Browsing by Author "Öksüz, Mustafa Ferhat"
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Publication A nationwide experience with the off label use of interleukin 1 targeting treatment in familial mediterranean fever patients(Wiley, 2016-10-01) Akar, Servet; Çetin, Pınar; Kalyoncu, Umut; Karadağ, Ömer; Sarı, İsmail; Çınar, Muhammed; Yılmaz, Sedat; Onat, Ahmet Mesut; Kısacık, Bünyamin; Erden, Abdülsamet; Balkarlı, Ayşe; Küçükşahin, Orhan; Öner, Sibel Yılmaz; Şenel, Soner; Tufan, Abdurrahman; Direskeneli, Haner; Öksüz, Mustafa Ferhat; Pehlivan, Yavuz; Bayndır, Özün; Keser, Gökhan; Aksu, Kenan; Omma, Ahmet; Kaşifoğlu, Timuçin; Ünal, Ali Uğur; Yıldız, Fatih; Balcı, Mehmet Ali; Yavuz, Şule; Erten, Şükran; Özgen, Metin; Sayarıoğlu, Mehmet; Doğru, Atalay; Çetin, Gözde Yıldırım; Alibaz-Öner, Fatma; Tezcan, Mehmet Engin; Pamuk, Ömer Nuri; Önen, Fatos; Öksüz, Mustafa Ferhat; PEHLİVAN, YAVUZ; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; JXF-7598-2024; AAG-8227-2021Publication Agreement of patient and physician global assessment of disease activity in adult onset still's disease(BMJ Publishing Group, 2016-06-01) Kalyoncu, U.; Kaşifoğlu, T.; Kısacık, B.; Öksüz, Mustafa Ferhat; Omma, A.; Bes, C.; Çınar, M.; Pamuk, O. N.; Küçükşahin, O.; Akar, S.; Aksu, K.; Yıldız, F.; Onat, A. M.; Kanitez, N. A.; Erden, A.; Dalkılıç, Ediz; Ermurat, Selime; Hayran, M.; Öksüz, Mustafa Ferhat; DALKILIÇ, HÜSEYİN EDİZ; Ermurat, Selime; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Bölümü; ABE-4424-2022; CMF-4757-2022; JXF-7598-2024Item Anti-TNF-α tedavi ile remisyon sağlanmış ve tedavisi kesilmiş romatoid artrit, ankilozan spondilit ve psöriatik artrit hastalarındaki hastalık sürecinin değerlendirilmesi(Uludağ Üniversitesi, 2016-07-29) Kutlu, Nagehan Di̇k; Coşkun, Belkıs Nihan; Tufan, Ayşe Nur; Öksüz, Mustafa Ferhat; Ermurat, Selime; Özkaya, Güven; Pehli̇van, Yavuz; Dalkılıç, Ediz; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.TNF-α inhibitör (TNFi) tedavisi ile remisyon elde edilmiş, tedaviye ara verilmiş inflamatuar romatolojik hastalık (İRH) tanılı bireylerin seyrini ortaya koymayı amaçladık. Hastalar geriye dönük olarak incelendi. C-reaktif protein (CRP), eritrosit sedimantasyon hızı (ESR) yanı sıra hastalık aktivite ölçütleri göz önünde bulunduruldu. Çalışmamıza 64 İRH (22 Romatoid Artrit (RA), 37 Ankilozan Spondilit (AS), 5 Psöriatik Artrit (PsA)) tanılı hasta dahil edildi. TNFi kesilmesiyle toplam 58 hastada reaktivasyon gelişmişti. Reaktivasyona kadar geçen süre ortalama 6 aydı. Hastaların 28’ inde (%46) ilk 6 ay içinde reaktivasyon görülürken, 47’ sinde (%73) ilk yılda reaktivasyon görülmüştü. TNFi kullanım süreleri ile reaktivasyon arasındaki ilişki incelendiğinde RA hastalarında TNFi kullanım süresi arttıkça reaktivasyona kadar geçen sürenin azalmış olduğu görüldü (p<0,05, r:-0,501). AS ve PsA hasta grubunda anlamlı ilişki görülmedi (p=0,899, r=0,023; p=0,102, r=- 0,803). TNFi kullanım süresi reaktivasyon sürecinde etkili olabilir. TNFi tedavisinin kesilmesiyle hastaların büyük çoğunluğunda reaktivasyon gelişmektedir.Item Assessment of damage and prognosis in patients with adult iga vasculitis: Retrospective multicentered cohort study(Bmj Publishing Group, 2017-06) Alibaz, Öner; Omma, Ahmet; Sarı, Alper; Karadağ, Ömer; Cansu, Döndü Üsküdar; Beş, Cemal; Yıldız, Fatih; Yılmaz, Sema; Balkarlı, Ayşe; Üreyen, S.; Direskeneli, Haner; Öksüz, Mustafa Ferhat; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.Item Clinical outcomes and