Browsing by Author "Haque, Shafiul"
Now showing 1 - 15 of 15
- Results Per Page
- Sort Options
Publication Antineoplastic action of sulforaphane on hela cells by modulation of signaling pathways and epigenetic pathways(Edizioni Minerva Medica, 2021-12-01) Sundaram, Madhumitha Kedhari; Almutary, Abdulmajeed G.; Alsulimani, Ahmad; Ahmad, Syed Rehan; Somvanshi, Pallavi; Bhardwaj, Tulika; Pellicano, Rinaldo; Fagoonee, Sharmila; Hussain, Arif; Haque, Shafiul; Haque, Shafiul; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0002-2989-121X; AAN-2946-2020BACKGROUND: Epigenetic modifications alter signaling and molecular pathways; moreover, they are an important therapeutic target. This study examined the effect of sulforaphane on molecular targets in HeLa cells.METHODS: Quantitative PCR of various molecular targets was performed. Activity of epigenetic enzymes was measured by ELISA and molecular docking analysis was conducted. Promoter methylation of some tumor suppressor genes was quantified using PCR based methylation array. In-silico protein-protein interaction network analysis was performed to understand the effect of transcriptional changes.RESULTS: Quantitative PCR demonstrated the transcriptional modulation of genes involved in proliferation, metastasis, inflammation, signal transduction pathways and chromatin modifiers. Sulforaphane reduced the enzymatic activity of DNA methyl transferases, histone deacetylases and histone methyltransferases. Molecular docking results suggest that sulforaphane competitively inhibited several DNA methyl transferases and histone deacetylases. Promoter 5'CpG methylation levels of selected tumor suppressor genes was found to be reduced which correlated with their transcriptional increase as well modulation of epigenetic enzymes. Further, protein-protein interaction network analysis discerned the participation of genes towards cancer pathways. Functional enrichment and pathway-based analysis represented the modulation of epigenetic and signaling pathways on sulforaphane treatment.CONCLUSIONS: The modulation in transcriptional status of epigenetic regulators, genes involved in tumorigenesis resulting in tumor suppressor genes demethylation and re-expression underscores the mechanism behind the anticancer effect of sulforaphane on HeLa cells.Item Biological remediation technologies for dyes and heavy metals in wastewater treatment: New insight(Elsevier Ltd, 2022-01) Singh, Arvind; Pal, Dan Bahadur; Mohammad, Akbar; Alhazmi, Alaa; Yoon, Taeho; Srivastava, Neha; Gupta, Vijai Kumar; Haque, Shafiul; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0002-2989-121X; EXU-4037-2022; 35793732800The pollution of the environment caused by dyes and heavy metals emitted by industries has become a worldwide problem. The development of efficient, environmentally acceptable, and cost-effective methods of wastewater treatment containing dyes and heavy metals is critical. Biologically based techniques for treating effluents are fascinating since they provide several benefits over standard treatment methods. This review assesses the most recent developments in the use of biological based techniques to remove dyes and heavy metals from wastewater. The remediation of dyes and heavy metals by diverse microorganisms such as algae, bacteria, fungi and enzymes are depicted in detail. Ongoing biological method's advances, scientific prospects, problems, and the future prognosis are all highlighted. This review is useful for gaining a better integrated view of biological based wastewater treatment and for speeding future research on the function of biological methods in water purification applications.Publication Covid-19 pandemic related excessive electronic media exposure and mental health in saudi arabia(Verduci Publisher, 2021-01-01) Alnohair, Sultan; Syed, Nabeel Kashan; Ahmed, Hussain; Sharaf, Futoun Z.; Alshehri, Fahad; Haque, Shafiul; Griffiths, Mark D.; Haque, Shafiul; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0002-2989-121X; EXU-4037-2022OBJECTIVE: Due to the continued spread of COVID-19 and the emergence of novel mutated viral variants, families all over the world are experiencing wide-ranging stress-ors that threaten not only their financial well-being but also their physical and mental health. The present study assessed the association between excessive electronic media exposure of pandemic-related news and mental health of the residents of Ha'il Province, Saudi Arabia. The present study also assessed the prevalence of perceived stress, fear of COVID-19, anxiety, depression, and loneliness due to COVID-19-related restrictions in the same population.MATERIALS AND METHODS: A total of 490 