Browsing by Author "KAYGISIZ, ONUR"

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15 and 30 w holmium: Yag laser lithotriptor in ureteroscopic lithotripsy: Which one is more effective and safe?
(Mary Ann Liebert, 2021-05-05) Kaygısız, Onur; Aydın, Yavuz Mert; Çicek, Mehmet Çağatay; Çelen, Sinan; Coşkun, Burhan; Kılıçarslan, Hakan; Kaygısız, Onur; KAYGISIZ, ONUR; Aydın, Yavuz Mert; AYDIN, YAVUZ MERT; Çicek, Mehmet Çağatay; ÇİÇEK, MEHMET ÇAĞATAY; Coşkun, Burhan; COŞKUN, BURHAN; Kılıçarslan, Hakan; KILIÇARSLAN, HAKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0002-9790-7295; 0000-0002-6287-6767; 0000-0002-0471-5404; 0000-0002-8242-9921; JCO-5169-2023; AFP-3055-2022; L-9439-2019
Background: Holmium:yttrium-aluminium-garnet (Ho:YAG) laser lithotripsy with ureteroscopy (URS) was a safe and successful treatment option for pediatric ureteral stones. We aimed to comparatively evaluate the outcomes of 15 and 30 W Ho:YAG laser lithotriptors in pediatric ureter stones.Materials and Methods: We retrospectively evaluated 55 children who underwent ureteroscopic laser lithotripsy to treat ureter stone size up to 15 mm between September 2009 and March 2020. Groups were formed according to the laser lithotriptor power 15 W (Group 15: n = 32), 30 W (Group 30: n = 23). The efficiency of laser lithotriptors was compared between the groups.Results: The age, gender, and stone characteristics (longest stone diameter, density, location and multiple stones) were similar between the groups. In the postop first month, stone-free status was achieved in all cases except one child in Group 15. The median operative time was significantly shorter in Group 30 (40 minutes) than in Group 15 (52.5 minutes) (P = .010). Clavien-Dindo class (CDC) 2 complications occurred in 2 children in both groups (P = .597). Although ureteric stenosis was observed in 1 patient in Group 15, no ureteric stenosis was seen in Group 30 during follow-up (median 16.1 months). Length of hospital stay (LoHS) and stone-free rates were similar between groups.Conclusion: URS with 15 and 30 W Ho:YAG laser lithotriptors is an effective treatment option for pediatric ureteral stones with a high success rate and low complication rates. In brief, 30 W Ho:YAG laser lithotriptors should be preferred over 15 W lithotriptors due to their shorter operative time with similar success rate.
Can ChatGPT, an artificial intelligence language model, provide accurate and high-quality patient information on prostate cancer?
(Elsevier Science Inc, 2023-10-10) Coşkun, Burhan; Ocakoğlu, Gökhan; Yetemen, Melih; Kaygısız, Onur; COŞKUN, BURHAN; OCAKOĞLU, GÖKHAN; YETEMEN, MELİH; KAYGISIZ, ONUR; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0002-8242-9921; 0000-0002-1114-6051; 0000-0002-9790-7295; AAH-9704-2021; L-9439-2019; AAH-5180-2021; JVM-2711-2024
OBJECTIVE To evaluate the performance of ChatGPT, an artificial intelligence (AI) language model, in providing patient information on prostate cancer, and to compare the accuracy, similarity, and quality of the information to a reference source. METHODS Patient information material on prostate cancer was used as a reference source from the website of the European Association of Urology Patient Information. This was used to generate 59 queries. The accuracy of the model's content was determined with F1, precision, and recall scores. The similarity was assessed with cosine similarity, and the quality was evaluated using a 5RESULTS ChatGPT was able to respond to all prostate cancer-related queries. The average F1 score was 0.426 (range: 0-1), precision score was 0.349 (range: 0-1), recall score was 0.549 (range: 0-1), and cosine similarity was 0.609 (range: 0-1). The average GQS was 3.62 +/- 0.49 (range: 1-5), with no answers achieving the maximum GQS of 5. While ChatGPT produced a larger amount of information compared to the reference, the accuracy and quality of the content were not optimal, with all scores indicating need for improvement in the model's performance. CONCLUSION Caution should be exercised when using ChatGPT as a patient information source for prostate cancer due to limitations in its performance, which may lead to inaccuracies and potential misunderstandings. Further studies, using different topics and language models, are needed to fully understand the capabilities and limitations of AI-generated patient information. UROLOGY 180: 35-58, 2023. (c) 2023 Elsevier Inc. All rights reserved.