survival in AA amyloidosis patients(Elsevier, 2016-12-29) Ayar, Yavuz; Ersoy, Alpaslan; Öksüz, Mustafa Ferhat; Ocakoğlu, Gökhan; Vuruşkan, Berna Aytaç; Yıldız, Abdülmecit; Işıktaş, Emel; Oruç, Ayşegül; Çelikçi, Sedat; Arslan, İsmail; Şahin, Ahmet Bilgehan; Güllülü, Mustafa; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı.; 0000-0002-0710-0923; 0000-0003-4607-9220; 0000-0002-7846-0870; 0000-0003-4607-9220; AAH-5180-2021; AAH-5054-2021; AAH-4002-2021; GSE-0029-2022; O-9948-2015; AAM-4927-2020; AAH-9746-2021; AGF-0767-2022; 55860143300; 35612977100; 56016440100; 15832295800; 56527372000; 56256977500; 25654785700; 55133912100; 56497114200; 7004617712; 57188809248; 6602684544Aim: Amyloid A amyloidosis is a rare complication of chronic inflammatory conditions. Most patients with amyloid A amyloidosis present with nephropathy and it leads to renal failure and death. We studied clinical characteristics and survival in patients with amyloid A amyloidosis. Methods: A total of 81 patients (51 males, 30 females) with renal biopsy proven amyloid A amyloidosis were analyzed retrospectively. The patients were divided into good and poor outcomes groups according to survival results. Results: Most of the patients (55.6%) had nephrotic range proteinuria at diagnosis. Most frequent underlying disorders were familial Mediterranean fever (21.2%) and rheumatoid arthritis (10.6%) in the good outcome group and malignancy (20%) in the poor outcome group. Only diastolic blood pressure in the good outcome group and phosphorus level in the poor outcome group was higher. Serum creatinine levels increased after treatment in both groups, while proteinuria in the good outcome group decreased. Increase in serum creatinine and decrease in estimated glomerular filtration rate of the poor outcome group were more significant in the good outcome group. At the time of diagnosis 18.5% and 27.2% of all patients had advanced chronic kidney disease (stage 4 and 5, respectively). Median duration of renal survival was 65 +/- 3.54 months. Among all patients, 27.1% were started dialysis treatment during the follow-up period and 7.4% of all patients underwent kidney transplantation. Higher levels of systolic blood pressure [hazard ratios 1.03, 95% confidence interval: 1-1.06, p = 0.036], serum creatinine (hazard ratios 1.25, 95% confidence interval: 1.07-1.46, p = 0.006) and urinary protein excretion (hazard ratios 1.08, 95% confidence interval: 1.01-1.16, p = 0.027) were predictors of end-stage renal disease. Median survival of patients with organ involvement was 50.3 +/- 16 months. Conclusion: Our study indicated that familial Mediterranean fever constituted a large proportion of cases and increased number of patients with idiopathic amyloid A amyloidosis. Additionally, it was observed that patient survival was not affected by different etiological causes in amyloid A amyloidosis.Item Comparing female-based contraceptive methods in patients with systemic lupus erythematosus, rheumatoid arthritis and a healthy population(Wiley, 2014-07) İnanç, Murat; Dalkılıç, Ediz; Tufan, Ayşe Nur; Öksüz, Mustafa Ferhat; Şahbazlar, Mustafa; Coşkun, Belkıs Nihan; Seniz, Nihan Belkıs; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı.; 0000-0003-0298-4157; AAG-7155-2021; AAG-8227-2021; 6506739457; 56076552900; 56016440100; 55260646400; 55646165400; 36087952200; 13205593600Aim: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is 10 times more prevalent in women, particularly those