residents of Ha'il Province participated in a cross-sectional online survey during a two-month period (March to April 2021). A validated 38-item self-report survey was used to collect the data.RESULTS: Significant associations were reported between excessive electronic media exposure and the prevalence of perceived stress (X-2 =140.56; p<.001), generalized anxiety (X-2 =74.55; p<001), depression (X-2 =71.58; p<.001), COVID-19-related fear (X-2 =24.54; p<.001), and loneliness (X-2 =11.46; p<.001). It was also found that participants without depressive symptoms were 0.28 times less likely to have been exposed to excessive electronic media exposure (AOR: 0.28; C.I. 0.16-0.48; p<.001). Similarly, participants with no stress/mild stress were 0.32 times less likely to have been exposed to excessive electronic media exposure (AOR: 0.32; C.I. 0.19-0.52; p<.001).CONCLUSIONS: The findings of the present study suggest an urgent need for educational resilience programs (online and in-person) for susceptible individuals (females, unemployed, urban residents, etc.). Such programs would help them to develop skills to cope with the psychological impact of the COVID-19 pandemic.Publication Effect of MHC linked 7-gene signature on delayed hepatocellular carcinoma recurrence(Mdpi, 2021-10-28) Tariq, Fomaz; Khan, Walizeb; Ahmad, Washaakh; Riaz, Syeda Kiran; Khan, Mahvish; Sherwani, Subuhi; Haque, Shafiul; Malik, Muhammad Faraz Arshad; Iftikhar, Muhammad Jahangir; Khan, Saif; Haq, Farhan; Haque, Shafiul; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0002-2989-121X; AAN-2946-2020Dysregulated immune response significantly affects hepatocellular carcinoma's (HCC) prognosis. Human Leukocyte Antigens are key in devising immune responses against HCC. Here, we investigated how HLAs modulate HCC development at the transcriptomic level. RNA-seq data of 576 patients from two independent cohorts was retrieved. The clinicopathological relevance of all HLA genes was investigated using Fisher-Exact, correlation, and Kaplan-Meier and cox regression survival tests. Clustering of ~800 immune-related genes against HLAs was completed using a ward-agglomerative method. Networks were generated using 40 HLA associated unique genes and hub genes were investigated. HLAs including HLA-DMA, HLA-DMB, HLA-DOA and HLA-DRB6 were associated with delayed recurrence in both discovery (204 HCC cases) and validation (372 HCC cases) cohorts. Clustering analyses revealed 40 genes associated with these four HLAs in both cohorts. A set of seven genes (NCF4, TYROBP, LCP2, ZAP70, PTPRC, FYN and WAS) was found co-expressed at gene-gene interaction level in both cohorts. Furthermore, survival analysis revealed seven HLA-linked genes as predictors of delayed recurrence. Multivariate analysis also predicted that mean expression of 7-gene is an independent predictor of delayed recurrence in both cohorts. We conclude that the expression of 7-gene signature may lead to improved patient prognosis. Further studies are required for consideration in clinical practice.Item Egypt's COVID-19 recent happenings and perspectives: A mini-review(Frontiers Media S.A., 2021-08-16) Saied, AbdulRahman A.; Metwally, Asmaa A.; Madkhali, Norah Abdullah Bazekh; Dhama, Kuldeep; Haque, Shafiul; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Anabilim Dalı.; 0000-0002-2989-121X; AAN-2946-2020; 35793732800The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected countries across the world. While the zoonotic aspects of SARS-CoV-2 are still under investigation, bats and pangolins are currently cited as the animal origin of the virus. Several types of vaccines against COVID-19 have been developed and are being used in vaccination drives across the world. A number of countries are experiencing second and third waves of the pandemic, which have claimed nearly four million lives out of the 180 million people infected globally as of June 2021. The emerging SARS-CoV-2 variants and mutants are posing high public health concerns owing to their rapid transmissibility, higher severity, and in some cases, ability to infect vaccinated people (vaccine breakthrough). Here in this mini-review, we specifically looked at the efforts and actions of the Egyptian government to slow down and control the spread of COVID-19. We also review the COVID-19 statistics in Egypt and the possible reasons behind the low prevalence and high case fatality rate (CFR%), comparing Egypt COVID-19 statistics with China (the epicenter of COVID-19 pandemic) and the USA, Brazil, India, Italy, and France (the first countries in which the numbers of patients infected with COVID-19). Additionally, we have summarized the SARS-CoV-2 