PubMed

Permanent URI for this collectionhttps://hdl.handle.net/11452/24864

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CK19, CK20, EGFR and HER2 status of circulating tumor cells in patients with breast cancer
(Sage Publications, 2012) Tunca, Berrin; Egeli, Ünal; Çeçener, Gülşah; Tezcan, Gülçin; Gökgöz, Şehsuvar; Taşdelen, İsmet; Bayram, Nuran; Tolunay, Şahsine; Umut, Görkem; Demirdöğen, Elif; Ertürk, Elif; Ak, Seçil; Çetintaş, Sibel; Evrensel, Türkkan; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/İktisadi ve İdari Bilimler Fakültesi/Ekonometri Bölümü.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı.; 0000-0001-5492-184X; 0000-0002-9732-5340; 0000-0002-3820-424X; 0000-0001-7904-883X; 0000-0002-1619-6680; 0000-0002-5956-8755; 0000-0002-9038-0515; 0000-0002-4483-9284; AAG-9068-2021; AAA-7047-2020; AAH-3843-2020; AAJ-1027-2021; AAP-9988-2020; AAH-1420-2021; ABI-6078-2020; AAI-1612-2021; F-8554-2017; 6602965754; 55665145000; 6508156530; 25650627600; 6603238737; 9637821500; 13609585600; 6602604390; 37058220200; 25644460900; 50261655300; 55253485700; 6505881756; 6603942124
Aims and background. The major cause of death in breast cancer patients is metastasis. Various biomarkers have been used for the early detection of circulating tumor cells in the peripheral blood of breast cancer patients. The aims of the current study were to analyze circulating tumor cells in the blood of breast cancer patients by investigating EGFR, CK19, CK20 and HER2 expression profiles and to evaluate their prognostic importance. Methods. CK19, CK20 and EGFR gene expression profiles were evaluated in the blood samples of 84 female patients with primary invasive ductal breast cancer and 20 healthy female volunteers using SYBR green-based real-time qPCR assays. HER2 expression analyses were conducted in 46 patients who had an HER2-positive primary tumor and in 30 healthy women to determine the cutoff level of positivity. Results. The positive rates of CK20, EGFR, CK19 and HER2 mRNA expression in the peripheral blood were 28.57% (24/84), 20.23% (17/84), 5.95% (5/84) and 2.17% (1/46), respectively. The high positive ratio of CK20 mRNA expression in the peripheral blood of breast cancer was identified for the first time in the current study. Significant differences were identified in CK20 expression status and several clinical parameters related with aggressiveness of tumors using a binary logistic regression analysis. Higher CK20-positive levels were observed in patients who had lymph node metastasis and advanced-grade primary tumors, which were estrogen receptor-negative. We have demonstrated that CK20 may be a novel biomarker that is useful to identify circulating tumor cells and predict breast cancer progression. Conclusions. The results suggest that the investigation of CK20 mRNA with other biomarkers in the peripheral blood of breast cancer patients may be useful to monitor the presence of disseminated tumor cells in the blood circulation and to predict the prognosis of breast cancer.
Job related affective well-being among primary health care physicians
(Oxford University, 2007-10) Yeşim, Uncu; Bayram, Nuran; Bilgel, Nazan; Uludağ Üniversitesi/Tıp Fakültesi/ Aile Hekimliği Anabilim Dalı.; Uludağ Üniversitesi/İktisadi ve İdari Bilimler Fakültesi/Ekonometri Bölümü.; 0000-0001-5492-184X; 0000-0002-5225-4403; 0000-0002-4539-5849; D-9597-2016; AAG-9068-2021; 8892370600; 13609585600; 7801564702
Background: Job related affective well-being is important for a healthy life and job satisfaction for all individuals, including physicians. The later group, however, is most often compromised. Objectives: We aimed to investigate a group of Turkish primary health care physicians' job related emotional perceptions and to assess their reactions in terms of stress, anxiety and depression. Methods: A descriptive, cross-sectional, self-reported questionnaire study was conducted. A total of 60 primary health care centres and 274 general practitioners who were working at these centres participated in the study. The response rate was 74%. Printed questionnaires were completed by the participants anonymously. We used the Job Related Affective Well-Being Scale (JAWS) and Depression Anxiety Stress Scale (DASS 42). Correlation analysis and hierarchic regression were performed. Results: Correlations between JAWS and DASS total scores were negative and statistically significant (r = -0.52; P< 0.01). Low pleasure/high arousal (LPHA) and low pleasure/low arousal (LPLA) variations that describe negative emotional states show a positive and significant relationship with depression, anxiety and stress values. The highest mean score was obtained for the high pleasure/low arousal (HPLA) status that can be interpreted to mean that our study group was pleased with their job but was not motivated. Conclusions: Physician's job related negative emotional perceptions are associated with reactions in terms of stress, anxiety and depression. For this reason, it is critical to consider primary care physicians' job related affectations and job related stimuli.