of reproductive age. The varying effects of pregnancy on SLE and the differences between available SLE treatments make pregnancy timing and contraceptive methods significant. We aimed to determine the contraceptive methods used by SLE patients in the north-west part of Turkey, and compared them with those used by rheumatoid arthritis (RA) patients and healthy controls. Method: The study was comprised of 113 SLE patients, and 84 RA patients at the Rheumatology Outpatient Clinic of Uludag University Medical Faculty. Results: Twenty-three (20.3%) out of 113 SLE patients, 18 (21.4%) out of 84 RA patients and 17 (18.6%) out of 92 healthy controls did not use any contraceptive methods. Use of the withdrawal and condom methods was more common among SLE patients, accounting for 61% (withdrawal 32.7%, condom 28.3%). Moreover, 52% of SLE and 50% of RA patients were neither given information about contraceptive methods nor offered a suggested method, compared to 34% in the health control group. Conclusions: The prevalence of oral contraceptive use is low in Turkey; notwithstanding the withdrawal and condom methods, which are frequently used despite their high failure risk. Although pregnancy timing is of great importance for SLE patients, necessary information and recommendations concerning contraceptive methods have been ignored and the use of effective methods is not a priority.Publication Comparison of adherence to disease modifying antirheumatic drugs in psoriatic arthritis and other rheumatic disease(Wiley, 2016-10-01) Balcı, Mehmet Ali; Öksüz, Mustafa Ferhat; Dönmez, Salim; Özen, Tuğçe; Dalkılıç, Ediz; Tufan, Ayşe Nur; Pehlivan, Yavuz; Pamuk, Ömer Nuri; Öksüz, Mustafa Ferhat; DALKILIÇ, HÜSEYİN EDİZ; Tufan, Ayşe Nur; PEHLİVAN, YAVUZ; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; JXF-7598-2024; CMF-4757-2022; GHE-4236-2022; AAG-8227-2021Publication Disease activity indices and body mass index: Cross-sectional analysis of a large psoriatic arthritis cohort(Wiley, 2015-10-01) Kalyoncu, Umut; Bayndar, Ozun; Yilmazer, Barış; Dalkılıç, Hüseyin Ediz; Aksu, Kenan; Öksüz, Mustafa Ferhat; Tarhan, E. Figen; Can, Meryem; Küçükşahin, Orhan; Kimyon, Gezmiş; Akyol, Lütfi; Onat, Ahmet Mesut; Kısacık, Bünyamin; Erden, Abdülsamet; Omma, Ahmet; Bakırlı, Duygu Ersözlü; Özişler, Cem; Gönüllü, Emel; Pehlevan, Seval; Solmaz, Dilek; Çınar, Muhammet; Çetin, Gözde; Tufan, Abdurrahman; Tufan, Müge Aydın; Kılıç, Levent; Erten, Şükran; Kaşifoğlu, Timuçin; Kobak, Şenol; Şenel, Soner; Akar, Servet; Özgen, Metin; Kasapoğlu-Günal, Esen; Yazısız, Veli; Yılmaz, Sedat; Dönmez, Salim; Doğan, İsmail; Köseoğlu, Hamide Kart; Erbasan, Funda; Yıldız, Fatih; Beş, Cemal; Balkarlı, Ayşe; Şahin, Ali; Mercan, Rıdvan; Arslan, Fatoş; Doğru, Atalay; Pay, Salih; Yavuz, Şule; Çakır, Necati; Kabasakal, Yasemin; Aydın, Sibel Z.; DALKILIÇ, HÜSEYİN EDİZ; CMF-4757-2022Publication Dose escalation and switching patterns of anti-tnf drugs in rheumatoid arthritis: A retrospective chart - review study in Turkey(Bmj Publishing Group, 2015-06-01) Kalyoncu, U.; Aydın, S. Z.; Dalkılıç, E.; Kaşifoğlu, T.; Kısacık, B.; Pamuk, O. N.; Yılmaz, S.; Yazıcı, A.; Yazısız, V.; Koca, S. S.; Öksüz, Mustafa Ferhat; DALKILIÇ, HÜSEYİN EDİZ; Öksüz, Mustafa Ferhat; Uludağ Üniversitesi/Romatoloji Bölümü; CMF-4757-2022; KQP-2558-2024Item Hairy cell leukemia presenting initially with symptoms of Behcet's disease(Wiley, 2014-07) Öksüz, Mustafa Ferhat; Coşkun, Belkıs Nihan; Tufan, Ayşe Nur; Oruçoğlu, Nurdan; Dalkılıç, Ediz; Öztürk