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Recent Submissions
Evaluation of diagnosis and treatment results in children with graves' disease with emphasis on the pubertal status of patients
(Freund Publishing House Ltd, 2008-08-01) Poyrazoğlu, Sükran; Saka, Nurcin; Baş, Firdevs; İşgüven, Pınar; Doğu, Ayşegül; Turan, Serap; Turan, Abdullah; Sarıkaya, Sevil; Adal, Erdal; Çizmeci, Filiz; Sağlam, Halil; Ercan, Oya; Memioğlu, Nihal; Guenoz, Hülya; Bundak, Ruveyde; Darendeliler, Feyza; Yıldız, Metin; Güran, Tülay; Akçay, Teoman; Akın, Leyla; Hatun, Şükrü; SAĞLAM, HALİL; Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0003-0710-5422 ; C-7392-2019
This retrospective study evaluated the clinical and laboratory characteristics at presentation and treatment results of patients with Graves' disease (GD) with respect to pubertal status. Records of 143 patients (108 F, 35 M) were reviewed in a multicenter study. At diagnosis., 38% of patients were prepubertal. Anti-thyroid drugs (ATD) were used as initial therapy. There was no significant difference in clinical and laboratory characteristics at diagnosis, during treatment and adverse reaction to ATD with respect to pubertal status. Twenty patients (7 prepubertal, 13 pubertal) reached remission on ATD. Surgery was performed in seven and radioiodine (RAI) in four patients. Duration of treatment needed to achieve remission was longer in prepubertal (4.2 +/- 1.0 yr) than in pubertal patients (3.1 +/- 1.3 yr) (p = 0.02). The rate of remission was not different between prepubertal (25.9%) and pubertal patients (33.3%) (p = 0.59). ATD were associated with low remission rate in pediatric GD and required longer duration of therapy in prepubertal patients. For definitive treatment in older children, RAI could be evaluated as the initial therapy.
Reevaluation of the electroencephalogram recordings of patients with nonconvulsive status epilepticus by using salzburg consensus criteria
(Wolters Kluwer Medknow Publications, 2022-04-01) Timer, Emin; Yilgor, Abdullah; Bebek, Nerses; Baykan, Betül; Oğuz-Akarsu, Emel; OĞUZ AKARSU, EMEL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; IZQ-0662-2023
Objective: Nonconvulsive status epilepticus (NCSE) is a challenge to diagnose in some cases, and recently, Salzburg consensus criteria for NCSE (SCC-NCSE) were developed to contribute to clinical practice. We aimed to investigate their validity and usefulness by reevaluating the electroencephalogram (EEG) examinations of our patients in this study. Materials and Methods: We retrospectively evaluated all EEG recordings of patients diagnosed with NCSE by experienced clinical neurophysiologists in our EEG laboratory over a period of 2 years. Two neurologists trained in EEG reanalyzed all EEG data and categorized these patients as NCSE, possible NCSE, or non-NCSE using the SCC-NCSE. Results: Twenty-nine patients with a mean age of 31.5 & PLUSMN; 25.9 were reanalyzed. According to the SCC-NCSE, 24 patients (82.7%) were diagnosed as NCSE. Eighteen patients (62%) who fulfilled all SCC-NCSE were diagnosed as NCSE, whereas six patients (20.7%) were diagnosed only as possible NCSE. Five patients (17.3%) did not fulfill SCC-NCSE; the reasons are the lack of additional secondary criteria in 2 patients with encephalopathy, the absence of full compliance with the criteria in other 2 patients, and a diagnosis of electrical status epilepticus during sleep in the last patient. Conclusion: The results of our study show that SCC-NCSE is highly consistent with clinical practice to decide for the diagnosis of NCSE. The evaluation of NCSE according to a set of new standardized criteria is thought to be difficult in practice, but it provides a more objective assessment. Therefore, we believe that its use should be encouraged to increase experience and the possibility of correct diagnosis.
Use of posaconazole for pulmonary mucormycosis in persistent febrile neutropenia: A case report
(Aves, 2011-04-01) Erbay-Apaydin, Fatma; Orhan, Bulent; Bilgi, Selçuk; Akalın, Halis; AKALIN, EMİN HALİS; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.; 0000-0001-7530-1279; AAU-8952-2020
Pulmonary mucormycosis is an opportunist fungal infection with high mortality. Posaconazole, an azole antifungal which has a proven efficacy against zygomycetes in vitro, has been shown to be useful as salvage therapy in various studies. We reported herein a lymphoma patient with persistent febrile neutropenia treated for invasive aspergillosis who developed pulmonary mucormycosis subsequently, and shared our experience on his treatment using posaconazole as salvage therapy following amphothericin B, which is thought to enhance survival because of the positive outcome achieved.
The histopathological and molecular diagnosis of myocardial sarcocystosis in sheep, and the immunohistochemical correlation of parasitic lesions with mmp-2 and mmp-9
(Univ Zagreb Vet Faculty, 2022-01-01) Yilmaz, Rahsan; Ayan, Adnan; Yumusak, Nihat; Akkoc, Ahmet; AKKOÇ, AHMET; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.; DTZ-3578-2022
This study was aimed at the histopathological and immunohistochemical level investigate cardiac tissue lesions caused by Sarcocystis spp. in sheep, and thereby, to collect detailed information on the presence of these parasites and the pathogenesis of sarcocystosis in ovine animals. PCR, a molecular diagnostic method, was used for the identification of the parasite species. Microscopic examination revealed that out of the 45 ovine cardiac tissue samples examined 23 contained Sarcocystis spp. cysts. The PCR analysis results showed that out of the 23 cardiac tissue specimens infected with sarcocysts, 7 were determined to be infected with Sarcocystis gigantea and 16 with Sarcocystis tenella. Immunohistochemical examination demonstrated that, semiquantitatively, MMP -9 staining was stronger than MMP -2 staining in the periphery of the parasite cysts.
Optical soliton solution analysis for the (2+1) dimensional kundu-mukherjee-naskar model with local fractional derivatives
(Springer, 2022-07-01) San, Sait; Seadawy, Aly R.; Yaşar, Emrullah; YAŞAR, EMRULLAH; Bursa Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Matematik Anabilim Dalı.; 0000-0003-4732-5753; AAG-9947-2021
In this paper, we investigate the local fractional Kundu-Mukherjee-Naskar (LFKMN) equation in (2+1) dimensional case. The Yang's local fractional calculus tool has fulfilled a significant character in defining the fractal behaviours in a fractal space or microgravity space that arise in applied nonlinear sciences. The travelling wave transformation of the non-differentiable type is introduced and we retrieve successfully the non-differentiable exact traveling wave solutions (soliton pulses in (2+1)-dimensions) of LFKMN equation with aid of generalized exp-function method in the form of generalized functions described on Cantor sets. With the help of Mathematica package program, 3D graphs were drawn for the special values of the parameters in the solutions, and the physical structures of the solutions obtained in this way were also observed. The solutions obtained can be used in the explanation of physical phenomena occurring in propagation of rogue waves in oceans and higher order optical solitons in optical fibers in current-like nonlinearities.The deduced explicit solutions will cause a new pathway of the nonlinear wave theory by the help of local fractional derivative. The proposed approach is demostrated to ensure a beneficial tool to solve the local fractional nonlinear evolution equations in applied nonlinear sciences.
