Browsing by Author "Ercan, I."

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Detection of parvovirus b19 dna in the lesional skin of patients with behcet's disease
(Wiley, 2007-03-01) Baskan, E. B.; Yılmaz, E.; Saricaoglu, H.; Alkan, G.; Ercan, I.; Mistik, R.; Adim, S. B.; Goral, G.; Dilek, K.; Tunali, S.; 0000-0002-3894-1231; 0000-0002-2382-290X; AAH-1388-2021
Background: There is disagreement in the current evidence for viral aetiologies in the pathogenesis of Behcet's disease (BD).Objectives: To investigate the presence of B19 DNA in skin lesions of patients with BD, compare with the skin of healthy controls and evaluate its role in the pathogenesis.Methods: In total, 40 patients diagnosed with BD according to the criteria proposed by the International Study Group for Behcet's Disease and routinely followed up at our centre were enrolled into the study. All the patients selected were in the active phase of disease. Skin and blood samples of patients with BD and of the healthy volunteers were examined for B19 serology, histopathology and genome expression.Results: The quantity of B19 DNA in nonulcerative BD lesions of was significantly different from ulcerative lesions in the study group and from the skin of the healthy controls (P < 0.01). For the nonulcerative lesions, real-time PCR analysis for B19 DNA was found to be 64% sensitive (95% CI 42.5-82.0) and 85% specific (95% CI 62.1-96.6) with a cut-off value of > 154 IU/mL (P < 0.001).Conclusions: To the best of our knowledge, this is the first study that provides evidence for a possible causal link between BD and parvovirus B19, and our data suggest the presence of the virus, particularly in intact, nonulcerative skin lesions of BD. Limitations to this study include the limited number of participants, and the fact that the exact source of B19 DNA was undetected.
Frequency of atopy and allergic disorders among adults with type 1 diabetes mellitus in the southern marmara region of turkey
(Springer, 2008-03-01) Duran, C.; Ediger, D.; Ersoy, C.; Coşkun, N. F.; Selimoğlu, H.; Ercan, I.; Kıyıcı, S.; Güçlü, M.; Sağlam, D. A.; Ertürk, E.; Tuncel, E.; İmamoğlu, S.; EDİGER, DANE; ERSOY, CANAN; Coşkun, N. Funda; Selimoğlu, Hadi; ERCAN, İLKER; Kıyıcı, Sinem; Güçlü, Metin; SAĞLAM, DİLEK; ERTÜRK, ERDİNÇ; Tuncel, Ercan; İMAMOĞLU, SÜLEYMAN; Uludağ Üniversitesi/Alerji Bilim Dalı/Göğüs Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Bilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Alerji Anabilim Dalı/Göğüs Hastalıkları Bilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0001-9560-180X; 0000-0002-2954-4293; 0000-0003-3604-8826; 0000-0002-2382-290X; 0000-0001-5082-9894; 0000-0003-3604-8826; AAJ-6536-2021; ABF-2367-2020; AAH-8861-2021; ABI-4847-2020; AAE-9142-2019; AAD-1271-2019; FWY-5938-2022; FGL-7924-2022; DNS-0810-2022; EBN-7188-2022; DEA-5443-2022
Aim: Autoimmune disorders are considered to be associated with a Th1 immune response whereas allergic diseases with a Th2 response. Studies mainly per-Formed on children revealed conflicting results regarding the association of atopy/allergic disease and autoimmune disorders. Therefore, we aimed to investigate the prevalence of allergic diseases in adult Type 1 diabetic patients. Methods: Eighty-nine Type 1 diabetic patients and 64 controls were enrolled into the study. Skin-prick test and European Community Respiratory Health Survey questionnaire were performed on all cases. Patients who gave at least one positive answer to questions about asthma in the questionnaire underwent pulmonary function test and methacholine challenge test. Results: Patients' mean age were similar in diabetic patients and controls (28.2 +/- 8.9 and 28.1 +/- 5.2 yr; respectively). In skin-prick test, the rate Of Positive response to at least one allergen was not significantly different in diabetes (29.2%) and in the control group (31.3%). In European Community Respiratory Health Survey questionnaire, diabetic patients waked up by an attack of cough more than controls did. The rate of physician-diagnosed asthma was similar in both groups. There was no difference between the 2 groups based on the answers of other questions about asthma and other allergic diseases such as allergic rhinitis, eczema, and drug allergy. Conclusion: We found that atopy frequencies were similar in an adult population of Type 1 diabetic patients and controls. Although asthmatic symptom prevalence is increased in diabetic patients, the incidence of current asthma was similar in both groups.
Students' views about doctor-patient communication, chronic diseases and death
(Wolters Kluwer Medknow Publications, 2008-03-01) Özçakır, A.; Uncu, Y.; Sadıkoğlu, G.; Ercan, I.; Bilgel, N.; ÖZÇAKIR, ALİS; UNCU, YEŞİM; Sadıkoğlu, G.; ERCAN, İLKER; Bilgel, Nazan; Uludağ Üniversitesi/Tıp Fakültesi/Aile Hekimliği Anabilim Dalı.; 0000-0002-2382-290X; D-9597-2016; AAP-9210-2020; AAG-8209-2021; FTO-3267-2022; CGS-7006-2022
Context: Students start their medical study with the opinion that saving lives and preventing deaths are the main goals of medicine. So, what will they do when faced with dying patients? How will they feel; how will they communicate? These are important, but often unspoken and neglected, issues.Objectives: We assessed the attitudes and opinions of first-year medical students regarding doctor-patient communication, chronic diseases, death, and dying patients at Uludag University Medical School in Bursa/Turkey. Our secondary objective was to delineate the educational needs related to this field.Methods: Cross-sectional survey of the first-year students in the class of 2004-2005. Students were evaluated using a questionnaire consisting of six questions and 18 Likert-type statements.Results: Completed questionnaires were received from 253 of the 265 (95.5%) students. According to the students, the most fatal diseases were cancer and AIDS. Students strongly agreed with the importance of talking to patients, where female students agreed more than males with this statement (p<0.05). Most students disagreed that patients should be informed that they are dying. Older students feared less for the death of patients. Female students would like to work in an environment where they can communicate with their patients and where they can be with them for a longer period.Conclusions: The results of this survey indicate that the need of providing palliative care, enhancing communication skills with terminally ill patients, and integrating different teaching strategies are important aspects of the undergraduate medical curriculum.