Browsing by Author "Uysal, Akın"
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Item Short and long term effects of granulocyte colony-stimulating factor during induction therapy in acute myeloid leukemia patients younger than 65: Results of a randomized multicenter phase III trial(Pergamon-Elsevier Science, 2011-03) Beksaç, Meral; Özcan, Muhit; Özçebe, Osman; Bayık, Mahmut; Paydaş, Semra; Büyükaşık, Yahya; İlhan, Osman; Gürman, Günhan; Uysal, Akın; Akan, Hamdi; Soydan, Ender Akcağlayan; Ali, Ridvan; Özçelik, Tülay; Özkalemkaş, Fahir; Tunalı, Ahmet; Uludağ Üniversitesi/Tıp Fakültesi/Hematoloji Anabilim Dalı.; AAG-8495-2021; 7201813027; 7005424333; 6601912387This prospective multicenter phase III clinical trial was designed to assess efficacy and safety of G-CSF as an adjunct to de novo AML remission induction therapy (www.clinicaltrials.gov.NCT00820976). Patients' characteristics were similar in both arms. G-CSF improved severity and duration of leukopenia. Three-year OS were similar (25.6 +/- 5.1% vs. 31.8 +/- 5.6%) in both arms except for patients with myeloblastic features. Significant factors for better survival were the use of G-CSF (p = 0.049), female sex (p = 0.05) and single induction cycle (p < 0.001) in multivariate analysis. Female patients performed better than male patients. Better survival obtained among female AML patients needs to be validated within the context of cytogenetic analysis.