Browsing by Author "Nakamura, Shinobu"

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    Reactive alveolar epithelium in chondroid hamartoma of the lung
    (Karger, 2005) Ebsen, Michael; Freudenberg, Nikolaus; Nakamura, Shinobu; Costabel, Ulrich; Guzman, Josune; Uzaslan, Esra; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; 8761653500
    Objective To determine the morphologic characteristics of the nonciliated epithelium found in chondroid hamartoma of the lung. Study Design The morphologic characteristics and immunohistochemical reaction for surfactant protein A of the nonciliated epithelium, in chondroid hamartoma of the lung was studied by immunohistochemistry. Alveolar epithelium in normal lung tissue and lung tissue surrounding primary lung cancer or metastatic lung lesions was used as a control. Results In all cases, the nonciliated epithelium in chondroid hamartoma showed the morphologic criteria of hyperplastic alveolar type II cells and a very strong positive surfactant protein A reaction in the cytoplasm, when compared with alveolar epithelium of the normal lung. Similar hyperplastic type II cells were also found in the alveolar lung around metastatic or primary lung tumors. Conclusion These findings may indicate that the nonciliated cells found in chondroid hamartoma of the lung are hyperplastic type H cells. This suggests that the alveolar epithelium found in chondroid hamartoma of the lung is a secondary reaction around the hamartoma and not a primary component of the lesion.
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    Surfactant protein A detection in large cell carcinoma of the lung
    (Lippincott Williams & Wilkins, 2006-03) Ebsen, Michael; Stuempel, Tina; Freudenberg, Nikolaus; Nakamura, Shinobu; Costabel, Ulrich; Guzman, Josune Josune; Uzaslan, Esra; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Hastalıkları Anabilim Dalı.; 8761653500
    Large cell carcinomas of the lung are undifferentiated malignant epithelial tumors that lack cytologic features of small cell carcinoma, glandular cell carcinoma, or squamous cell differentiation. Lung surfactant protein A (SP-A) is produced by alveolar type 11 cells and Clara cells. Most bronchioloalveolar carcinomas of the lung react positively for SP-A. Positive SP-A staining of large cell carcinoma of the lung could indicate that at least part of these tumors have the same cellular origin or differentiation as bronchioloalveolar carcinoma. The authors determined the SP-A staining of 63 large cell carcinomas of the lung by IHC. In 20 of the 63 (32%), the tumors stained positive for SP-A. This may imply that about one third of large cell carcinomas of the lung have a similar cellular origin or differentiation as bronchioloalveolar carcinoma. The significance of this finding for prognosis and new forms of treatment remains to be determined.