Browsing by Author "Pekkolay, Zafer"
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Publication Identifying clinical characteristics of hypoparathyroidism in Turkey: HIPOPARATURK-NET study(Springer, 2022-02) Değertekin, Ceyla Konca; Yavuz, Dilek Gogas; Pekkolay, Zafer; Saygılı, Emre; Uğur, Kader; Koca, Arzu Or; Ünübol, Mustafa; Topaloğlu, Ömercan; Aydoğan, Berna İmge; Kutbay, Nilüfer Özdemir; Hekimsoy, Zeliha; Yılmaz, Nusret; Balcı, Mustafa Kemal; Tanrıkulu, Seher; Ünsal, Yasemin Aydoğan; Ersoy, Canan; Omma, Tülay; Keskin, Müge; Yalçın, Mehmet Muhittin; Yetkin, İlhan; Soylu, Hikmet; Karaköse, Melia; Yılmaz, Merve; Karakılıç, Ersen; Pişkinpaşa, Hamide; Batman, Adnan; Akbaba, Gülhan; Elbuken, Gülşah; Bahadir, Cigdem Tura; Kılınç, Faruk; Bilginer, Muhammet Cüneyt; İyidir, Özlem Turhan; Cantürk, Zeynep; Yılmaz, Banu Aktaş; Sayıner, Zeynel Abidin; Eroğlu, Mustafa; ERSOY, CANAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Hastalıkları Bilim Dalı; AAH-8861-2021Hypoparathyroidism is an orphan disease with ill-defined epidemiology that is subject to geographic variability. We conducted this study to assess the demographics, etiologic distribution, treatment patterns and complication frequency of patients with chronic hypoparathyroidism in Turkey. This is a retrospective, cross-sectional database study, with collaboration of 30 endocrinology centers located in 20 cities across seven geographical regions of Turkey. A total of 830 adults (mean age 49.6 +/- 13.5 years; female 81.2%) with hypoparathyroidism (mean duration 9.7 +/- 9.0 years) were included in the final analysis. Hypoparathyroidism was predominantly surgery-induced (n = 686, 82.6%). The insulting surgeries was carried out mostly due to benign causes in postsurgical group (SG) (n = 504, 73.5%) while patients in nonsurgical group (NSG) was most frequently classified as idiopathic (n = 103, 71.5%). The treatment was highly dependent on calcium salts (n = 771, 92.9%), calcitriol (n = 786, 94.7%) and to a lower extent cholecalciferol use (n = 635, 76.5%) while the rate of parathyroid hormone (n = 2, 0.2%) use was low. Serum calcium levels were most frequently kept in the normal range (sCa 8.5-10.5 mg/dL, n = 383, 46.1%) which might be higher than desired for this patient group. NSG had a lower mean plasma PTH concentration (6.42 +/- 5.53 vs. 9.09 +/- 7.08 ng/l, p < 0.0001), higher daily intake of elementary calcium (2038 +/- 1214 vs. 1846 +/- 1355 mg/day, p = 0.0193) and calcitriol (0.78 +/- 0.39 vs. 0.69 +/- 0.38 mcg/day, p = 0.0057), a higher rate of chronic renal disease (9.7% vs. 3.6%, p = 0.0017), epilepsy (6.3% vs. 1.6%, p = 0.0009), intracranial calcifications (11.8% vs. 7.3%, p < 0.0001) and cataracts (22.2% vs. 13.7%, p = 0.0096) compared to SG. In conclusion, postsurgical hypoparathyroidism is the dominant etiology of hypoparathyroidism in Turkey while the nonsurgical patients have a higher disease burden with greater need for medications and increased risk of complications than the postsurgical patients.Publication Turkish nationwide survey of glycemic and other metabolic parameters of patients with Diabetes mellitus (TEMD study)(Elsevier, 2018-12-01) Sönmez, Alper; Haymana, Cem; Bayram, Fahri; Salman, Serpil; Dizdar, Oğuzhan