Browsing by Author "Uǧraş, Nesrin"

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Anatomical restrictions in the transsphenoidal, transclival approach to the upper clival region: A cadaveric, anatomic study
(Churchill Livingstone, 2013) Aktaş, Ulaş; Yılmazlar, Selçuk; Uǧraş, Nesrin; Uludağ Üniversitesi/Tıp Fakültesi/Nöroşirürji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0003-3633-7919; AAH-2716-2021; AAH-5070-2021; 55122917500; 6603059483; 55386535600
Objective: Tumours in the clival region are difficult to remove surgically. Before the 1970s, clival tumours had very high mortality and morbidity rates. Methods: An anatomic dissection was performed on 24 spheno-occipital bone blocks obtained from 28 adult cadavers. The internal carotid artery, paraclival carotid tubercle, sixth cranial nerve and dorsum sellae in the upper clival region were analyzed qualitatively and quantitatively. For the histological evaluation, 4 samples were decalcified and sagittal sections were cut. From the eight blocks obtained, 32 incisions were made in the axial plane, and the tissue was analyzed. Results: Using microscopy, a clival recess was clearly identified in 15 of the 24(62.5%) samples. Paraclival carotid tubercles were observed in 19 (79.16%) of the samples. In the upper clival and petroclival region, the sixth cranial nerve had directional changes at the dural porus, the petrous apex and the lateral wall of the cavernous segment of the internal carotid artery. At the dorsum sellae level, the distance between the medial surfaces of both internal carotid arteries was a mean of 15.33 +/- 2.12 mm. This distance at the pharyngeal tubercle was a mean of 38.95 +/- 4.67 mm. On all the histological sections, the distance of the sixth cranial nerve from the dural porus to the cavernous sinus was within the basilar plexus, along with the subarachnoid membranes around it. On the petrous apex level, the sixth cranial nerve was fixed to the petrous apex and the internal carotid artery with connective tissue formed by dense collagen fibres. The sixth cranial nerve and the internal carotid artery are tightly surrounded by dense collagen connective tissue, and the relative proximity between the carotids on the dorsum sellae level can be easily damaged during the transsphenoidal-transclival approach. Similarly, due to the ligamentous fixation on the dural porus and the petrous apex surfaces, there is a high risk of injury to the carotid artery and sixth cranial nerve. Conclusion: This study determines the relationship between the sixth cranial nerve and the internal carotid artery at the upper clivus and to provide morphologic details that is essential for the risks of transclival surgery.
Co-occurrence of choroidal pigmented ganglioneuroma and plexiform neurofibroma in a patient with neurofibromatosis 1
(Wiley, 2014-04) Özgün, Gonca; Adım, Şaduman Balaban; Uǧraş, Nesrin; Yazıcı, Bülent; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göz Hastalıkları Anabilim Dalı.; 0000-0001-8889-1933; AAA-5384-2020; AAH-2716-2021; 35520074800; 15730076300; 55386535600; 7005398015
Coexistence of MACC1 and NM23-H1 dysregulation and tumor budding promise early prognostic evidence for recurrence risk of early-stage colon cancer
(Wiley, 2018-02) Öztürk, Ersin; Aksoy, Seçil A. K.; Uǧraş, Nesrin; Tunca, Berrin; Ceylan, Serkan; Tezcan, Gülçin; Yılmazlar, Tuncay; Yerci, Ömer; Egeli, Ünal; Çeçener, Gülşah; Uludağ Üniversitesi/Tıp FakültesiGenel Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0001-7904-883X; 0000-0002-5956-8755; 0000-0002-3820-424X; 0000-0002-3760-9755; 0000-0002-1619-6680; AAH-1420-2021; AAH-3843-2020; AAP-9988-2020; ADM-8457-2022; AAH-2716-2021; ABI-6078-2020; 35070171400; 36668149100; 55386535600; 6602965754; 57200378423; 25650627600; 6701800362; 6603810549; 55665145000; 6508156530
The tumor-node-metastasis (TNM) classification, the presence of a mucinous component, and signet ring cells are well-known criteria for identifying patients at a high risk for recurrence and determining the therapeutic approach for early-stage colon cancer (eCC). Nevertheless, recurrence can unexpectedly occur in some eCC cases after surgical resection. The aims of the present study were to evaluate the relation of dysregulated MACC1, c-MET, and NM23-H1 expression with the histopathological features of tumors in recurrence formation in eCC cases. A total of 100 sporadic eCC patients without poor prognosis factors were evaluated in this study. The relationship between the altered expression of MACC1, c-MET, and NM23-H1 and pathological microenvironmental features, including the presence of tumor budding and desmoplasia, were assessed. The primary outcomes, including 5-year overall survival (OS) and disease-free survival (DFS), were also measured. Compared with nonrecurrent patients, the expression level of MACC1 was 8.27-fold higher, and NM23-H1 was 11.36-fold lower in patients with recurrence during the 5-year follow-up (p = 0.0345 and p=0.0301, respectively). In addition, the coexistence of high MACC1 and low NM23-H1 expression and tumor budding was associated with short OS (p < 0.001). We suggest that the combination of reduced NM23-H1, induced MACC1, and the presence of tumor budding are promising biomarkers for the prediction of recurrence and may aid the stratification of patients with stage II colon cancer for adjuvant chemotherapy.
