Browsing by Author "Aydin, Zeki"

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Adult minimal change disease in turkey: The results of Turkish society of nephrology glomerular diseases working group
(Oxford University, 2020-06-01) Yilmaz, Murvet; Sipahioglu, Murat; Dervisoglu, Erkan; Aydemir, Nihal; Uzun, Sami; Istemihan, Zulal; Tatar, Erhan; Berktas, Haci Bayram; Kayalar, Arzu Ozdemir; Sumnu, Abdullah; Sahin, Gizem Kumru; Cetinkaya, Hakki; Kazan, Sinan; Kocyigit, Ismail; Gokalp, Cenk; Hasbal, Nuri Bads; Ucar, Ayse Serra; Ozelsancak, Ruya; Taymez, Dilek Guven; Yadigar, Serap; Alagoz, Selma; Aslan, Bilal Burcak; Yaylaci, Selcuk; Aydin, Zeki; Jabrayilov, Jabrayil; Turgutalp, Kenan; Dursun, Belda; Sahin, Garip; Unsai, Oktay; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.
Demographic, clinical and laboratory characteristics of adult-onset minimal change disease in Turkey: Turkish Society of Nephrology-Glomerular Diseases (TSN-GOLD) Working Group
(Springer, 2022-09-30) Aydin, Zeki; Yilmaz, Murvet; Sipahioglu, Murat; Dervisoglu, Erkan; Aydemir, Nihal; Uzun, Sami; Istemihan, Zulal; Unsal, Oktay; Tatar, Erhan; Berktas, Haci Bayram; Ozdemir, Arzu; Sumnu, Abdullah; Kumru, Gizem; Cetinkaya, Hakki; Kazan, Sinan; Kocyigit, Ismail; Gokalp, Cenk; Hasbal, Baris; Artan, Ayse Serra; Ozelsancak, Ruya; Taymez, Dilek; Yadigar, Serap; Alagoz, Selma; Aslan, Bilal Burcak; Yaylaci, Selcuk; Jabrayilov, Jabrayil; Turgutalp, Kenan; Dursun, Belda; Sahin, Garip; Ünsal, Oktay; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Nefroloji Bilim Dalı.; JJK-9214-2023
Purpose In our study, diagnostic and demographic characteristics of patients diagnosed with minimal change disease (MCD) by biopsy, clinical and laboratory findings in our country were investigated. Methods Data were obtained from the Turkish Society of Nephrology Glomerular Diseases (TSN-GOLD) Working Group database. Demographic characteristics, indications for biopsy, diagnosis of the glomerular diseases, comorbidities, laboratory and biopsy findings of all patients were recorded. The data presented are cross-sectional and includes application data for the biopsy period. Results Of 3875 patients, 233 patients with MCD (median age 35.0 years) were included in the study, which constitutes 6.0% of the total glomerulonephritis database. Renal biopsy was performed in 196 (84.1%) patients due to nephrotic syndrome. Median serum creatinine was 0.7 (0.6-1.0) mg/dl, mean eGFR was 104 +/- 33 ml/min/1.73 m(2) and median proteinuria 6000 mg/day. The number of patients under the age of 40 years was 139 (59.7%) (Group A), and the number of patients aged 40 years and over was 94 (40.3%) (Group B). Compared to Group A, global sclerotic glomeruli (24 vs. 43, p < 0.001) interstitial inflammation (15 vs. 34, p < 0.001), interstitial fibrosis (20 vs. 31, p = 0.001, vascular changes (10 vs. 25, p < 0.001) and tubular atrophy (18 vs. 30, p < 0.001) were found to be significantly higher in Group B. There was no difference in immunofluorescent staining properties between the two groups. Conclusion Our data are generally compatible with the literature. Chronic histopathological changes were more common in patients aged 40 years and older than younger patients. Studies investigating the effects of these different features on renal survival are needed.
The longitudinal evolution of post-COVID-19 outcomes among hemodialysis patients in Turkey
(Elsevier Science Inc, 2022-06-03) Ozturk, Savas; Turgutalp, Kenan; Arici, Mustafa; Gorgulu, Numan; Tonbul, Halil Zeki; Eren, Necmi; Gencer, Vedat; Ayli, Mehmet Deniz; Pembegul, Irem; Dolarslan, Murside Esra; Ural, Zeynep; Colak, Hulya; Ozler, Tuba Elif; Can, Ozgur; Demir, Mehmet Emin; Altunoren, Orcun; Huddam, Bulent; Onec, Kursad; Demirelli, Bulent; Aydin, Zeki; Altun, Eda; Alagoz, Selma; Ayar, Yavuz; Eser, Zeynep Ebru; Berktas, Bayram; Yilmaz, Zulfukar; Ates, Eser Uslu; Yuksel, Enver; Sahin, Gizem Kumru; Aktar, Merve; Cebeci, Egemen; Dursun, Belda; Kocak, Sibel Yucel; Yıldız, Abdülmecit; Kazan, Sinan; Gok, Mahmut; Sengul, Erkan; Tugcu, Murat; Ozturk, Ramazan; Kahvecioglu, Serdar; Kara, Ekrem; Kaya, Bulent; Sahin, Garip; Sakaci, Tamer; Sipahi, Savas; Kurultak, Ilhan; Durak, Beyza Algul; Altiparmak, Mehmet Riza; Ecder, Sabahat Alisir; Karadag, Serhat; Dincer, Mevlut Tamer; Ozer, Hakan; Bek, Sibel Gokcay; Ulu, Memnune Sena; Gungor, Ozkan; Bakir, Elif Ari; Odabas, Ali Riza; Seyahi, Nurhan; Yildiz, Alaattin; Ates, Kenan; YILDIZ, ABDULMECİT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; HIG-9032-2022