Nazlıoğlu, Hülya; Pehlivan, Yavuz; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0003-0298-4157; AAG-8227-2021; AAG-7155-2021; 56016440100; 55646165400; 56076552900; 57199625557; 6506739457; 56124533600; 13205593600Vasculitis is relatively uncommon in lymphoproliferative disease and may predate the diagnosis of lymphoproliferative disease. Many vasculitides have been associated with hairy cell leukemia (HCL), including polyarteritis nodosa (PAN) and leukocytoclastic vasculitis. We herein report a case whose initial presentation was like Behcet's disease (BD) (arthritis, oral and genital ulcerations, papulopustular skin lesions) in addition to pancytopenia, but turned out to have HCL. Because of the overlap between their symptoms, like oral ulcerations, skin lesions, arthritis and constitutional findings, HCL and BD may mimic each other. We should keep in mind other reasons for vasculitis such as lymphoproliferative disease, especially whose who have hematological abnormalities such as pancytopenia.Item Impacts of Anti-TNF treatment on improvement in work place and household productivity in patients with psoriatic arthritis(Wiley, 2016-10) Karadağ, Ömer; Onat, Ahmet Mesut; Küçükşahin, Orhan; Kaşifoğlu, Timuçin; Kısacık, Bünyamin; Pamuk, Ömer Nuri; Yılmaz, Neslihan; Koca, Süleyman Serdar; Yazısız, Veli; Ocakcı, Pınar Talu; Sayarlıoğlu, Mehmet; Terzioğlu, Ender; Erten, Sükran; Kalyoncu, Umut; Dalkılıç, Ediz; Öksüz, Mustafa Ferhat; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; CMF-4757-2022; INW-5232-2023Publication Ki-67 proliferation index in renal biopsy samples of patients with systemic lupus erythematosus(Clinical, 2015-05-01) Dalkılıç, Ediz; Pehlivan, Yavuz; Ermurat, Selime; Coşkun, Belkıs Nihan; Tufan, Ayşe Nur; Öksüz, Mustafa Ferhat; Yerci, Ömer; Güllülü, Mustafa; DALKILIÇ, HÜSEYİN EDİZ; PEHLİVAN, YAVUZ; Ermurat, Selime; COŞKUN, BELKIS NİHAN; Tufan, Ayşe Nur; Öksüz, Mustafa Ferhat; YERCİ, ÖMER; GÜLLÜLÜ, MUSTAFA; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Bölümü; Uludağ Üniversitesi/Tıp Fakültesi/Patholoji Bölümü; AAG-8227-2021; AAG-7155-2021; ABE-4424-2022; CMF-4757-2022; GHE-4236-2022; JXF-7598-2024; GKD-6344-2022; CTG-8811-2022Item MEFV genindeki 138.ve 165.kodon polimorfizmlerinin ilevi Akdeniz Ateşi hastalığına etkisinin araştırılması(Uludağ Üniversitesi, 2012) Öksüz, Mustafa Ferhat; Dilek, Kamil; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.Ailevi Akdeniz Ateşi (AAA,FMF)'den sorumlu olduğu bildirilmiş Mediterranaen Fever (MEFV) geninde, bugüne kadar birçok mutasyon tanımlanmıştır. Çalışmalarda genotip fenotip ilişkisinin bulunduğu ileri sürülmektedir. Çalışmamızda, bölgemizdeki MEFV mutasyon sıklıklarının belirlenmesi ve bilinen mutasyonların dışında hastalığın oluşumunda ve seyrinde etkili olabilecek 138. kodon (A-G) ve 165. kodon (C-A) gen polimorfizmlerinin hastalığa olan etkisini araştırmayı amaçladık.Çalışmaya, MEFV geninde mutasyon saptanan ve kinik olarak da AAA tanısı doğrulanan 116 olgu, kontrol grubu olarak ise MEFV geninde mutasyon saptanmayan ve klinik olarak da AAA tanısı dışlanan 95 kişi alındı. MEFV geninin 2. ve 10. ekzonunda bulunan en yaygın 10 mutasyonu belirlemek için DNA dizi analizi yöntemi kullanıldı. İstatistiksel analizde, p<0.05 değeri anlamlı kabul edildi.MEFV mutasyon analizleri sonucunda; en sık % 41.8 oranıyla M694V mutasyon aleli ve ikinci sıklıkta ise % 14.8 oranıyla M680I mutasyon aleli bulundu.MEFV geni 138. kodonda gözlenen G polimorfik alelin sıklığı hasta grubunda % 46, kontrol grubunda ise % 68 bulundu. Yine MEFV geni 165. kodonda gözlenen A polimorfik alleli hasta grubunda % 45, kontrol grubunda ise % 67 saptandı. Hasta ve kontrol grupları her iki polimorfik alel sıklığı açısından karşılaştırıldığında, istatistiksel olarak anlamlı fark bulundu (p<0.001).MEFV mutasyon tiplerinin ve gen polimorfizmlerinin (138. kodon ve 165. kodon) klinik bulgular ve amiloidoz ile ilişkisinin olmadığı görüldü(p>0.05).