Embryonal rhabdomyosarcoma of the common bile duct and porta hepatis in an infant: A rare presentation
(AVES, 2013-01-14) Uǧraş, Nesrin; Yalçınkaya, Ülviye; Sevinir, Betül Berrin; Emiroğlu, Remzi; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; AAH-8924-2021; AAH-1570-2021; AAH-2716-2021; 55386535600; 6508300295; 6603199915; 7003899294
An extremely rare cause of gastric outlet: Breast lobular carcinoma metastases to stomach
(Wiley-Hindawi, 2014-05) Sarkut, Pınar Tasar; Özer, Ali; Gülcü, Barış; Öztürk, Ersin; Gökgöz, Şehsuvar; Uǧraş, Nesrin; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0003-1825-6736; AAH-2716-2021; AAU-4896-2020; 55806454400; 57194509547; 56618783200; 35070171400; 6603238737; 55386535600
Immunohistochemical detection of p53 and MDM2 expressions in liposarcoma with World health organization classification
(Wolters Kluwer Medknow Publications, 2013) Arıcı, Akgül; Özgür, Tümay; Uǧraş, Nesrin; Yalçınkaya, Ulviye; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; AAH-8924-2021; AAH-2716-2021; 55386535600; 6508300295
Background: Liposarcomas are among the most common soft tissue sarcomas in adulthood. Aim: The purpose of the study is to perform a histopathologic typing according to World Health Organization (WHO) classification of cases diagnosed with liposarcoma and to examine the difference of p53 and MDM2 expressions. Materials and Methods: The haematoxylin-eosin stained sections of 48 subjects enrolled in the study have been evaluated on the basis of the WHO classification for liposarcoma and sections stained using p53 and MDM2. Statistical Analysis Used: Chi-Square test was applied. Results: 20 subjects were diagnosed with well-differentiated liposarcoma (WLS), 16 myxoid liposarcoma (ML), 7 pleomorphic liposarcoma (PL), and 5 de-differentiated liposarcoma (DLS). The number of cases stained positive with MDM2 and p53 were positive correlated in all subjects (P = 0.02). p53 and MDM2 positivity increased in high grade tumors (P = 0.01). Conclusion: p53 and MDM2 immuno-reactivity was found to be potentially useful in liposarcoma diagnosis but a definitive implication would be rather unhealthy due to the small number of cases in our study.
Lack of any prognostic relationship between adiponectin receptor (Adipo R1/R2) expression for early/ advanced stage gastric cancer
(Asian Pacific Organization Cancer Prevention, 2014) Ayyıldız, Talat; Dolar, Enver; Uǧraş, Nesrin; Dizdar, Oğuzhan Sıtkı; Adım, Şaduman Balaban; Yerci, Ömer; Uludağ Üniversitesi/Tıp Fakültesi/Gastroenteroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; 0000-0001-8944-2793; AAH-2716-2021; AAG-9177-2021; 6602075084; 55386535600; 55202193000; 15730076300; 6603810549
Introduction: Adiponectin (ApN) is a complement C1q-related protein, mainly secreted from adipose tissue, that signals through ApN receptor1 (Adipo-R1) and ApN receptor 2 (Adipo-R2). Low serum ApN concentrations are associated with obesity-related malignancies. However, there are very few studies on any prognostic role of ApN receptors in gastric cancer. Objectives: The aim of this study is to investigate the relationship between AdipoR1/R2 expression and early/advanced stage gastric cancer in terms of clinicopathologic characteristics and survival. Materials and Methods: Eighteen patients with early and 39 with advanced stage gastric cancer who underwent surgical gastric resection were included in this study. Results: Adipo-R1 expression was low in 2 of the 18 patients with early stage gastric cancer (11.1%), while 4 had low Adipo-R2 expression (22.2%). In those with advanced stage gastric cancer, 7 of 39 had low Adipo-R1 expression (17.9%) and 16 had low Adipo-R2 expression (41%). Adipo-R2 expression was significantly higher (p=0.011) in moderately differentiated tumors when compared to well-differentiated tumors. While there was nearly a statistically significant relationship between TNM stage (T, tumor size; N, regional lymph node; M, whether distant metastases exist) and Adipo-R2 expression (p=0.054), there was no relationship between Adipo-R1/-R2 expression with tumor stage and survival. Conclusion: Adipo-R1/-R2 expression has no prognostic significance of in early/advanced stage gastric cancer.