variants, vaccines used in Egypt, and the use of medicinal plants as preventive and curative options.Publication Hopelessness among medical students caused due to covid-19 pandemic linked educational hiatus: A case study of Bursa Uludag University, Türkiye(MDPI, 2023-02-01) Aydın, Mevlüt Okan; Özkaya, Güven; Kafa, İlker Mustafa; Haque, Shafiul; Alper, Züleyha; AYDİN, MEVLÜT OKAN; ÖZKAYA, GÜVEN; KAFA, İLKER MUSTAFA; ALPER, ZÜLEYHA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıp Eğitimi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Anatomi Anabilim Dalı.; 0000-0002-8060-8803; 0000-0003-0297-846X; 0000-0001-8309-0934; A-4421-2016; ABE-2261-2020; AAI-3331-2021; AAG-7125-2021The COVID-19 pandemic has caused disruptions in medical education, leading to feelings of hopelessness among students regarding their medical careers. However, effective institutional crisis-response approaches can mitigate these feelings of hopelessness. This study evaluated changes in the levels of hopelessness among Turkish medical students due to interruptions in their education caused by the pandemic between March and July 2020, using the Beck Hopelessness Scale in three selected periods. A statistical survey was conducted with a total of 3580 participants in three different periods to study the impact of various contributing factors, such as socio-economic status, family problems, health problems, and lack of working environment, on the levels of hopelessness in conjunction with active COVID-19 cases and the effect of institutional interventions for the continuation of medical education during the pandemic. The analysis revealed a direct relationship between contributing factors and hopelessness scores at the end of the selected three periods. Additionally, active COVID-19 cases and institutional crisis-response strategies were found to be indirectly associated with students' hopelessness. An increase in students' hopelessness was found to be related to an increase in active COVID-19 cases in the country, a lack of continuing education practices, and the role of contributing factors. Conversely, a decrease in hopelessness was associated with effective institutional crisis-response strategies. These findings suggest that educational settings dealing with practical subjects should prioritize preparedness for crisis situations.Item An insight into probiotics bio-route: Translocation from the mother's gut to the mammary gland(MDPI, 2021-08-02) Selvamani , Shanmugaprakasham; Dailin, Daniel Joe; Gupta, Vijai Kuma; Wahid, Mohd; Keat, Ho Chin; Natasya, Khairun Hani; Sayyed, R. Z.; Abd Malek, Roslinda; Theodoros, Varzakas; Abomoelak, Bassam; Sukmawati, Dalia; El Enshasy, Hesham Ali; Haque, Shafiul; 0000-0002-2989-121X; AAN-2946-2020; 35793732800Human breast milk (HBM) is unique in its composition as it is adapted to fulfil the newborns' nutritional requirement and helps in improving the health of newborns. Besides various nutrients, the human milk also contains diverse group of microbiotas. The human milk microbiota has a remarkable impact on the growth and development of a newborn. Additionally, the human milk microbiota enhances the colonization of microbes in the gut of infants. Debates about the origin of HBM microbial flora remain premature and contradictory in some cases. Recent data suggest that the maternal gut microbiota has a major impact on microbial composition, areolar skin, and from the infant's oral cavity. The current review investigates the possible route of microbial transfer from the maternal gut to mammary gland and suggests that it might occur through the entero-mammary pathway. It involves precise selection of probiotic microorganisms from the gut, as the human gut hosts trillions of microorganisms involved in gut homeostasis and other metabolic pathways. Gastrointestinal lymphatic vessels, macrophages, and dendritic cells are shown to play a significant role in the microbial transmission. Furthermore, the role of microbial factors in the development of neonatal immunity and translocation of secretory IgA (SIgA) cells from the intestinal lumen to GALT and finally to mammary glands via entero-mammary link are discussed.Item Integrated biohydrogen production via lignocellulosic waste: Opportunity, challenges & future prospects(Elsevier Sci Ltd, 2021-10) Singh, Tripti; Alhazmi, Alaa; Mohammad, Akbar; Srivastava, Neha; Sharma, Shalini; Singh, Rajeev; Yoon, Taeho; Gupta, Vijai Kumar; Haque, Shafiul; Uludağ Üniversitesi/Tıp Fakültesi; EXU-4037-2022; 35793732800Hydrogen production through biological route is the cleanest, renewable and potential way to sustainable energy generation. Productions of hydrogen via dark and photo