Browsing by Author "Dirican, Melehat"
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Publication Analysis of inappropriate repeated laboratory testing(Walter De Gruyter Gmbh, 2022-05-09) Bozyiğit, Cengiz; Odabaşı, Merve Sena; Dirican, Melehat; DİRİCAN, MELEHAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.Objectives Laboratory services are an important part of the healthcare system. However many requested tests may be considered inappropriate or unnecessary. We evaluated laboratory use in a period of 3 years in terms of the inappropriate test repeats. Methods We analyzed inappropriate repeat rate (IRR) of hemoglobin A1c (HbA1c), 25-OH vitamin D [25(OH)D], thyroid-stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), anti-thyroid peroxidase antibody (anti-TPO), vitamin B12, folate, iron, ferritin and total cholesterol in the light of clinical guidelines. Results IRR of 3 year was found to be 10% on average (4.2-15.5%). In TSH, FT3, and FT4 parameters, IRR was between 4.2 and 5.3%, while it was between 12.9 and 15.5% for 25(OH)D, iron, ferritin, and total cholesterol. In all tests (except anti-TPO), IRRs were found to be higher in inpatients for each of the 3 years. Inappropriate repetition of total cholesterol, iron, and ferritin parameters were more frequent in men. Inappropriate repeats were performed in all parameters (except HbA1c) after a result that had been in the reference range. Conclusions Examined test repetitions were mostly inappropriate. To reduce the inappropriate laboratory test requests, it is important to analyze the causes and to ensure cooperation between laboratory specialists and clinicians.Item Fetuin-a levels in kidney transplant recipients with cardiac valvular calcification(Oxford Üniversity, 2017-05) Koca, Nizameddin; Ersoy, Alparslan; Şensoy, Barış; Kirhan, Emine; Oruç, Ayşegül; Güllülü, Sümeyye; Ersoy, Canan; Dirican, Melehat; Sarandöl, Emre; Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Onkolojisi Anabilim Dalı.; 0000-0002-0342-9692; 0000-0003-1457-4366; 0000-0002-0710-0923; 0000-0002-2593-7196; AAH-4002-2021; V-9228-2017; AAL-5648-2021; AAH-8861-2021; AAH-5054-2021; ABE-1716-2020; AAG-6985-2021Item Plasma lecithin-cholesteryl acyl transferase and cholesteryl ester transfer protein activity in angiographically confirmed coronary artery disease(Elsevier, 1999-09) Yeşilbursa, Dilek; Serdar, Zehra; Dirican, Melehat; Serdar, Akın; Güllülü, Sümeye; Coşkun, S.; Baran, İbrahim; Cordan, Jale; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.Publication Short term effect of laparoscopic sleeve gastrectomy on clinical, renal parameters and urinary ngal levels in diabetic and non diabetic obesity(Editura Acad Romane, 2019-07-01) Elbasan, Onur; Şişman, P.; Peynirci, Hande; Yabacı, Ayşegül; Dirican, Melehat; DİRİCAN, MELEHAT; Gül, Özen Öz; ÖZ GÜL, ÖZEN; Cander, Soner; CANDER, SONER; Ersoy, Canan; ERSOY, CANAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; 0000-0001-8580-9471; AAH-8861-2021; AAG-6985-2021; AAI-1005-2021Background. Although diseases such as diabetes, hypertension, obstructive sleep apnea and hyperlipidemia are clearly documented as obesity associated diseases, it is not well-known whether obesity causes renal pathologies. The aim of the present study was to evaluate the effect of weight loss following laparoscopic sleeve gastrectomy on clinical, renal parameters and urinary Neutrophil gelatinase-associated lipocalin (NGAL) levels in diabetic and non-diabetic obese patients.Methods. Nineteen morbidly obese patients (10 diabetic and 9 non diabetic) who underwent laparoscopic sleeve gastrectomy were evaluated clinically (anthropometric measurements) and biochemically before surgery and at 6 months from surgery.Results. Significant decreases in weight, BMI, FPG, PPG and HbA1c levels were observed in the diabetic group when the baseline and 6th month parameters of the patients were compared. There was also a significant decrease in SBP and DBP. At 6th month following laparoscopic sleeve gastrectomy, renal parameters such as creatinine, mAlb/creatinine, NGAL/creatinine did not differ in the diabetic group. In the nondiabetic group, serum creatinine levels were significantly decreased, but other renal parameters such as mAlb/creatinine and NGAL/creatinine were not significantly different.Conclusions. Our findings revealed significant decreases in weight, body mass index and glycemic parameters after sleeve gastrectomy in diabetic and non-diabetic patients, while no significant alteration was noted in renal functions, urinary NGAL and microalbumin levels.