Browsing by Author "Kasapoğlu, Fikret"

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Acute invasive fungal rhinosinusitis: Evaluation of 26 patients treated with endonasal or open surgical procedures
(Sage Publications, 2010-11) Kasapoğlu, Fikret; Coşkun, Hakan; Özmen, Ömer Afşin; Akalın, Halis; Ener, Beyza; Uludağ Üniversitesi/Tıp Fakültesi/Kulak, Burun ve Boğaz Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı.; 0000-0002-9698-0546; 0000-0002-4803-8206; AAI-3877-2021; A-1452-2019; AAU-8952-2020; AAG-8523-2021; 56254721200; 13610800100; 55407733900; 57207553671; 15053025300
OBJECTIVE: Acute invasive fungal rhinosinusitis (AIFRS) is a serious disease with a high mortality and morbidity rate, which almost always affects immunocompromised patients and/or patients with diabetes mellitus. Our purpose was to present the diagnostic and therapeutic management and outcome of these patients. STUDY DESIGN: Case series with chart review SETTING: Tertiary care university hospital SUBJECTS AND METHODS: Twenty-six patients, who were operated on because of AIFRS between September 1999 and June 2009. were retrospectively evaluated in this study. Endoscopic surgery was used in 19 patients, and open surgical debridement was performed in seven patients RESULTS: Overall survival rate of the patients in the open surgery group (4 of 7, 57 1%) was similar to that of the endoscopically treated group (9 of 19:47 3%) Thirteen patients (50%) died of complications related to the underlying disease (9 of 13; 69 2%) and AIFRS (4 of 13, 30 7%). AIFRS-specific survival rate is 765 percent, 90 percent (9 of 10) and 57.1 percent (4 of 7) for endoscopic and open surgery groups, respectively Four patients who died had pathological diagnosis of mucormycosis (P = 0 52) CONCLUSION: AIFRS can be successfully treated with a combination of endonasal surgical debridement and antifungal medications Endonasal approach is suitable for patients diagnosed in the early stages of the disease and provides a less traumatic option in those patients who already have a poor health status Open surgery should be preferred in the presence of intraorbital extension, palatinal, and/or intracerebral involvement Reversing the underlying disease process and immunosuppression is as important as the surgical and antifungal treatment.
Akut invaziv fungal rinosinüzit: 18 vakanın klinik analizi
(Uludağ Üniversitesi, 2012-06-12) Demir, Uygar Levent; Öztosun, Ege; Tecimer, Sevilay Hançer; Kasapoğlu, Fikret; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Hastalıkları Anabilim Dalı.
Bu çalışmanın amacı kliniğimizde akut invaziv fungal rinosinüzit (AİFR) tanısıyla cerrahi debridman uyguladığımız hastaların klinik verilerinin retrospektif olarak değerlendirilmesidir. Çalışmaya Uludağ Üniversitesi Tıp Fakültesi KBB Anabilimdalı'nda Mart 2010 ile Mayıs 2012 tarihleri arasında AİFR nedeniyle opere edilen 18 hasta dahil edilmiştir. Bu hastaların primer hastalıkları, nötropeni durumu, izole edilen patojen mantarlar, invaze olan bölgeler, uygulanan cerrahi modaliteler ve sağkalım oranları kayıtlardan tespit edilerek incelendi. Hastaların 11'inde (%61,1) hematolojik malignite, 4'ünde diabetes mellitus (%22,2), 2'sinde (%11,1) aplastik anemi ve birinde (%5,5) nefrotik sendrom tanısı bulunmaktaydı. İnvaziv fungal patojenlerin dağılımı ise; 4 (% 22,2) hastada mukor ve 14 (%77,7) hastada ise aspergillus şeklinde olup, aspergillus flavus 9/18 (%50) oranı ile en sık izole edilen patojendir. En sık etkilenen anatomik yapı ise septal mukoza ve septal kartilajdır (%88,8). Hastaların genel sağkalım oranı %33,3 (6/18) olarak tespit edilmiştir. AİFR, immünosüprese hastalarda hızlı ilerleyerek mortal seyredebilen bir enfeksiyon olduğundan, erken tanı konması ve sonrasında zaman kaybedilmeden yapılacak cerrahi ile birlikte agresif antifungal tedavi verilmesi prognoz açısından oldukça önemlidir.
Bilateral chronic otitis media and CSF otorrhea; the only presenting feature of Wegener's granulomatosis
(Aves, 2012) Demir, Uygar Levent; Kasapoğlu, Fikret; Öztürk, İdil; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.; AAI-3877-2021; 56868421800; 56254721200; 55323305300
Wegener's Granulomatosis (WG) is an autoimmune disease. The lungs, kidneys and upper respiratory organs are major sites of organ involvement. Although nose, ear and throat involvement can be observed in most of cases during the natural course, their individual involvement is quite rare. A case with bilateral refractory chronic otitis media and spontaneous CSF fistula that was diagnosed as WG is presented.
