Browsing by Author "Demirdöǧen, Ezgi"

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    Low-grade urinary albumin excretion in normotensive/non-diabetic obstructive sleep apnea patients
    (Springer, 2008-08) Ursavaş, Ahmet; Karadağ, Mehmet; Güllü, Mustafa; Demirdöǧen, Ezgi; Coşkun, Funda; Onart, Seçuk; Gözü, Ramazan Oktay; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz-Baş Boyun Cerrahisi Anabilim Dalı.; 0000-0002-7400-9089; 0000-0003-3604-8826; 0000-0002-9027-1132; AAI-3169-2021; AAH-9812-2021; AAD-1271-2019; AAG-8744-2021; 8329319900; 6601970351; 6602684544; 14062849300; 21734137500; 7801637934; 15836640800
    Previous studies have indicated that high levels of urinary albumin excretion (UAE) are associated with an increased incidence of cardiovascular morbidity and mortality. This study examined the association between UAE and obstructive sleep apnea syndrome (OSAS). The study included 35 newly diagnosed OSAS patients and 11 nonapneic controls. Subjects with diabetes mellitus, hypertension, a history of renal failure, cardiac failure, coronary heart disease, collagen tissue disease, high serum creatinine, and urinary infection, and who use angiotensin-converting enzyme inhibitors and were women were excluded from the study. A single void morning urine sample at the baseline examination was used to measure UAE. There were no significant differences in the age, body mass index (BMI), and smoking habits of the OSAS patients and controls. UAE of the OSAS group was significantly higher than that of the control group (23.3 +/- 6.1 mu g/min vs. 6.5 +/- 2.1 mu g/min, respectively; P=0.002). UAE was positively correlated to length of time spent at an oxygen saturation of < 90% (r=0.503, P=0.002) and BMI (r=0.361, P=0.033). Regression analyses (r(2)=0.504, P < 0.0001) showed that the length of time spent at an oxygen saturation of < 90% (P < 0.0001) was risk factor for UAE, independent of age and BMI. Our study supports the notion that low-grade UAE is associated with non-hypertensive/non-diabetic OSAS, independent of age and BMI. Low-grade UAE may be a marker for subclinical vascular damage that predisposes OSAS patients to future cardiovascular disease.
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    Prognostic importance of central thrombus in hemodynamically stable patients with pulmonary embolism
    (Via Medica, 2017) Şentürk, Ayşegül; Özsu, Savaş Sedat; Duru, Serap; Çakır, Ebru; Ulaşlı, Sevinç Sarınç; Kayhan, Servet; Güzel, Aygül; Yakar, Fatih; Berk, Serdar; Demirdöǧen, Ezgi; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; 0000-0002-7400-9089; AAH-9812-2021; 14062849300
    Uludağ University, School of Medicine, Department of Pulmonary Medicine, Bursa, TurkeyBackground: The association between mortality and localization of central thrombus in hemodynamically stable patients with pulmonary embolism (PE) is unclear. Sufficient data are not available to help clinicians to select between low molecular weight heparin (LMWH), unfractionated heparin (UFH) and thrombolytics for the management of central thrombus. The present study aims to investigate whether central thrombus in the pulmonary artery affects 30-day mortality rate, and to compare the outcomes of different treatment approaches in patients with central thrombus. Methods: This multi-central, prospective, observational study included 874 hemodynamically stable patients with PE confirmed by multidetector computed tomography scan. The localization of the emboli was evaluated and categorized as central (saddle or at least one main pulmonary artery), lobar or distal. The primary study outcome was 30-day all-cause mortality. Results: Localization of the emboli was central in 319 (36.5%) patients, lobar in 264 (30.2%) and distal in 291 (33.2%) patients. Seventy-four (8.5%) patients died during the 30-day follow-up period. All-cause mortality rate was 11.9%, 6.8% and 6.2% in patients with central, lobar, and distal emboli, respectively (p < 0.001). Multivariate analysis did not show that hemodynamically stable central thrombus was an independent predictor of mortality. Additionally, mortality rate was not significantly different between UFH, LMWH and thrombolytic therapy groups. Conclusions: The present study showed that central thrombus was not an independent predictor of mortality in hemodynamically stable PE patients. LMWH and UFH were similarly effective in the treatment of this patient group.