Browsing by Author "Orhan, Elif Kocasoy"
Now showing 1 - 7 of 7
- Results Per Page
- Sort Options
Item Characterization of migraineurs having allodynia results of a large population-based study(Lippincott Williams & Wilkins, 2015-09-08) Baykan, Betül; Ekizoğlu, Esme; Orhan, Elif Kocasoy; Saip, Sabahattin; Siva, Aksel; Ertaş, Mustafa; Karlı, Necdet; Zarifoğlu, Mehmet; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; 6506587942; 6603411305Objective: Allodynia reflects the clinical correlate of central sensitization, but it is usually neglected in clinical headache management. We aimed to report the prevalence and previously unnoticed associations of allodynia in migraineurs by a nationwide face-to-face questionnaire-based study by physicians. Methods: A total of 5323 households were examined for headache according to the diagnostic criteria of International Classification of Headache Disorders-II. Detailed headache features, premonitory signs, demographics, socio-economic status, and hormonal status of female individuals were analyzed with regard to the presence of allodynia in patients with definite migraine. Results: Allodynia was present in 61.1% of migraineurs in the general population of Turkey. The duration and severity of attacks (P < 0.0001), photophobia (P = 0.001), phonophobia, and also osmophobia (P < 0.0001), as well as premonitory signs (P = 0.018), showed significant associations with allodynia. Migraineurs with aura or family history of migraine more often reported allodynia in comparison with those without (P = 0.001 and 0.028, respectively). Allodynic migraineurs had a higher rate of physician consults and high levels on the Migraine Disability Assessment questionnaire, reflecting increased burden of headache. Furthermore, migraineurs with allodynia had high probability of attacks close to menses. Migraine improved during pregnancy, but it worsened after menopause or during oral contraceptive use in individuals experiencing allodynia when compared with those without allodynia. Discussion: The duration, severity, and disability of migraine attacks, photophobia, phonophobia, and osmophobia, as well as premonitory signs, showed significant associations with allodynia in the general population. Moreover, migraineurs with aura or family history of migraine more often reported allodynia, and allodynic migraneurs were more sensitive to hormonal changes. Allodynia, which seems to indicate higher tendency to central sensitization, should be implemented in daily headache practice to predict the prognosis and high levels of migraineous involvement.Item Migraine incidence in 5 years: A population-based prospective longitudinal study in Turkey(BMC, 2015-12-01) Baykan, Betül; Ertaş, Mustafa; Uludüz, Derya; Uygunoğlu, Uğur; Ekizoğlu, Esme; Orhan, Elif Kocasoy; Saip, Sabahattin; Siva, Aksel; Karlı, Necdet; Zarifoğlu, Mehmet; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; JDE-9380-2023; EHN-5825-2022; 6506587942; 6603411305Background: The incidence of migraine has been investigated only in a few studies worldwide and it is not known in our country. We, therefore, aimed to estimate the migraine incidence in a previously accomplished population-based prevalence study sample of 5323 individuals in the year 2008. Methods: The former Turkish headache prevalence study has been completed as a nationwide, randomized, home-based study of face-to-face examination by physicians trained for headache diagnosis by using ICHD criteria. Five years after this study an optimized survey including 50 questions was performed to estimate the migraine incidence in migraine-free individuals in the previous study, with a 56.4 % responder rate. Two validation studies for this survey were performed prior and after the study each in 100 subjects by comparing the gold standard of expert diagnosis of headache, showing high rate of reliability (Crohnbach alpha: 0.911 and 0.706, respectively). Results: Migraine incidence was estimated as 2.38 % (2.98 % in women and 1.93 % in men) per year in 2563 migraine-free individuals; if the population at risk is defined as the group without any headaches, the migraine incidence decreased to 1.99 %. The chronic migraine (CM) incidence [without medication overuse (MOH)] was 0.066 % and that of MOH was 0.259 %. We found a significant burden of the disease on the occupational functionality as well as on social and family life, even in the early years of the migraine. The family history of headaches especially in the fathers could be useful to predict new cases of migraine, besides the well-known risk factor, diagnosis of depression, whereas income and education did not seem to relate to migraine onset. Conclusions: Our study with a large population-based nation-wide sample, using ICHD-II criteria, with structured headache interviews as well as blinded re-validation of the questionnaire diagnoses showed a 2.38 % incidence rate of migraine in Turkey, higher than most of the other previous reports; a finding which could be related to genetic factors and also to the methodological differences in the study designs. Moreover the incidence of CM was found to be 0.066 %.Item One-year prevalence and the impact of migraine and tension-type headache in Turkey: A nationwide home-based study in adults(BMC, 2012-03) Ertaş, Mustafa; Baykan, Betül; Orhan, Elif Kocasoy; Saip, Sabahattin; Önal, Ayşe Emel; Siva, Aksel; Zarifoğlu, Mehmet; Karlı, Necdet; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; 6603411305; 6506587942Several studies have shown that the prevalence of migraine and tension-type headache (TTH) varied between different geographical regions. Therefore, there