Browsing by Author "Çomunoğlu, Nil"

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Age-related histopathological changes in the cardiac conducting system in the Turkish population: An evaluation of 202 autopsy cases
(Via Medica, 2012-08) Çomunoğlu, Cem; Çomunoğlu, Nil; Eren, Bülent; Tanrıöver, Özlem; Gündoǧmuş, Ümit Naci; Eren, Filiz; Türkmen, Nursel; Uludağ Üniversitesi/Tıp Fakültesi/Adli Tıp Anabilim Dalı.; 8715251700
Background: Histopathological features of the cardiac conducting system (CCS) in the Turkish population have not been investigated previously. Material and methods: We examined CCS of 202 autopsy heart specimens dissected between the years 2004 and 2005 in Bursa Forensic Medicine Institution. Of the 202 cases from all age groups, 154 were males and 48 were females. Results: In our cases, an increase in fibrous and adipose tissue concordant with age, indicating an age-related nature, were detected. Fibrous and fatty tissue infiltration appeared at the age of 35. Fatty infiltration started between the ages 20 and 34 years at the sinoatrial node (SAN). There was no relationship between obesity and fatty tissue infiltration in SAN and atrioventricular node (AVN). In 4 cases calcification and in 19 cases inflammation was observed. Amyloid accumulation was not present. In 7 cases myocardial infarction not involving CCS was seen. In 1 case fibroelastoma was detected. Conclusions: In the Turkish population age-related fibrosis and fatty infiltration in CCS appeared at the age of 35 years and increased with age. Fatty infiltration in the SAN started at a younger age than that reported in the literature. In cases where the cause of death could not be determined, we could not detect lethal pathological features. However, we think that examination of the CCS will improve the quality of autopsy diagnosis.
Clusterin expression in non-neoplastic adenohypophyses and pituitary adenomas: Cytoplasmic clusterin localization in adenohypophysis is related to aging
(Humana Press, 2008) Ekici, Asiye Isin Dogan; Çomunoğlu, Nil; Eren, Bülent; Türkmen, Nursel; Fedakar, Recep; Uludağ Üniversitesi/Tıp Fakültesi/Adli Tıp Anabilim Dalı.; 0000-0002-2319-1757; AAA-6280-2020; AAU-7408-2020; AAK-8096-2021; AAX-8590-2021; AAX-8590-2021; 8725969000; 8715251700; 8725968900
Clusterin is a circulating multifunctional glycoprotein produced in several kinds of epithelial and neuronal cells. Clusterin is upregulated during different physiological and pathological states, such as senescence, type-2 diabetes mellitus, Alzheimer disease, and in various neoplasms. Herein, we investigated the immunohistochemical expression of clusterin in non-neoplastic adenohypophysis of human autopsy subjects and pituitary adenomas. We also investigated the association of clusterin increase with age in adenohypophysis of autopsy subjects. Immunohistochemically, clusterin was found positive in the cytoplasm of all adenoma cases, and in the cytoplasm of parenchymal cells, stellate cells, mixed cell follicles and in colloidal material inside of the follicles of non-neoplastic adenohypophysis as well. Clusterin expression in pituitary adenomas was found significantly higher than in non-neoplastic adenohypophyses. In addition, in non-neoplastic adenohypophysis, a significant increase in clusterin expression levels between young (<= 30 years), middle aged (31 to 60 years), and older (>= 61 years) subjects (p<0.00001, analysis of variance [ANOVA]) was found. In addition to clusterin accumulation, presence of calcification (p<0.045, ANOVA) and presence of large follicles with colloid accumulation (p< 0.004, ANOVA) were also statistically significant factors related to aging in non-neoplastic adenohypophysis. In conclusion, the present study demonstrated that clusterin expression was found in non-neoplastic adenohypophysis and in upregulated amounts in pituitary adenomas. This study also demonstrated that in non-neoplastic adenohypophyses, increase of clusterin positive cells; histopathological findings of calcification or presence colloidal material accumulation in large follicles were associated with age. To our knowledge, immunohistochemical localization of clusterin in pituitary adenomas was not reported previously.
