Browsing by Author "Tekeli, Hakan"

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Assessment of patients with intracerebral hemorrhage or hemorrhagic transformation in the VENOST study
(Karger, 2021-01-01) Duman, Taşkın; Yayla, Vildan; Uludüz, Derya; Göksu, Eylem Özaydın; Yürekli, Vedat Ali; Genç, Hamit; Utku, Uygar; Çınar, Nilgün; Tekeli, Hakan; Sungur, Mehmet Ali; Tokuç, Firdevs Ezgi; Uzuner, Nevzat; Şenol, Mehmet Güney; Yılmaz, Arda; Gökçe, Mustafa; Demirci, Seden; Küsbeci, Özge Yılmaz; Uzuner, Gülnur Tekgöl; Şahin, Şevki; Çağlayan, Hale Zeynep Batur; Açıkgöz, Mustafa; Özdağ, Fatih; Baybaş, Sevim; Ekmekci, Hakan; Çabalar, Murat; Yaman, Mehmet; Bektaş, Hesna; Kaplan, Yüksel; Göksel, Başak Karakurum; Milanlıoğlu, Aysel; Orken, Dilek Necioğlu; Aluçlu, Mehmet Ufuk; Çolakoğ, Şenalu; Tüfekci, Ahmet; Bakar, Mustafa; Nazlıel, Bijrn; Taşçilar, Nida; Göksan, Baki; Kozak, Hasan Hüseyin; Mısırlı, Handan; Küçükoğlu, Hayriye; Midi, İpek; Mengüllüoğlu, Necdet; Aytaç, Emrah; Yeşilot, Nilüfer; İnce, Birsen; Yalın, Osman Özgür; Güneş, Taşkın; Oruç, Serdar; Domac, Füsun Mayda; Öztürk, Şerefnur; Karahan, Ali; Erdoğan, Hacı Ali; Afşar, Nazire; BAKAR, HACI MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; EKN-8251-2022
Introduction: Cerebral venous and sinus thrombosis (CVST) may lead to cerebral edema and increased intracranial pressure; besides, ischemic or hemorrhagic lesions may develop. Intracerebral hemorrhages occur in approximately one-third of CVST patients. We assessed and compared the findings of the cerebral hemorrhage (CH) group and the CVST group. Materials and Methods: In the VENOST study, medical records of 1,193 patients with CVST, aged over 18 years, were obtained from 35 national stroke centers. Demographic characteristics, clinical symptoms, signs at the admission, radiological findings, etiologic factors, acute and maintenance treatment, and outcome results were reported. The number of involved sinuses or veins, localizations of thrombus, and lesions on CT and MRI scans were recorded. Results: CH was detected in the brain imaging of 241 (21.1%) patients, as hemorrhagic infarction in 198 patients and intracerebral hemorrhage in 43 patients. Gynecologic causes comprised the largest percentage (41.7%) of etiology and risk factors in the CVST group. In the CH group, headache associated with other neurological symptoms was more frequent. These neurological symptoms were epileptic seizures (46.9%), nausea and/or vomiting (36.5%), altered consciousness (36.5%), and focal neurological deficits (33.6%). mRS was >= 3 in 23.1% of the patients in the CH group. Discussion and Conclusion: CVST, an important cause of stroke in the young, should be monitored closely if the patients have additional symptoms of headache, multiple sinus involvement, and CH. Older age and parenchymal lesion, either hemorrhagic infarction or intracerebral hemorrhage, imply poor outcome.
Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study
(Kare Publ, 2021-01-01) Duman, Taşkın; Cinar, Nilgün; Uludüz, Derya; Domaç, Füsun Mayda; Öztürk, Şerefnur; Yayla, Vildan; Karahan, Ali Yavuz; Afşar, Nazire; Sungur, Mehmet Ali; Göksu, Eylem Özaydın; Yürekli, Vedat Ali; Genç, Hamit; Utku, Uygar; Şahin, Şevki; Tekeli, Hakan; Tokuç, Firdevs Ezgi; Uzuner, Nevzat; Şenol, Mehmet Güney; Yılmaz, Arda; Gökçe, Mustafa; Demirci, Seden; Küsbeci, Özge Yılmaz; Uzuner, Gülnur Tekgöl; Çağlayan, Hale Zeynep Batur; Açıkgöz, Mustafa; Kurucu, Hatice; Özdağ, Mehmet Fatih; Baybas, Sevim; Ekmekci, Hakan; Çabalar, Murat; Yaman, Mehmet; Bektaş, Hesna; Kaplan, Yüksel; Göksel, Başak Karakurum; Milanlıoğlu, Aysel; Orken, Dilek Necioğlu; Aluclu, Mehmet Ufuk; Çolakoğlu, Sena; Tüfekci, Ahmet; Bakar, Mustafa; Nazliel, Bijen; Taşcılar, Nida; Göksan, Baki; Kozak, Hasan Hüseyin; Mısırlı, Cemile Handan; Küçükoğlu, Hayriye; Midi, İpek; Mengülluoğlu, Necdet; Aytaç, Emrah; Yeşilot, Nilüfer; İnce, Birsen; Yalın, Osman Özgür; Güneş, Taşkın; Oruç, Serdar; Demir, Serkan; BAKAR, HACI MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; EKN-8251-2022
Objectives: Headache is the most common complaint in cerebral venous sinus thrombosis (CVST) and it may sometimes be the only symptom in these patients. This retrospective and prospective study was an investigation of any differences in terms of clinical risk factors, radiological findings, or prognosis in patients with CVST who presented with isolated headache (IH) and cases with other concomitant findings (non-isolated headache [NIH]).Methods: A total of 1144 patients from a multicenter study of cerebral venous sinus thrombosis ( VENOST study) were enrolled in this research. The demographic, biochemical, clinical, and radiological aspects of 287 IH cases and 857 NIH cases were compared.Results: There were twice as many women as men in the study group. In the IH group, when gender distribution was evaluated by age group, no statistically significant difference was found. The onset of headache was frequently subacute and chronic in the IH group, but an acute onset was more common in the NIH group. Other neurological findings were observed in 29% of the IH group during follow-up. A previous history of deep, cerebral, or other venous thromboembolism was less common in the IH group than in the NIH group. Transverse sinus involvement was greater in the IH group, whereas sagittal sinus involvement was greater in the NIH group. The presence of a plasminogen activator inhibitor (PAI) mutation was significantly greater in the IH group.Conclusion: IH and CVST should be kept in mind if a patient has subacute or chronic headache. PAI, which has an important role in thrombolytic events, may be a risk factor in CVST. Detailed hematological investigations should be considered. Additional studies are needed.