Browsing by Author "Ataergin, Selmin"

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    Aloe vera-induced acute toxic hepatitis in a healthy young man
    (Elsevier, 2006) Özet, Ahmet; Ataergin, Selmin; Kanat, Özkan; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim.
    The popularity and use of herbal medicine products are gradually increasing among healthy individuals. Yet, hepatic toxicity is a potential complication of these compounds that may lead to hepatic insufficiency[1]. Clinicians are likely to encounter cases of herbal remedy-related acute or chronic hepatitis at any time, even in healthy individuals. Here, wereport a case of aloe vera-induced acute hepatitis.A 24-year-old previously healthy man was hospitalized with complaints of jaundice, pruritus, fatigue, and right upper abdominal discomfort, together with mild nausea and vomit-ing. He had no previous history of liver disease, blood transfusion, or alcohol consumption. He had been taking aloe vera capsules containing 500 mg of the extractAloebarbadensismiller (1 capsule/day) for 3 weeks before presentation because he thought it would contribute to“healthier living”. He did not take any other medication concurrently with aloe vera. On admission, the patient's physical examination was normal, except for icteric pigmentation of the sclera and skin. Laboratory studies revealed total bilirubin9 mg/dl (normal v1.0 mg/dL), conjugated bilirubin 8.2 mg/dL(normalb0.2 mg/dL), aspartate aminotransferase 2550 U/L(normal 40 U/L), alanine aminotransferase 2400 U/L(normal 40 U/L), alkaline phosphatase 400 U/L (normal 155 U/L), gamma glutamyl transpeptidase 140 U/L (normal 49 U/L), and prothrombin activity 72% (INR 1.3). Full Blood count, serum electrolytes, glucose, creatinine, total protein, and immunoglobulin G, A, and M levels were within normal ranges. Serologic examinations for acute viral hepatitis(A, B, C, delta, E, cytomegalovirus, parvovirus, Epstein-Barr Virus, herpes virus, and human immunodeficiency virus) were all negative. Autoimmune hepatitis, Wilson's disease, andBudd-Chiari syndrome were ruled out by appropriate immunological and imaging methods. Abdominal ultrasound was also normal. A liver biopsy revealed marked portal and acinar infiltrates predominantly consisting of lymphocytes,monocytes, and eosinophils along with bridging necrosis,which were consistent with drug-induced hepatitis.
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    Modified outpatient dexamethazone, cytarabine and cisplatin regimen may lead to high response rates and low toxicity in Lymphoma
    (Karger, 2010) Özet, Ahmet; Ataergin, Selmin; Arpacı, Fikret; Kuzhan, Okan; Kömürcü, Şeref; Öztürk, Bekir; Öztürk, Mustafa; Kanat, Özkan; Uludağ Üniversitesi/Tıp Fakültesi/Onkoloji Anabilim Dalı.; 55881548500
    Objective: Our purpose was to investigate the efficacy of and establish a toxicity profile for a modified regimen of dexamethasone, cytarabine and cisplatin (DHAP) for lymphoma outpatients. Subjects and Methods: Fifty-one lymphoma patients, 26 with Hodgkin's disease and 25 with non-Hodgkin's lymphoma, were included. The patients' median age was 32 years (range: 17-61). Twenty had progressive/refractory disease and 31 relapsed disease. Twenty-five were in clinical stage I/II and 26 in clinical stage III/IV before the initiation of salvage chemotherapy. DHAP consisted of dexamethasone (40 mg i.v. on days 1-4), cytarabine (2 g/m(2) i.v. as 3-hour infusion on days 2 in the evening and 3 in the morning) and cisplatin (35 mg/m(2) as 2-hour infusion on days 1-3) were administered every 21 days. A total of 154 cycles of modified DHAP were administered, with a median of 3 cycles per patient (range: 2-4). Results: The main toxicity was myelosuppression. WHO grade III-IV neutropenia and grade III-IV thrombocytopenia were observed in 27 (52.9%) and 21 (41%) patients, respectively. The overall response rate (85% for Hodgkin's disease and 95% for non-Hodgkin's lymphoma) was 88.3% (39.2% complete response and 49.1% partial response). Conclusion: The results showed that this outpatient schedule of DHAP was well tolerated and an effective salvage regimen.
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    Small cell carcinoma of the large bowel: A rare, but very aggressive malignancy
    (Lippincott Williams & Wilkins, 2006-10) Özet, Ahmet; Ataergin, Selmin; Komürcü, Şeref; Öngürü, Önder; Kanat, Özkan; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı.; 55881548500