Sıtkı; Gürkan, Eren; Çarlıoğlu, Ayse Kargili; Barçin, Cem; Sabuncu, Tevfik; Satman, İlhan; Güldiken, Sibel; Aytürk, Semra; Yılmaz, Murat; Aşık, Mehmet; Dinccag, Nevin; Çakmak, Ramazan; Türker, Fulya; İdiz, Cemile; Hacışahinoğullari, Hülya; Bağdemir, Elif; Yıldız, Buşra; Yumuk, Volkan Demirhan; Haliloğlu, Özlem; Sancak, Seda; Özsarı, Levent; Çağıltay, Eylem; Deyneli, Oğuzhan; İmre, Eren; Gönen, Sait; Boysan, S. Nur; Altuntaş, Yüksel; Öztürk, Feyza Yener; Mert, Meral; Pişkinpaşa, Hamide; Aydın, Hasan; İmamoğlu, Sazı; Ersoy, Canan; Özgül, Özen; Küçüksaraç Kıyıcı, Sinem; Çetinarslan, Berrin; Selek, Alev; Doğru, Teoman; Kırık, Ali; Kebapçı, Nur; Efe, Belgin; Kaya, Ahmet; Cordan, İlker; Baldane, Süleyman; Kirac, Cem Onur; Demirci, İbrahim; Capa, Zehra; Cesur, Mustafa; Yetkin, Ilhan; Çorapçıoğlu, Demet; Canlar, Şule; Yıldız, Okan Bulent; Sendur, Süleyman Nahit; Cakir, Bekir; özdemir, Didem; Çorakci, Ahmet; Kutlu, Mustafa; Bascil Tutuncu, Neslihan; Bozkuş, Yusuf; Çakal, Erman; Demirbaş, Berrin; Ertek, Sibel; Altay, Mustafa; Dağdeviren, Murat; Abedi, Amir Hassein; Çetinkalp, Sevki; Özışık, Hatice; Oruk, GÜzide Gonca; Yener, Serkan; Saydam, Başak Özgen; Güney, Engin; Unubol, Mustafa; Yaylalı, Güzin Fidan; Topsakal, Şenay; Hekimsoy, Zeliha; Akbaba, Gülhan; Aslan, İbrahim; Balcı, Mustafa Kemal; Dalkıran, Şefika; Akbay, Esen; Gül, Kamile; Agbaht, Kemal; Yılmaz, Müge Özsan; Bozkırlı, Emre; Tetiker, B. Tamer; Altuntaş, Seher Çetinkaya; Atmaca, Ayşegül; Durmuş, Elif Tutku; Mete, Türkan; Kutlutürk, Faruk; Küçükler, Ferit Kerim; Dikbaş, Oğuz; Akın, Şafak; Nuhoğlu, İrfan; Ersöz, Halil Önder; Bayraktaroğlu, Taner; Şişman, Pınar; Şahin, İbrahim; Çetin, Sedat; Capoğlu, İlyas; Akbaş, Emin Murat; Üçler, Rıfkı; Eren, Mehmet Ali; Tuzcu, Alpaslan Kemal; Pekkolay, Zafer; Özkaya, Mesut; Araz, Mustafa; TEMD Study Grp; ERSOY, CANAN; Özgül, Özen; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Anabilim Dalı; AAH-8861-2021; DLV-5369-2022Aims: Turkey has the highest prevalence of diabetes in Europe. It is therefore essential to know the overall cardiovascular risk and reveal the predictors of metabolic control in Turkish adults with diabetes mellitus.Methods: A nationwide, multicenter survey consecutively enrolled patients who were under follow up for at least a year. Optimal control was defined as HbA1c <7%, home arterial blood pressure (ABP) <135/85 mmHg, or LDL-C <100 mg/dL. Achieving all parameters indicated triple metabolic control.Results: HbA1c levels of patients (n = 5211) were 8.6 +/- 1.9% (71 +/- 22 mmol/mol) and 7.7 +/- 1.7% (61 +/- 19 mmol/mol), in Type 1 and Type 2 diabetes, respectively. Glycemic control was achieved in 15.3% and 40.2%, and triple metabolic control was achieved in 5.5% and 10.1%, respectively. Only 1.5% of patients met all the criteria of being non-obese, nonsmoker, exercising, and under triple metabolic control. Low education level was a significant predictor of poor glycemic control in both groups.Conclusions: Few patients with Type 2, and even fewer with Type 1 diabetes have optimal metabolic control in Turkey. TEMD study will provide evidence-based information to policy makers to focus more on the quality and sustainability of diabetes care in order to reduce the national burden of the disease.