Browsing by Author "Ural, Kerem"

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Clinical and histopathological findings in German shepherd dogs with hookworm dermatitis and the usage of eprinomectin in the therapy
(Lithuanian Veterinary Acad, 2012) Ural, Kerem; Özyıldız, Zafer; Yılmaz, Rahşan; Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-0944-2230; ABG-8940-2020; 15057258600
Clinical and histopathological findings in a litter of German Shepherd dogs consisting of seven puppies with acute inflammation confined to the footpads were reported. Affected footpads were characteristically erythematous, swollen and painful. Lesions were present on all four feet in 3/7 cases and on the rear feet in 4/7 cases. None of the dogs had evidence of ectoparasitism. Fecal flotation, deep skin scrapings, bacterial and fungal cultures, and skin biopsies were performed in all dogs. Fecal flotation and histopathological examination revealed Ancylostoma caninum as the cause of pododermatitis. These lesions resolved in response to topical eprinomectin applications, suggesting that clinical signs were linked to hookworm pododermatitis.
D-dimer levels as a procoagulative marker in association with disease progress during giardiasis in dogs
(Univ Cordoba, 2017-12) Haydardedeoğlu, Ali Evren; Ural, Kerem; Ural, Deniz Alıç; Orman, Abdülkadir; Uludağ Üniversitesi/Veteriner Fakültesi/Zooteknik Anabilim Dalı.; 0000-0001-9138-4422; AAG-9134-2021; 24335834100
Objective. The present study was conducted to measure D-dimer concentrations and assess their value in disease activity in dogs with giardiasis. Furthermore another purpose was to analyze correlation between cyst excretion and D-dimer levels to those of dogs naturally infected with Giardia sp. Materials and methods. D-dimer analysis were performed in three groups of dogs; (i) 15 dogs with giardiasis to those of treated with secnidazol, (ii) 10 dogs with giardiasis, left untreated as control group, then were compared to those of (iii) 17dogs without giardiasis, used to detect reference ranges for D-dimer values as control group. was a correlation between D-dimer levels and logarythmic cyst counts. Results. The D-dimer range in healthy dogs was < 0.1 mg/L. In dogs with giardiasis, the D-dimer concentrations were greater than those of healthy dogs (p<0.05) and (p<0.01), respectively. The mean initial plasma D-dimer level was 2.84 +/- 0.50 and 2.99 +/- 0.61 ng/L in treated and untreated control groups. At the final follow-up evaluation on day 10 was 0.27 +/- 0.50 and 2.14 +/- 0.61 ng/L, in treated and untreated control groups, respectively, which was significantly lower in treated group (p<0.001). The area under curve (AUC) of the receiver operating characteristics for d-dimer was 0.922 (z-value = 12.977, p<0.0001). (95% CI: 0.780-0.885). At a cut-off value of 0.1 ng/L, the D-dimer measurement had a sensitivity of 87.2%, a specificity of 90.9%. Conclusions. As a result D-dimer concentrations measured in giardiasis support the probable link between probable pro-thrombotic and inflammatory condition.
Köpeklerde xylazine uygulamasına bağlı gelişen bulantı ve kusmanın önlenmesinde antihistaminik kullanımı
(Uludağ Üniversitesi, 2006-04-04) Börkü, M. Kazım; Özkanlar, Yunusemre; Hanedan, Başak; Ural, Kerem
Bir α2 adrenoreseptör agonisti olan xylazine uygulamasına bağlı olarak köpeklerde bradikardi, hipotansiyon, hipopnea, bulantı ve kusma gibi yan etkiler görülebilmektedir. Bu çalışma xylazine hydrochloride’e bağlı oluşan bulantı ve kusmanın önlenmesinde bir H1 reseptör antagonisti olan mepyramine maleate’ın etkinliğinin araştırılması amacıyla yapıldı. Çalışmada 30 köpek kullanıldı ve köpekler 10’arlı 3 gruba ayrıldı. Çalışmada antihistaminik uygulamasının yapıldığı an 0. dakika kabul edilerek, birinci guruptakilere 1 mg/kg, ikinci gruptakilere 2 mg/kg dozda intramuskuler (i.m.) mepyramine ve üçüncü gruptakilere ise eşit miktarda i.m. serum fizyolojik enjeksiyonu yapıldı. Bütün köpeklere bu enjeksiyonlardan 20 dakika sonra 2,2 mg/kg dozda i.m. xylazine enjekte edildi. Xylazine enjeksiyonundan sonra birinci ve ikinci gruptakilerden birer köpek kusarken üçüncü gruptakilerden sekiz köpek kustu. Üçüncü gruptakilerden dokuzunda bulantı gözlenirken, birinci grupta 2 ve ikinci grupta 3 köpekte bulantı saptandı. Birinci ve ikinci gruplarda mepyramine uygulamasından sonraki 40., 60. ve 80. dakikalarda (xylazine uygulamasından sonraki 20., 40. ve 60. dakikalar) pulzasyon ve respirasyon önemli (P<0,001) oranda düşerken, beden ısılarındaki düşüşün istatistiksel önemi yoktu. Sonuç olarak, köpeklerde mepyramine’in xylazine’e bağlı bulantı ve kusmanın önlenmesinde etkili olduğu, diğer parametrelerde istatistik önemi bulunan bir değişikliğin olmadığı belirlendi.