Browsing by Author "Fapohunda, Stephen Oyedele"
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Item Anti-Aflatoxigenc potentials of two Nigerian herbs on albino rats(Uludağ Üniversitesi, 2009) Fapohunda, Stephen Oyedele; Akintewe, Tosin; Olarinmoye, Ayodefi; Ezekiel, Chinbudu NgoziThe anti-aflatoxigenic activity of methanolic and ethanolic extracts of Phyllanthus niruri and Pseudocedrella kotschyi were studied in male and female Wister albino rats fed with aflatoxin –contaminated chow (112ppb) for 20 d. Morbidity studies arising from the dietary aflatoxin were carried out. Packed Cell Volume (PCV), fasting blood sugar (FBS), haemoglobin concentration (HB), total white blood cells (WBC), and serum bilirubin (SB) were profiled.. Extracts from both herbs lowered the PCB, blood glucose, Hb, WBC and SB levels in the test male than in control at P<0.05 using the ANOVA test for significance. The ethanolic extracts of Pseudocedrella and the methanolic extract of Phyllanthus were the most effective anti-aflatoxigenic agents in the male as they reduced the blood parameter levels by 50% of the positive control. The results were not so in the females. Post-mortem examination revealed kidney discoloration and paleness, mild to moderate hepatomegaly and enlarged spleen in the positive control while test rats showed normal morphology for these organs. The 2 local herbs are good candidates for the management of aflatoxicosis in mammals.Item Enzyme-related aflatoxin production in vital organs of rats fed with Aspergillus species- inoculated rat chow(Uludağ Üniversitesi, 2007-04-01) Fapohunda, Stephen Oyedele; Awoyinka, Olayinka Anthony; Olajuyigbe, Olufunmiso Olusola; Ezekiel, Chibundu Ngozi; Esiaba, IjeomaWister strain Albino rats were fed with 40 mL distilled water and 20g of rat chow inoculated with Aspergillus tamarii Kita IMI 393765 and Aspergillus flavus Link IMI 393766 daily for 7 days. A progressive weight loss and reduced sluggishness accompanied very high activity at OD 540 of hepato-specific enzymes-Glutamate oxalate transaminase and Glutamate pyruvate transaminase in the heart and kidney of rats having continuous 7-day contact with Aspergillus flavus. Statistical analyses revealed significance at 0.05 % level of probability. A corresponding high aflatoxin level (above 20 ppb) was also determined in all the vital organs. Both enzyme and aflatoxin levels were comparatively lower in the liver and perforations were recorded in the gastrointestinal tract, leading to content leakage. Lower values, though higher than the control, were recorded in those fed on Aspergillus tamarii-inoculated rat chow, which also experienced no GI tract damage.