Communication adjustment of patients with a laryngectomy in Turkey: Analysis by type of surgery and mode of speech
(Routledge Journals, 2011) Evitts, Paul M.; Miller, Julia Sterne; Kasapoğlu, Fikret; Demirci, Uğur; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.; AAI-3877-2021; 56254721200; 48161059700
Previous studies have routinely shown that individuals with a laryngectomy (IWL) have a decreased quality of life (QoL). However, the questionnaires frequently used are not specifically designed for persons with laryngeal cancer and may not reflect the issues of most concern to IWL. The purpose of this study was to investigate (1) the overall communication adjustment of IWL in Turkey, (2) the differences in communication adjustment among types of surgery for the treatment of laryngeal cancer, and (3) the differences in communication adjustment among types of speech following treatment for laryngeal cancer. Fifty-two patients (50 males and two females) who underwent surgical treatment for laryngeal cancer (i.e. total, supraglottic, frontolateral, vertical, supracricoid) and were being seen for follow-up care were recruited from an ENT clinic in Bursa, Turkey. Patients were provided with a written translation of the Self-Evaluation of Communication Experiences after Laryngectomy (SECEL) which yielded information on three subscales (General, Environment, and Attitude) and a Total score. Kruskall-Wallis and Wilcoxon signed ranks nonparametric tests of significance showed that overall adjustment was within the well-adjusted range for all types of surgery and modes of speech with two exceptions: Mean scores for supracricoid laryngectomy with cricohyoidopexy (28.5) and esophageal speech (29.3) were both within the poorly adjusted range on the Environment subscale [lowest mean score = 8.7 (supraglottic)]. Total mean scores ranged from 19.8 (supraglottic) to 49.9 (esophageal speech). Mean scores of the General subscale ranged from 4.0 (electrolaryngeal speech) to 7.7 (tracheoesophageal speech). Mean scores of the Attitude subscale ranged from 6.2 (supraglottic) to 19 (electrolaryngeal). Results of the Kruskall-Wallis test also showed a significant difference between type of surgery for the Environment subscale (p = 0.003), the Attitude subscale (p = 0.039), and the Total score (p = 0.007). The results suggest that overall, IWL in Turkey are well-adjusted to their new voice. However, results also showed that certain conservation surgeries (i.e. supraglottic, frontolateral, vertical) yielded more favorable outcomes than either supracricoid laryngectomy or speech following total laryngectomy. This finding is most likely related to the amount of tissue preserved following conservation surgery, in particular the preservation of the vocal folds.
Comparison of 3-months treatment adherence and estimating residual apnea hypopnea index between home versus in-laboratory auto-titrating positive airway pressure titration
(Wiley, 2020-07-01) Aydın, Özge Güçlü; Ursavaş, Ahmet; Kasapoğlu, Fikret; Ocakoğlu, Gökhan; Karadağ, Mehmet; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; 0000-0002-9027-1132; AAI-3877-2021; AAH-5180-2021; HLG-6346-2023; AAG-8744-2021; 8329319900; 56254721200; 15832295800; 6601970351
Purpose We aimed to assess the accuracy of home titration in estimating apnea hypopnea index (AHI) and optimal pressure values and to compare improvements in subjective daytime sleepiness, sleep quality and quality of life, along with 3-months treatment adherence of patients that received at-home versus in-laboratory auto-titrating positive airway pressure (APAP) titration. Materials and Methods In patients with a diagnosis of obstructive sleep apnea syndrome (OSAS), a study arm of laboratory attended APAP titration was compared with a study arm of home titration using an APAP device for three days. Subjective questionnaires were evaluated before and after 3 months of treatment. Results Fifty-three patients with newly diagnosed OSAS were enrolled. There was a significant positive correlation between PSG AHI and APAP AHI (r(s) = 0.43,P = 0.003) and the fixed pressure for the APAP arm was positively correlated with the APAP PSG arm of the study (r(s) = 0.71,P < 0.001). When the Bland-Altman graphs were compared, it was seen that the measurements obtained by the APAP AHI method were 0.3 units higher than the PSG AHI measurements, and that the mean of the measurement differences between the two methods was not different than 0 (P[H-0: Mean = 0] = 0.551). After 3 months of treatment, average nightly use was slightly higher in the APAP arm (P = 0.387). Conclusions The results indicate that both titration methods were not clinically inferior in terms of a fixed optimal pressure, residual events, 3-months treatment adherence and change in subjective sleepiness, sleep quality and quality of life after treatment.
