Browsing by Author "Çetin, Melike"

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Bir buzağıda salter-harris tip ı metacarpus kırığının açılı kama plağı ile sağaltımı
(Uludağ Üniversitesi, 2016-12-12) Salcı, Hakan; Canatan, Uygur; Çetin, Melike; Uludağ Üniversitesi/Veteriner Fakültesi.
Bu olgu sunumu ile bir buzağıda Salter-Harris Tip I metacarpus kırığında uyguladığımız 90° açılı kama plağının postoperatif klinik ve radyolojik bulgularının rapor edilmesi amaçlanmıştır. Holstein melezi, 3,5 aylık, dişi bir buzağı ön bacağında kırık şikayeti ile kliniklerimize getirildi. Klinik muayenede, buzağının vital parametreleri normaldi ancak inspeksiyonda sağ ön ekstremitede şiddetli topallık, metacarpophalangeal eklem proksimalinde şişkinlik ve sıyrık yarası gözlendi. Ortopedik muayenede, bölgede spesifik kırık bulguları saptandı. Radyografik muayenede, sağ metacarpusun distal fizeal hattan kırılarak (Salter-Harris Tip I) disloke olduğu belirlendi. Hasta sahibine bilgi verildi ve genel anestezi hastanın operasyonuna karar verildi. Kırığın redüksiyonu sonrası fiksasyon için 90° açılı kama plağı kullanıldı. Plağın kama kısmı epifiz kısma çakıldı ve plaka vidalarla proksimal fragmente tespit edildi. Postoperatif atel destekli bandaj uygulandı. Rutin analjezik ve antibiyotik uygulama prosedürü reçete edildi. Buzağının postoperatif 15. gün kontrolünde, kırık bölgesinde stabilizasyonun devam ettiği, buzağının ilgili ekstremitesini bandajsız kullanabildiği gözlendi.
Echocardiographic diagnosis and surgical correction of aortopulmonary window in a Belgian Shepherd Dog (Malinois)
(Ankara Üniversitesi, 2015-01-01) Kocaturk-Ocal, Meric; Salcı, Hakan; Çetin, Melike; Karapınar, Tolga; Yılmaz, Zeki; KOCATÜRK, MERİÇ; SALCI, HAKAN; Çetin, Melike; YILMAZ, ZEKİ; Uludağ Üniversitesi/Veteriner Fakültesi.; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; 0000-0002-2849-1222; 0000-0001-9836-0749; A-9637-2008; V-5578-2017; T-4623-2019; AAB-1790-2022
A 20-month-old, female Belgian Malinois Dog was referred for evaluation on exercise intolerance. A high-grade machinery murmur, tachycardia, and cardiomegaly were observed. An aortopulmonary window was diagnosed by a color-Doppler echocardiography showing a turbulent blood flow shunting from the proximal part of ascendance aorta to the main pulmonary artery. This cardiac anomaly was corrected by surgery. Dog was treated by furosemide, pimobendan, and enalapril during post-operative 7 days. 1-year after the surgery, life quality of the patient was perfectly good. This is the first report of this rare congenital heart disease and its successful outcome of surgically correction in Belgian Malinois Dogs.
