Browsing by Author "Bonaventura, Marguerite"

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The predicted probability of having positive non-sentinel lymph nodes in patients who received neoadjuvant chemotherapy for large operable breast cancer
(Wiley, 2008-09) Johnson, Ronald; Ahrendt, Gretchen; Bonaventura, Marguerite; Falk, Jeffrey; Keenan, Donald; Soran, Atilla; Evrensel, Türkkan; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı.; 0000-0002-9732-5340; AAJ-1027-2021; 6603942124
The accuracy of the nomogram in women with positive sentinel nodes following neoadjuvant chemotherapy (NCT) is unknown. The aim of this study was to evaluate the accuracy of the nomogram in patients receiving NCT. Between December 1999 and December 2005, we identified 233 patients who had a positive sentinel lymph node biopsy (SLNB) and complete axillary lymph node dissection at Magee-Womens Hospital of University of Pittsburgh Medical Center. Thirty-two patients (14%) had presented with clinically N0 breast cancer (BC) for which NCT was administered. The computerised BC nomogram was used to calculate the probability of non-sentinel node metastases utilising tumour size before NCT and after NCT for the same patient. The discrimination of the nomogram was assessed by calculating the area under (AUC) the receiver operating characteristic curve (ROC). The median patient age was 51.5 (range: 39-66) years in the NCT group of patients. Twelve patients (37%) had positive axillary non-sentinel lymph nodes (NSLNs). The nomogram was first validated in our institution for 201 patients without NCT and the predicted accuracy of the nomogram by the AUC was 0.73. The area under the ROC was identical regardless of whether pre- or posttreatment tumour size was used to determine predicted probability of NSLN metastases (0.66). The predictive accuracy of the nomogram was found to have less power for patients receiving NCT (0.66) than the non-NCT group of patients.
The predictive probability of two different breast cancer nomograms for non sentinel axillary lymph node metastasis in positive sentinel lymph node biopsy
(Aves, 2008-07-01) Gür, Akif Serhat; Ünal, Bülent; Johnson, Ronald; Ahrendt, Gretchen; Bonaventura, Marguerite; Evrensel, Türkkan; Soran, Atilla; EVRENSEL, TÜRKKAN; Uludağ Üniversitesi/Tıp Fakültesi/Medikal Onkoloji Anabilim Dalı.; 0000-0002-9732-5340; AAJ-1027-2021
INTRODUCTION: Non sentinel axillary lymph node metastasis (NSLNM) occurs in 35-50% of breast cancer (BC) patients having positive sentinel lymph nodes (SLN). A nomogram which includes 8 variables was developed at Memorial Sloan Kettering Cancer Center (MSKCC) in 2003 and it has been validated at sources outside that institution. The Stanford University group recently reported their nomogram which evaluated 3 variables. AIM: The aim of this study is to evaluate the predictability of two different scoring systems wherein 3 or 8 variables are used in the same patient groups.MATERIALS and METHODS: We identified 201 patients who had a positive SLN biopsy and completion axillary lymph node dissection at Magee-Womens Hospital of UPMC over a 5 year period. The computerized BC nomograms developed by MSKCC and Stanford University were used to calculate the probability of non-sentinel lymph node metastases. Area Under (AUC) Receiver Operating Characteristics Curve (ROC) was calculated for each nomogram and the values more than 0.70 have been accepted that presents considerable discrimination.RESULTS: Sixty-six of 201 patients (32.8%) had positive axillary NSLNM. The mean predicted probability of positive NSLNM was 25.4% (3-93), and 66.3% (7-100) for the MSKCC and Stanford nomograms, respectively. The AUC values were 0.73 and 0.67 for MSKCC and Stanford nomograms, respectively.DISCUSSION and CONCLUSION: Nomograms for predicting the probability of NSLNM in BC patients have been in use for 5 years. It is clear there are discrepancies in the results of nomograms among the studies using the same scoring system. Notwithstanding the Stanford nomogram is easier to implement as it considers only 3 variables in our study, we found the MSKCC nomogram to be more predictive than the Stanford nomogram Nomograms developed at outside institutions should be used with caution when counseling patients regarding the risk of additional nodal disease.
What is the predicted probability of having positive non-sentinel lymph nodes in patients who received neoadjuvant chemotherapy (NCT) for locally advanced breast cancer?
(Elsevier, 2006) Soran, Atilla; Ahrendt, Gretchen; Koçer, Belma; Bonaventura, Marguerite; Falk, Jeffrey; Keenan, Donald; Johnson, Ronald; Evrensel, Türkkan; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı.; 0000-0002-9732-5340; AAJ-1027-2021