Prevalence of depression, anxiety, stress, and anger in turkish prisoners
(Wiley, 2013-05-17) Ünver, Yener; Yüce, Mehmet; Bayram, Nuran; Bilgel, Nazan Gönül; Uludağ Üniversitesi/İktisadi ve İdari Bilimler Fakültesi/Kamu Maliyesi Bölümü.; Uludağ Üniversitesi/İktisadi ve İdari Bilimler Fakültesi/Ekonometri Bölümü.; Uludağ Üniversitesi/Tıp Fakültesi/Aile Hekimliği Anabilim Dalı.; 0000-0001-5492-184X; 0000-0002-4539-5849; AAG-9068-2021; AAG-7390-2021; 57091324400; 13609585600; 7801564702
In Turkey, prison studies are rare and the mental health status of prisoners has not received proper attention. The purpose of this cross-sectional and descriptive study was to assess the prevalence of depression, anxiety, stress, and anger among a group of Turkish prisoners. Two self-reporting instruments (the Depression Anxiety Stress Scale-42 and Multidimensional Anger Scale) were filled out by 685 prisoners. Prisoners in the study group were found to be depressive, anxious, and stressed. Anger symptoms and aggressive behaviors were found to be at a moderate level. Prisoners with a history of being subjected to domestic violence in childhood had higher depression, anxiety, and stress scores than those without such a history. Young prisoners, those who had been previously imprisoned, with substance dependency and higher stress and anxiety levels reported more anger symptoms than others. Psychological support, together with stress and anger management programs, seems to be essential.
The promoter hypermethylation status of GATA6, MGMT, and FHIT in glioblastoma
(Springer/Plenum Publishers, 2012-03) Çeçener, Gülşah; Tunca, Berrin; Egeli, Ünal; Bekar, Ahmet; Tezcan, Gülçin; Ertürk, Elif; Bayram, Nuran; Tolunay, Şahsine; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nöroşirurji Anabilim Dalı.; Uludağ Üniversitesi/İktisadi ve İdari Bilimler Fakültesi/Ekonometri Bölümü.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-1619-6680; 0000-0001-5492-184X; 0000-0002-5956-8755; 0000-0002-3820-424X; 0000-0001-7904-883X; AAK-3371-2021; AAH-3843-2020; AAP-9988-2020; AAH-1420-2021; F-8554-2017; AAI-1612-2021; ABI-6078-2020; AAG-9068-2021; 6508156530; 6602965754; 55665145000; 6603677218; 25650627600; 50261655300; 13609585600; 6602604390
Glioblastoma (GBM) is an aggressive and lethal cancer, accounting for the majority of primary brain tumors in adults. GBMs are characterized by large and small alterations in genes that control cell growth, apoptosis, angiogenesis, and invasion. Epigenetic alterations also affect the expression of cancer genes, either alone or in combination with genetic mechanisms. The current evidence suggests that hypermethylation of promoter CpG islands is a common epigenetic event in a variety of human cancers. A subset of GBMs is also characterized by a locus-specific and genome-wide decrease in DNA methylation. Epigenetic alterations are important in the molecular pathology of GBM. However, there are very limited data about these epigenetic alterations in GBM. Alterations in promoter methylations are important to understand because histone deacetylases are targets for drugs that are in clinical trial for GBMs. The aim of the current study was to investigate whether the promoter hypermethylation of putative tumor suppressor genes was involved in GBM. We examined the methylation status at the promoter regions of GATA6, MGMT, and FHIT using the methylation-specific polymerase chain reaction in 61 primary GBMs. Our results reveal that there is no promoter hypermethylation of FHIT in the examined GBM tissue specimens. In contrast, the promoter hypermethylation of GATA6 and MGMT was detected in 42.8 and 11.11% of GBMs, respectively. The frequency of MGMT promoter hypermethylation was low in the group of patients we evaluated. In conclusion, our study demonstrates that promoter hypermethylation of MGMT is a common event in GBMs, whereas GATA6 is epigenetically affected in GBMs. Furthermore, inactivation of FHIT by epigenetic mechanisms in GBM may not be associated with brain tumorigenesis.
