Browsing by Author "Mousa, Shaker A"
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Item Targeted delivery of cisplatin to tumor xenografts via the nanoparticle component of nano-diamino-tetrac(Future Medicine, 2017-02) Sudha, Thangirala; Bharali, Dhruba J; Darwish, Noureldien H.E.; Keating, Kelly A; Lin, Hung-Yun; Davis, Paul J.; Mousa, Shaker A; Yalçın, Murat; Coşkun, Melis Debreli; Uludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı.; Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.; 0000-0002-5600-8162; AAG-6956-2021; AAF-3992-2020; 57192959734; 57193066146Aim: Nano-diamino-tetrac (NDAT) targets a receptor on integrin alpha v beta 3; alpha v beta 3 is generously expressed by cancer cells and dividing endothelial cells and to a small extent by nonmalignant cells. The tetrac (tetraiodothyroacetic acid) of NDAT is covalently bound to a poly(lactic-co-glycolic acid) nanoparticle that encapsulates anticancer drugs. We report NDAT delivery efficiency of cisplatin to agent-susceptible urinary bladder cancer xenografts. Materials & methods: Cisplatin-loaded NDAT (NDAT-cisplatin) was administered to xenograft-bearing nude mice. Tumor size response and drug content were measured. Results: Intratumoral drug concentration was up to fivefold higher (p < 0.001) in NDAT-cisplatin-exposed lesions than with conventional systemic administration. Tumor volume reduction achieved was NDAT-cisplatin > NDAT without cisplatin > cisplatin alone. Conclusion: NDAT markedly enhances cisplatin delivery to urinary bladder cancer xenografts and increases drug efficacy.