Browsing by Author "Bican, Aylin"
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Item Course of adolescent headache: 4-year annual face-to-face follow-up study(BMC, 2010-08) Karlı, Necdet; Bican, Aylin; Zarifoğlu, Mehmet; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; 6506587942; 18036596400; 6603411305The objective of this study is to investigate the course of the diagnosis and characteristics of headache in 12- to 17-year-old adolescents during a follow-up period of 4 years. Headache prevalence and characteristics, and even the type of headache show important changes during adolescence. The course of adolescent headache might reveal important insight into the pathophysiology of headache. Subjects who received a single headache diagnosis were invited to participate in a follow-up study consisting of annual face-to-face evaluation of the subjects for 4 years. Subjects who had only one type of headache and who agreed to participate were included in the study. Each subject had four annual semi-structured interviews with a neurology resident. The International Classification of Headache Disorders second edition was used for case definitions. A total of 87 subjects completed the study: 64 girls (73.56%) and 23 boys (26.44%) (p = 0.016). The headache type included migraine in 50 adolescents (57.47%), tension type headache in 24 (27.59%), secondary headache in 5 (5.7%), and non-classifiable headache in 8 (9.2%). Headache has not remitted in any of the subjects. Headache diagnosis has changed in eighteen (20.69%) subjects at least once during the follow-up period. There was transformation of headache type in 4 of 50 with migraine (8%), 10 of 24 with tension-type headache (TTH) (41.7%), and 4 of 13 with other headaches (30.8%). In conclusion, transition of headache types from one type to another (more than once in some adolescents) and variability of diagnosis throughout the years strongly support the continuum theory of headaches.Item Course of adolescent headache: 4-years prospective follow-up study(Sage Publications, 2009-10) Bican, Aylin; Karlı, Necdet; Zarifoğlu, Mehmet; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.Publication Electro-clinical analysis of ictal kissing automatism(Wiley, 2015-02-01) Taşkıran, E.; Carpraz, I.; Bilir, E.; Bican, Aylin; Bora, İbrahim; Chassoux, F.; Aydoğdu, I.; Özkara, C.; BİCAN DEMİR, AYLİN; BORA, İBRAHİM HAKKI; Uludağ Üniversitesi; CEN-7664-2022; ENI-7759-2022Item Hipertermik nöbet oluşturulan sıçanlarda pilokarpin sonrası status modelinde GABA-A ile etki eden propofolün etkisinin araştırılması ve hipokampal nöronal hasarın morfolojik değerlendirilmesi(Uludağ Üniversitesi, 2009) Bican, Aylin; Bora, İbrahim; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.Çalışmamızda, pilokarpin ile oluşturulan deneysel status epileptikus (SE) modelinde, epilepsi patogenezinin daha iyi anlaşılabilmesi ve SE tedavi yöntemlerinin geliştirilmesine katkıda bulunmak için, genç erişkin sıçanlara hipertermi uygulanarak febril konvülsiyon modeli oluşturulması, SE tedavisi olarak GABA-A üzerinden etki gösteren ve genel anestezik bir madde olan Propofol uygulanması ve epileptogenez sürecinde oluşacak olan mezial temporal lobun önemli bir kısmını oluşturan hipokampus ve dentat girusun morfolojik değişiklerini değerlendirmeyi amaçladık.Çalışmamızda Uludağ Üniversitesi Deney Hayvanları Yetiştirme ve Araştırma Merkezi'nden sağlanan 30-36 gr ağırlığında 21-22 günlük 28 adet Wistar albino türü genç-erişkin erkek sıçan ile 250-350 gr ağırlığında 21 adet Wistar albino türü erişkin erkek sıçan olmak üzere toplam 49 adet sıçan kullanıldı.Deneysel çalışma, kontrol ve tedavi grubu olmak üzere başlıca 2 grup şeklinde planlandı. İlk basamakta genç erişkin sıçanlara hipertermi (45°C ) uygulanarak febril konvülsiyon gözlendi. Yüksek doz (380 mg/kg ) pilokarpin ile deneysel SE oluşturuldu, SE'a girme oranı, SE latansı, 24 saatlik yaşam şansı ve SE tedavisi olarak genel anestezik bir madde olan Propofol uygulanması yapıldı ve tedaviye yanıt oranı değerlendirildi. Febril konvülsiyonun, pilokarpinin ve propofolun mezial temporal lobun önemli bir kısmını oluşturan hipokampus ve dentat girus üzerine olan morfolojik değişikleri değerlendirildi.Sonuç olarak, hipertermi oluşturulan ve pilokarpin ile status epileptikus gerçekleştirilen deneysel hayvan modelimizde özellikle hipokampus ve dentat girusta hücre hasarına neden olduğu, kontrol grupları ile karşılaştırmalar sonucu elde edildi. Status epileptikus modelinde propofolun etkili olduğu ve hipertermi sonucu epilepsiye zemin oluşturulan deneysel modelimizde de etkili olduğu sonucuna varıldı. Epileptik nöbetlerle ilişkili hasarların önlenmesi epileptogenezin temeline yönelik klinik yaklaşımlarla geliştirilebilir.Publication Long term video EEG monitorization(Kare, 2012-01-01) Bican, Aylin; Bilir, Erhan; Bora, İbrahim; BİCAN