Browsing by Author "Uludüz, Derya"

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Assessment of patients with intracerebral hemorrhage or hemorrhagic transformation in the VENOST study
(Karger, 2021-01-01) Duman, Taşkın; Yayla, Vildan; Uludüz, Derya; Göksu, Eylem Özaydın; Yürekli, Vedat Ali; Genç, Hamit; Utku, Uygar; Çınar, Nilgün; Tekeli, Hakan; Sungur, Mehmet Ali; Tokuç, Firdevs Ezgi; Uzuner, Nevzat; Şenol, Mehmet Güney; Yılmaz, Arda; Gökçe, Mustafa; Demirci, Seden; Küsbeci, Özge Yılmaz; Uzuner, Gülnur Tekgöl; Şahin, Şevki; Çağlayan, Hale Zeynep Batur; Açıkgöz, Mustafa; Özdağ, Fatih; Baybaş, Sevim; Ekmekci, Hakan; Çabalar, Murat; Yaman, Mehmet; Bektaş, Hesna; Kaplan, Yüksel; Göksel, Başak Karakurum; Milanlıoğlu, Aysel; Orken, Dilek Necioğlu; Aluçlu, Mehmet Ufuk; Çolakoğ, Şenalu; Tüfekci, Ahmet; Bakar, Mustafa; Nazlıel, Bijrn; Taşçilar, Nida; Göksan, Baki; Kozak, Hasan Hüseyin; Mısırlı, Handan; Küçükoğlu, Hayriye; Midi, İpek; Mengüllüoğlu, Necdet; Aytaç, Emrah; Yeşilot, Nilüfer; İnce, Birsen; Yalın, Osman Özgür; Güneş, Taşkın; Oruç, Serdar; Domac, Füsun Mayda; Öztürk, Şerefnur; Karahan, Ali; Erdoğan, Hacı Ali; Afşar, Nazire; BAKAR, HACI MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; EKN-8251-2022
Introduction: Cerebral venous and sinus thrombosis (CVST) may lead to cerebral edema and increased intracranial pressure; besides, ischemic or hemorrhagic lesions may develop. Intracerebral hemorrhages occur in approximately one-third of CVST patients. We assessed and compared the findings of the cerebral hemorrhage (CH) group and the CVST group. Materials and Methods: In the VENOST study, medical records of 1,193 patients with CVST, aged over 18 years, were obtained from 35 national stroke centers. Demographic characteristics, clinical symptoms, signs at the admission, radiological findings, etiologic factors, acute and maintenance treatment, and outcome results were reported. The number of involved sinuses or veins, localizations of thrombus, and lesions on CT and MRI scans were recorded. Results: CH was detected in the brain imaging of 241 (21.1%) patients, as hemorrhagic infarction in 198 patients and intracerebral hemorrhage in 43 patients. Gynecologic causes comprised the largest percentage (41.7%) of etiology and risk factors in the CVST group. In the CH group, headache associated with other neurological symptoms was more frequent. These neurological symptoms were epileptic seizures (46.9%), nausea and/or vomiting (36.5%), altered consciousness (36.5%), and focal neurological deficits (33.6%). mRS was >= 3 in 23.1% of the patients in the CH group. Discussion and Conclusion: CVST, an important cause of stroke in the young, should be monitored closely if the patients have additional symptoms of headache, multiple sinus involvement, and CH. Older age and parenchymal lesion, either hemorrhagic infarction or intracerebral hemorrhage, imply poor outcome.
Cerebral venous sinus thrombosis in women: Subgroup analysis of the VENOST study
(Hindawi, 2020-05-15) Uludüz, Derya; Sahin, Sevki; Duman, Taşkın; Öztürk, Şerefnur; Yayla, Vildan; Afşar, Nazire; Uzuner, Nevzat; Midi, Ipek; Çınar, Nilgün; Sungur, Mehmet Ali; Domaç, Füsun Mayda; İnce, Birsen; Göksan, Baki; Mısırlı, Cemile Handan; Bakar, Mustafa; Kozak, Hasan Hüseyin; Çolakoğlu, Sena; Karahan, Ali Yavuz; Göksu, Eylem Özaydın; Özdağ, Fatih; Şenol, Mehmet Güney; Yürekli, Vedat Ali; Aluçlu, Ufuk; Demir, Serkan; Küçükoğlu, Hayriye; Oruç, Serdar; Yeşilot, Nilüfer; Küsbeci, Özge Yımaz; Nazliel, Bijen; Tokuç, Firdevs Ezgi Uçan; Bektaş, Hesna; Taşcılar, Fatma Nida; Aytaç, Emrah; Gökçe, Mustafa; Çağlayan, Hale Zeynep Batur; Tüfekci, Ahmet; Uzuner, Gülnur; Örken, Dilek Necioğlu; Yalın, Osman Özgür; Utku, Uygar; Yılmaz, Arda; Genç, Hamit; Çabalar, Murat; Milanlıoğlu, Ayşel; Ekmekci, Hakan; Zeydan, Burcu; Baybas, Sevim; Kablan, Yüksel; Göksel, Başak Karakurum; Açıkgöz, Mustafa; Kurucu, Hatice; Demirci, Seden; Güneş, Taşkın; BAKAR, HACI MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; EKN-8251-2022
