Browsing by Author "Anak, Sema"
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Item Prognostic significance of the TEL-AML1 fusion gene in pediatric acute lymphoblastic leukemia in Turkey(Lippincott Williams and Wilkins, 2003-03) Özbek, Uǧur; Sırma, Sema; Ağaoğlu, Leyla; Yüksel, Lebriz; Anak, Sema; Yıldız, İnci; Devecioğlu, Omer; Timur, Çetin; Gedikoğlu, Gündüz; Meral, Adalet; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; 0000-0002-1201-7542; 0000-0001-5319-0547; U-6138-2017; C-9513-2017; 6602571317Purpose: The t(12;21) translocation is the most common reciprocal chromosomal rearrangement in pediatric acute lymphoblastic leukemia (ALL). This translocation fuses two genes, TEL and AML1, and results in the production of the TEL-AML1 fusion protein. The authors investigated the incidence and prognostic significance of the TEL-AML1 fusion gene in patients with ALL in Turkey. Methods: The authors analyzed 219 children with ALL using the reverse transcription-polymerase chain reaction. Results: The TEL-AML1 fusion transcript was detected in 20.1% (44/219) of newly diagnosed children with ALL. TEL-AML1-positive patients had precursor B-cell ALL and were 3 to 10 years old at diagnosis. TEL-AML1-positive patients had a significantly lower rate of relapse compared with TEL-AML1-negative patients. TEL-AML1-positive patients have a higher overall survival rate than TEL-AML1-negative patients. Conclusions: These data support that the presence of TEL-AML1 at diagnosis is an independent favorable prognostic indicator in patients with ALL in Turkey.Item The outcome of children treated with MRC-AML protocols in six referral centres, Turkey(Wiley, 2008-04) Turkiz, Gürsel; Hazar, V; Sarper, Nazan; Özgen, U; Anak, Sema; Güneş, Adalet Meral; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları; EXD-8400-2022