Comparison of clinical results in nasal tip augmentation either via face to face or back to back technique with autogenous auricular conchal cartilage
(Lippincott Williams & Wilkins, 2015-06-28) Şahin, Murat Sertan; Kasapoğlu, Fikret; Demir, Uygar Levent; Özmen, Ömer Afşin; Coşkun, Hakan; Basut, Oğuz; Sahin, Murat Sertan; KASAPOĞLU, FİKRET; DEMİR, UYGAR LEVENT; ÖZMEN, ÖMER AFŞIN; COŞKUN, HAMDİ HAKAN; BASUT, OĞUZ İBRAHİM; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Cerrahisi Anabilim Dalı.; 0000-0002-4718-0083; 0000-0002-9698-0546; 0000-0002-0881-1444; A-1452-2019; AAI-3877-2021; BBC-2978-2021; CNQ-7672-2022; DVC-7511-2022; CFJ-8210-2022
Objective:To compare the objective and subjective findings between patients who underwent nasal tip augmentation surgery via two different methods using autogenous auricular conchal cartilage.Materials and Methods:This study included the data of 21 patients who underwent nasal tip augmentation surgery. The patients were randomly divided in two groups according to the technique used to form a double layer columellar strut graft; either face to face (group 1) and back to back (group 2). All patients were assessed via nasal obstruction symptom evaluation scale (NOSE) and via acoustic rhinometry and rhinomanometry at preoperative and postoperative 1st and 6th months.Results:There was statistically significant improvement in symptom score in both patient groups with no difference inbetween. Total nasal resistance decreased nonsignificantly at the end of 6th month in both groups; 13.1Pa/cm(3) to 8.6Pa/cm(3) and 10.3Pa/cm(3) to 9.5Pa/cm(3) respectively. There was no significant increment in MCA values for both groups except left MCA1.Conclusions:We achieved good results in tip augmentation via both techniques. An autogenous conchal cartilage is a good alternative to replace lacking caudal septal cartilage. It provides safe and stable support to the nasal tip. However, further comprehensive studies with larger sample size and long follow-up are required to elucidate any difference between these two techniques.
Comparison of the effectiveness of brandt-daroff vestibular training and epley canalith repositioning maneuver in benign paroxysmal positional vertigo long term result: A randomized prospective clinical trial
(Professional Medical Publications, 2018-05-25) Çetin, Yaser Said; Özmen, Ömer Afşin; Demir, Uygar Levent; Kasapoğlu, Fikret; Basut, Oğuz; Coşkun, Hakan; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.; 0000-0002-9698-0546; AAI-3877-2021; A-1452-2019; 55407733900; 56868421800; 56254721200; 6602318367; 13610800100
Objective: Benign paroxysmal positional vertigo (BPPV) is the most common peripheral cause of vertigo. It can be defined as transient vertigo induced by rapid change in head position, associated with a characteristic paroxysmal positional nystagmus. Posterior canal benign paroxysmal positional vertigo is the most frequent form of BPPV. The aim of our study was to investigate and compare the effectiveness of Epley maneuver and Brand-Daroff home exercises for the treatment of posterior canal BPPV. Methods: A total of 50 patients between 27 and 76 years of age who were diagnosed with unilateral posterior canal into BPPV were randomized prospectively into two groups. In Group-1, modified particle repositioning maneuver and in Group-2 Brandt-Daroff exercises were utilized as treatment. Patients were followed weekly. Cure weeks were recorded. The patients were followed for 12 to 24 months for recurrence. Results: The recovery rates at the first, second and third week controls were 76%, 96% and 100% for Group-1 (modified Epley maneuver) and 64%, 88% and 100% for Group-2 (Brandt-Daroff exercises) respectively. The recovery rates were similar for both groups. The average follow-up duration was 18 months. In Group 1, 7 patients (28%) and in Group 2, 5 patients (20%) had recurrence, which was also similar with no statistical difference. Conclusion: It was concluded that both Brandt-Daroff Exercises and Modified Epley maneuvers were almost equally effective in the treatment of BPPV.
