Browsing by Author "Kebudi, Rejin"
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Item Central nervous system fungal infections in children with leukemia, risk factors and outcome: A multicentric study(Amer Inst Physics, 2018-11-29) Kebudi, Rejin; Karaman, Serap; Kızılocak, Hande; Karakaş, Zeynep; Demirağ, Bengü; Kaya, Zühre; Yaralı, Hüsniye Neşe; Çalışkan, Umran; Karagün, B. Şahin; Albayrak, Canan; Yılmaz, Şebnem; Karapınar, Deniz; Ünal, Ekrem; Tahta, Neryal; Güzelküçük, Zeliha; Koçak, Ülker; Celkan, Tiraje; Evim, Melike Sezgin; Güneş, Adalet Meral; Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Hematoloji Anabilim Dalı.; AAH-1452-2021Item Hepatic focal nodular hyperplasia developing after childhood cancers: Two-center's experience from Turkey(Akad Doktorlar Yayınevi, 2014) Tuğcu, Deniz; Kebudi, Rejin; Akıcı, Ferhan; Yekeler, Ensar; Aydoğan, Gönül; Şalcıoğlu, Zafer; Akçay, Arzu; Sen, Hülya Sayılan; Görgün, Ömer; Demirkaya, Metin; Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik Onkoloji Anabilim Dalı.; 24331130000Even though Focal nodular hyperplasia (FNH) is a rare lesion of the liver in children, it is reported at increased rates in treated pediatric cancer patients. The aim of this retrospective study is to describe the clinical and radiological characteristics and clinical course of patients diagnosed as FNH after primary malignancy in childhood. We retrospectively evaluated the diagnostic work-up, radiologic findings, clinical course and outcome of 8 patients, diagnosed as FNH after pediatric cancer treatment at the Department of Pediatric Hematology-Oncology of the Kanuni Sultan Suleyman Training and Research Hospital and Istanbul University, Oncology Institute, between 1993 and 2011. FNH lesions were diagnosed in 8 of 1600 solid tumors (0.5%) after a median interval of 8 (2-18) years, from the termination of the antineoplastic therapy for the primary cancer. Five patients had a history of neuroblastoma and two patients had rhabdomyosarcoma and one of them had primitive neuroectodermal tumor. FNH was incidentally found at USG or MRI performed during routine follow-up. Two children underwent surgical biopsies to rule out liver metastases. The lesions were stable for a median of 12 months (3-108 months) follow-up, no malign transformation was detected. FNH may be encountered as a radiological finding during follow-up in pediatric malignancies without hematopoetic stem cell transplantation and may be misdiagnosed as liver metastasis. FNH should be considered in the differential diagnosis of liver lesions encountered during follow up children with cancer. After the diagnosis of these benign lesions radiologically without biopsy, close imaging follow-up is recommended.Publication Hepatosplenic fungal infections in children with leukemia-risk factors and outcome: A multicentric study(Lippincott Williams & Wilkins, 2019-05-01) Celkan, Tiraje; Kızılocak, Hande; Evim, Melike; Güneş, Adalet Meral; Özbek, Namık Y.; Yaralı, Neşe; Ünal, Ekrem; Patıroğlu, Türkan; Karapınar, Deniz Yılmaz; Sarper, Nazan; Zengin, Emine; Karaman, Serap; Koçak, Ülker; Kürekçi, Emin; Özdemir, Canan; Tuğcu, Deniz; Uysalol, Ezgi; Dikme, Gürcan; Adaletli, İbrahim; Kuruoğlu, Sebuh; Kebudi, Rejin; SEZGİN EVİM, MELİKE; MERAL GÜNEŞ, ADALET; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Hematoloji-Onkoloji Bilim Dalı; AAH-1452-2021; JGX-6145-2023Background: Invasive fungal infections, including hepatosplenic fungal infections (HSFI), cause significant morbidity and mortality in children with leukemia. There are not enough data to support for the best approach to diagnosis of HSFI in children, nor for the best treatment. Procedure: In this multicentric study, we assessed the demographic data, clinical and radiologic features, treatment, and outcome of 40 children with leukemia and HSFI from 12 centers. Results: All cases were radiologically diagnosed with abdominal ultrasound, which was performed at a median of 7 days, of the febrile neutropenic episode. Mucor was identified by histopathology in 1, and Candida was identified in blood cultures in 8 patients. Twenty-two had fungal infection in additional sites, mostly lungs. Nine patients died. Four received a single agent, and 36 a combination of antifungals. Conclusions: Early diagnosis of HSFI is challenging because signs and symptoms are usually nonspecific. In neutropenic children, persistent fever, back pain extending to the shoulder, widespread muscle pain, and increased serum galactomannan levels should alert clinicians. Abdominal imaging, particularly an abdominal ultrasound, which is easy to perform and available even in most resource-limited countries, should be recommended in children with prolonged neutropenic fever, even in the absence of localizing signs and symptoms.