Can chatgpt, an artificial intelligence language model, provide accurate and high-quality patient information on prostate cancer? reply
(Elsevier Science Inc, 2023-10-10) Coşkun, Burhan; COŞKUN, BURHAN; Ocakoğlu, Gokhan; OCAKOĞLU, GÖKHAN; Yetemen, Melih; YETEMEN, MELİH; Kaygısız, Onur; KAYGISIZ, ONUR; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0002-1114-6051; 0000-0002-9790-7295; L-9439-2019; AAH-5180-2021
Characteristics of deceased donors used for kidney transplantation: Single-center experience
(Frontiers Media Sa, 2019-10-01) Ersoy, Alparslan; Elgin, Ersin; Akgür, Suat; Yıldız, Abdülmecit; Kaygısız, Onur; Oflaz, Rafet; Selimoğlu, Kerem; Oruç, Ayşegül; Ünsal, Oktay; Coşkun, Burhan; Aydın, Mehmet Fethullah; Keskin, Sahriye; Kordan, Yakup; Vuruşkan, Hakan; ERSOY, ALPARSLAN; Elgin, Ersin; AKGÜR, SUAT; YILDIZ, ABDULMECİT; KAYGISIZ, ONUR; Oflaz, Rafet; Selimoğlu, Kerem; ORUÇ, AYŞEGÜL; Ünsal, Oktay; COŞKUN, BURHAN; Aydın, Mehmet Fethullah; Keskin, Sahriye; Kordan, Yakup; VURUŞKAN, HAKAN; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Nefroloji Bilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Organ ve Doku Nakli Merkezi.; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0002-9790-7295 ; 0000-0002-0710-0923 ; 0000-0002-0342-9692; 0000-0002-5665-7402; AAH-5054-2021; DXA-2790-2022; EJA-1761-2022; HIG-9032-2022; AAM-9726-2020; DJU-5362-2022; CDS-3299-2022; AAH-4002-2021; JJY-8484-2023; AAH-9704-2021; AAJ-8220-2020; CZH-6714-2022; GAF-0095-2022; EFH-9523-2022
Comparison of patient satisfaction rates for the malleable and two piece-inflatable penile prostheses
(Aves, 2014-12-01) Kılıçarslan, Hakan; Kaynak, Yurdaer; Gökçen, Kaan; Coşkun, Burhan; Kaygısız, Onur; KILIÇARSLAN, HAKAN; COŞKUN, BURHAN; KAYGISIZ, ONUR; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0002-9790-7295 ; JIT-9412-2023; AAH-9704-2021; AAM-9726-2020
Objective: To compare patient/partner satisfaction with AMS 600-650 and AMS Ambicore penile implants (American Medical Systems, Minneapolis, USA) in patients with erectile dysfunction.Material and methods: The modified Erectile Dysfunction Inventory of Treatment Satisfaction (EDITS) questionnaires at six months after implantation of 46 patients who underwent AMS 600-650 (n=23) or Ambicore placement (n=23) between 1/1/2008 and 1/1/2013 were analyzed.Results: The percentages of patients with AMS 600-650 who reported to be satisfied, very satisfied and neither satisfied nor dissatisfied with their prostheses were 34.78% (n=8), 30.43% (n=7) and 34.78% (n=8), respectively. For patients with AMS Ambicore, these percentages were 73.91% (n=17), 13.04% (n=3) and 13.04% (n=3), respectively. These overall satisfaction rates were significantly different between patients with AMS 600-650 and Ambicore (p=0.013). For patients with AMS 600-650, the percentages of patients who reported to be very likely, neither likely nor unlikely, or very unlikely to continue using their prosthesis were 30.43% (n=7), 34.78% (n=8), and 34.78% (n=8) while for patients with AMS Ambicore, these percentages were 65.21%, 21.33%, and 13.04%, respectively. These percentages were different between patients with AMS 600-650 and Ambicore (p=0.018).Conclusion: The two-piece inflatable penile prosthesis was found to be more successful in overall satisfaction and more likely for continued use when compared to the malleable penile prosthesis.