Comparison of videonystagmography and audiological findings after stapedotomy; CO2 laser vs perforator
(Aves, 2016-04-01) Karaca, Sait; Basut, Oğuz; Demir, Uygar Levent; Özmen, Ömer Afşin; Kasapoğlu, Fikret; Coşkun, Hakan; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.; 0000-0002-9698-0546; A-1452-2019; AAI-3877-2021; 55088015000; 6602318367; 56868421800; 55407733900; 56254721200; 13610800100
OBJECTIVE: Various types of laser, microdrill, and perforator are effectively used in the surgical treatment of otosclerosis. However, they have certain disadvantages along with advantages. The aim of this study was to evaluate the effects of carbon dioxide (CO2) laser and perforator stapedotomy techniques on audiological outcomes and postoperative vestibular functions via videonystagmography (VNG). MATERIALS and METHODS: This prospective and randomized clinical study was conducted in an academic tertiary medical center. Sixty-nine patients diagnosed with otosclerosis who underwent stapedotomy were enrolled in this study. Patients were divided into two groups based on the technique used in stapedotomy: CO2 laser and perforator. Postoperative hearing gain and VNG findings were the main outcome measures. Subsequently, the two study groups were compared for analysis. RESULTS: The preoperative air-bone gap was 32.7 +/- 8.9 decibel (dB) in the study population and it was improved to 12.9 +/- 8.4 dB after operation. There were no differences in VNG findings and vertigo symptoms between the laser and perforator groups at postoperative day 2. There was no significant gain difference regarding the air conduction, bone conduction, and air-bone gap between the two groups (p=0.294, p=0.57, and p=0.37, respectively). CONCLUSION: Both CO2 laser and perforator stapedotomy have successful audiological outcomes with no difference in postoperative vestibular disturbance.
Correlation between clinical findings and eosinophil/neutrophil ratio in patients with nasal polyps
(Springer, 2015-04) Tecimer, S. Hancer; Kasapoğlu, Fikret; Demir, Uygar Levent; Özmen, Ömer Afşin; Çoşkun, Hakan H.; Basut, Oğuz İbrahim; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz ve Baş ve Cerrahi Anabilim Dalı.; 0000-0002-9698-0546; A-1452-2019; AAI-3877-2021; 56254670700; 56254721200; 56868421800; 55407733900; 13610800100; 6602318367
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a frequent disease which can be classified as eosinophilic or neutrophilic based on dominant inflammatory cell type at tissue. The aim of this study was to evaluate the clinical relevance of classifying nasal polyps as eosinophilic or neutrophilic on treatment outcomes. The study was conducted with 40 patients who underwent either surgical or medical treatment with the diagnosis of CRSwNP. The patients were classified into two groups for further assessment up to eosinophil intensity at polyp tissue. All patients were examined by nasal endoscopy and paranasal computed tomography (CT). Before treatment, subjective symptom score, nasal endoscopy score, and CT score were measured. Subsequently, they were reevaluated by similar diagnostic tests after either medical or surgical treatment at sixth month. The preoperative subjective symptom score, endoscopy score, and paranasal CT score were compared between chronic rhinosinusitis (CRS) with eosinophilic nasal polyps (E-NP) (CRSwE-NP) group and CRS with neutrophilic nasal polyps group and there was no difference between the two groups (p = 0.369, p = 0.310 and p = 0.494 respectively). Although after treatment in both groups symptom score and endoscopy score were significantly improved but not the CT score, we found no difference in between the groups at sixth month. In most of the previous studies, patients with CRSwE-NP were assumed to have poor prognosis and high recurrence rate despite surgical or medical treatment. However, we did not find any association between eosinophilic or neutrophilic nature of nasal polyp tissue and disease severity.
Does antenatal magnesium sulphate improve hearing function in premature newborns?
(Galenos Yayıncılık, 2019-12-02) Kasapoğlu, Işıl; Çetinkaya, Bilge Demir; Altay, Mehmet Aral; Orhan, Adnan; Özkan, Hilal; Çakır, Salih Çağrı; Toker, Rabia tütüncü; Kasapoğlu, Fikret; Özerkan, Kemal; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kadın Hastalıkları ve Doğum Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.; 0000-0002-3129-334X; 0000-0002-7558-8166; 0000-0001-6845-9991; 0000-0001-5761-4757; 0000-0002-9685-956X; ABI-4540-2020; V-5292-2019; AAH-9834-2021; AAH-9791-2021; A-8779-2013; 55800494800; 36923039100; 53863297800; 56671094200; 16679325400; 57205555920; 55958250400; 56254721200; 6603345841
Objective: To evaluate whether antenatal magnesium sulphate (MgSO4) exposure has a neuroprotective effect against hearing impairment in premature newborns. Material and Methods: Retrospective cohort study was performed with prematurely (<37 weeks) delivered newborns at a tertiary university hospital. Newborns of 92 women who received MgSO4 infusions (study group) for various indications were compared to newborns of 147 women who did not receive MgSO4 infusions (control group). All eligible premature newborn underwent hearing screening by auditory brainstem response (ABR) testing before being discharged from the hospital. Results: The fail rate for ABR hearing screening was 3.3% (n= 3) in the study group and 10.9% (n=16) in the control group (p=0.034). The rate of concurrent use of betamethasone was higher in the study group (72.8%; n=67) compared to control group (29.2%; n=43) (p<0.001). Other neonatal parameters, such as the number of neonates who were small for gestational age and the rate of microcephaly were similar between the groups (p=0.54, p=0.48, respectively). After adjusting for co-variates including the use of betamethasone and gestational age at delivery, no statistically significant association between antenatal administration of MgSO4 and ABR fail rates were found (p=0.07). Conclusion: These results do not suggest a significant benefit in terms of hearing impairment in premature newborns when antenatal MgSO4 infusion was given.
