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Browsing by Author "000-0002-9534-736X"

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    Contingent role of phoenixin and nesfatin-1 on secretions of the male reproductive hormones
    (Wiley, 2019-12) Güvenç, Gökçen; Altınbaş, Burçin; Kaşıkçı, Esra; Özyurt, Ebru; Baş, Ayşenur; Udum, Duygu; Niaz, Nasir; Yalçın, Murat; Uludağ Üniversitesi/Veteriner Fakültesi.; 0000-0002-1413-3651; 000-0002-9534-736X; 0000-0003-1591-510X; 0000-0001-7052-1694; 0000-0002-5600-8162; AAR-6815-2021; IYS-2646-2023; CZB-8484-2022; GDW-7164-2022; AAH-5167-2021; AAC-4975-2022; AAG-6956-2021; 56529426800; 55356919300; 57209073902; 57211540698; 57211534062; 31967936400; 7060367600; 57192959734
    Phoenixin (PNX) and nesfatin-1 are localised in the hypothalamus and the pituitary gland. Moreover, the most of the PNX-expressing neurons in the hypothalamus also co-express nesfatin-1. These outcomes may suggest that there is an interaction between PNX and nesfatin-1, at least in terms of neuroendocrine-mediated regulations. Hence, the study was planned to find out the effects of centrally delivered PNX and nesfatin-1 on male sex hormones or to show the interactive association of intracerebroventricularly (ICV) injected PNX+nesfatin-1 combination on the release of male hormones. PNX and nesfatin-1, single or together, were delivered ICV to different male Wistar Albino rat groups. Both PNX and nesfatin-1 induced a significant enhancement in plasma FSH, LH and testosterone without inducing any alteration in plasma GnRH in the rats. The central combinatorial treatment of both the neuropeptides produced a more potent rise in male plasma hormone levels than treating with single neuropeptide. In summary, our preliminary data show that centrally delivered PNX and nesfatin-1 can affect plasma male hormone levels. Moreover, that the combinatorial treatment with both the neuropeptides in male rats leading to a more potent effect on the plasma male hormone levels might suggest that both these neuropeptides act synergistically in terms of regulation of male HPGA.