Browsing by Author "Demir, Bilge Cetinkaya"

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    Laparoscopic evacuation of an early pregnancy
    (Elsevier Science Inc, 2019-03-01) ÖZERKAN, KEMAL; ÇETİNKAYA DEMİR, BİLGE; ORHAN, ADNAN; Orhan, Adnan; Demir, Bilge Cetinkaya; Kasapoglu, Işıl; Uncu, Gürkan; UNCU, GÜRKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/KAdın Hastalıkları ve Doğum Anabilim Dalı.; 0000-0002-7558-8166; 0000-0001-6845-9991; AAH-9791-2021; K-2269-2016; AAH-9834-2021; V-5292-2019; AAT-3479-2021
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    The possible role of serum leptin in preeclampsia
    (IMR Press, 2016) Doster, Y.; Demir, Bilge Cetinkaya; Atalay, Mehmet Aral; Durusoy, Emine Emsal; Kuçükkomürcü, Şakir; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; AAH-9834-2021; 36923039100; 53863297800; 55836312500; 6507291599
    Background: It is theorized that adipokines play a critical role in the pathophysiology of preeclampsia, particularly with their pro-inflammatory and inflammatory features. Aim: To investigate serum leptin levels in pregnancies complicated with preeclampsia and severe preeclampsia. Materials and Methods: Maternal serum leptin levels were analyzed by solid phase enzyme amplified sensitivity immunoassay (EASIA) method in 23 patients with mild preeclampsia, 29 patients with severe preeclampsia, and 28 healthy pregnant controls. Results: Mean serum leptin levels did not differ statistically between patients with mild preeclampsia, severe preeclampsia, and the controls (10.77 ng/ml, 13.40 ng/ml, and 8.43 ng/ml, respectively). Also, there was no relationship between serum leptin levels and the gestational ages of the participants. Discussion: Serum leptin levels are not associated with preeclampsia. Leptin measurements are not affected with the gestational age. The role of leptin in the pathophysiology of preeclampsia should be evaluated cautiously.
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    Pregnancy and kidney transplantation: A single-center experience
    (Aves, 2022-07-01) Ayar, Yavuz; Sayılar, Emel Işıktaş; Demir, Bilge Cetinkaya; ÇETİNKAYA DEMİR, BİLGE; ERSOY, ALPARSLAN; OCAKOĞLU, GÖKHAN; YILDIZ, ABDULMECİT; ORUÇ, AYŞEGÜL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Jinekoloji ve Doğum Anabilim Dalı.; 0000-0003-4607-9220; 0000-0002-1114-6051; 0000-0002-0342-9692; 0000-0001-6845-9991; AAH-5180-2021; AAH-4002-2021
    Objective: The possibility of pregnancy increases with kidney transplantation in patients with chronic kidney disease. However, graft dysfunction, risk of fetal growth retardation, and fetal anomaly should be monitored closely. In this study, renal and obstetric outcomes were analyzed in pregnant kidney recipients who were followed in our center.Methods: We analyzed 140 reproductive-aged patients who underwent renal transplantation between January 2009 and May 2015, and clinical and laboratory data were evaluated retrospectively.Results: Twenty-four patients became pregnant (17.1%). In pregnant group, median age was significantly lower than nonpregnant group (P =.014). The median age of pregnant group at the time of transplantation was also significantly lower than non-pregnant patients (P <.001). The rate of pregnant patients was 66.7% in 18-25 year age group (P =.008). The rate of urinary tract infection in non-pregnant group was higher than pregnant group (P =.03). Live birth rates were 83.3% and 45.8% of those whose birth weight was higher than 2500 g. The increased level of daily urinary proteinuria and the time from diagnosis of renal failure to transplantation had significant effect on pregnancy (odds ratio = 13.81;95% CI: 2.06-92.45; P =.007 and odds ratio = 3.25;95% CI: 1.11-9.48; P =.031, respectively). Low serum creatinine level had significant protective effect (odds ratio = 0.001; 95% CI: 0-0.30, P =.018). The patients in 18-25 age group were 48.39 times more eligible for pregnancy compared to those in >35 age group (odds ratio = 48.39; 95% CI: 1.26-1860.72; P =.037). Rejection episodes were observed in 1 of pregnant women and 11 of non-pregnant women (P >.05).Conclusion: Pregnancy is possible in kidney transplant recipients of reproductive age. Calcineurin inhibitors and azathioprine seem to be safe. Maternal age, low-serum creatinine, and urinary proteinuria affect pregnancy. The close monitoring of renal function and fetal parameters is very important.
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    Wilms' tumor 1 protein expression in endometrial adenocarcinoma and endometrial intra-epithelial neoplasia
    (Wiley, 2016-01-24) Atik, Yeliz; Usubütün, Alp; Ertürk, Fatma Yılmaz; Demir, Bilge Cetinkaya; Ozan, Hakan; Baykara, Sema; Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; AAH-9834-2021; 36923039100; 7003908072; 54945413500
    AimTo investigate the expression of Wilms' tumor 1 (WT1) protein in endometrial adenocarcinoma (EC) and endometrial intra-epithelial neoplasia (EIN). MethodsWT1 protein expression was determined on immunohistochemistry in 30 EC patients and in 20 EIN patients. WT1 protein expression in proliferative (n = 7), secretory (n = 9) and atrophic endometrium (n = 9) and benign endometrial polyps (n = 28) was used as the control group. Cellular and vascular WT1 staining was scored semiquantitatively. ResultsCellular WT1 staining was 67% and vascular positivity was 73% in the EC group. In the EIN group the cellular staining was 100% and vascular staining was 85%. Although all EIN samples were positive for cellular WT1 staining, median cellular staining score was similar to that of EC (median, 2; range, 1-3; IQR, 1.75 vs 2, 0-3, 0.75, respectively). Increasing EC grade and stage were not associated with cellular or vascular WT1 staining score. ConclusionWT1 is expressed in EIN.