Eagle's syndrome: Pre, per and postoperative views of a case
(Galenos Yayıncılık, 2009-09-01) Kasapoğlu, Fikret; Erişen, L.; KASAPOĞLU, FİKRET; Erişen, L.; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz ve Baş Boyun Cerrahisi Anabilim Dalı; AAI-3877-2021; ETY-7294-2022
In this case report we present the preoperative radiological images, peroperative and postoperative views of a 36-years-old female Eagle's syndrome patient. The diagnosis and differential diagnosis of this syndrome have become quite easy after technological advances, such as three dimensional computed tomographic reconstruction and digital imaging.
Effects of levobupivacaine versus bupivacaine infiltration on postoperative analgesia in pediatric tonsillectomy patients: A randomized, double-blind, placebo-controlled study
(Sage Publications, 2011-07) Özmen, Suay; Özmen, Ömer Afşin; Kasapoğlu, Fikret; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.; 0000-0002-9698-0546; AAI-3877-2021; A-1452-2019; 55407733900; 56254721200
Objectives: We compared the effects of levobupivacaine hydrochloride, bupivacaine hydrochloride, and saline injections in alleviating posttonsillectomy pain. Methods: Between November 2009 and April 2010, we recruited 60 patients (36 male and 24 female) between 2 and 12 years of age into the study. After informed consent was obtained from the parents, patients admitted for tonsillectomy were randomized into 3 groups by means of sealed envelopes. Group 1 (20 patients; mean age, 6.45 +/- 2.78 years) received 0.9% sodium chloride (saline solution), group 2 (20 patients; mean age, 5.60 +/- 2.70 years) received 0.25% levobupivacaine hydrochloride, and group 3 (20 patients; mean age, 5.85 +/- 2.43 years) received 0.5% bupivacaine hydrochloride infiltrated around each tonsil. Pain was evaluated with McGrath's face scale. Results: The postoperative pain scores at 1 and 5 hours were similar among the groups (p > 0.05). The pain scores in the levobupivacaine group were lower than those in the saline group at 13 hours (p < 0.017). The pain scores in the bupivacaine and levobupivacaine groups were significantly lower than those in the saline group from 17 to 21 hours until day 6 (p > 0.017). There was no difference between the levobupivacaine and bupivacaine groups (p > 0.017). Conclusions: Local infiltration of levobupivacaine is a relatively safe and effective method and is equivalent to use of bupivacaine for posttonsillectomy pain.
The efficacy of nasal surgery in obstructive sleep apnea syndrome: A prospective clinical study
(Springer, 2012-02) Erişen, Levent; Sufioğlu, Mansur; Özmen, Ömer Afşin; Kasapoğlu, Fikret; Demir, Uygar Levent; Ursavaş, Ahmet; Onart, Selçuk; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; 0000-0002-9698-0546; AAI-3877-2021; A-1452-2019; AAI-3169-2021; 42662501600; 55407733900; 56254721200; 56868421800; 8329319900; 7801637934
The aim of this study was to investigate the effects of surgical intervention for nasal pathologies on obstructive sleep apnea syndrome (OSAS) and continuous positive airway pressure (CPAP) titrations in patients with OSAS. The study was designed as a prospective case control study. Between December 2007 and June 2010, 31 patients (26 men and 5 women) who were diagnosed with OSAS with polysomnography and confirmed to have obstructive nasal pathology were enrolled in the study. The average age of the patients was 53 +/- A 9.6 (range 33-68 years) and the body mass index ranged from 22 to 40.6 kg/m(2) with an average of 30.3 +/- A 4.1. The patients were evaluated with Epworth Sleepiness Scale, OSAS Complaints Questionnaire, visual analog scale, and CPAP titration before and 3 months after nasal surgery. As three patients did not attend the control polysomnography, data analysis was performed on 28 patients. Although there was a significant improvement in the nasal passage and subjective complaints, namely, snoring frequency, apnea and daytime sleepiness, the difference between preoperative and postoperative AHI values was not statistically significant. Postoperative CPAP titration results indicated a decrease both in pressures and in AHI in comparison to preoperative values. These reductions were not statistically significant, although the decrease in CPAP pressures was close to significance (p = 0.062). Nasal pathologies should be treated in all patients with OSAS, particularly those undergoing CPAP treatment. However, patients should be counseled that favorable results might not be achieved after nasal surgery.