Quality of life among Turkish immigrants in Sweden
(Springer, 2007-10) Demirhan, Haydar; Bayram, Nuran; Thorburn, Daniel; Bilgel, Nazan; Uludağ Üniversitesi/İktisadi ve İdari Bilimler Fakültesi/Ekonomi Bölümü.; Uludağ Üniversitesi/Tıp Fakültesi/Aile Sağlığı Anabilim Dalı.; 0000-0001-5492-184X; 0000-0002-4539-5849; AAG-9068-2021; 13609585600; 7801564702
Ojectives To assess quality of life among Turkish immigrants in Sweden by using the WHOQOL-100 scale and to evaluate the domains' contribution to explain the variance in the quality of life of the immigrants. Our hypothesis was QOL among Turkish immigrants in Sweden are better than Turkish people who are living in their home country. Materials and methods This study was performed in the districts of Stockholm where Turkish immigrants have mostly settled. With the help and guidance of the Turkish Association, a sample of 520 participants was selected. We collected the demographic data by printed questionnaires, and to measure the quality of life, we used the WHOQOL-100 scale Turkish version. For analysis, we used the SPSS V.13.0 and R package programs, variance analyses, and Bayesian regression. Results The quality of life among the sample of Turkish immigrants was found to be moderate, but higher than the sample of the Turkish population. The quality of life of male immigrants was found to be higher than for females. Swedish-born Turks had better quality of life perceptions. Conclusions Turkish immigrants' quality of life perceptions were better than those of the Turkish sample. The best scores were received from the third generation. The first generation and female immigrants need attention in order to receive higher quality of life perceptions.
Turkish general practitioners and complementary/alternative medicine
(Mary Ann Liebert, 2007-11) Mazıcıoğlu, M. Mümtaz; Özçakır, Aliş; Sadıkoğlu, Ganime; Bayram, Nuran; Bilgel, Nazan; Beyhan, Işık; Uludağ Üniversitesi/İktisadi ve İdari Bilimler Fakültesi/Ekonometri Bölümü.; Uludağ Üniversitesi/Tıp Fakültesi/Aile Hekimliği Anabilim Dalı.; 0000-0001-5492-184X; 0000-0001-5588-2037; 0000-0002-4539-5849; AAG-9068-2021; AAG-8209-2021; 9733230000; 22956348700; 13609585600; 7801564702; 23027059100
Background: Complementary and alternative medicine (CAM) is in the spotlight of society. However, what is the position of physicians at this point? Objectives: To determine general practitioners' (GP) knowledge, attitudes, and approaches to CAM. Methods: All GPs (n = 521) practicing in Bursa Province, Turkey were surveyed by a questionnaire. Results: Responses from 49% of GPs were analyzed. Alltogether, most of our physicians (96.5%) had not received any education about CAM, wanted to learn more (74.4%), and their knowledge levels were low (60.8%). About half of them (51%) believed in the efficiency of CAM, whereas 38.0% did not. GPs desire more information about herbal medicine and acupuncture. Only 29% of GPs were using some type of CAM for themselves. Conclusions: GPs are aware of the subject's importance and want to learn more about CAM and improve their knowledge. It would be reasonable to provide training possibilities for GPs, primarily for the CAM types highly used by the population and most requested by the physicians.

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