Comparison of ureteroscopic laser lithotripsy with laparoscopic ureterolithotomy for large proximal and mid-ureter stones
(Karger, 2015-01-01) Kaygısız, Onur; Coşkun, Burhan; Kılıçarslan, Hakan; Kordan, Yakup; Vuruşkan, Hakan; Özmerdiven, Gökhun; Yavacaoğlu, İsmet; KAYGISIZ, ONUR; COŞKUN, BURHAN; KILIÇARSLAN, HAKAN; Kordan, Yakup; VURUŞKAN, HAKAN; Özmerdiven, Gökhun; Yavacaoğlu, İsmet; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Bölümü; 0000-0002-9790-7295; 0000-0002-8242-9921; 0000-0002-9947-848X; AAH-9704-2021; L-9439-2019; JCO-5169-2023; AAM-9726-2020; JIT-9412-2023; GAF-0095-2022; EFH-9523-2022; JIF-9579-2023; EIN-0828-2022
Objectives: To compare the effectiveness and complications of ureteroscopic laser lithotripsy with laparoscopic ureter laparoscopic ureterolithotomy in mid- or proximal portion of large ureteral stones. Material and Methods: We reviewed patients with large (>15 mm) ureteral stone and those who underwent ureteroscopic laser lithotripsy CURS group) or laparoscopic ureterolithotomy (LU group). The first attempt was considered successful in patients who had residual fragments smaller than 2 mm and no conversion of the primary procedure to another. Results: Sixty patients (URS group 29, LU group 31) met inclusion criteria. FURS was used as an adjunctive procedure in one patient for URS group and in two patients for LU group in the same season. LU had a higher success rate and the first-day stone-free rate when compared with URS. Number of procedures was also significantly higher in URS group. There was no difference in stone-free rates at the first and third months, and length of hospitalization and operation were higher in the LU group. Only two patients in the LU group and one patient in the URS group had major complications. Conclusions: Laparoscopy is an effective option of large proximal and mid-ureter stone treatment; however, URS provides similar stone-free rates at three months as a minimal invasive procedure.
Determination of urinary stone composition using biochemical analysis of fluid samples taken during ureterorenoscopic laser lithotripsy
(Springer, 2019-11-01) Arslan, İ. Ethem; Kılıçarslan, Hakan; KILIÇARSLAN, HAKAN; Çiçek, M. Çağatay; Günseren, K. Omur; Ocakoğlu, Gökhan; OCAKOĞLU, GÖKHAN; Kaygısız, Onur; KAYGISIZ, ONUR; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0002-9245-1241; 0000-0002-0471-5404; 0000-0001-8673-3093; 0000-0002-1114-6051; 0000-0002-9790-7295; ABC-9924-2020; AAM-9726-2020; ABD-3885-2020; L-9439-2019; AAH-5180-2021; HLG-6346-2023
Purpose The present study aims to biochemically analyze the fluid samples containing stone dust taken during the perioperative period to determine the role of fluid in the prediction of stones in patients treated with ureterorenoscopic procedures. Our secondary aim is to investigate the role of both fluid analysis and stone analysis in predicting the results of the metabolic analysis.Methods Comparative analyses were performed using fluid samples containing stone dust from 93 patients. Biochemical analysis of fluid containing stone dust was conducted; stone fragments were examined at a separate location using X-ray diffractometry(XRD). Metabolic analysis was performed to patients who provided stone-free status 1 month later. The results of chemical analysis were compared with the results of the XRD analysis.Results Patients' stone type was determined with high accuracy using biochemical analysis. Differences were noted in ten patients following biochemical analysis and XRD analysis. Biochemical analysis predicted metabolic disorders in more patients than XRD analysis, particularly for those patients with multiple stone compositions. However, no significant differences between the results of biochemical and XRD analysis methods were found (kappa = 0.27; p = 0.002). Moreover, biochemical analysis results revealed metabolic disorders in five patients; these findings were missed by XRD analysis.Conclusion Biochemical analysis of fluid taken perioperatively during ureterorenoscopic laser lithotripsy to treat urinary system stone disease was found to determine stone composition with high accuracy. Biochemical analysis of fluid samples taken during the perioperative period is, thus, an easy, reliable and cost-effective test to assess stone composition in patients undergoing ureterorenoscopic procedures.