Efficacy of nasal surgery on snoring
(Galenos Yayıncılık, 2010-09-01) Sufiolu, M.; Özmen, Ömer Afşin; Kasapoğlu, Fikret; Ursavaş, Ahmet; Erisen, L.; Onart, S.; Sufiolu, M.; ÖZMEN, ÖMER AFŞIN; KASAPOĞLU, FİKRET; URSAVAŞ, AHMET; Erisen, L.; Onart, S.; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı; 0000-0002-9698-0546; A-1452-2019; AAI-3877-2021; AAI-3169-2021; GCI-1390-2022; ETY-7294-2022; FQP-9099-2022
Objectives: The aim of the study was to investigate the effect of corrective nasal surgeries on snoring in patients diagnosed as simple snorers.Methods: Seventeen patients who were presented with the complaint of snoring as suggested by their partners and had apnea hypopnea index less than 5 in polysomnography, and were operated on due to nasal pathology were included in the study. Patients were evaluated prior to surgery and 3 months after surgery with body mass index, snoring complaints inventory and visual analog scala (VAS) for symptoms of snoring and apnea, nasal obstruction and post-operative satisfaction.Results: In the post-operative assessment, significant improvement was observed in the nasal passage compared to pre-operative level. This finding was approved subjectively on survey study as increase of nasal passage in 71% of the patients. Decrease in snoring was found in 65% of the patients. VAS scores revealed a significant reduction in the loudness of the snoring in the post-operative period.Conclusion: Correction of the nasal pathology leads to reduction in the frequency and loudness of the snoring. Consequently, nasal pathologies should definitely be treated in patients with snoring. However, it should be borne in mind that these diseases are multifactorial and multi-leveled. Thus, successful results may not be obtained in all of the patients and they should be counseled accordingly.
Electrophysiological comparison of peripheral nerve repair methods: An animal study
(Mediterranean Soc Otology & Audiology, 2008-01-01) Basut, Oğuz; Noyan, Behzat; Kasapoğlu, Fikret; BASUT, OĞUZ İBRAHİM; Noyan, Behzat; KASAPOĞLU, FİKRET; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz-Baş ve Boyun Cerrahisi Anabilim Dalı.; AAI-3877-2021; CFJ-8210-2022; FRE-9096-2022
OBJECTIVES: The aim of this study was to increase the experience with N-butyl-2-cyanoacrylate in peripheral nerve anastomosis, to compare this group with primary suture, cyanoacrylate and control groups and to present our results and experience.MATERIALS AND METHODS: In the study, 49 adult male Sprague Dawley species rats were used, in the years 2004 and 2005. The study was planned as 4 groups; control group (n=10), suture group (n=12), cyanoacrylate group (n=14) and N-butyl 2-cyanoacrylate group (n=13). The right sciatic nerves of the rats were operated under general anesthesia in all groups. To measure the nerve conduction velocity (NCV), electrical stimulations were given by a stimulator using electrodes which were placed to the proximal end of the sciatic nerves and then the nerve conduction speeds were calculated by using a computer program.RESULTS: In the control group NCV was 58.6 +/- 0.7 m/s at the beginning and 55 +/- 1.3 m/s three months after the procedure and there was no statistically significant difference between them (p > 0.05). In the suture group, NCV at the beginning of the experiments was 57.1 +/- 0 6 m/s and., after three months, it was found to be 36.2 +/- 0.6 m/s (p < 0.01). In the cyanoacrylate group, the NCV before and three months after the experiments were 58.4 +/- 0.4 m/s and 44.7 +/- 1.1 m/s, respectively (p < 0.01). The NCV in the N-butyl 2-cyanoacrylate group was 58.5 +/- 0.4 m/s at the beginning and, after three months, it was found 47.4 +/- 1.2 m/s (p < 0.01).CONCLUSIONS: Our results support that, in the peripheral nerve repair, it is possible to get better electrophysiologic results by using N-butyl 2-cyanoacrylate and cyanoacrylate compared to the traditional microsuture technique.
Endolarengeal eksizyonla tedavi edilen larenks kondrosarkomu: Olgu sunumu
(Uludağ Üniversitesi, 2016-07-25) Durgut, Osman; Akyıldız, Metin Yüksel; Saraydaroğlu, Özlem; Kasapoğlu, Fikret; Özmen, Ömer Afşin; Demir, Uygar Levent; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.
