Browsing by Author "Martinez, Silvia"
Now showing 1 - 2 of 2
- Results Per Page
- Sort Options
Item Prognostic value of serum acute-phase proteins in dogs with parvoviral enteritis(Wiley, 2010-09) Martinez, Silvia; Tvarijonaviciute, Asta; Ceron, Jose Joaquin; Kocatürk, Meriç; Eralp, Oya; Yılmaz, Zeki; Uludağ Üniversitesi/Veterinerlik Fakültesi/Klinik Bilimler Bölümü.; 0000-0001-9836-0749; 36437200800; 24472964600; 35944810500OBJECTIVE: To evaluate the acute-phase protein response in dogs with parvoviral enteritis as predictor of the clinical outcome. Methods: Canine parvovirus infection was diagnosed based on the compatible clinical findings and confirmed by the canine parvovirus antigen test in 43 dogs of less than six months of age. Blood samples for complete blood cell count and acute-phase proteins (C-reactive protein, haptoglobin, ceruloplasmin and albumin) were collected before treatment. Twenty-three dogs died during or after treatment (non-survival) and the rest recovered (survival). Five healthy dogs were enrolled as control. Results: Serum C-reactive protein, ceruloplasmin and haptoglobin levels in dogs with parvoviral enteritis were higher (P < 0.001, P < 0.01 and P < 0.001, respectively), but serum albumin was lower (P < 0.001) than those in controls. Mean C-reactive protein and ceruloplasmin values in non-survival were higher (P < 0.01) than those for survival dogs. C-reactive protein was found to be superior to ceruloplasmin, haptoglobin and albumin for distinguishing survival from non-survival dogs. Values higher than 92.4 mg/l for C-reactive protein had a sensitivity of 91% to predict mortality. Clinical Significance: The magnitude of the increase in serum acute-phase proteins in dogs with parvoviral enteritis could be a useful indicator of the prognosis of the disease. In acute-phase proteins, C-reactive protein is a potent predictor of mortality in dogs with parvoviral enteritis.Item Tei index (myocardial performance index) and cardiac biomarkers in dogs with parvoviral enteritis(Elsevier, 2012-02) Martinez, Silvia; Tvarijonaviciute, Asta; Ceron, Jose; Kocatürk, Meriç; Eralp, Oya; Yılmaz, Zeki; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0002-4242-8609; 0000-0001-9836-0749; AAG-2943-2020; 36437200800; 24472964600; 35944810500Tei index (myocardial performance) and cardiac biomarkers were evaluated in dogs with parvoviral enteritis (PVE). Tei index was calculated as isovolumic contraction time plus isovolumic relaxation time divided by ejection time. Myocardial and skeletal muscle damages were assessed by serum levels of cardiac troponin I (cTnI), creatine (phospho) kinase, lactate dehydrogenase and aspartate aminotransferase. Serum magnesium level was also determined. According to treatment response, dogs were divided into the survivor (n = 20) and non-survivor groups (n = 23). Seven healthy dogs served as controls. The mean value of the Tei index was higher in non-survivors, compared with survivors (p < 0.02) and healthy controls (p < 0.01). Serum level of cTnI in non-survivors was higher than that of survivors and controls (p < 0.05). Tei index showed the highest sensitivity and specificity to predict mortality. The findings of an elevated Tei index and an increase in serum cTnI are factors associated with a poor prognosis in cases of canine parvovirosis.