Malignant melanoma of the stomach in an elderly patient
(AVES, 2014-09-27) Çubukçu, Erdem; Ölmez, Ömer Fatih; Kanat, Özkan; Pekgöz, Murat; Uǧraş, Nesrin; Deligönül, Adem; Manavoǧlu, Osman; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Onkoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Gastroenteroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; AAH-2716-2021; 53986153800; 26435400000; 55881548500; 36010142900; 55386535600; 37088030300; 6602587152
Overexpression of miR-21 Is Associated With Recurrence in Patients With Hepatitis B Virus-Mediated Hepatocellular Carcinoma Undergoing Liver Transplantation
(Elsevier, 2019-05) Dündar, Halit Ziya; Aksoy, Fuat; Aksoy, Seçil Ak; Taşar, Pınar; Uǧraş, Nesrin; Tunca, Berrin Türkei; Egeli, Ünal; Çeçener, Gülşah; Yerci, Ömer; Kaya, Ekrem; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Tıp Bilimleri/Genel Cerrahi Bölümü.; 0000-0001-5808-9384; 0000-0002-1619-6680; 0000-0002-3820-424X; 0000-0001-7904-883X; HII-8895-2022; ABI-6078-2020; AAP-9988-2020; AAH-2716-2021; AAH-1420-2021; 55453773300; 57208705658; 57193933334; 57208702845; 55386535600; 6602965754; 55665145000; 6508156530; 6603810549; 7004568109
Liver transplantation (LT) is the best treatment option for hepatitis B virus (HBV)e mediated hepatocellular carcinoma (HCC). Nevertheless, recurrence is the most important issue after LT. The aims of the present study were to evaluate the relation of dysregulated expression of microRNAs (miRNAs) in recurrence formation in HBV-mediated HCC cases. A total of 42 HBV-mediated HCC patients were evaluated in this study. Among 21 miRNAs, the expression level of miR-106a and miR-21 were higher and miR-143 and miR145 were lower in patients with HCC compared with noncancerous liver tissues (P = .0388, P = .0214, P = .0321, and P = .002, respectively). Compared with nonrecurrent patients, the expression level of miR-21 was 3.54-fold higher and miR-145 was 2.42-fold lower in patients with recurrence during the 5-year follow-up (P = .004 and P = .032; respectively). In addition, according to multivariate Cox regression analysis, the overexpression of miR-21 was found to be a prognostic indicator in HBV-mediated HCC patients (P = .002). In conclusion, we show a significant association between high expression of miR-21 and recurrence in HBV-mediated HCC. Therefore, up-regulation of miR-21 could serve as a promising prognostic marker for HCC.
Relationship between HER-2, COX-2, p53 and clinicopathologic features in gastric adenocarcinoma. Do these biomarkers have any prognostic significance?
(AVES, 2013-06-28) Uǧraş, Nesrin; Özgün, Gonca; Ocakoğlu, Gökhan; Yerci, Ömer; Öztürk, Ersin; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; AAH-2716-2021; AAH-5180-2021; 55386535600; 35520074800; 15832295800; 6603810549; 35070171400
Background/Aims: The aim of this study was to examine the expression of HER-2, p53 and COX-2 in gastric adenocarcinoma and to investigate whether these markers were useful in predicting the clinicopathologic features. Materials and Methods: Primary gastric adenocarcinoma specimens were obtained from 56 patients who underwent total/subtotal gastrectomy with extended lymphadenectomy between December 2011 - December 2012. We investigated the association between the expression of these markers and clinicopathologic factors by immunohistochemistry. Results: COX-2 positive cases were detected in 28 (50%) of the 56 patients and COX-2 expression was significantly correlated with presence of perineural invasion (p=0,032). 37 cases (66.1%) were defined positive for p53. The expression of p53 was significantly correlated with increasing age (p=0,003), but there was no correlation with other clinicopathological variables. Among the 56 primary gastric cancers, 9 (16.1%) cases showed intermediate (2+) positive expression and 7 (12.5%) cases showed (3+) positive expression for HER-2. No significant correlations were determined between HER-2 and the other variables. Conclusion: Although, this study failed to show any relationship between HER-2 and clinicopathological factors, but our results demondtrated that COX-2 expression might serve as a powerful indicator for estimating perineural invasion, which is an independent worse prognostic factor for survival in gastric adenocarcinoma. Additionally, detecting the expression of p53 can assist with the treatment options for elderly patients with gastric adenocarcinoma. A better understanding of HER-2, COX-2 and p53 expression in gastric adenocarcinoma may improve the staging strategies and influence new treatment modalities.
An uncommon presentation of invasive lobular carcinoma of breast: An incidental finding after Cholecsytectomy
(AVES, 2013-08-13) Adım Balaban, Saduman; Akyıldız, Elif Ülker; Uǧraş, Nesrin; Emirog̈lu, Remzi; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; AAH-2716-2021; 56939319000; 55901306600; 55386535600; 7003899294