Occult papillary thyroid carcinoma: Prevalence at autopsy in Turkish people
(Lippincott Williams & Wilkins, 2011-06) Tanrıöver, Özlem; Çomunoğlu, Nil; Eren, Bülent; Çomunoğlu, Cem; Gündoğmuş, Ümit Naci; Doğan, Müzeyyen; Türkmen, Nursel; Uludağ Üniversitesi/Tıp Fakültesi/Adli Tıp Anabilim Dalı.; 8715251700
The epidemiological features of occult papillary thyroid carcinoma (OPTC) at autopsy have not previously been reported in Turkish people. This study provides data on the prevalence of OPTC in people from the Marmara region in Turkey. The study includes thyroid glands from 93 male and 15 female cadavers between 18 and 80 years of age. The thyroid glands were removed, fixed and sectioned at 2-mm intervals. The sections were stained with hematoxylin and eosin, and were examined by a single pathologist. A total of 108 thyroid glands were examined. Macroscopic lesions were found in 36 (33.3%) glands (95% confidence interval = 24-42). OPTC was found in four (3.7%) cases (95% confidence interval = 1.0-7.5). It was concluded that in the Turkish people from the Marmara region, the prevalence of OPTC found at autopsy was relatively low. No age or sex predilection was detected. European Journal of Cancer Prevention 20:308-312.
Pericardial thymoma: An unusual cause of sudden death
(Acad Medicine Singapore, 2008-03) Şenel, Berna; Türkmen, Nursel; Çomunoğlu, Nil; Eren, Bülent; Fedakar, Recep; Uludağ Üniversitesi/Tıp Fakültesi/Adli Tıp Anabilim Dalı.; 0000-0002-8296-5484; 0000-0002-1054-6467; AAA-6280-2020; AAK-8096-2021; AAH-6287-2021; AAX-8590-2021; 8715251700; 55629968600; 8725969000; 8725968900
The relationship between histomorphological characteristics and Ki-67 proliferation index in meningiomas
(Comenius Univ, 2010) Öz, Bengi; Çomunoğlu, Nil; Akı, Hilal; Akyıldız, Elif Ülker; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı.; 55901306600
Objectives: This study had two aims. The first was to use the Ki 67 proliferation index (Ki-67 PI) to study the relationship between the proliferation potential and histopathological features such as mitosis, necrosis, loss of architecture, small cell change, hypercellularity, pleomorphism, brain invasion, dura invasion, bone invasion, and histological grade. The second aim was to compare primary and recurrent meningioma with respect to morphological characteristics and Ki-67 PI values. Background: Meningiomas are tumors whose histological features do not predict their biological behavior. Despite their slow growth and even after total resection, recurrence may occur Methods: A total of 245 meningioma cases in whom Ki-67 PI was studied were included in the study. The cases were assessed with respect to 10 morphological characteristics, and a possible significant relationship between these and Ki 67 PI was statistically tested. Results: We found a statistically significant relationship between Ki-67 PI and mitotic activity, necrosis, loss of architecture, small cell change,brain invasion. In contrast to brain invasion, no significant relationship was present between dura or bone invasion and Ki-67 PI. We identified asignificant increase in the histological grade, mitotic activity and Ki-67 PI value of recurrent tumors, as compared to primary ones Conclusion: Ki-67 PI values overlap in different grades. This overlapping might be due to the heterogeneity of biological activity within the tumor tissue (Tab. 2, Fig. 7, Ref. 21).
An unusual cause of sudden death: Cardiac myxoma
(Springer, 2007-05) Çomunoğlu, Nil; Türkmen, Nursel; Eren, Bülent; Fedakar, Recep; Uludağ Üniversitesi/Tıp Fakültesi/Adli Tıp Anabilim Dalı.; 0000-0002-8296-5484; AAH-6287-2021; AAK-8096-2021; 8715251700; 8725969000; 8725968900
Primary tumors of the heart are rare; the most common cardiac tumor is atrial myxoma. Sudden death may occur in patients with atrial myxoma, tumor embolization, or obstruction of blood flow at the mitral or tricuspid valve. This report describes an unusual cause of sudden death and the autopsy findings for a 73-year-old man with left atrial myxoma.