Çalışmamız, bildiğimiz kadarıyla Güney Marmara bölgesinde MEFV mutasyonların sıklığını bildiren ilk çalışmadır. Bulgularımız,138.kodon (G-A) ve 165.kodon (C-A) polimorfizmlerinin hastalık gelişimine etkisinin olabileceğini göstermektedir. MEFV geninde bulunan bu polimorfizmleri araştıran daha fazla olgu sayılı çalışmalara gereksinimin olduğunu düşünmekteyiz.Item A multicenter report of biologic agents for the treatment of secondary amyloidosis in Turkish rheumatoid arthritis and ankylosing spondylitis patients(Springer, 2016-05-16) Pehlivan, Yavuz; Öksüz, Mustafa Ferhat; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; AAG-8227-2021; 57220381538; 56016440100In this multicenter, retrospective study, we evaluated the efficacy and safety of biologic therapies, including anti-TNFs, in secondary (AA) amyloidosis patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA). In addition, the frequency of secondary amyloidosis in RA and AS patients in a single center was estimated. Fifty-one AS (39M, 12F, mean age: 46.7) and 30 RA patients (11M, 19F, mean age: 51.7) with AA amyloidosis from 16 different centers in Turkey were included. Clinical and demographical features of patients were obtained from medical charts. A composite response index (CRI) to biologic therapy-based on creatinine level, proteinuria and disease activity-was used to evaluate the efficacy of treatment. The mean annual incidence of AA amyloidosis in RA and AS patients was 0.23 and 0.42/1000 patients/year, respectively. The point prevalence in RA and AS groups was 4.59 and 7.58/1000, respectively. In RA group with AA amyloidosis, effective response was obtained in 52.2 % of patients according to CRI. RA patients with RF positivity and more initial disease activity tended to have higher response rates to therapy (p values, 0.069 and 0.056). After biologic therapy (median 17 months), two RA patients died and two developed tuberculosis. In AS group, 45.7 % of patients fulfilled the criteria of good response according to CRI. AS patients with higher CRP levels at the time of AA diagnosis and at the beginning of anti-TNF therapy had higher response rates (p values, 0.011 and 0.017). During follow-up after anti-TNF therapy (median 38 months), one patient died and tuberculosis developed in two patients. Biologic therapy seems to be effective in at least half of RA and AS patients with AA amyloidosis. Tuberculosis was the most important safety concern.Publication Neutrophil lymphocyte ratio can be a valuable marker in defining disease activity in patients who have started antitumor necrosis factor (tnf) drugs for ankylosing spondylitis(Aves, 2014-09-01) Coşkun, Belkis Nihan; COŞKUN, BELKIS NİHAN; Öksüz, Mustafa Ferhat; Ermurat, Selime; Tufan, Ayse Nur; Oruçoğlu, Nurdan; Doğan, Akif; Dalkılıç, Ediz; Pehlivan, Yavuz; PEHLİVAN, YAVUZ; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0002-8613-5373; AAG-7155-2021; AAG-8227-2021; ABE-4424-2022; D-2589-2017Objective: Neutrophil lymphocyte ratio (NLR) has emerged as a