Effect of operation timeline on frequency of surgical complication in deceased donor kidney transplantation
(Frontiers Media SA, 2019-10-01) Ersoy, Alparslan; Düger, Hakan; Dizdar, Oğuzhan Sıtkı; Yıldız, Abdülmecit; Akgür, Suat; Kaygısız, Onur; Oruç, Ayşegul; Ünsal, Oktay; Coşkun, Burhan; Kordan, Yakup; Türker, Gürkan; Vuruşkan, Hakan; ERSOY, ALPARSLAN; Düger, Hakan; Dizdar, Oğuzhan Sıtkı; YILDIZ, ABDULMECİT; AKGÜR, SUAT; KAYGISIZ, ONUR; ORUÇ, AYŞEGÜL; Ünsal, Oktay; COŞKUN, BURHAN; Kordan, Yakup; TÜRKER, YUNUS GÜRKAN; VURUŞKAN, HAKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı/Nefroloji Bilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Anestezi ve Reanimasyon Anabilim Dalı.; 0000-0001-5478-3192; 0000-0002-9790-7295; 0000-0002-0342-9692; 0000-0002-8242-9921; 0000-0002-9947-848X; 0000-0002-3019-581X; AAM-9726-2020; AAH-5054-2021; AAI-6642-2021; AAH-4002-2021; IZP-9361-2023; AAH-9704-2021; BBE-2157-2022; HIG-9032-2022; EJA-1761-2022; JJY-8484-2023; AAH-9704-2021; GAF-0095-2022; EFH-9523-2022
Factors influencing lymphocel development after kidney transplantation: Single center experience
(Oxford University Press, 2015-05-01) Sayılar, Emel Işıktaş; Ersoy, Alparslan; Ayar, Yavuz; Aydın, Mehmet Fethullah; Şahin, Ahmet Bilgehan; Coşkun, Burhan; Kaygısız, Onur; Yıldız, Abdulmecit; Kordan, Yakup; Vuruşkan, Hakan; SAYILAR, EMEL IŞIKTAŞ; ERSOY, ALPARSLAN; AYAR, YAVUZ; AYDIN, MEHMET FETHULLAH; ŞAHİN, AHMET BİLGEHAN; COŞKUN, BURHAN; KAYGISIZ, ONUR; YILDIZ, ABDULMECİT; KORDAN, YAKUP; VURUŞKAN, HAKAN; 0000-0003-4607-9220; 0000-0002-5665-7402; 0000-0002-7846-0870; 0000-0002-8242-9921; 0000-0002-9790-7295; 0000-0002-9947-848X; 0000-0002-0710-0923; AAH-5054-2021; O-9948-2015; L-9439-2019; JCO-5169-2023; AAH-9704-2021; AGF-0767-2022; AAJ-8220-2020; AAM-4927-2020; GSE-0029-2022; W-2575-2017; AAM-9726-2020; HIG-9032-2022; GAF-0095-2022; EFH-9523-2022
Factors influencing lymphocele development after kidney transplant: Single center experience
(Başkent Üniversitesi, 2023-03-01) Sayılar, Emel Işıktaş; Ersoy, Alparslan; Ayar, Yavuz; Aydın, Mehmet Fethullah; Şahin, Ahmet Bilgehan; Coşkun, Burhan; Kaygısız, Onur; Yıldız, Abdülmecit; Kordan, Yakup; Vuruşkan, Hakan; Sayılar, Emel Işıktaş; ERSOY, ALPARSLAN; Ayar, Yavuz; Aydın, Mehmet Fethullah; ŞAHİN, AHMET BİLGEHAN; COŞKUN, BURHAN; KAYGISIZ, ONUR; YILDIZ, ABDULMECİT; Kordan, Yakup; VURUŞKAN, HAKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0003-4607-9220; 0000-0002-5665-7402; 0000-0002-7846-0870; 0000-0002-8242-9921; 0000-0002-9790-7295; 0000-0002-9947-848X; AAJ-8220-2020; O-9948-2015; AAH-9704-2021; L-9439-2019; JCO-5169-2023; AAM-4927-2020; HYA-4372-2023; CPX-5894-2022; HIG-9032-2022; GAF-0095-2022; EFH-9523-2022
Objectives: Lymphocele is a well-known postoperative surgical complication after kidney transplant. In this study, our aim was to analyze incidence, risk factors, and outcomes of posttransplant lymphocele in a large cohort.Materials and Methods: This observational study included 395 consecutive patients (219 males and 176 females) who underwent kidney transplant procedures from 183 living and 212 deceased donors in our center between January 2007 and 2014. A lymphocele was diagnosed with ultrasonography.Results: The incidence of lymphoceles in our cohort was 31.9% (n = 126). There were no significant differences with regard to body mass indexes, age of donors, deceased donor ratios, acute rejection episodes, and history of abdominal surgery between those with and without lymphoceles. The pretransplant serum albumin levels (3.29 +/- 0.67 vs 3.48 +/- 0.69 g/dL; P = .009) in the lymphocele group and diabetes mellitus ratios (15.9% vs 4.5%; P < .001) in the nonlymphocele group were lower than levels shown in the other group. The lymphocele ratio in patients who received cyclosporine was higher than that shown in patients who did not received it (37.5% vs. 27.4%; P = .032). There was no difference in lymphocele incidence between patients who were taking and those who were not taking mammalian target of rapamycin inhibitors, mycophenolate mofetil, or mycophenolate sodium. In regression analysis, presence of diabetes mellitus, transplant from deceased donors, older age of donors, and lower albumin levels were independent risk factors for posttransplant lymphocele occurrence.Conclusions: Posttransplant lymphocele was a relatively common surgical complication in our cohort. We concluded that diabetes mellitus, use of kidneys from deceased donors, older donor age, and hypoalbuminemia were independent risk factors for lymphocele development.
