Browsing by Author "Acar, Hazal Cansu"

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    Proven food-induced acute urticaria and predictive factors for definitive diagnosis in childhood
    (Karger, 2021-02-18) Aydoğan, Metin; Topal, Erdem; Uysal, Pınar; Acar, Hazal Cansu; Cavkaytar, Özlem; Demirkale, Zeynep Hızlı; Aydoğmuş, Çiğdem; Yakıcı, Nalan; Aydemir, Sezin; Akkelle, Emre; Şimşek, Işıl Eser; Kaplan, Fatih; Arga, Mustafa; Yücel, Esra; Çoğurlu, Mujde Tuğba; Erdoğan, Mehmet Sarper; Tamay, Zeynep; Güler, Nermin; Yeşil, Yakup; Çekiç, Şükrü; Sapan, Nihat; Çokuğraş, Haluk; Kıykım, Ayça; Günaydın, Nursen Ciğerci; Tuncel, Tuba; Orhan, Fazıl; Özdemir, Öner; Özdemir, Cevdet; ÇEKİÇ, ŞÜKRÜ; SAPAN, NİHAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Alerji ve İmmünoloji Anabilim Dalı.; 0000-0002-9574-1842; L-1933-2017; FUI-8766-2022
    Background: Urticaria can be the only sign of a food allergy or can be seen together with other signs and symptoms of a food allergy. Objective: To determine the demographic, etiologic, and clinical features of food-induced acute urticaria in childhood. Methods: Patients suspected of food-induced acute urticaria were included in this prospective cross-sectional multicenter study. Results: Two hundred twenty-nine urticaria cases were included in this study. Seventeen patients who did not meet the inclusion criteria of the study were excluded. Of the 212 included cases, 179 (84.4%) were diagnosed with definitive food-induced acute urticaria. The most common foods causing acute urticaria were cow's milk, hen's eggs, and nuts in 56.4, 35.2, and 19% of cases, respectively. The positive predictive value of a history of milk-induced acute urticaria together with a milk-specific IgE >5 kU/L for cow's milk-induced acute urticaria was 92% (95% CI: 81-96%). A history of cow's milk-induced and/or hen's egg-induced acute urticaria was consistent with a definitive diagnosis of food-induced urticaria (Chen's kappa: 0.664 and 0.627 for milk and eggs, respectively). Urticaria activity scores were higher in patients with food-induced acute urticaria (p = 0.002). Conclusion: Cow's milk, hen's eggs, and nuts were the most common allergens in the etiology of childhood food-induced acute urticaria. Although the urticaria activity score provides guidance for diagnosis, an oral food challenge is often essential for the definitive diagnosis of a patient with a history of food-induced acute urticaria.