valuable and reliable method for follow-up of systemic inflammatory disease. We herein aimed to evaluate the role of NLR in the clinical follow-up of inflammation and also to compare its relationship with other measures, such as erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI).Material and Methods: A total of 35 active ankylosing spondylitis (AS) and 38 healthy volunteers were included in the study. The patient group was enrolled for treatment with one anti-tumor necrosis factor (TNF) drug. Total blood count, ESR, CRP, and BASDAI score were obtained before and 3 months following the treatment. NLR was found with a mathematical calculation of the ratio of neutrophils with lymphocytes.Results: The mean NLR value of the control group and patients was 1.90 +/- 0.89 and 2.67 +/- 1.17, respectively (p< 0.05). After a 3-month course of treatment, the patient group had a mean NLR value of 1.8 +/- 0.7, which was significantly lower than pretreatment values (p< 0.001). The posttreatment mean ESR, CRP, and BASDAI scores were significantly lower than mean baseline scores (p< 0.001, p= 0.007, p< 0.001, respectively). Also, NLR was found to be correlated with BASDAI, ESR, and CRP (r= 0.388, p< 0.001; r= 0.455, p< 0.0001; and r= 0.3389, p< 0.005, respectively).Conclusion: Neutrophil lymphocyte ratio could be a reliable and easily accessible method for follow-up of patients with AS.Item Neutrophil lymphocyte ratio can be a valuable marker in defining disease activity in patients with as(BMJ Publishing Group, 2014-06) Pehlivan, Yavuz; Coşkun, Belkıs N.; Öksüz, Mustafa Ferhat; Dalkılıç, Ediz; Tufan, Abdurrahman; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; 0000-0001-6244-9362; 0000-0003-0298-4157; A-7613-2016; AAG-8227-2021; AAG-7155-2021Item Patients' concerns regarding biological agents in rheumatology(Wiley, 2018-01) Kimyon, Gezmiş; Zengin, Orhan; Küçük, Adem; Şahin, Ali; Tomas, Nazmiye; Kısacık, Bünyamin; Akar, Servet; Onat, Ahmet Mesut; Pehlivan, Yavuz; Oruçoğlu, Nurdan; Pehlivan, Seda; Öksüz, Mustafa Ferhat; Dalkılıç, Ediz; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; Uludağ Üniversitesi/Sağlık Bilimleri Fakültesi/Hemşirelik Bölümü.; 0000-0002-1670-0672; 0000-0002-8613-5373; B-5037-2017; AAG-8227-2021; ABG-1164-2020; 13205593600; 57199625557; 23095733400; 56016440100; 6506739457ObjectiveThe potential side effects of biological agents may increase the anxiety levels of patients and influence not only their desire to use these therapies but also their concordance to treatment. This study aimed to determine the level and prevalence of drug-related concern in patients treated with biological agents and to acquire additional information regarding the related causes. Materials and MethodsA total of 1134 patients who were using biological agents for at least 3months with a diagnosis of rheumatic diseases were enrolled. General anxiety levels were evaluated using the State-Trait Anxiety Inventory (STAI). ResultsThe most common cause for drug-related concerns was the potential side effects of the drugs (59.5%). Among the potential side effects, cancer risk was the most common cause for concern (40.1%), followed by the risk of tuberculosis activation (30.7%). Anxiety levels were higher in patients who experienced side effects than in other patients, and this difference was statistically significant (P<0.05). STAI trait and state scores were moderately correlated with anxiety levels related to the drug (P<0.001). ConclusionAnxiety