Introduction: Hemodialysis (HD) patients have increased risk for short-term adverse outcomes of COVID-19. However, complications and survival at the post-COVID-19 period have not been published extensively.Methods: We conducted a national, multicenter observational study that included adult maintenance HD patients recovered from confirmed COVID-19. A control HD group without COVID-19 was selected from patients in the same center. We investigated the characteristics and outcomes in the follow-up of HD patients and compare them with the non-COVID-19 group.Results: A total of 1223 patients (635 patients in COVID-19 group, 588 patients in non-COVID-19 group) from 47 centers were included in the study. The patients' baseline and HD characteristics were almost similar. The 28th-day mortality and mortality between 28th day and 90th day were higher in the COVID-19 group than non-COVID-19 group (19 [3.0%] patients vs. none [0%]; 15 [2.4%] patients vs. 4 [0.7%] patients, respectively). The presence of respiratory symptoms, rehospitalization, need for home oxygen therapy, lower respiratory tract infection, and arteriovenous (AV) fistula thrombosis was significantly higher in the COVID-19 group in both the first 28 days and between 28 and 90 days. In the multivariable analysis, age (odds ratio [OR] [95% CI]: 1.029 [1.004-1.056]), group (COVID-19 group vs. non-COVID-19 group) (OR [95% CI]: 7.258 [2.538-20.751]), and vascular access type (tunneled catheter/AV fistula) (OR [95% CI]: 2.512 [1.249-5.051]) were found as independent parameters related to 90-day mortality.Conclusion: In the post-COVID-19 period, maintenance HD patients who have had COVID-19 have increased rehospitalization, respiratory problems, vascular access problems, and high mortality compared with the non-COVID-19 HD patients.
The relationship between glomerular igg staining and poor prognostic findings in patients with iga nephropathy: The data from tsn-gold working group
(BMC, 2021-10-28) Turgutalp, Kenan; Cebeci, Egemen; Turkmen, Aydin; Derici, Ulver; Seyahi, Nurhan; Eren, Necmi; Dede, Fatih; Basturk, Taner; Sahin, Gulizar Manga; Yilmaz, Murvet; Sipahi, Savas; Sahin, Garip; Ulu, Sena; Tatar, Erhan; Gundogdu, Ali; Kazancioglu, Rumeyza Turan; Sevinc, Can; Gungor, Ozkan; Sahin, Idris; Kutlay, Sim; Kurultak, Ilhan; Aydin, Zeki; Altun, Bulent; Dursun, Belda; Yilmaz, Zulfikar; Uzun, Ozcan; Suleymanlar, Gultekin; Candan, Ferhan; Sezer, Siren; Tanburoglu, Derya Basak; Bahcebasi, Zerrin Bicik; Taymez, Dilek; Akcali, Esra; Oygar, Deren; Istemihan, Zulal; Bardak, Simge; Akcay, Omer Faruk; Dincer, Mevlut Tamer; Dervisoglu, Erkan; Yenigun, Ezgi; Turkmen, Kultigin; Ozturk, Savas; Güllülü, Mustafa; GÜLLÜLÜ, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0003-0245-1844; 0000-0001-7427-618X; 0000-0002-2708-3470; 0000-0002-0409-2710; 0000-0001-6829-121X; 0000-0002-5068-4231; 0000-0002-9594-4121; 0000-0002-4069-9181; 0000-0002-8683-3737; 0000-0001-5607-1375; 0000-0002-6648-6053; 0000-0002-4017-0640; 0000-0002-6851-4871; 0000-0002-0961-3810; P-9618-2015; HKV-4703-2023; GRX-9954-2022; V-1616-2019; AAA-8435-2020; AFR-4244-2022; JYQ-2550-2024; S-7661-2016; AAS-4390-2020; Q-6320-2019; R-1388-2018
Background Galactose-deficient IgA1 (Gd-IgA1) has an increased tendency to form immunocomplexes with IgG in the serum, contributing to IgAN pathogenesis by accumulating in the glomerular mesangium. Several studies showed that glomerular IgG deposition in IgAN is an important cause of mesangial proliferation and glomerular damage. This study aims to determine the association of the positivity of IgG and the intensity of IgG staining with a poor renal prognosis. Methods A total of 943 IgAN patients were included in the study. Glomerular IgG staining negative and positive patients were compared using Oxford classification scores, histopathological evaluations, proteinuria, eGFR, albumin, blood pressures. IgG positive patients were classified as (+), (++), (+++) based on their staining intensity, and the association with the prognostic criteria was also evaluated. Results 81% (n = 764) of the patients were detected as IgG negative, while 19% (n = 179) were positive. Age, gender, body mass index, blood pressure, proteinuria, eGFR, uric acid values were similar in IgG positive and negative patients who underwent biopsy (p > 0.05). Intensity of glomerular IgG positivity was not found to be associated with diastolic and systolic blood pressure, urea, uric acid, age, eGFR, albumin, proteinuria (p > 0.05 for all, r = - 0.084, r = - 0.102, r = - 0.006, r = 0.062, r = 0.014, r = - 0.044, r = - 0.061, r = - 0.066, r = 0.150, respectively). There was no difference for histopathological findings between IgG (+), IgG (++), IgG (+++) groups (for all, p > 0.05). Conclusion Glomerular IgG negativity and positivity detected by routine IFM in IgAN patients is not associated with poor renal prognostic risk factors.