DEMİR, AYLİN; BORA, İBRAHİM HAKKI; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı; CEN-7664-2022; ENI-7759-2022Long term video EEG monitorisation is an essential step in the evaluation of patients with intractable epilepsy before the decision of epilepsy surgery. Considerations for long term monitorisation in the evaluation of the onset zone of seizures will be discussed in this paper.Item Neuroimaging in narcolepsy(Elsevier, 2010-02) Bican, Aylin; Bora, İbrahim Hakkı; Algın, Oktay; Hakyemez, Bahattin; Özkol, Volkan; Alper, Eray; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nükleer Tıp Anabilim Dalı.; 0000-0002-3425-0740; 0000-0002-3877-8366; AAI-2318-2021; 18036596400; 6602914249; 23995109100; 6602527239; 35330464900; 7006827670Item Obstrüktif uyku apne sendromu progresyonuna etki eden faktörlerin incelenmesi(Uludağ Üniversitesi, 2010-12-13) Yıldız, Ayçin; Bora, İbrahim; Bican, Aylin; Ocakoğlu, Gökhan; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.Obstrüktif uyku apne sendromu (OUAS) üzerine etkili olabilecek etyolojik ve/veya çeşitli komorbid durumların hafiften ağıra doğru giden klinik spektrum üzerindeki yerlerini araştırmaktır. Çalışmaya horlama, gündüz aşırı uyku hali ve yakınları tarafından bildirilen apne semptomlarından bir ya da daha fazlası ile başvuran ve bir gece uyku laboratuvarında yatırılarak tanısal polisomnografi (PSG) yapılan 172 olgu dâhil edildi. Apne hipopne indeksine (AHİ) göre hastalar 4 gruba ayrıldı. Basit horlama hastaları kontrol grubu olarak kabul edildi. Hastalar AHİ değerlerine göre basit horlama 50 (%29.1) , hafif OUAS 38 (%22.1), orta OUAS 43 (%25) ve ağır OUAS 41 (%23.8) olarak gruplandırıldı. Erkek cinsiyet ve vücut kitle indeksi ağır şiddette OUAS grubunda, hipertansiyon ve hiperlipidemi orta şiddette OUAS grubunda istatistiksel açıdan anlamlı olarak fazla saptandı (P <0.05). OUAS şiddetinin ağırlaşmasına vücut kitle indeksi ve diyabetin sinir ve kaslar üzerinde yarattığı fonksiyon bozukluğunun daha etkili olabileceği düşünülmektedir.Item Polysomnographic (Examination) evaluation and cap scoring of patients with continuous spikes and waves during slow sleep syndrome(Journal Neurological Sciences-Turkish, 2011) Özdemir, Özlem; Bican, Aylin; Okan, Mehmet Sait; Bora, İbrahim Hakkı; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Anabilim Dalı.; 26647804400; 8036596400; 6701707256; 6602914249Objective: In our study, we aimed to demonstrate presence of sleep disorder which may associate with Continuous Spike and Waves during Slow Sleep Syndrome (CSWS) clinical picture and to define changes in sleep structure of those patients by recording polysomnographs and full night sleep electroencephalogram (EEG) in our patients. Methods: The study population included totally 10 patients (7 boys and 3 girls) with diagnosis of followed by Pediatric Neurology Department, Uludag University and a control group consisted of 10 healthy individuals with similar age and sex distribution. Results: It is observed that there is no statistical difference between CSWS patients and control group in terms of total sleep time, Non-REM 1 (Stage-1), Non-REM 2 (Stage-2) and Non-REM 3+ Non-REM 4(Stage-3, Stage-4). It was found that REM period was shorter and the difference was statistically significant (p < 0.05). It was observed that 60 % of patients with CSWS had non-scored epochs. Mean Cyclic alternating pattern (CAP) value in patients with CSWS was 45 % and it was 25.8 % in control group and it was found to be statistically significant in patients. (p < 0,001). Conclusions: We found that sleep EEG records of patients with CSWS were more pathologic than that of control group and that integrity of sleep is deteriorated in patient group. However, we could not find any pathology related with primary sleep disorder. We believe that this study may clear up a way for future studies which may make contributions.Publication Preliminary experience from the turkey epilepsy pregnancy registry(Wiley, 2015-02-01) Güveli, B. Tekin; Bican, Aylin; Güler, S. Keskin; Bora, İbrahim; Gürses, C.; Türkiye Epilepsi Gebelik Kayıt Defteri; BİCAN DEMİR, AYLİN; BORA, İBRAHİM HAKKI; Bursa Uludağ Üniversitesi; CEN-7664-2022; ENI-7759-2022Publication Sleep measurements in women with dysthymic disorder and insomnia(Springer, 2015-01-01) Kotan, Zeynep; Bican, Aylin; Kotan, Vahap Ozan; Bora, İbrahim; Yalvac, Hayriye Dilek; Özkaya, Güven; Akkaya, Cengiz; BİCAN DEMİR, AYLİN; BORA, İBRAHİM HAKKI; ÖZKAYA, GÜVEN; AKKAYA, CENGİZ; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı.; 0000-0003-0798-4850; 0000-0002-1456-2499; A-4421-2016; ENI-7759-2022 ; CEN-7664-2022; EKJ-8427-2022To determine the effects of trazodone, mirtazapine and hydroxyzine on sleep profiles of dysthymic disorder (DD) women with selective serotonin reuptake inhibitor (SSRI) treatment and compare their polysomnographic