Background. Early diagnosis of cerebral venous sinus thrombosis (CVST) associated with reproductive health-related risk factors (RHRF) including pregnancy, puerperium, and oral contraceptive (OC) use can prevent severe neurological sequelae; thus, the symptoms must be documented in detail for each group.Methods. Out of 1144 patients with CVST, a total of 777 women were enrolled from a multicenter for the study of cerebral venous sinus thrombosis (VENOST). Demographic, biochemical, clinical, and radiological aspects were compared for 324 cases with RHRF and 453 cases without RHRF.Results. The mean age of the RHRF (-) group (43.2 +/- 13 years) was significantly higher than of the RHRF (+) group (34 +/- 9years). A previous history of deep venous thrombosis (3%), isolated cavernous sinus involvement (1%), cranial neuropathy (13%), comorbid malignancy (7%), and its disability scores after 12 months (9%) were significantly higher in the RHRF (-) group. The RHRF (+) group consisted of 44% cases of puerperium, 33% cases of OC users and 23% of pregnant women. The mean age was found to be higher in OC users (38 +/- 9years). A previous history of deep venous thrombosis was slightly higher in the pregnancy subgroup (4%). Epileptic seizures were more common in the puerperium group (44%).Conclusion. The results of our study indicate that the risk of CSVT increases parallel to age, OC use, and puerperium period. In addition, when considering the frequency of findings and symptoms, epileptic seizures in the puerperium subgroup of the RHRF (+) group and malignancies in the RHRF (-) group may accompany the CSVT. In daily practice, predicting these risks for the CSVT and early recognition of the symptoms will provide significant benefits to patients.
Course of migraine and TTH over the years - what happens? A longitudinal nationwide study
(Lippincott Williams & Wilkins, 2016-04-05) Karlı, Necdet; Baykan, Betül; Zarifoğlu, Mehmet; Ertaş, Mustafa; Uludüz, Derya; Uygunoğlu, Uğur; Ekizoğlus, Esme; Orhan, Elif; Saip, Sabahattin; Siva, Aksel; ZARİFOĞLU, MEHMET; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; EHN-5825-2022
Headache as the sole presenting symptom of cerebral venous sinuses thrombosis: Subgroup analysis of data from the VENOST study
(Kare Publ, 2021-01-01) Duman, Taşkın; Cinar, Nilgün; Uludüz, Derya; Domaç, Füsun Mayda; Öztürk, Şerefnur; Yayla, Vildan; Karahan, Ali Yavuz; Afşar, Nazire; Sungur, Mehmet Ali; Göksu, Eylem Özaydın; Yürekli, Vedat Ali; Genç, Hamit; Utku, Uygar; Şahin, Şevki; Tekeli, Hakan; Tokuç, Firdevs Ezgi; Uzuner, Nevzat; Şenol, Mehmet Güney; Yılmaz, Arda; Gökçe, Mustafa; Demirci, Seden; Küsbeci, Özge Yılmaz; Uzuner, Gülnur Tekgöl; Çağlayan, Hale Zeynep Batur; Açıkgöz, Mustafa; Kurucu, Hatice; Özdağ, Mehmet Fatih; Baybas, Sevim; Ekmekci, Hakan; Çabalar, Murat; Yaman, Mehmet; Bektaş, Hesna; Kaplan, Yüksel; Göksel, Başak Karakurum; Milanlıoğlu, Aysel; Orken, Dilek Necioğlu; Aluclu, Mehmet Ufuk; Çolakoğlu, Sena; Tüfekci, Ahmet; Bakar, Mustafa; Nazliel, Bijen; Taşcılar, Nida; Göksan, Baki; Kozak, Hasan Hüseyin; Mısırlı, Cemile Handan; Küçükoğlu, Hayriye; Midi, İpek; Mengülluoğlu, Necdet; Aytaç, Emrah; Yeşilot, Nilüfer; İnce, Birsen; Yalın, Osman Özgür; Güneş, Taşkın; Oruç, Serdar; Demir, Serkan; BAKAR, HACI MUSTAFA; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; EKN-8251-2022
Objectives: Headache is the most common complaint in cerebral venous sinus thrombosis (CVST) and it may sometimes be the only symptom in these patients. This retrospective and prospective study was an investigation of any differences in terms of clinical risk factors, radiological findings, or prognosis in patients with CVST who presented with isolated headache (IH) and cases with other concomitant findings (non-isolated headache [NIH]).Methods: A total of 1144 patients from a multicenter study of cerebral venous sinus thrombosis ( VENOST study) were enrolled in this research. The demographic, biochemical, clinical, and radiological aspects of 287 IH cases and 857 NIH cases were compared.Results: There were twice as many women as men in the study group. In the IH group, when gender distribution was evaluated by age group, no statistically significant difference was found. The onset of headache was frequently subacute and chronic in the IH group, but an acute onset was more common in the NIH group. Other neurological findings were observed in 29% of the IH group during follow-up. A previous history of deep, cerebral, or other venous thromboembolism was less common in the IH group than in the NIH group. Transverse sinus involvement was greater in the IH group, whereas sagittal sinus involvement was greater in the NIH group. The presence of a plasminogen activator inhibitor (PAI) mutation was significantly greater in the IH group.Conclusion: IH and CVST should be kept in mind if a patient has subacute or chronic headache. PAI, which has an important role in thrombolytic events, may be a risk factor in CVST. Detailed hematological investigations should be considered. Additional studies are needed.