Echocardiographic, magnetic resonance angiography and pathologic results of an iliac arterial thromboembolism (Saddle thrombus) in a cat
(Kafkas Universitesi, 2016) Salcı, Hakan; Kocatürk, Meriç; İpek, Volkan; Çetin, Melike; Kahraman, M. Müfit; Yılmaz, Zeki; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.; 0000-0001-5874-7797; 0000-0001-9836-0749; V-5578-2017; T-4623-2019; ABZ-7197-2022; JIU-4079-2023; CYB-9080-2022; A-9637-2008; 8680329000; 36437200800; 57201969000; 56393942900; 6701778876; 35944810500
Evaluation of pulmonary infection risk in dogs with pulmonary contusion
(Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 2017-03-31) Salcı, Hakan; Kahya, Serpil; Çetin, Melike; Akkoç, Ahmet; Bayram, Ahmet Sami; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Mikrobiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; 0000-0003-0684-0900; T-4623-2019; AAH-2842-2021; ABB-7580-2020; 8680329000; 35368679200; 56393942900; 55584229300; 8347194000
There is a dilemma about usage and selection of the antibiotics following pulmonary contusion. Thus, this study aimed to evaluate pulmonary infection risk in dogs with pulmonary contusion. In total, eleven dogs with pulmonary contusion included in the study. Diagnosis of the pulmonary contusion and its degrees were determined based on the clinical and radiological findings. Under general anesthesia, bronchoscopy and bronchoalveolar lavage (BAL) was applied on 0, 24 and 48(th) h and BAL samples were collected. Cytological examination, culture and antibiotic susceptibility analysis of the BAL samples were performed. Clinically, mild, moderate and severe degree pulmonary contusions were diagnosed, but radiological results pointed out severe degree of pulmonary contusion in all dogs. Bronchoscopy showed the hemoptysis in all dogs except one. Cytologically, all preparations had the inflammatory results at 0(th) hour and these were increased at 24 and 48(th) hours. Additionally, evidence of infection was determined in the cytological preparations of four dogs (case 1, 2, 5 and 8) taken at 0, 24 and 48(th) hours. These cytological results were compatible with microbiological results of case 1, 2, 5 and 8. Pasteurella multocida in case 1 and 2, and Escherichia coli in case 5 and 8 was cultured microorganism from the BAL samples, separately. While P. multocida was resistant to gentamicin, erythromycin and oxytetracycline; E. coli was resistant only sulfamethoxazole/trimethoprim. In conclusion, it may be stated that pulmonary contusion triggers inflammation process, and if there is a pathogenic opportunistic flora in the lower respiratory tracts, the pulmonary infections might accompany with inflammation process. Thus, if it is able, antibiotic usage must be planned considering to the results of BAL culture and antibiogram tests.
Histologic and electromyographic evaluation of neuroregenerative effect of stromal vascular fraction following neuroanastomosis
(Kafkas Üniversitesi, 2020-03-23) Acar, Hilal; Çerçi, Ece; Khezri, Marzieh Karimi; Çetin, Melike; Canatan, Uygur; Şen, Mehmet Metin; Aslan, Vildan; Sarıl, Canan Altıncı; Temiz, Elif Mekik; Taşkapılıoğlu, Mevlüt Özgür; Erdost, Hatice; Salcı, Hakan; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nöroşirürji Anabilim Dalı.; 0000-0001-5472-9065; 0000-0003-0154-9938; 0000-0001-9650-0891; 0000-0001-5323-6891; 000-0003-1547-7293; 0000-0001-6548-8754; AAH-9216-2021; AAI-6861-2021; AAW-5254-2020; ABB-8161-2020; 57209653860; 57212212053; 57216947212; 56393942900; 57189443508; 57216950078; 57200994296; 57216954758; 57216945905; 25936798300; 6505787570; 8680329000
