Browsing by Author "Taslimi, Parham"

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    Effects of some phenolic compounds on the inhibition of α-glycosidase enzyme-immobilized on Pluronic®F127 micelles: An in vitro and in silico study
    (Elsevier, 2021-10-28) Kassa, Solomon Bezabeh; Taslimi, Parham; Özel, Şahin; Gür, Bahri; Gülçin, İlhami; Önganer, Yavuz; ÖZEL, ŞAHİN; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Kimya Bölümü.; JHC-0846-2023
    This study aimed to consider the activity of immobilized alpha-glycosidase, significant enzyme defined in serum glucose adjustment, on Pluronic (R) F127 micelles and to compare the results with theoretical molecular docking studies. The phenolic molecules were used for the activity studies, which play a crucial role in the inhibition of alpha-glycosidase by providing conservation against pathogen factors. The immobilization of alpha-glycosidase on Pluronic (R) F127 micelles showed higher kinetic activity towards p-nitrophenyl-D-glucopyranoside (pNPG) than the free one. The inhibition profiles from some phenolic molecules were observed impressively with IC50 values between 20.47 and 1118.68 nM and K-i values between 18.51 and 1087.53 nM against immobilized alpha-glycosidase. In addition, the inhibition effects of the studied phenolic compounds have been tested with calculated negative binding energies from theoretical molecular docking studies. Negative binding energy values were as - 6.1 and - 8.3 kcalmol(-1) for p-coumaric acid and tetrakis compounds, respectively.
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    The effects of wireless electromagnetic fields on the activities of carbonic anhydrase and acetylcholinesterase enzymes in various tissues of rats
    (Wiley, 2018-03) Koçyiğit, Ümit Muhammet; Taslimi, Parham; Soylu, Sinan; Dastan, Sevgi Durna; Gülçin, İlhami; Gürses, Fatih; Uludağ Üniversitesi/İnegöl İşletme Fakültesi/Yönetim Bilişim Sistemleri Bölümü.; CSX-6323-2022; 57201211974
    The purpose of our study is to assist in understanding the effects of wireless electromagnetic waves on carbonic anhydrase (CA) and acetylcholinesterase (AChE) enzymes activities in the different tissues of the rats. For this purpose, two different groups each of which contains eight rats (n=8) were formed as being control group and wireless electromagnetic wave-administered group. The rats were necropsied after 60min from the injection of chemicals into the rats intraperitoneally. The different tissues of the rats were extracted. CA and AChE enzymes activities were measured for each tissue. All the experimental results were provided in mean +/- S.D. Statistical significance was identified to be P<0.05. It was observed that there were significant changes of enzyme activities in wireless-administered group in salivary gland, stomach, colon, liver, and striated muscle tissues.