Investigation of VHL gene associated with miR-223 in clear cell renal cell carcinoma
(Springer, 2021-11-26) Ünal, Ufuk; Çeçener, Gülşah; Ünlü, Havva Tezcan; Vuruşkan, Berna Aytaç; Erdem, Ecem Efendi; Egeli, Ünal; Nazlıoğlu, Hülya Öztürk; Kaygısız, Onur; Tunca, Berrin; Vuruşkan, Hakan; Ünal, Ufuk; ÇEÇENER, GÜLŞAH; Ünlü, Havva Tezcan; AYTAÇ VURUŞKAN, BERNA; Erdem, Ecem Efendi; EGELİ, ÜNAL; ÖZTÜRK NAZLIOĞLU, HÜLYA; KAYGISIZ, ONUR; TUNCA, BERRİN; VURUŞKAN, HAKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0003-4913-3616; 0000-0002-3820-424X; 0000-0002-0910-4258; 0000-0001-7904-883X; 0000-0002-9790-7295; 0000-0002-1619-6680; AAH-1420-2021; L-9439-2019; GYU-0252-2022; ABC-1357-2020; AAP-9988-2020; GYU-0252-2022; EEJ-1452-2022; ESY-2704-2022; FLN-9596-2022; ABI-6078-2020; EFH-9523-2022
Background Clear cell type renal cell carcinoma (ccRCC) is the most common renal cell carcinoma (RCC). In this study, we examined the expressions of VHL and miR-223 in ccRCC patients' tissues to investigate the possible role in the development of ccRCC.Methods and results This study collected five expression profiles (GSE36139, GSE3, GSE73731, GSE40435, and GSE26032) from Gene Omnibus Data. Expressions of VHL and miR-223 in paraffinized tumor and normal tissues of 100 Turkish patients' ccRCC tissues were determined by bioinformatic data mining and real-time quantitative polymerase chain reaction (qRT-PCR). The VHL gene was subjected to mutational analysis by DNA sequencing, and pVHL was analyzed using western blotting. Our study's t-test and Pearson correlation analysis showed that VHL gene expression in tumoral tissues with a - 0.39-fold decrease was not significantly lower than normal tissues (p = 0.441), and a 0.97-fold increase miR-223 (p = 0.045) was determined by real-time PCR. Also, as a result of DNA sequence analysis performed in the VHL gene, it was found that 26% of the patients have mutations. The mutations for (VHL):c.60C>A (p.Val20=) and (VHL):c.467delA (p.Tyr156Leu) was detected for the first time in Turkish patients.Conclusions The present study demonstrated that the differences in the expression levels of miR-223 have the potential to be biomarkers to determine the poor prognosis in ccRCC.