Kondrosarkomlar, larenksin nadir görülen malign tümörleridir ve sıklıkla krikoid kıkırdaktan kaynaklanır. Larenksin kondrosarkomları için genellikle kabul edilmiş tedavi şekli, larenks fonksiyonlarının korunduğu konservatif cerrahi yaklaşımlardır. Bu yazıda krikoid kartilajdan kaynaklanan larengeal kondrosarkomlu 61 yaşında erkek hasta literatür bilgisi eşliğinde sunulmuştur.
Endolaryngeal cordectomy using cold instruments for treatment of T1 glottic cancers
(Springer, 2007-03-27) Kasapoğlu, Fikret; Erişen, Levent M.; Çoşkun, Hakan H.; Basut, Oǧuz İbrahim; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.; C-3960-2015; AAI-3877-2021; 56254721200; 6602590279; 13610800100; 6602318367
In the treatment of early-stage glottic cancers, radiotherapy and surgery have similar success rates. In our department, we have been using cold instruments coupled with surgical microscope and/or telescopes for several years in treatment of early stage glottic cancers. Our aims were, to present our experience with endolaryngeal resection of T1 glottic cancers with cold instruments coupled with surgical microscope and telescopes, to present our oncological results, to discuss the advantages of endolaryngeal cordectomy over open cordectomy or RT and to discuss whether laser is obligatory for this approach or not.Our study includes retrospective analysis of 38 patients with T1 glottic cancer, who have been treated with endolaryngeal surgery as the primary treatment. The median follow-up was 24 months. The most commonly performed procedure was type-II cordectomy (38.5%). Overall survival rate was 94.7%, while the disease-specific survival rate was 100%. Local recurrences occurred in two patients at 8th and 11th months, postoperatively. In the first patient, type-Vc cordectomy and in the second type-Va cordectomy had been performed. Both patients with recurrences could be salvaged by fronto-lateral laryngectomy, and are still alive in their 38th and 6th months following salvage surgery. Therefore, the local control rate and larynx preservation rate with endolaryngeal cordectomy were 94.7 and 100%, respectively, in this study group. All patients had a voice quality sufficient for communicating easily over telephone. We believe that lasers are not obligatory to perform endolaryngeal cordectomy for treatment of T1 glottic cancers, as the same oncological and similar functional outcomes may be achieved with the traditional cold instruments.
Endoskopik juvenil nazofarengeal anjiofibrom cerrahisi - Uludağ KBB sonuçları
(Uludağ Üniversitesi, 2011-03-17) Kasapoğlu, Fikret; Durgut, Osman; Şen, Ersin; Özmen, Ö. Afşın; Ceyhan, Aydın; Coşkun, Hakan; Basut, Oğuz; Onart, Selçuk; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.
Bu çalışmanın amacı Juvenil Nazofarengeal Anjiofibrom (JNA)’un cerrahisinde endoskopik yaklaşımla tedavi edilen olgu serisinin sonuçlarını ortaya koymaktır. Geriye dönük olarak 1995 ile 2010 yılları arasında ve Uludağ Üniversitesi Kulak Burun Boğaz Anabilim Dalı’nda JNA nedeniyle tedavi edilen toplam 18 hasta incelendi. Nisan 2007 – Mart 2010 tarihleri arasında endoskopik olarak rezeksiyon uygulanan 6 hasta değerlendirmeye alındı. Tanı, fizik muayene bulguları ve radyolojik bulgular ile konuldu. Tüm hastalara cerrahiden 24 saat öncesinde selektif anjio-embolizasyon uygulandı. Hastaların yaşları 14 ile 21 arasında değişmekte olup tümü erkekti. Hastalar en sık burun tıkanıklığı (6/6 %100) ve burun kanaması (5/6 %83) semptomlarıyla kliniğimize başvurdu. Beş hastada endoskopik yaklaşımla eksizyon uygulandı. Bir hastada endoskopik ve transmaksiller yaklaşımlar kombine edildi. Bir hastada yineleme görüldü. Radyolojik olarak saptanan yinelemede büyüme ve semptom olmadığı için hasta takip edilmektedir. Postoperatif dönemde hiçbir hastada cerrahiye veya embolizasyona bağlı komplikasyon gelişmedi. JNA tedavisinde endoskopik yaklaşım, preoperatif embolizasyon uygulanması halinde güvenle uygulanabilecek bir yöntemdir. Endoskopik yaklaşım hasta morbiditidesini önemli ölçüde azalttığından öncelikle seçilecek tedavi yöntemi olmalıdı
Hipofarenks kanserlerinde primer cerrahi ve kemoradyoterapi ve kurtarma cerrahisinin onkolojik ve fonksiyonel sonuçlarının karşılaştırılması
(Bursa Uludağ Üniversitesi, 2021) Yavuz, Hüseyin Barkın; Kasapoğlu, Fikret; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.
