Browsing by Author "Turkmen, Kultigin"

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    The efficacy of cinacalcet in the treatment of hyperparathyroidism in turkish hemodialysis patient population
    (Türk Nefroloji Diyaliz Transplantasyon Dergisi, 2016-01-01) Altunoren, Orcun; Gungor, Ozkan; Eren, Necmi; Tanrisev, Mehmet; Hur, Ender; Turkmen, Kultigin; Yavuz, Yasemin Coskun; Sahin, Osman Zikirullah; Saglam, Funda; Turan, Mehmet Nuri; Yaprak, Mustafa; Ulutas, Ozkan; Kocyigit, Ismail; Oguz, Ayten; Ari, Elif; Ada, Sibel; Yıldız, Abdulmecit; Azak, Alper; Korkmaz, Ahmet Edip; Yavuz, Demet; Dogan, Ibrahim; Tekce, Hikmet; Sert, Mehmet; Kaya, Bulet; Bakirdogen, Serkan; Kose, Sennur; Sakaci, Tamer; Pembegul, Irem; Aytug, Ferhan; Guclu, Aydin; Akgul, Bulent; Yilmaz, Mahmut Ilker; YILDIZ, ABDULMECİT; Uludağ Üniversitesi/Tıp Fakültesi.; HIG-9032-2022
    OBJECTIVE: Cinacalcet reduces parathyroid hormone levels by increasing the sensitivity of the parathyroid gland to calcium. In this study, we firstly aimed to evaluate the efficacy of cinacalcet in Turkish hemodialysis patients.MATERIAL and METHODS: 4483 hemodialysis patients were screened and 469 patients who had used cinacalcet were included in the study. The patients were divided into 4 groups according to drug usage durations (Group 1: 3 months, Group 2: 6 months, Group 3: 9 months and Group 4: 12 months). The patients' Parathormone, Ca, P and CaxP levels at the 3rd, 6th, 9th and 12th months were compared to the start of treatment and previous months.RESULTS: The levels of Parathormone, Ca, P and CaxP significantly decreased compared to their initial levels in all groups (from 1412 pg/ml to 1222 pg/mL for Parathormone, p< 0,001) in the 3rd month. However, this reduction was not continued in the subsequent months (Parathormone: 1381 pg/ml for the 12th month).CONCLUSION: Cinacalcet may not provide adequate benefit in control of hyperparathyroidism in Turkish hemodialysis patient population.
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    The relationship between glomerular igg staining and poor prognostic findings in patients with iga nephropathy: The data from tsn-gold working group
    (BMC, 2021-10-28) Turgutalp, Kenan; Cebeci, Egemen; Turkmen, Aydin; Derici, Ulver; Seyahi, Nurhan; Eren, Necmi; Dede, Fatih; Basturk, Taner; Sahin, Gulizar Manga; Yilmaz, Murvet; Sipahi, Savas; Sahin, Garip; Ulu, Sena; Tatar, Erhan; Gundogdu, Ali; Kazancioglu, Rumeyza Turan; Sevinc, Can; Gungor, Ozkan; Sahin, Idris; Kutlay, Sim; Kurultak, Ilhan; Aydin, Zeki; Altun, Bulent; Dursun, Belda; Yilmaz, Zulfikar; Uzun, Ozcan; Suleymanlar, Gultekin; Candan, Ferhan; Sezer, Siren; Tanburoglu, Derya Basak; Bahcebasi, Zerrin Bicik; Taymez, Dilek; Akcali, Esra; Oygar, Deren; Istemihan, Zulal; Bardak, Simge; Akcay, Omer Faruk; Dincer, Mevlut Tamer; Dervisoglu, Erkan; Yenigun, Ezgi; Turkmen, Kultigin; Ozturk, Savas; Güllülü, Mustafa; GÜLLÜLÜ, MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0003-0245-1844; 0000-0001-7427-618X; 0000-0002-2708-3470; 0000-0002-0409-2710; 0000-0001-6829-121X; 0000-0002-5068-4231; 0000-0002-9594-4121; 0000-0002-4069-9181; 0000-0002-8683-3737; 0000-0001-5607-1375; 0000-0002-6648-6053; 0000-0002-4017-0640; 0000-0002-6851-4871; 0000-0002-0961-3810; P-9618-2015; HKV-4703-2023; GRX-9954-2022; V-1616-2019; AAA-8435-2020; AFR-4244-2022; JYQ-2550-2024; S-7661-2016; AAS-4390-2020; Q-6320-2019; R-1388-2018
    Background Galactose-deficient IgA1 (Gd-IgA1) has an increased tendency to form immunocomplexes with IgG in the serum, contributing to IgAN pathogenesis by accumulating in the glomerular mesangium. Several studies showed that glomerular IgG deposition in IgAN is an important cause of mesangial proliferation and glomerular damage. This study aims to determine the association of the positivity of IgG and the intensity of IgG staining with a poor renal prognosis. Methods A total of 943 IgAN patients were included in the study. Glomerular IgG staining negative and positive patients were compared using Oxford classification scores, histopathological evaluations, proteinuria, eGFR, albumin, blood pressures. IgG positive patients were classified as (+), (++), (+++) based on their staining intensity, and the association with the prognostic criteria was also evaluated. Results 81% (n = 764) of the patients were detected as IgG negative, while 19% (n = 179) were positive. Age, gender, body mass index, blood pressure, proteinuria, eGFR, uric acid values were similar in IgG positive and negative patients who underwent biopsy (p > 0.05). Intensity of glomerular IgG positivity was not found to be associated with diastolic and systolic blood pressure, urea, uric acid, age, eGFR, albumin, proteinuria (p > 0.05 for all, r = - 0.084, r = - 0.102, r = - 0.006, r = 0.062, r = 0.014, r = - 0.044, r = - 0.061, r = - 0.066, r = 0.150, respectively). There was no difference for histopathological findings between IgG (+), IgG (++), IgG (+++) groups (for all, p > 0.05). Conclusion Glomerular IgG negativity and positivity detected by routine IFM in IgAN patients is not associated with poor renal prognostic risk factors.