In this study, histologic and electromyographic (EMG) evaluation of neuroregenerative effect of stromal vascular fraction (SVF) following periferal nerve anastomosis was aimed. Totally, 31 Wistar Albino, male rats (weighing about 300 g) were studied, and these rats were grouped according to surgical techniques performed on the right sciatic nerve: group I (GRI) micro suture (n=7), group II (GRII) micro suture + SVF (n=7), group III (GRIII) fibrin glue (n=7) and group IV (GRIV) fibrin glue + SVF (n=7). Fat tissue was taken from 3 rats to prepare SVF, and SVF was produced by non-enzymatic method. The left sciatic nerve of all rats was evaluated for EMG as control. Under general anesthesia, after transversal incision of the sciatic nerve, microsurgical epineural repair technique was performed with 10/0 nonabsorbable suture. EMG examinations were performed in terms of conduction rate, amplitude, distal latency and spontaneous muscle activity at 0th day and postoperative (PO) 1st and 8th weeks. EMG results between and within the groups were statistically evaluated by one-way analysis of variance. Rats in all groups were sacrificed by decapitation at PO 8th week and histological examinations of the sciatic nerves were performed following preparation of the neural tissues. EMG examination results showed the highest nerve conduction in GRI, the highest amplitude in GRIII, normal latency in GRII and longer distal latency in GRIV at PO 8th week. Amplitude and conduction velocity increased gradually in all groups. In needle EMG, the best muscle membrane stabilization was achieved in GRII and GRIV at PO 8th week. Statistically, the values of amplitude, distal latency, conduction velocity, and spontaneous muscle activity were found to be at normal levels at PO 8th week in all groups (P>0.05). In the histological results, although fibroconnective tissue reactions in the anastomosis area had similar scores in GRII and GRIV, maximum fibroconnective tissue reaction and the best axonal regeneration was seen in GRI and GRIII, respectively. In addition, GRI and GRII had the most inflammatory cells accumulation in the suture region, and less inflammatory cells were seen in the anastomosis area of GRIII and GRIV. As a conclusion, fibrin glue presents good electrophysiological and histological results; however, it is clear that local SVF usage on the nerve anastomosis area can be a good choice to decrease fibroconnective tissue reaction and inflammation.
Bir koyunda aşil tendo rupturu sağaltımında uygulanılan kompresyon vidası ile geçici calcaneo-tibial fiksasyon
(Uludağ Üniversitesi, 2015-12-30) Çetin, Melike; Akgül, Mustafa Barış; Kurt, Hasan; Salcı, Hakan; Uludağ Üniversitesi/Veteriner Fakültesi.
Merinos ırkı, 1,5 yaşlı bir koyun sağ arka ekstremitesini kullanamıyor şikayeti ile kliniklerimize getirildi. İnspeksiyonda, koyun sağ metatarsusları üzerine basmaktaydı. Aşil tendosunun palpasyonda tendojen gerginliğin olmadığı hissedildi. Tanısal görüntüleme yöntemleri yardımıyla (radyoloji ve ultrasonografi) aşil tendo rupturu tanısı doğrulandı. Genel anestezi altında rupture olmuş aşil tendosu Bunnell-Mayer yöntemi ile dikildi ve tendonun iyileşmesine destek olması için tarsal eklemin normal konumda bir kompresyon vidası ile geçici olarak calcenao-tibial fiksasyonu sağlandı. Postop
Bir lori ırkı papağanda (lorius garrulus) rastlanan lipom olgusu
(Uludağ Üniversitesi, 2014-04-04) Akgül, Mustafa Barış; Şen, İsmail Altuğ; İpek, Volkan; Demirer, Aylin Alasonyalılar; Çetin, Melike; İntaş, Deniz Seyrek; Uludağ Üniversitesi/Veteriner Fakültesi.
Bu olgu sunumunda 21 yaşlı, erkek, lori ırkı (lorius garrulus) bir papağanda belirlenen tümöral oluşumun tanısı ve sağaltımından bahsedilmektedir. Hasta kliniğimize bir aydır boyun bölgesinde şişkinlik geliştiği şikayeti ile getirdi. Klinik muayenede boynun sağ tarafında ceviz büyüklüğünde, üzerindeki tüyler dökülmüş, katı-esnek kıvamda, sınırları belirgin bir yapı saptandı. Genel anestezi altında kitle ekstirpasyonu gerçekleştirildi. Örneğin histopatolojik değerlendirmesi sonucunda lipom olduğu belirlendi.
