Browsing by Author "Tecles, F."
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Item Inflammatory and oxidative biomarkers of disease severity in dogs with parvoviral enteritis(Wiley, 2015-02-01) Tvarijonaviciute, A.; Martinez-Subiela, S.; Tecles, F.; Kocaturk, M.; Eralp, O.; Yilmaz, Z.; Ceron, J. J.; Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Bölümü.; 0000-0002-2849-1222; 0000-0002-4242-8609; 0000-0001-9836-0749; 0000-0002-8654-1793; V-5578-2017; CNQ-3124-2022; A-9637-2008; H-9043-2015; 36437200800; 24472964600; 35944810500; 7004887203Objectives: To study changes in serum C-reactive protein, haptoglobin, ceruloplasmin and albumin concentration, total anti-oxidant capacity and paraoxonase-1 and butyrylcholinesterase activity in dogs with parvoviral enteritis of different degrees of clinical severity.Methods: Prospective study of 9 healthy and 43 dogs with parvoviral enteritis that were classified into mildly, moderately and affected groups.Results: Dogs with parvoviral enteritis had a significant increase in C-reactive protein compared with healthy dogs, with an increase of higher magnitude in animals with more severe clinical signs. All dogs with parvoviral enteritis had a significant increase in haptoglobin concentration compared with healthy dogs, but with no difference according to disease severity. There was a decrease in paraoxonase-1 activity in parvoviral enteritis.Clinical significance: Major increases of C-reactive protein concentrations in dogs with parvoviral enteritis are a marker of disease severity. In addition, higher values for anti-oxidants in severe cases compared with mild and moderate cases suggest a possible compensatory anti-oxidant mechanism.