fermentations are considered to be more sustainable and economical approach over numerous existing biological modes. Nevertheless, both the biological modes suffer from certain limitations like low yield and production rate, and because of these practical implementations are still far away. Therefore, the present review provides an assessment and feasibility of integrated biohydrogen production strategy by combining dark and photo-fermentation as an advanced biochemical processing while using lignocellulosics biomass to improve and accelerate the biohydrogen production technology in a sustainable manner. This review also evaluates practical viability of the integrated approach for biohydrogen production along with the analysis of the key factors which significantly influence to elevate this technology on commercial ground with the implementation of various environment friendly and innovative approaches.Item Lead removal from synthetic wastewater by biosorbents prepared from seeds of artocarpus heterophyllus and Syzygium Cumini(Elsevier Ltd, 2022-01) Giri, Deen Dayal; Alhazmi, Alaa; Mohammad, Akbar; Srivastava, Neha; Thakur, Vijay Kumar; Gupta, Vijai Kumar; Pal, Dan Bahadur; Haque, Shafiul; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Bölümü.; 0000-0002-2989-121X; EXU-4037-2022; 35793732800The present investigation deals with removal of lead (Pb+2) ions from waste water using biosorbent prepared from seeds of Artocarpus heterophyllus (SBAh) and Syzygium cumini (SBSc). Biosorbents surface has been characterized through FT-IR spectroscopy to probe the presence of functional groups. Response surface methodology enabled optimized conditions (Pb+2 concentration 2 mu g/mL, pH 5.8 and bioadsorbent dose 60 mg) resulted in Pb+2 removal similar to 96% for SBAh and similar to 93% for SBSc at agitation speed 300 rpm. The adsorption capacity has been found to be 4.93 mg/g for SBAh and 3.95 mg/g for SBSc after 70 min. At optimal experimental conditions, kinetics of biosorption was explained well by inter-particle diffusion model for SBAh (R-2 = 0.99) whereas Elovich model best fitted for SBSc (R-2 = 0.98). Further, both the biosorbents followed Temkin adsorption isotherm model.Publication Peer-assisted skills learning in structured undergraduate medical curriculum: An experiential perspective of tutors and tutees(Wolters Kluwer Medknow Publications, 2022-05) Aydin, Mevlüt Okan; Kafa, İlker Mustafa; Özkaya, Güven; Alper, Züleyha; Haque, Shafiul; AYDİN, MEVLÜT OKAN; KAFA, İLKER MUSTAFA; ALPER, ZÜLEYHA; ÖZKAYA, GÜVEN; 0000-0002-8060-8803; 0000-0001-8309-0934; 0000-0002-8349-9868; AAI-3331-2021; AAG-7125-2021; ABE-2261-2020; FQT-8976-2022Background and Aims: This study aims to evaluate the implication of peer-assisted learning model adopted in students' clinical skills training from the perspective of tutees and tutors at the end of a peer-tutored clinical skills program and peer tutors themselves. Subjects and Methods: This cross-sectional study was conducted in the Faculty of Medicine, Bursa Uludag in between January and March 2018. Following the clinical skills training, a questionnaire designed to assess the views of tutees and peer tutors was filled out on a voluntary basis by 159 tutees and 43 tutors. The statistical analysis of the collected and processed data was analyzed by using IBM SPSS 23.0 statistical program. The statistical significance level was maintained as alpha = 0.05. Results: According to the Likert scale, satisfaction with the tutors and the educational environment was high in general. The 2nd term tutees provided more negative feedback compared to other terms. Among all the terms, the most positive answers were provided by the 3rd term students. Although the tutors found themselves fully skilled in communication with colleagues, there were striking differences between the tutors in the 5th and 6th terms of providing a good role model for pre-clinical terms students. Conclusion: Considering peer assisted learning (PAL)'s positive responses from this study, the adoption of PAL has been started to be used as a supplementary teaching method for the clinical skills training at the Faculty of Medicine, Bursa Uludag University. PAL is considered a successful education model since it is cost-efficient for undergraduate medical training and improves the professional skills of both teacher and learner students. It can be availed of as an alternative method in medical faculties where especially the number of academic members is insufficient.Publication Phytochemicals from indian ethnomedicines: Promising prospects for the management of oxidative stress and cancer(MDPI, 2021-10-01) Fatima, Nishat; Baqri, Syed Shabihe