Our results of pediatric kidney transplantation; Single center experience, Uludag University department of pediatric nephrology
(Springer, 2015-09-01) Dönmez, Osman; Akacı, Okan; Kaygısız, Onur; Uysal, Berfin; Ciğerdelen, Nuray; DÖNMEZ, OSMAN; Akacı, Okan; KAYGISIZ, ONUR; Uysal, Berfin; Ciğerdelen, Nuray; Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0002-2148-1160; 0000-0002-9790-7295; AFO-2965-2022; AAA-8778-2021; L-9439-2019; GRJ-8581-2022; AAM-9726-2020
RNA-based markers in biopsy cores with atypical small acinar proliferation: Predictive effect of T2E fusion positivity and MMP-2 upregulation for a subsequent prostate cancer diagnosis
(Wiley, 2019-02-01) Eryılmaz, I. Ezgi; Vuruşkan, Berna Aytaç; Kaygısız, Onur; Egeli, Ünal; Tunca, Berrin; Kordan, Yakup; Çeçener, Gülşah; ERYILMAZ, IŞIL EZGİ; AYTAÇ VURUŞKAN, BERNA; KAYGISIZ, ONUR; TUNCA, BERRİN; ÇEÇENER, GÜLŞAH; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0002-9790-7295; 0000-0001-7904-883X; 0000-0002-1619-6680; 0000-0002-9947-848X; 0000-0002-3820-424X; ABI-6078-2020; AAP-9988-2020; AAH-1420-2021; L-9439-2019; AAM-9726-2020; AAH-9746-2021; GWV-3548-2022
Background Atypical small acinar proliferation (ASAP) is a precursor lesion of prostate cancer (PC), and PC develops from this suspicious focus or an unsampled malignant gland nearby. However, PC-related molecular alterations that could guide the timing of repeat biopsies and help monitor PC risk in ASAP-diagnosed patients have not been investigated. The purpose of this study was to first investigate the expression of seven different PC-related RNAs that included serine 2 (TMPRSS2): erythroblastosis virus E26 oncogene homolog (ERG) gene (TMPRSS2-ERG, T2E) fusion, alpha-methylacyl-CoA racemase (AMACR), kallikrein related peptidase 3 (KLK3), androgen receptor (AR), prostate cancer specific antigen 3 (PCA3), and matrix metalloproteinases (MMP)-2 and 9. Methods PC-related RNAs were evaluated using a real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR) system in pathologically ASAP-diagnosed prostate biopsy cores from 55 patients presenting with a normal digital rectal examination and a PSA level of 4-10 ng/mL. Results We detected that positive T2E fusion status (P = 0.013) and the expression of AMACR (P = 0.016), AR (P = 0.016) and MMP-2 (P = 0.013) were independently and significantly associated with PC risk in ASAP patients. There were also several statistically significant correlations between expression levels. Additionally, we demonstrated that T2E fusion positive ASAP patients with higher MMP-2 expression were more likely to be diagnosed with PC at a subsequent biopsy during the follow-up period (P = 0.003). Conclusions Although, more clinical validations are needed for the stratification of PC risk in ASAP-diagnosed biopsy cores, our current results indicate that the coexistence of T2E fusion positivity with MMP-2 upregulation may help clinicians adjust their biopsy timetable and/or assessment of PC risk in ASAP-diagnosed patients with a PSA level of 4-10 ng/mL.
The effects of laparoscopic urologic surgery on cardiac functions: A pulse wave velocity study
(Aves, 2020-07-01) Çiçek, Mehmet Çağatay; Kaynak, Yurdaer; Gunseren, Kadir Ömur; Kaygısız, Onur; Vuruşkan, Hakan; ÇİÇEK, MEHMET ÇAĞATAY; GÜNSEREN, KADİR ÖMÜR; KAYGISIZ, ONUR; VURUŞKAN, HAKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0002-0471-5404; 0000-0001-8673-3093; 0000-0002-9790-7295; ABC-9924-2020; L-9439-2019; HGM-5995-2022 ; EFH-9523-2022
Objective: The aim of this study is to evaluate the effects of laparoscopic urologic surgery on cardiac functions by the parameter pulse wave velocity (PWV), a noninvasive method.Material and methods: Between July 2012 and February 2013, a total of 47 patients were included in this prospective controlled study. Patients who have been scheduled for laparoscopic surgery (LS) (n=30) and open surgery (n=17) were enrolled in the study. Preoperative, perioperative, and postoperative cardiovascular parameters were measured by a PWV instrument, and the results were compared between laparoscopic (L) group and open (C) group.Results: In the L group, compared to preoperative values, perioperative systolic arterial pressure, diastolic arterial pressure, and mean arterial pressure increased considerably, by 2.6%, 7.9%, and 4.7%, respectively. This was in contrary to reductions in these parameters by 9.5%, 5.7%, and 10%, respectively, in the C group. For the I. group, cardiac output (CO) and cardiac index (CI) were increased in the perioperative period and decreased in the postoperative period. For the C group, there were no changes in measurements of perioperative and postoperative CO and CI. However, these changes in CO and CI were not significantly different between the L and C groups. Postoperative large artery elasticity index decreased in both groups. However, these changes did not represent significant difference between groups.Conclusion: Compared to open surgery, LS may cause increases in perioperative blood pressures. In addition, increased blood pressures may last even on the first postoperative day. These effects may be more important for patients with high cardiovascular risk.