measurements with controls. Among 36 patients trazodone receiving (n=9), mirtazapine receiving (n=8), hydroxyzine receiving (n=8) and only SSRI receiving (n=11) patients were compared to each other and to controls in terms of polysomnographic (PSG) findings. Rapid eye movements (REM) ratio and sleep onset time (SO) were higher; slow wave sleep (non-REM3) ratio and total sleep duration (TSD)) and sleep efficiency (SE) were lower in patients when compared with controls. Increased REM ratio and SO; decreased non-REM3 ratio and TSD and SE were found in both only SSRI receiving patients and hydroxyzine receiving patients when compared with controls. Only SSRI receiving patients also showed increased non-REM1 ratio. Trazodone or mirtazapine receiving patients showed no difference than controls. When PSG assessment is considered, it can be suggested that both trazodone and mirtazapine improve sleep problems in DD patients with SSRI treatment, but hydroxyzine does not.Item Sociodemographics, clinical features, and psychiatric comorbidities of patients with psychogenic nonepileptic seizures: Experience at a specialized epilepsy center in Turkey(W B Saunders, 2011-07) Bora, İbrahim Hakkı; Taşkapılıoğlu, Özlem; Seferoǧlu, Meral; Kotan, Ozan Vahap; Bican, Aylin; Özkaya, Güven; Akkaya, Cengiz; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0003-0297-846X; AAK-6623-2020; A-4421-2016; 6602914249; 23037226400; 25636262100; 6504322056; 18036596400; 16316866500; 14061855100Patients with psychogenic nonepileptic seizures (PNESs) or pseudoseizures are known to have psychiatric comorbidities. In the present retrospective analysis, we examined the sociodemographics, clinical characteristics, and psychiatric diagnoses of patients with PNESs. Our aim is to demonstrate the contribution of the consulting psychiatrists to the presumed psychiatric diagnoses of the neurologists. We used data from long-term video EEG monitoring (LVEM) performed at a specialized epilepsy center in Turkey. The study group comprised 67 patients (mean age: 30 years, 75% female) diagnosed with PNESs following LVEM of approximately 5 days' duration. Two hundred thirty-three episodes were recorded. Most of the patients experienced a PNES on the first day. All of the patients were taking antiepileptic drugs (AEDs) at the time of admission: 56.7% were taking antidepressant (AD) drugs. All of the PNES patients were diagnosed with conversion disorder by both the neurologists and the psychiatrists. Most of the PNES patients were using multiple AEDs. Cooperation between neurologists and psychiatrists and ongoing education for both neurologists and psychiatrists about PNES are needed in appropriate diagnosing and management of patients with PNESItem What is the efficacy of nasal surgery in patients with obstructive sleep apnea syndrome?(Lippincott Williams & Wilkins, 2010-11) Bican, Aylin; Kahraman, Ahmet; Bora, İbrahim Hakkı; Kahveci, Ramazan; Hakyemez, Bahattin; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Plastik Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; 0000-0002-3425-0740; AAI-2318-2021; AAG-4626-2019; 18036596400; 36851439600; 6602914249; 6602079953; 6602527239Purpose: Obstructive sleep apnea syndrome (OSAS) is characterized by repetitive episodes of partial or complete obstruction of the upper airway during sleep and is associated with increasing respiratory efforts, with a consequent oxyhemoglobin desaturation, sleep fragmentation, and daytime symptoms, most commonly excessive sleepiness. The effectiveness of continuous positive airway pressure (CPAP) is undoubtedly high in treating those patients who use it regularly, but for those who refuse it, the success rate is 0. It is for this subset of patients that surgical therapy can be useful. The purpose of this study was to evaluate the effects of nasal surgery on nasal resistance, sleep apnea, sleep quality, and nasal volumetric measurement in adult male patients with OSAS. Methods: Twenty male patients with complaints of hypersomnia and snoring were included in the study. Polysomnography of patients with the prediagnosis of OSAS was planned. All patients underwent CPAP treatment before and after surgery. Patients, who had anatomic structural defects causing nasal valve shrinkage, were operated on at the Plastic Reconstructive and Aesthetic Department. Volumetric measurements of the nose were obtained before and after the operation. Results: In our study, it was observed that respiratory tract space of patients increased subsequent to the surgery, and thereby OSAS level decreased, and tolerating CPAP device was easier. Measurements of internal nasal valve vertex and fields and external nasal valve fields before and after operation were significant. Conclusions: Surgical relief of this nasal obstruction may improve quality of life in patients with OSAS.