Raza; Alsulimani, Ahmad; Fagoonee, Sharmila; Slama, Petr; Kesari, Kavindra Kumar; Roychoudhury, Shubhadeep; Haque, Shafiul; Haque, Shafiul; Bursa Uludağ Üniversitesi/Tıp Fakültesi; AAN-2946-2020Oxygen is indispensable for most organisms on the earth because of its role in respiration. However, it is also associated with several unwanted effects which may sometimes prove fatal in the long run. Such effects are more evident in cells exposed to strong oxidants containing reactive oxygen species (ROS). The adverse outcomes of oxidative metabolism are referred to as oxidative stress, which is a staple theme in contemporary medical research. Oxidative stress leads to plasma membrane disruption through lipid peroxidation and has several other deleterious effects. A large body of literature suggests the involvement of ROS in cancer, ageing, and several other health hazards of the modern world. Plant-based cures for these conditions are desperately sought after as supposedly safer alternatives to mainstream medicines. Phytochemicals, which constitute a diverse group of plant-based substances with varying roles in oxidative reactions of the body, are implicated in the treatment of cancer, aging, and all other ROS-induced anomalies. This review presents a summary of important phytochemicals extracted from medicinal plants which are a part of Indian ethnomedicine and Ayurveda and describes their possible therapeutic significance.Publication Recent advances in synaptosomal proteomics in alzheimer's disease(Bentham Science, 2021-01-01) Ahmad, Faraz; Haque, Shafiul; Chavda, Vishal; Ashraf, Ghulam Md; Haque, Shafiul; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0002-2989-121X; AAN-2946-2020The current meta-analysis of the cohort review was designed to elucidate the progress made in neuroproteomics of the synaptosome. The association of the comprehensive synaptic proteome and its link to physiological or pathological setting is rapidly mounting. Chemical synapses in the brain are focal hot spots for interneuronal signalling, signal transduction, and its plasticity. Structurally, synapses comprise axon termini or the presynapse (vesicles filled with neurotransmitters that function as molecular signals), synaptic clefts (extracellular matrix and adhesion molecules), and Postsynaptic Density or PSD (with receptors for neurotransmitters that rely upon the chemical signalling). The pre- and post-synaptic clefts are responsible for mediating and regulating neurotransmitter release, their receptor binding, and perception rely on chemical signals. Moreover, short- and long-term structural and functional alterations that are necessary for the optimal higherorder brain functions are also mainly dependent on the protein dynamics at the synapses. Not surprisingly, disruptions in synaptic physiology are considered as the major pathogenic mechanisms underlying the progression of several neurodegenerative disorders, including Alzheimer's disease. This review briefly discusses the subcellular fractionation protocols and the related biochemical approaches for the isolation of synaptic compartments. Besides, it discusses the progress made in understanding the pathological alterations in the synaptic proteome in neurodegenerative disorders, particularly focussing on Alzheimer's disease dementia.Publication Sustainable green approach to synthesize Fe₃O₄/α-Fe₂O₃ nanocomposite using waste pulp of Syzygium cumini and its application in functional stability of microbial cellulases(Nature Portfolio, 2021-12-21) Srivastava, Neha; Srivastava, Manish; Alhazmi, Alaa; Mohammad, Akbar; Khan, Saif; Pal, Dan Bahadur; Haque, Shafiul; Singh, Rajeev; Mishra, P. K.; Gupta, Vijai Kumar; Haque, Shafiul; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0002-2989-121X; AAN-2946-2020Synthesis of nanomaterials following green routes have drawn much attention in recent years due to the low cost, easy and eco-friendly approaches involved therein. Therefore, the current study is focused towards the synthesis of Fe₃O₄/alpha-Fe₂O₃ nanocomposite using waste pulp of Jamun (Syzygium cumini) and iron nitrate as the precursor of iron in an eco-friendly way. The synthesized Fe₃O₄/alpha-Fe₂O₃ nanocomposite has been extensively characterized through numerous techniques to explore the physicochemical properties, including X-ray diffraction, Fourier transform infrared spectroscopy, Raman spectroscopy, Ultraviolet-Vis spectroscopy, field emission scanning electron microscope, high resolution transmission electron microscope and vibrating sample magnetometer. Further, efficiency of the Fe₃O₄/alpha-Fe₂O₃ nanocomposite has been evaluated to improve the incubation temperature, thermal/pH