Browsing by Author "Li, Kevin"

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • No Thumbnail Available
    Item
    Enzymatic generation of highly anticoagulant bovine intestinal heparin
    (Amer Chemical, 2017-10-26) Fu, Li; Li, Kevin; Hirakane, Makoto; Lin, Lei; Grover, Navdeep; Datta, Payel; Yu, Yanlei; Zhao, Jing; Zhang, Fuming; Mousa, Shaker A.; Dordick, Jonathan S.; Linhardt, Robert J.; Yalçın, Murat; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı.; 0000-0002-5600-8162; AAG-6956-2021; 57192959734
    Unlike USP porcine heparin, bovine intestinal heparin (BIH) has a low anticoagulant activity. Treatment with 6-OST-1,-3, and/or 3-OST-1 afforded two remodeled heparins that met USP heparin activity and Mw specifications. We explored the pharmacodynamics and pharmacokinetics in a rabbit model. We conclude that a modest increase in the content of 3-O-sulfo groups in BIH increases the number of antithrombin III binding sites, making remodeled BIH behave similarly to pharmaceutical heparin.