Çalışmanın amacı; hipofarenks kanserinde primer kemoradyoterapi (KRT) ve primer cerrahi ve kurtarma cerrahisi uygulanmış hastaların onkolojik ve fonksiyonel sonuçlarının karşılaştırılmasıdır. Retrospektif olarak incelenen, toplamda 69 hasta çalışmaya dahil edildi. Bu hastalardan 38’i primer KRT grubu, 19’u primer cerrahi grubu ve 12’si kurtarma cerrahisi grubu olarak ayrıldı. Primer KRT grubu 38 hasta ile primer cerrahi grubundaki 19 hastanın tamamı birlikte analiz edildi. Primer cerrahi grubunda 13 hastaya flep ile rekonstrüksiyon uygulanmış olduğu tespit edildi ve primer cerrahi grubundaki rekonstrüksiyon uygulanmış 13 hasta ile flep ile rekonstrüksiyon uygulanmış kurtarma cerrahisi grubundaki 12 hasta ayrıca değerlendirildi. Primer KRT (38 hasta) ve primer cerrahi grupları (19 hasta) arasında hastalıksız sağkalım (p=0,293) ve genel sağkalım (p=0,323) açısından istatistiki anlamlı farklılık bulunmadı. Lenf nodu metastazı hastalıksız sağkalım açısından önemli prognostik faktör olarak saptandı (p=0,025). Flep ile rekonstrüksiyon uygulanmış kurtarma cerrahisi grubu (12 hasta) ve flep ile rekonstrüksiyon uygulanmış primer cerrahi grubu (13 hasta) arasında komplikasyon oranları açısından istatistiki anlamlı farklılık bulunmadı (p=0,202). Genel sağkalım açısından gruplar arasında istatistiki anlamlı farklılık saptanmadı (p=0,060). Hastalıksız sağkalım açısından ise; kurtarma cerrahisi grubunda istatistiki anlamlı olarak daha düşük bulundu (p=0,036). Primer küratif tedavi olarak KRT ve cerrahi arasında sağkalım açısından anlamlı farklılık saptanmamıştır. Primer cerrahi ve kurtarma cerrahisi grupları arasında komplikasyon oranları açısından anlamlı farklılık iii saptanmadı. Kurtarma cerrahisinin sağkalıma katkısının oldukça düşük olduğu saptandı.
Is it the middle ear disease or the reconstruction material that determines the functional outcome in ossicular chain reconstruction
(Lippincott Williams & Wilkins, 2012-06) Demir, Uygar Levent; Karaca, Sait; Özmen, Ömer Afşin; Kasapoğlu, Fikret; Coşkun, Hamdi Hakan; Basut, Oğuz; Uludağ Üniversitesi/Tıp Fakültesi/Kulak Burun Boğaz Anabilim Dalı.; 0000-0002-9698-0546; AAI-3877-2021; A-1452-2019; 56868421800; 55088015000; 55407733900; 56254721200; 13610800100; 6602318367
Objectives: To evaluate the effects and the predictive value of environmental risk factors on the success of different reconstruction materials used in ossiculoplasty. Study Design: Retrospective case review. Setting: Tertiary referral university hospital. Patients: Between January 2007 and October 2010, 110 patients who underwent ossiculoplasty with or without mastoidectomy due to chronic otitis media were enrolled in the study. All patients were classified into 1 of the 3 risk groups (mild, moderate, and severe) according to their measured Middle Ear Risk Index score. Interventions: The patients underwent exploratory tympanotomy, tympanoplasty, or tympanomastoidectomy (canal wall-up or wall-down), all with ossicular reconstruction. The ossicular reconstructions were performed using either bone cement, autologous bone interposition, or allograft material. Main Outcome Measures: For each patient, the air-conduction threshold and air-bone gap (ABG) were measured at the 12th month after ossiculoplasty. The ABG gain and air-conduction improvement were compared with preoperative values. The correlation of the success of ossiculoplasty with the middle ear risk group of patients was investigated. Moreover, the efficacy of different types of reconstruction material on the success of ossiculoplasty in the same risk group was evaluated. Results: In the mild-and moderate-risk groups, the ABG gain (p = 0.001 and p = 0.014) and air-conduction improvement (p G 0.001 for both) were statistically significant, whereas those changes were found to be insignificant in the severe-risk group. Moreover, the ABG gain and air-conduction improvement in none of the risk groups revealed a significance in favor of any of the used reconstruction materials. Conclusion: The results of this study revealed that none of the reconstruction materials or specific techniques have a superiority in the functional outcomes in patients from the same middle ear risk group. We conclude that the success of ossiculoplasty is highly correlated with the pathophysiological status of the middle ear and is independent of the type of replacement material.