The relationship between surgical complications and graft outcomes after kidney transplantation
(Wiley, 2019-10-01) Düger, Hakan; Ersoy, Alparslan; Dizdar, Oğuzhan Sıtkı; Yıldız, Abdulmecit; Oruç Ayşegül; Ünsal, Oktay; Akgür, Suat; Kordan, Yakup; Kaygısız, Onur; Coşkun, Burhan; Vuruskan, Hakan; Düger, Hakan; ERSOY, ALPARSLAN; Dizdar, Oğuzhan Sıtkı; YILDIZ, ABDULMECİT; ORUÇ, AYŞEGÜL; Ünsal, Oktay; AKGÜR, SUAT; Kordan, Yakup; KAYGISIZ, ONUR; COŞKUN, BURHAN; VURUŞKAN, HAKAN; Uludağ Üniversitesi/Tıp Fakültesi/Dermatoloji Bölümü; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Bölümü; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Bölümü; 0000-0001-5478-3192; 0000-0002-0342-9692; 0000-0002-9947-848X; 0000-0002-9790-7295; 0000-0002-8242-9921; AAM-9726-2020; AAH-5054-2021; AAH-4002-2021; AAH-9704-2021; IZP-9361-2023; JCO-5169-2023; L-9439-2019; D-6213-2013; GPK-6118-2022
Ureteral wall thickness at the stone site: A critical predictor of success and complications in children undergoing semi-rigid ureteroscopy
(Elsevier, 2021-10-07) Kırlı, Elif Altınay; Bülbül, Emre; Kaygısız, Onur; Yeni, Sezgin; Can, Günay; Tutar, Onur; Onal, Bülent; KAYGISIZ, ONUR; YENİ, SEZGİN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0001-5143-6507; 0000-0002-9790-7295; L-9439-2019 ; GFT-1275-2022
IntroductionWe retrospectively assessed the role of ureteral wall thickness (UWT) at the ureteral stone site in predicting the stone-free status and the complication rates in children undergoing semi-rigid ureterorenoscopy (URS).Patients and methodsThe children who underwent URS and had undergone non-contrast abdominal computerized tomography before the URS were included in the study. The following protocol was used to determine the outcome. Immediately before removing the stent, all children were evaluated by ultrasound (US) and plain film (KUB) for residual stones in the upper urinary tract and after removing the double J stent, the presence of stone fragments in the ureter was checked with URS. The children were considered stone-free if no residual fragments were identified in radiologic imaging and the evaluation of the ureter by URS. The case was accepted as a failure if any fragments were seen on immediate US, KUB, and/or during URS just after the stent removal. The patients who could not complete the standard primary URS procedure due to stone-related reasons (patients for whom we could not pass the safety guidewire behind the stone and/or the procedure was terminated due to pyuria during the procedure) were also accepted as a failure. The possible factors related to the patient, stone, ureter, and the operation that could affect the outcome and the complications following the URS were evaluated.ResultsThe children's median age was six years (1-17 years). Among the 89 children included in the study, 69 (78%) were stone-free, and 20 (22%) presented residual stone after the first URS session. The ROC analysis revealed that a UWT value of 4.5 mm (sensitivity 60%, specificity 92%) was the optimal cut-off value predictive of the URS outcome. The regression analysis revealed UWT >4.5 mm (p = 0.006) and multiple stone presentation (p = 0.005) as independent risk factors for residual stone. Complications were detected in 15 (17%) children. Thick ureteral wall (p = 0.012) and longer operative time (p = 0.016) were defined as the independent risk factors for complications.DiscussionIncreased UWT is associated with the adverse outcomes of URS due to tissue hypertrophy, edema, and mucosal bleeding may cause difficulty in removing the stone. The thick ureteral wall might increase the risk of complications due to the necessity of manipulating the instruments or the involuntary forceful use of instruments while removing the stone.ConclusionUWT was the only independent variable affecting both increased failure and complication rates in children undergoing URS.
