Browsing by Author "Koseler, Aylin"
Now showing 1 - 1 of 1
- Results Per Page
- Sort Options
Item Interaction of a new copper(II) complex by bovine serum albumin and dipeptidyl peptidase-IV(Elsevier, 2018-09-28) Koseler, Aylin; Zeytunluoğlu, Ali; Zorlu, Yunus; Aydın, Rahmiye; İnci, Duygu; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü.; 0000-0002-0483-9642; AAH-8936-2021; G-2201-2019; 55082306300; 56261495600Dipeptidyl peptidase-IV (DPP-IV) is one of the mammalian serine proteases participated in the pathogenesis of diseases and DPP-IV inhibitors are now widely used as antidiabetic drugs. A new water soluble ternary copper (II) complex,-[Cu(PY-Phen) (phe) (H2O)]NO3 center dot H2O-(py-phen:pyrazino[2,3f][1,10]phenanthroline, phe:phenylalanine), has been synthesized and characterized by CHN analysis, ESI-MS, FTIR and single-crystal X-ray diffraction techniques. Fluorescence spectroscopy was researched to study the interaction between the complex and bovine serum albumin (BSA) and dipeptidyl peptidase-IV (DPP-IV). Chromophore of BSA and DPP-IV enzyme is changed upon addition of the complex. Additionally, the complex was shown to have promising inhibitory activities against DPP-IV with lower IC50 value. This study may provide new insights into the development of effective agents against diabetes.