Browsing by Author "Canda, Aras Emre"
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Publication Fall of another myth for colon cancer: Duration of symptoms does not differ between right- or left-sided colon cancers(Aves, 2019-08-01) Öztürk, Ersin; Kuzu, Mehmet Ayhan; Öztuna, Derya; Işık, Özgen; Canda, Aras Emre; Balık, Emre; Erkasap, Serdar; Yoldaş, Tayfun; Akyol, Cihangir; Demirbaş, Sezai; Özoğul, Bünyamin; Topcu, Ömer; Gedik, Ercan; Baca, Bilgi; Ergüner, İlknur; Aşoğlu, Oktar; Erkek, Bülent; Yılmazlar, Tuncay; Reis, Erhan; Gençosmanoğlu, Rasim; Aslar, Ahmet Kessaf; Konan, Ali; Öztürk, Ersin; IŞIK, ÖZGEN; YILMAZLAR, AHMET TUNCAY; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; 0000-0002-9541-5035; 0000-0001-8593-5101; 0000-0003-1924-0795; JGW-0566-2023; AAW-9602-2020; CKK-3621-2022Background/Aims: Patients with colorectal cancer continue to present with relatively advanced tumors that are associated with poor oncological outcomes. The aim of the present study was to assess the association between localization, symptom duration, and tumor stage.Materials and Methods: A prospective, multicenter cohort study was conducted on patients newly diagnosed with a histologically proven colorectal adenocarcinoma. Standardized questionnaire-interviews were performed. Data were collected on principal presenting symptoms, duration of symptoms (time to first presentation to a doctor and time to diagnosis) and treatment, diagnostic procedures, tumor site, and stage of the tumor (tumor, node, and metastasis (TNM)).Results: A total of 1795 patients with colorectal cancer were interviewed (mean age: 60.76 +/- 13.50 years, male patients: 1057, patients aged >50 years: 1444, colon/rectal cancer: 899/850, right side/left side: 383/1250, stage 0-1-2/stage 3-4: 746/923). No statistically significant correlations were found between duration of symptoms and either tumor site or stage. Principal presenting symptoms were significantly associated with left colon cancer. Patients who had "anemia," "change in bowel habits," "anal pruritus or discharge," " weight loss," and "tumor in right colon" had a significantly longer symptom time.Conclusion: Symptom duration is not associated with localization, nor is the tumor stage. Diagnosis of colorectal cancer at an earlier stage may be best achieved by screening of the population.Item Randomized controlled trial of 8 weeks' vs 12 weeks' interval between neoadjuvant chemoradiotherapy and surgery for locally advanced rectal cancer(Wiley, 2019-09-30) Terzi, Cem; Bingül, Muhammet Bahattin; Arslan, Naciye Çiğdem; Canda, Aras Emre; Obuz, Funda; Görken, İlknur Birkay; Ünlü, Mehtat; Öztop, İlhan; Işık, Özgen; Yılmazlar, Tuncay; Uğraş, Nesrin; Kanat, Özkan; Öztürk, Ersin; Kurt, Malerie; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Tıp Bilimleri/Genel Cerrahi Bölümü.; 0000-0002-9541-5035; 0000-0002-9541-5035; P-5779-2019; AAW-9602-2020; ABH-2238-2021; AAH-2716-2021; 36600543700; 6701800362; 55386535600; 55881548500; 35070171400; 8843050600Aim The aim was to compare the pathological complete response (pCR) rate at 8 compared to 12 weeks' interval between completion of neoadjuvant chemoradiotherapy (CRT) and surgery in patients with locally advanced rectal cancer. Method This was a randomized trial which included a total of 330 patients from two institutions. Patients with locally advanced (T3-4N0M0, TxN+M0) rectal cancer were randomized into 8- and 12-week interval groups. All the patients received long-course CRT (45 Gy in 1.8 Gy fractions and concomitant oral capecitabine or 5-fluorouracil infusion). Surgery was performed at either 8 or 12 weeks after CRT. The primary end-point was pCR. Secondary end-points were sphincter preservation, postoperative morbidity and mortality. Results Two-hundred and fifty-two patients (n = 125 in the 8-week group, n = 127 in the 12-week group) were included. Demographic and clinical characteristics were similar between groups. The overall pCR rate was 17.9% (n = 45): 12% (n = 15) in the 8-week group and 23.6% (n = 30) in the 12-week group (P = 0.021). Sphincter-preserving surgery was performed in 107 (85.6%) patients which was significantly higher than the 94 (74%) patients in the 12-week group (P = 0.016). Postoperative mortality was seen in three (1.2%) patients overall and was not different between groups (1.6% in 8 weeks vs 0.8% in 12 weeks, P = 0.494). Groups were similar in anastomotic leak (10.8% in 8 weeks vs 4.5% in 12 weeks, P = 0.088) and morbidity (30.4% in 8 weeks and 20.1% in 12 weeks, P = 0.083). Conclusion Extending the interval between CRT and surgery from 8 to 12 weeks resulted in a 2-fold increase in pCR rate without any difference in mortality and morbidity.