The milk protein polymorphism in saanen goats
(Indian Veterinary Journal, 2008-02) Türkyılmaz, Özhan; Çetin, Melike; Uludağ Üniversitesi/Veterinerlik Fakültesi/Biyokimya Anabilim Dalı.; ECA-3440-2022; CIO-6717-2022; 6506025005; 57197086676
Ruminant's caseins have been characterized in the bovine species (Gonyon et al., 1987, Eenennaam et al., 1991). In goat, genetic polymorphism has been described for alpha(s1) - alpha(s2) K and beta-casein (Bouinol et al., 1994; Jordana et al., 1996). In this study, it was aimed to investigate the milk protein polymorphism in Saanen goats.
Multinodular thyroid gland hypertrophy in a camel
(Camel Publishing, 2016-06) Salcı, Hakan; İpek, Volkan; Çetin, Melike; Akgül, Gülşah; Sönmez, Gürsel; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0001-5874-7797; T-4623-2019; ABZ-7197-2022; AAP-7233-2020; CIO-6717-2022; CBU-1718-2022; 8680329000; 57201969000; 56393942900; 56604015400; 55167435000
This case report include the clinical, haematology, radiology, ultrasound and cytology results of the multinodular thyroid hyperplasia in a camel. A fourteen-year-old, Tulu breed, male camel was presented with the complaint of respiratory sounds and gradually enlarging a swelling under the neck for one year. Clinical examination revealed a massive swelling, which was bilateral, symmetric, and located ventral and 1/3 cranial part of the neck and suspected to be the cause of the respiratory sounds. Routine haematology of the camel was normal but thyroid function tests had low TSH, high level T3 and T4. Radiology revealed peritracheal soft tissue opacity and tracheal deviation. Ultrasonographic examination revealed the heterogenic mass and numerous different echogenities (anechoic, hyperechoic) in the parenchyma (multinodular appearance). Ultrasound guided fine needle aspiration and then cytology was performed. Cytology pointed to thyroid hyperplasia. Iodine therapy was planned. After two months, the swelling regressed to about 30% rate and abnormal respiratory sounds also disappeared.
Palatoschisis, brachygnathia inferior and accessory mandibular mass in a Simmental breed calf
(Sivar-Soc Italiana Veterinari Animali Reddito, 2020-06) Şen, Mehmet; Canatan, Uygur; Özfırat, Erencan; Çetin, Melike; Salcı, Hakan; Bursa Uludağ Üniversitesi/Veteriner Fakültesi.; 0000-0001-9650-0891; 0000-0001-6548-8754
Congenital anomalies in calves are encountered in different regions of the body. Generally, anomalies are seen in fronto-nasal, maxillar or mandibular regions. In addition several pathologies such as meningocele, cleft palate, nasal dermoid cyst, gingival vascular hamartoma are reported on the head. The aim of the present case report was to describe clinical and surgical result of palathoschisis, brachygnathia inferior and accessory mandibular mass in a Simmental calf. A 3-day-old male calf was referred with the complaint of milk discharge from the nose after suckling and an atypical structure in the mouth. At clinical examination, submandibular lymph nodes were swollen and physical examination results were normal. Oral examination revealed a cleft palate (palatoschisis), short lower jaw (brachygnathia inferior) and a pedunculated accessory mandibular mass midway between palatum durum and molle. However, the calf presented a good suction reflex. The accessory mandible was connected to the cleft palate and contained tooth-like structures. At palpation, the end portion of this mass was hard while its peduncle was soft in consistency. Radiographic exams on latero-lateral and ventro-dorsal projections of the cranium were carried out. The patient was subjected to surgical treatment; it was sedated with xylazine chloridrate (0.1 mg/kg im) and general anaesthesia was induced with ketamine chloridrate (4 mg/kg im). After tracheal intubation, general anesthesia was maintained with 2% isoflurane plus oxygen. The accessory mandible was removed by dissecting the surrounding tissues. Congenital cleft was closed through application of n degrees 0 suture silk with simple interrupted stitches. On the following day, the calf was discharged from the clinic with a postoperative recommended therapy including antibiotics (penicillin-streptomycin, 1x1.5 cc, im, for 5 days), analgesic (flunixin meglumin, 1.1 mg/kg, iv, for 3 days) and oral antiseptic (10% glycerin iode) drugs. According to the information obtained from the owner on the 15th postoperative day, calf 's appetite was normal and chewing movements were reported to be relatively good. As a result, multiple anomaly including palatoschisis, brachygnathia inferior and accessory mandible in a calf may occured in clinical practice and as in this case, the observed pathology was corrected by surgical intervention, and postoperative results were favorable.