stability of the crude cellulase enzymes obtained from the lab isolate fungal strain Cladosporium cladosporioides NS₂ via solid state fermentation. It is found that the presence of 0.5% Fe₃O₄/alpha-Fe₂O₃ nanocomposite showed optimum incubation temperature and thermal stability in the long temperature range of 50-60 degrees C for 15 h along with improved pH stability in the range of pH 3.5-6.0. The presented study may have potential application in bioconversion of waste biomass at high temperature and broad pH range.Publication Targeted inhibition of fibroblast growth factor receptor 1-GLI through AZD4547 and GANT61 modulates breast cancer progression(Frontiers Media Sa, 2021-10-13) Riaz, Syeda Kiran; Khan, Walizeb; Wang, Fen; Khaliq, Tanwir; Malik, Amber; Razia, Eisha Tir; Khan, Jahangir Sarwar; Haque, Shafiul; Hashem, Anwar M.; Alkhayyat, Shadi S.; Azhar, Najiah Esam; Harakeh, Steve; Ansari, Mohammad Javed; Haq, Farhan; Malik, Muhammad Faraz Arshad; Haque, Shafiul; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0002-2989-121X; AAN-2946-2020The underlying mechanism of fibroblast growth factor receptor 1 (FGFR1) mediated carcinogenesis is still not fully understood. For instance, FGFR1 upregulation leads to endocrine therapy resistance in breast cancer patients. The current study aimed to identify FGFR1-linked genes to devise improved therapeutic strategies. RNA-seq and microarray expression data of 1,425 breast cancer patients from two independent cohorts were downloaded for the analysis. Gene Set Enrichment Analysis (GSEA) was performed to identify differentially expressed pathways associated with FGFR1 expression. Validation was done using 150 fresh tumor biopsy samples of breast cancer patients. The clinical relevance of mRNA and protein expression of FGFR1 and its associated genes were also evaluated in mouse embryonic fibroblasts (MEFs) and breast cancer cell line (MDA-MB-231). Furthermore, MDA-MB-231 cell line was treated with AZD4547 and GANT61 to identify the probable role of FGFR1 and its associated genes on cells motility and invasion. According to GSEA results, SHH pathway genes were significantly upregulated in FGFR1 patients in both discovery cohorts of breast cancer. Statistical analyses using both discovery cohorts and 150 fresh biopsy samples revealed strong association of FGFR1 and GLI1, a member of SHH pathway. The increase in the expression of these molecules was associated with poor prognosis, lymph node involvement, late stage, and metastasis. Combined exposures to AZD4547 (FGFR1 inhibitor) and GANT61 (GLI1 inhibitor) significantly reduced cell proliferation, cell motility, and invasion, suggesting molecular crosstalk in breast cancer progression and metastasis. A strong positive feedback mechanism between FGFR1-GLI1 axis was observed, which significantly increased cell proliferation and metastasis. Targeting FGFR1-GLI1 simultaneously will significantly improve the prognosis of breast cancer in patients.Publication The interplay of the unfolded protein response in neurodegenerative diseases: A therapeutic role of curcumin(Frontiers Media, 2021-10-18) Mukherjee, Sitabja; Mishra, Awdhesh Kumar; Peer, G. D. Ghouse; Bagabir, Sali Abubaker; Haque, Shafiul; Pandey, Ramendra Pati; Raj, V. Samuel; Jain, Neeraj; Pandey, Atul; Kar, Santosh Kumar; Haque, Shafiul; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0002-2989-121X; AAN-2946-2020Abnormal accumulation of misfolded proteins in the endoplasmic reticulum and their aggregation causes inflammation and endoplasmic reticulum stress. This promotes accumulation of toxic proteins in the body tissues especially brain leading to manifestation of neurodegenerative diseases. The studies suggest that deregulation of proteostasis, particularly aberrant unfolded protein response (UPR) signaling, may be a common morbific process in the development of neurodegeneration. Curcumin, the mixture of low molecular weight polyphenolic compounds from turmeric, Curcuma longa has shown promising response to prevents many diseases including current global severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and neurodegenerative disorders. The UPR which correlates positively with neurodegenerative disorders were found affected by curcumin. In this review, we examine the evidence from many model systems illustrating how curcumin interacts with UPR and slows down the development of various neurodegenerative disorders (ND), e.g., Alzheimer's and Parkinson's diseases. The recent global increase in ND patients indicates that researchers and practitioners will need to develop a new pharmacological drug or treatment to manage and cure these neurodegenerative diseases.