is a need of a nationwide prevalence study for headache in our country, located between Asia and Europe. This nationwide study was designed to estimate the 1-year prevalence of migraine and TTH and analyse the clinical features, the impact as well as the demographic and socio-economic characteristics of the participant households in Turkey. We planned to investigate 6,000 representative households in 21 cities of Turkey; and a total of 5,323 households (response rate of 89%) aged between 18 and 65 years were examined for headache by 33 trained physicians at home on the basis of the diagnostic criteria of the second edition of the International Classification of Headache Disorders (ICHD-II). The electronically registered questionnaire was based on the headache features, the associated symptoms, demographic and socio-economic situation and history. Of 5,323 participants (48.8% women; mean age 35.9 +/- A 12 years) 44.6% reported recurrent headaches during the last 1 year and 871 were diagnosed with migraine at a prevalence rate of 16.4% (8.5% in men and 24.6% in women), whereas only 270 were diagnosed with TTH at a prevalence rate of 5.1% (5.7% in men and 4.5% in women). The 1-year prevalence of probable migraine was 12.4% and probable TTH was 9.5% additionally. The rate of migraine with aura among migraineurs was 21.5%. The prevalence of migraine was highest among 35-40-year-old women while there were no differences in age groups among men and in TTH overall. More than 2/3 of migraineurs had ever consulted a physician whereas only 1/3 of patients with TTH had ever consulted a physician. For women, the migraine prevalence was higher among the ones with a lower income, while among men, it did not show any change by income. Migraine prevalence was lower in those with a lower educational status compared to those with a high educational status. Chronic daily headache was present in 3.3% and the prevalence of medication overuse headache was 2.1% in our population. There was an important impact of migraine with a monthly frequency of 5.9 +/- A 6, and an attack duration of 35.1 +/- A 72 h, but only 4.9% were on prophylactic treatment. The one-year prevalence of migraine estimated as 16.4% was similar or even higher than world-wide reported migraine prevalence figures and identical to a previous nation-wide study conducted in 1998, whereas the TTH prevalence was much lower using the same methodology with the ICHD-II criteria.Item The persistence versus interchangeability of migraine and tension-type headaches in a 5-year population-based validated survey(Sage Publications, 2020-01) Baykan, Betül; Ertaş, Mustafa; Orhan, Elif Kocasoy; Saip, Sabahattin; Siva, Aksel; Akarsu, Emel Oğuz; Zarifoğlu, Mehmet; Karlı, Necdet; Bursa Uludağ Üniversitesi/Uludağ Tıp Fakültesi/Nöroloji Anabilim Dalı.; AAA-8936-2021; EHN-5825-2022; JDE-9380-2023; 55982762500; 6603411305; 6506587942Objective The aim of this population-based validated study was to determine the course of tension-type headache and migraine and to evaluate the predictors of persistence. Methods We evaluated the course of headache in a large population from the first assessment in 2008 through a second assessment in 2013. Then we examined the factors associated with persistent migraine and persistent tension-type headache. Results Our study in 2013 revealed that only 42.9% of definite migraineurs in 2008 received the same diagnosis again, and of the remaining migraineurs 23.3% were newly diagnosed as definite tension-type headache; 11.6% evolved into probable tension-type headache, 6.4% changed to probable migraine, and 15.8% were headache free. The 17.7% of patients with definite tension-type headache in 2008 were newly diagnosed as having probable tension-type headache, 14.7% as having definite migraine, 6.4% as having probable migraine, and 28.9% as headache free in 2013, and only 32.3% received the definite tension-type headache diagnosis again. Binary logistic regression analysis showed nausea, throbbing and severe headache were the significant parameters for persistent migraine. A multiple regression analysis model with stepwise variable selection revealed that nausea, throbbing and severe headache and osmophobia remained in the final model as predictors of migraine persistence. We found no predictive factor for persistent tension-type headache. Conclusion Migraine and tension-type headache did not seem to show a simple bidirectional linear worsening from headache-free state to definite migraine or vice versa, hence the transitions between them are more chaotic, reflecting that there are still unknown modifiers and modulators. Certain headache characteristics of migraine might predict persistent migraine.Item Potential risk factors for migraine: Data from a population-based incidence study(Lippincott Williams & Wilkins, 2016-04-05) Baykan, Betül; Ertaş, Mustafa; Ekizoğlu, Esme; Uludüz, Derya; Uygunoğlu, Uğur; Orhan, Elif Kocasoy; Saip, Sabahattin; Siva, Aksel; Karlı, Necdet; Zarifoğlu, Mehmet; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; 0000-0002-7734-6451; JDE-9380-2023; EHN-5825-2022Item Prevalence of migraine in Turkey: A nationwide home based study(Elsevier, 2009-10) Ertaş, Mustafa; Baykan, Betül; Orhan, Elif Kocasoy; Saip, Sebah; Önal, Emel; Siva, Aksel; Zarifoğlu, Mehmet; Karlı, Necdet; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.Item Prevalence of migraine in Turkey: A nationwide home-based study(Sage Publications, 2009-10) Ertaş, Mustafa; Baykan, Betül; Orhan, Elif Kocasoy; Saip, Sebah; Siva, Aksel; Önal, Emel; Zarifoğlu, Mehmet; Karlı, Necdet; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.