Pulmoner kontüzyonlu köpeklerde klinik, laboratuvar, radyolojik ve bronkoskopik bulguların karşılaştırılması
(Uludağ Üniversitesi, 2019-12-24) Çetin, Melike; Salcı, Hakan; Uludağ Üniversitesi/Sağlık Bilimleri Enstitüsü/Cerrahi Anabilim Dalı.
Bu çalışmada pulmoner kontüzyonlu (PK) köpeklerde klinik, laboratuvar, radyolojik ve bronkoskopik bulguların karşılaştırılması amaçlandı. Çalışma materyalini kliniklere getirilen farklı ırk, yaş ve cinsiyette, PK tanısı konmuş toplam 26 adet köpek oluşturdu. Köpeklerin genel muayene, rutin hematolojik, kan gazı analizi, radyolojik ve genel anestezi altında bronkoskopik muayeneleri yapıldı. Bronkoskopi sonrası, sitoloji için bronkoalveolar lavaj (BAL) yapıldı. Tüm elde edilen bulgular kaydedildi. PK’nın radyolojik derecelendirmesine göre olgular grup 1 (n=16) (orta derece) ve grup 2 (n=10) (şiddetli derece) olarak ikiye ayrıldı. Her iki gruptaki olguların genel muayene, hematolojik değerler ile kan gazı analiz parametreleri gruplar arası olarak anlamlılık yönünden Mann Whitney U testi ile istatistiksel olarak analiz edildi. Genel muayenede pulzasyon ve respirasyonda yükselme, mukozal solgunluk, akciğer seslerinde anormallikler; hematolojik muayenede total lökosit ve nötrofilde yükselme, hematokrit ve trombosit değerlerinde düşme; kan gazı analizlerinde belirgin asidemi ve hipoksemi ile karşılaşıldı. Radyolojik olarak alveoler ve intersitisyel desen görünümlerine ilaveten 13 pnömotoraks, 4 plevral efüzyon, 2 kosta kırığı, 1 akciğer atelektazisi ve 1 yelken göğüs (flail chest) tanındı. Trakeobronkoskopide 9 şiddetli, 3 orta ve 7 hafif derecede kanama, 3 solgun ve 8 hiperemik mukoza gözlendi. Sitolojide, farklı olgularda nötrofil artışı, dökülmüş epitel hücresi, eritrosit, mukoprotein iplikler, makrofaj hücreleri, bakteri ve hiposelüler yapı gözlendi. İstatistiksel olarak gruplar arasında genel muayene, rutin hematolojik ve kan gazı analizi bulguları bakımından anlamlı bir farklılık saptanmadı. Sonuç olarak, sunulan çalışmada elde edilen genel muayene, rutin hematolojik ve kan gazı analizleri, radyolojik muayene ile birlikte trakeobronkoskopi ve BAL sıvısı sitolojisinin, PK’lı köpeklerin solunum sisteminin değerlendirilmesinde önemli olduğu görülerek, bu bulguların gerek veteriner pratiğe ve gerekse akademik çalışmalara katkı sağlayacağı kanısına varılmıştır.