related to biological agents may significantly affect the patients' anxiety levels. Awareness regarding the patients' concerns and expectations related to the drug is important to ensure drug adherence and concordance to treatment.Item The psoriatic arthritis registry of Turkey: Results of a multicentre registry on 1081 patients(Oxford University, 2016-09-09) Öksüz, Mustafa Ferhat; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Romatoloji Anabilim Dalı.; 56016440100Objective. The aim was to assess the characteristics of PsA, find out how well the disease is controlled in real life, demonstrate the treatments and identify the unmet needs. Methods. The PsA registry of Turkey is a multicentre Web-based registry established in 2014 and including 32 rheumatology centres. Detailed data regarding demographics for skin and joint disease, disease activity assessments and treatment choices were collected. Results. One thousand and eighty-one patients (64.7% women) with a mean (S.D.) PsA duration of 5.8 (6.7) years were enrolled. The most frequent type of PsA was polyarticular [437 (40.5%)], followed by oligoarticular [407 (37.7%)] and axial disease [372 (34.4%)]. The mean (S.D.) swollen and tender joint counts were 1.7 (3) and 3.6 (4.8), respectively. Of these patients, 38.6% were on conventional synthetic DMARD monotherapy, 7.1% were on anti-TNF monotherapy, and 22.5% were using anti-TNF plus conventional synthetic DMARD combinations. According to DAS28, 86 (12.4%) patients had high and 105 (15.2%) had moderate disease activity. Low disease activity was achieved in 317 (45.7%) patients, and 185 (26.7%) were in remission. Minimal disease activity data could be calculated in 247 patients, 105 of whom (42.5%) had minimal disease activity. The major differences among sexes were that women were older and had less frequent axial disease, more fatigue, higher HAQ scores and less remission. Conclusion. The PsA registry of Turkey had similarities with previously published registries, supporting its external validity. The finding that women had more fatigue and worse functioning as well as the high percentage of active disease state highlight the unmet need in treatment of PsA.Publication The effect of rheumatoid factor and anti-cyclic citrullinated peptide positivity on drug survival of abatacept in patients with rheumatoid arthritis in routine care: The results from turkbio registry(Wiley, 2015-10-01) Ertenli, İhsan; Karadağ, Ömer; Pehlivan, Yavuz; Dalkılıç, Ediz; Onat, Ahmet Mesut; Kısacık, Bünyamin; Can, Gerçek; Akar, Servet; Çapar, Sedat; Kalyoncu, Ümut; Öksüz, Mustafa Ferhat; Tarhan, Emine Figen; Akkoç, Nurullah; PEHLİVAN, YAVUZ; DALKILIÇ, HÜSEYİN EDİZ; Oksuz, Mustafa Ferhat; Uludağ Üniversitesi/Tıp Fakültesi/Romatoloji Anabilim Dalı.; AAG-8227-2021; CMF-4757-2022; JXF-7598-2024Publication The relationship between formal education level and delay in diagnosis and disease activity in patients with rheumatoid arthritis(BMJ Publishing Group, 2015-06-01) Öksüz, Mustafa Ferhat; YıIdırım, F.; Şahin, Bilgehan Ahmet; Göçken, Abdulkadir; Tufan, Ayşe Nur; Oruçoğlu, Nurdan; Dalkılıç, Ediz; Pehlivan, Yavuz; Öksüz, Mustafa Ferhat; YıIdırım, F.; ŞAHİN, AHMET BİLGEHAN; Göçken, Abdulkadir; Tufan, Ayşe Nur; Oruçoğlu, Nurdan; DALKILIÇ, HÜSEYİN EDİZ; PEHLİVAN, YAVUZ; Uludağ Üniversitesi/Tıp Fakültesi; 0000-0002-7846-0870; 0000-0002-8613-5373; D-2589-2017; AAM-4927-2020; AAG-8227-2021; JXF-7598-2024; EHU-6506-2022; CQX-7131-2022; GHE-4236-2022; CMF-4757-2022