Migraine incidence in 5 years: A population-based prospective longitudinal study in Turkey
(BMC, 2015-12-01) Baykan, Betül; Ertaş, Mustafa; Uludüz, Derya; Uygunoğlu, Uğur; Ekizoğlu, Esme; Orhan, Elif Kocasoy; Saip, Sabahattin; Siva, Aksel; Karlı, Necdet; Zarifoğlu, Mehmet; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; JDE-9380-2023; EHN-5825-2022; 6506587942; 6603411305
Background: The incidence of migraine has been investigated only in a few studies worldwide and it is not known in our country. We, therefore, aimed to estimate the migraine incidence in a previously accomplished population-based prevalence study sample of 5323 individuals in the year 2008. Methods: The former Turkish headache prevalence study has been completed as a nationwide, randomized, home-based study of face-to-face examination by physicians trained for headache diagnosis by using ICHD criteria. Five years after this study an optimized survey including 50 questions was performed to estimate the migraine incidence in migraine-free individuals in the previous study, with a 56.4 % responder rate. Two validation studies for this survey were performed prior and after the study each in 100 subjects by comparing the gold standard of expert diagnosis of headache, showing high rate of reliability (Crohnbach alpha: 0.911 and 0.706, respectively). Results: Migraine incidence was estimated as 2.38 % (2.98 % in women and 1.93 % in men) per year in 2563 migraine-free individuals; if the population at risk is defined as the group without any headaches, the migraine incidence decreased to 1.99 %. The chronic migraine (CM) incidence [without medication overuse (MOH)] was 0.066 % and that of MOH was 0.259 %. We found a significant burden of the disease on the occupational functionality as well as on social and family life, even in the early years of the migraine. The family history of headaches especially in the fathers could be useful to predict new cases of migraine, besides the well-known risk factor, diagnosis of depression, whereas income and education did not seem to relate to migraine onset. Conclusions: Our study with a large population-based nation-wide sample, using ICHD-II criteria, with structured headache interviews as well as blinded re-validation of the questionnaire diagnoses showed a 2.38 % incidence rate of migraine in Turkey, higher than most of the other previous reports; a finding which could be related to genetic factors and also to the methodological differences in the study designs. Moreover the incidence of CM was found to be 0.066 %.
Potential risk factors for migraine: Data from a population-based incidence study
(Lippincott Williams & Wilkins, 2016-04-05) Baykan, Betül; Ertaş, Mustafa; Ekizoğlu, Esme; Uludüz, Derya; Uygunoğlu, Uğur; Orhan, Elif Kocasoy; Saip, Sabahattin; Siva, Aksel; Karlı, Necdet; Zarifoğlu, Mehmet; Uludağ Üniversitesi/Tıp Fakültesi/Nöroloji Anabilim Dalı.; 0000-0002-7734-6451; JDE-9380-2023; EHN-5825-2022
Reliability and validity of the geriatric depression scale in detection of poststroke minor depression
(Taylor & Francis, 2009) Ertan, Turan; Ertan, Sibel; Cankurtaran, Eylem Şahin; Aki, Özlem Erden; Uludüz, Derya; İnce, Birsen; Sivrioğlu, Enver Yusuf; Sivrioğlu, Konçuy; Kirli, Selçuk; Uludağ Üniversitesi/Tıp Fakültesi/Psikiyatri Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı.; AAG-8211-2021; AAG-8193-2021; 14062563200; 56245687600; 14019745700
Objective: The aim of this study was to assess the validity and reliability of the 30-item Geriatric Depression Scale (GDS) as a screening tool for minor depression in poststroke patients. Method: Literate patients older than 18 years of age, diagnosed to have stroke, were eligible for the study. Standardized Mini Mental Status Examination (S-MMSE) and GDS were applied to all patients. The GDS was readministered 7 days later for retest reliability. Results: A total of 85 participants-49 nondepressed and 36 with minor depression-were eligible for the study. Cronbach's alpha coefficient was .89 in internal consistency analysis. The GDS scores were significantly higher (p < .001) in the depressed participants reflecting a high discriminant validity. The highest sum of sensitivity and specificity values of 1.44 (sensitivity = .69, specificity = .75) and 1.45 (sensitivity = .66, specificity = .79) were obtained for cutoff scores of 10/11 and 11/12, respectively. The area under receiver operating characteristics curve was .82. The test-retest reliability analysis revealed a high Pearson correlation coefficient (r = .75). Conclusion: Our findings suggest that the 30-item GDS has high discriminant validity, internal consistency, and test-retest reliability and reasonably useful cutoff scores; thus it can be used as a screening tool for minor depression in the poststroke population.