Browsing by Author "Öztürkmen, Yusuf"
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Publication Bone loss following cementless hemiarthroplasty for the treatment of femoral neck fracture(Springer Heidelberg, 2020-01-31) Murat, Mert; Ermutlu, Cenk; Ünkar, Ethem Ayhan; Topalhafızoğlu, Sertaç; Şenel, Ahmet; Öztürkmen, Yusuf; ERMUTLU, CENK; Uludağ Üniversite/Tıp Fakültesi/Ortopedi ve Travmatoloji Anabilim Dalı.; AAB-2795-2021Background With the advances in medicine, an increasing number of the ageing population are a public health concern in terms of age-related complications. Among them, displaced neck fractures often require surgical intervention or arthroplasty to achieve the mobilization of the elderly and good life quality. The aim of the study is to monitor the changes in bone mineral density (BMD) around the femoral stem and the effects on functional outcomes in patients treated with cementless hemiarthroplasty following femoral neck fracture. Materials and Methods Seventy-one patients aged 70 years or older who were treated with cementless hemiarthroplasty for a displaced femoral neck fracture were prospectively followed for 2 years. The percent change in the periprosthetic BMD in each Gruen zone was compared to the baseline using dual-energy X-ray absorptiometry (DEXA). Demographic factors [age, body mass index (BMI), and sex] that could possibly influence BMD and the clinical outcome were evaluated. Results Fifty-one patients were available for the final follow-up. The mean age was 76.5 (range 70-89) years. The mean BMI was 28.9 (range 22.7-37.2). The mean Harris hip score at the final follow-up was 84.3 (range 72-93). There was a significant decrease in BMD in all Gruen zones (p < 0.001), except in zone 3 (R3, p = 0.547). The reduction in BMD was highest in the calcar and the greater trochanter region. The femur diaphysis was relatively spared, with zone 3 showing no significant bone mineral loss. The age and BMI of the patients were not correlated with the postoperative change in BMD in any of the Gruen zones. The degree of reduction in bone density was not correlated with the clinical outcome. Conclusions Cementless hemiarthroplasty for the treatment of femoral neck fracture in elderly patients achieves a good clinical outcome despite significant bone loss around the femoral stem. The reduction in BMD is more pronounced in the metaphyseal region.Publication Effects of repeated intravenous doses of tranexamic acid on closed tibial fracture healing: Experimental study based on the rat model(Turkish Assoc Orthopaedics Traumatology, 2023-09-01) Doğan, İbrahim; Birişik, Fevzi; Kalyenci, Ahmet Sinan; Bozkurt, Erol Rüstü; Öztürkmen, Yusuf; Bilgin, Yücel; BİLGİN, YÜCEL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Ortopedi ve Travmatoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Ortopedi ve Travmatoloji Anabilim Dalı.Objective: The aim of this study was to assess the effects of tranexamic acid on fracture healing in the rat tibia closed fracture model.Methods: Sixty-four male Sprague-Dawley rats were included in this study, where closed fracture and intramedullary nailing were performed on their right tibial diaphyses. They were divided into 2 main groups, the experimental group, which was given weekly tranexamic acid injections, and the control group, which received no additional treatment. Eight rats from each group were sacrificed and evaluated for fracture healing at the first experimental group and control group, second experimental group and control group, third experimental group and control group, and fourth experimental group and control group weeks. Fracture healing was radiologically assessed according to the "Spencer Index" and "Lane and Sandhu Scoring System," and histologically evaluated according to the scoring system devised by Huo et al.Results: According to the Spencer Index, the mean union score was statistically significantly higher in the E3 group than in the third con-trol group (P = .014). Furthermore, the mean union score was statistically significantly higher in the fourth experimental group compared to the fourth control group (P = .047). According to the Lane and Sandhu Scoring System, only the mean union scores of the E3-4 groups were statistically significantly higher than the mean union scores of the C3-4 groups (P = .048). There was no histological difference between groups in terms of union, according to the criteria defined by Huo et al (P > .05).Conclusion: This study showed us that repeated intravenous administrations of tranexamic acid had no negative effect on fracture heal-ing in the rat tibia fracture model. Although tranexamic acid demonstrated better radiological healing in the late period, it had no effect on histological union.