüz, H; Meral, İsmail; Ak, İbrahim; Mert, Nihat; Bursa Uludağ Üniversitesi/Ziraat Fakültesi.; 0000-0001-7185-3316; HJH-5486-2023Publication Long-term persistent indocyanine green (icg) fluorescence after intravitreal icg administration for macular surgery(Assoc Research Vision Ophthalmology Inc, 2003-05-01) Avcı, Remzi; Yıldız, M.; Kaderli, Berkant; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; 0000-0001-9581-4856; AAH-1885-2021Publication Serum free choline and phospholipid-bound choline concentrations and endocrine responses during and after coronary bypass surgery.(Amer Assoc Clinical Chemistry, 2003-06-01) İlçöl, Yeşim Özarda; Gören, S.; Moğol, Evren; Ulus, İsmail; Şahin, Şükran; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Anabilim Dalı.; AAL-8873-2021; D-5340-2015Publication The effects of dry period and various lactation stages on blood Na+ and K+ concentrations in holstein cows(Ecole Nationale Veterinaire Toulouse, 2003-12-01) Çetin, Mustafa; Galip, N.; Polat, Ü.; POLAT, ÜMİT; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı. ; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Biyokimya Anabilim Dalı.; 0000-0001-7542-6602; B-3607-2015This study was carried out on eighty Holstein dairy cows of four years of age and in their second lactation from Bursa region of Turkey. Twenty of them were in dry period and the rest were in lactation period. The days 48-51(st), 147-161(st) and 180. and over were accepted as first, second and third period, respectively. Blood samples taken from animals into heparinized tubes were analysed for erythrocyte sodium, erythrocyte potassium, whole blood sodium, whole blood potassium and haematocrit. There was no statistically significant effect of lactation periods on examined parameters except haematocrit.Publication Interleukin-10 IFN-γ cytokine gene polymorphisms can be risk factors for chronic myelogenous leukemia(Elsevier, 2004-01-01) Baştürk, Bikay; Evke, Elif; Tunalı, Ahmet; Karakuş, Sema; Evke, Elif; Tunalı, Ahmet; Uludağ Üniversitesi/Tıp Fakültesi/Genetik Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Hemotoloji Anabilim Dalı.; COH-2496-2022; ECL-6239-2022Publication Production of chimeric cattle embryos by reaggregation of blastomeres obtained from day 4 bovine embryos(Tubitak Scientific & Technological Research Council Turkey, 2004-01-01) Sağırkaya, Hakan; SAĞIRKAYA, HAKAN; Bursa Uludağ Üniversitesi/Veteriner Fakültesi.; AAH-8821-2021The aim of this study was to investigate the possibility of producing chimeric bovine embryos by reaggregating blastomeres of disaggregated day 4 bovine embryos. Oocytes were obtained from a slaughterhouse. Selected oocytes were matured, fertilized and cultured in vitro. Fertilization day was taken as day 0. Blastomeres of day 4 embryos were disaggregated and then pooled together. Chimeric embryos were randomly constructed by reaggregating blastomeres in empty zonae pellucidae. Non-chimeric handled control embryos were produced by transferring blastomeres from each embryo into their own empty zonae pellucidae. A total of 79 day 4 cattle embryos were used for disaggregation of blastomeres, and 27 chimeric and 12 non-chimeric handled control embryos were obtained from them. The rates of blastocyst formation of chimeric and non-chimeric handled control embryos were 40.7% (11/27) and 50.0% (6/12). respectively, and the difference between them was not statistically important (P > 0.05). These results showed the possibility of producing chimeric cattle embryos by reaggregating blastomeres obtained from day 4 embryos.Publication Renal carcinoma in a cat(Indian Veterinary Journal, 2004-02-01) Sevimli, Alper; Mısırhoğlu, D.; Gölcü, Esin; Yılmaz, Zeki; YILMAZ, ZEKİ; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0001-9836-0749; A-9637-2008Publication Effect of the paramunity activator baypamun on canine transmissible venereal tumour(Indian Veterinary Journal, 2004-03-01) ÖZYİĞİT, MUSA ÖZGÜR; Mısırlıoğlu, D.; CANGÜL, İBRAHİM TACİ; Kahraman, MM; Seyrek-İntas, K; Sevimli, A.; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.; AAH-7292-2019; AAR-6478-2021; AAB-4360-2021An investigation was undertaken to evaluate the effect of Baypamun*, a Parapox ovis based paramunity activator, in the prophylaxis and treatment of experimentally induced canine venereal tumour (TVT).