The effect of rat adipose-derived stem cells in bone tissue regeneration
(Kafkas Univ, Veteriner Fakultesi Dergisi, 2022-04-05) İlhan, Tuncay; İLHAN, TUNCAY; SALCI, HAKAN; Akkoç, Cansel G. Özgüden; Çetin, Melike; Incebıyık, Ece; Canatan, Uygur; CANATAN, UYGUR; Salcı, Hakan; ERDOST, HATİCE; Erdost, Hatice; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Genel Cerrahi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı; 0000-0003-0712-0892; JDC-5958-2023; F-2822-2017
Stem cell approaches has been increasing in the conventional medicine. This study was planned to determinate the efficacy of adipose-derived stem cells (ADSCs) on the bone fracture's regeneration by histologically, morphologically and radiologically. Primarily isolated cells were cultivated and identified for the obtaining of the third passage mesenchymal stem cells in the cell culture laboratory. The right tibias (applicated ADSCs) were planned as experimental group and the left tibias were studied as control on the clinically healthy 10 rats. The middle diaphysis of the right and left tibias was transversally cut by a thin saw and then fixed by intramedullary pin. Before surgical closure of the incised area, 106 ADSCs were injected on an absorbent material, which covered the cut site of the right tibia, in experimental group. At postoperative 45th day, cranio-caudal and lateral radiographs of the tibias pointed out that there was callus formation in the caudal and lateral parts of the right tibia. After sacrification of the animals, preparations were made for histological examinations. The results indicate that there were clear differences in the mitotic activity; and also, the experimental tibias were found to be rich in blood vessel network. As a conclusion, it was found that ADSCs can have a positive potential effect on osteogenesis in bone tissue.
Tracheobronchoscopic, cytological and microbiological results of tracheal and bronchial collapse in dogs
(Polish Soc Veterinary Sciences Editorial Office, 2017-07-31) Salcı, Hakan; Çetin, Melike; Kahya, Serpil; Akkoç, Ahmet; Yılmaz, Özge; Canatan, Uygur; Çeşme, Hilal; Aslan, Vildan; Altıncı, Canan; Khider, Mohammed; Yılmaz, Zeki; Bayram, Ahmet Sami; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Mikrobiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; 0000-0001-9836-0749; 0000-0003-0684-0900; 0000-0002-6227-1098; AAI-6861-2021; AAH-2842-2021; AAG-7421-2021; T-4623-2019; A-9637-2008; ABB-7580-2020; 8680329000; 56393942900; 35368679200; 55584229300; 56524019400; 57189443508; 56951171800; 57200994296; 57200984827; 57200991560; 35944810500; 8347194000
The aim of this study was to evaluate the tracheobronchoscopic, cytological and microbiological results of tracheal and bronchial collapse in dogs. In total, 8 dogs were included in the study. Clinically, tracheal palpations of the dogs were reflective of tracheal disease, and all dogs coughed on tracheal palpation. Vital parameters and hematological values of the dogs were within the normal ranges. Radiological views of the respiratory tracts and thorax were largely normal, but distinctive tracheal contours were noted in cases 3 and 6. Tracheobronchoscopy was performed under general anesthesia, and endoscopic findings (mucosal surfaces and color, prominent appearance of vessels, chondral ring abnormalities of the trachea, and the presence of bronchial and tracheal collapse) were scored. Bronchoalveolar lavage (BAL) was performed to collect samples for cytological and microbiological analysis. Five cases had tracheal collapse, and two cases had right bronchial collapse. Concurrent tracheal and right bronchial collapse were diagnosed in one case. Cytological results were not indicative of inflammation or infection, but Escherichia coli was isolated from case 2 (bronchial collapse) and case 3 (tracheal collapse). Antibiotic susceptibility results revealed that the organisms were susceptible to sulfamethoxazole/trimethoprim. Statistically, there were no significant differences between the cases in terms of total endoscopic scores. In conclusion, tracheal and/or bronchial collapse should only be diagnosed by tracheobronchoscopic examination. Cytological and microbiological analyses of the BAL fluid in these cases do not always provide valuable data for clinical practitioners.