Ureteral wall thickness at the stone site: A critical predictor of success and complications in children undergoing semi-rigid ureteroscopy
(Elsevier, 2021-06-01) Bülbül, E.; Kırlı, Elif Altınay; Kaygısız, Onur; Yeni, Sezgin; Can, Günay; Tutar, Onur; Onal, Bülent ; KAYGISIZ, ONUR; YENİ, SEZGİN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0002-9790-7295; GFT-1275-2022; L-9439-2019
Ureterorenoscopic lithotripsy for pediatric kidney stones using holmium: Yttrium-aluminum-garnet laser devices: 15 W vs 30 W
(Mary Ann Liebert, Inc, 2022-03-07) KAYGISIZ, ONUR; ÇİÇEK, MEHMET ÇAĞATAY; YENİ, SEZGİN; Yeni, Sezgin; Çicek, Mehmet Çağatay; Coşkun, Burhan; COŞKUN, BURHAN; Kılıçarslan, Hakan; KILIÇARSLAN, HAKAN; Turan, Levent; TURAN, LEVENT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0002-9790-7295; 0000-0001-5143-6507; 0000-0002-0471-5404; 0000-0002-8242-9921; L-9439-2019; AAH-9704-2021; JCO-5169-2023
Introduction: We aimed to compare the effectiveness of 15- and 30-W holmium: yttrium-aluminum-garnet (Ho:YAG) laser devices used in the treatment of pediatric kidney stones.Methods: Eighty-six consecutive pediatric patients who underwent retrograde intrarenal surgery (RIRS) between February 2010 and August 2020 were enrolled in the study. After exclusion criteria were applied, the data of 79 children were evaluated retrospectively. Patients were divided into two groups according to the laser device power of 15 W (Group 15: N = 30) and 30 W (Group 30: N = 49). The groups were compared according to demographic characteristics, stone feature, and clinical efficacy.Results: The age, gender, height, weight, and stone characteristics were similar between the groups. The mean operation time was shorter in Group 30. The stone-free rate after the first RIRS session (SF1) was 66.7% in Group 15 and 83.3% in Group 30. The SF1 for 20-mm or larger kidney stones was found to be 0% in Group 15 and 62.5% in Group 30. However, there was no statistically significant difference between the two groups in terms of stone-free rate.Conclusions: In pediatric kidney stone treatment, 30-W Ho:YAG laser devices should be preferred as they shorten the operation time compared with 15-W devices and provide the final stone-free status with fewer procedures, especially in large kidney stones.
Which frequency is better for pediatric shock wave lithotripsy? Intermediate or low: A prospective randomized study
(Springer, 2021-04-22) Kaygısız, Onur; Çiçek, Mehmet Çağatay; Mert, Ahmet; Akesen, Selcan; Sarandöl, Emre; Kılıçarslan, Hakan; KAYGISIZ, ONUR; ÇİÇEK, MEHMET ÇAĞATAY; AKESEN, SELCAN; SARANDÖL, EMRE; KILIÇARSLAN, HAKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; 0000-0002-9790-7295; 0000-0002-0471-5404; 0000-0003-4236-3646; 0000-0002-2593-7196; L-9439-2019; HGM-5995-2022; ELR-9087-2022; DXM-3644-2022; FGY-3115-2022
Purpose Shock wave lithotripsy (SWL) is the first option in the treatment of pediatric kidney stones; however, optimal frequency is still uncertain. The aim of this study was to compare low frequency [60 shocks per minute (SWs/min)] and intermediate frequency [90 SWs/min] in terms of lithotripsy success, complications, cardiac arrhythmia, anesthesia time, secondary procedures, and efficiency quotient (EQ) in children. Methods Seventy-eight consecutive children who received SWL for radiopaque renal stones between July 2016 and January 2020 were randomly divided into two groups: Group 60 (SWL frequency: 60 SWs/min) and Group 90 (SWL frequency: 90 SWs/min). After exclusion (remaining 71 children), Group 60 (n = 38) and Group 90 (n = 33) were compared using univariate analysis. Results The median age of children (37 girls, 34 boys) was 5 (1-16) years. Patient demographics and stone features were similar between the groups. Success rate after the last SWL session was 81.6% (n = 31) for Group 60 and 87.9% (n = 29) for Group 90 (p = 0.527). Stone-free rate after the first, second, and third sessions was 42.1%, 18.4%, and 21.1% for Group 60 and 48.5%, 27.3%, and 12.1% for Group 90, respectively. Additional treatment rate was similar between the groups. In Group 60, the EQ was 57.83, and it was 64.07 in Group 90. Median total anesthesia time was significantly longer in Group 60 (74.5 min) than in Group 90 (32 min; p < 0.001). Conclusion Intermediate frequency and low-frequency pediatric SWL have similar success rates; however, intermediate-frequency SWL has a shorter anesthesia time.