Browsing by Author "VURUŞKAN, HAKAN"

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Angiomyofibroblastoma-like tumor of the scrotum: A case report and review of literature
(De Gruyter Poland Sp Zoo, 2012-01-01) AYTAÇ VURUŞKAN, BERNA; YALÇINKAYA, ÜLVİYE; Yalçinkaya, Ulviye; Vuruşkan, Hakan; VURUŞKAN, HAKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; AAH-8924-2021; AAH-9746-2021
Angiomyofibroblastoma-like tumor is a rare mesenchymal tumor of men. It commonly occurs during the fifth to eighth decades of life and mainly involves the inguinoscrotal region. It is derived from perivascular stem cells and has capacity of lipoid and myofibroblastic differentiation. Histopathologically this tumor in the male genitalia mimics female angiomyofibroblastoma but there are morphological and immunohistochemical differences between these lesions. We report a case of an angiomyofibroblastoma- like tumor that arose in the scrotal region in a 40-year-old man.
Challenging risk factors for right and left laparoscopic adrenalectomy: A single centre experience with 272 cases
(Brazilian Soc Urol, 2019-07-01) Kordan, Yakup; Günseren, Kadir Ömür; GÜNSEREN, KADİR ÖMÜR; Çiçek, Mehmet Cağatay; ÇİÇEK, MEHMET ÇAĞATAY; Vuruşkan, Hakan; VURUŞKAN, HAKAN; Yavaşçaoğlu, İsmet; YAVAŞCAOĞLU, İSMET; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0001-8673-3093; 0000-0002-0471-5404; 0000-0002-9947-848X; ABC-9924-2020
Purpose: This study aimed to compare perioperative and postoperative results of right and left laparoscopic adrenalectomy (LA), and to evaluate the impact of challenging factors on these outcomes.Materials and Methods: A total of 272 patient's medical records that underwent single side LA between October 2006 and September 2017 were retrospectively reviewed. The patients were divided into 2 groups according to operation side. Moreover, pheochromocytoma, metastatic masses and adrenal lesions >5cm in size were considered to be difficult adrenalectomy cases and the outcomes of these cases were compared between two groups.Results: 135 patients (49.6%) underwent right LA and 137 patients (50.4%) underwent left LA. Operation time, estimated blood loss (EBL) and hospitalization time were similar between the groups (p=0.415, p=0.242, p=0.741, respectively). Although EBL was higher on the right side than the left (p=0.038) in the first 20 cases, after this learning period has been completed, there was no significant difference between the groups. In patients with pheochromocytoma, metastatic mass and a mass >5cm in size, despite bleeding complications were clinically higher on the right side, this difference was not statistically significant.Conclusions: During the learning period of LA, EBL is higher on the right side. Due to the greater risk of bleeding complications on the right side even on the hands of experienced surgeons, extra care and preoperative planning are required in patients with pheochromocytoma, metastatic masses and masses >5cm in size.
Characteristics of deceased donors used for kidney transplantation: Single-center experience
(Frontiers Media Sa, 2019-10-01) Ersoy, Alparslan; Elgin, Ersin; Akgür, Suat; Yıldız, Abdülmecit; Kaygısız, Onur; Oflaz, Rafet; Selimoğlu, Kerem; Oruç, Ayşegül; Ünsal, Oktay; Coşkun, Burhan; Aydın, Mehmet Fethullah; Keskin, Sahriye; Kordan, Yakup; Vuruşkan, Hakan; ERSOY, ALPARSLAN; Elgin, Ersin; AKGÜR, SUAT; YILDIZ, ABDULMECİT; KAYGISIZ, ONUR; Oflaz, Rafet; Selimoğlu, Kerem; ORUÇ, AYŞEGÜL; Ünsal, Oktay; COŞKUN, BURHAN; Aydın, Mehmet Fethullah; Keskin, Sahriye; Kordan, Yakup; VURUŞKAN, HAKAN; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Nefroloji Bilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Organ ve Doku Nakli Merkezi.; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0002-9790-7295 ; 0000-0002-0710-0923 ; 0000-0002-0342-9692; 0000-0002-5665-7402; AAH-5054-2021; DXA-2790-2022; EJA-1761-2022; HIG-9032-2022; AAM-9726-2020; DJU-5362-2022; CDS-3299-2022; AAH-4002-2021; JJY-8484-2023; AAH-9704-2021; AAJ-8220-2020; CZH-6714-2022; GAF-0095-2022; EFH-9523-2022
Clinical course of angiomyolipom in our cases
(Aves, 2006-03-01) VURUŞKAN, HAKAN; Çalışkan, Zülküf; Vuruşkan, Hakan; Kordan, Yakup; Sökmen, Ali; Yavaşcaoğlu, İsmet; YAVAŞCAOĞLU, İSMET; Oktay, Bülent; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0002-9947-848X
Introduction: The aim of the study is to determine the factors that affect the clinical course of angiomyolipomas (AML)Materials and Methods: Between January 1992 and November 2003, 24 patients were diagnosed clinically and radiologically to have angiomyolipoma. They were followed prospectively for a mean of 4.6 years (range: 2-11 years). Patients were divided into 3 groups; Group 1: Patients with a solitary lesion, Group2: Patients with multiple lesions associated with tuberous sclerosis and Group 3: Patients with multiple lesions having no tuberous sclerosis. According to the size of the lesion (lesions <4 cm and lesions >4cm) patients were also subdivided into 2 groups. The lesions were followed regularly every 6 month with ultrasonography. These 3 groups were compared in terms of symptoms, size and the percentage of the growth of the lesion.Results: The median age of the patients was 43 (31-59). 13 patients in group 1, 1 patient in group 2 and 4 patients in group 3 had lesions <4 cm and 1 patient in group 1, 2 patients in group 2 and 3 patients in group 3 had lesions >4 cm. In 3 patients from group 2 and 2 patients from group 3 the lesions were bilateral. 7 cases out of 24 (29.1%) were diagnosed incidentally. Patients were found to have 8 different symptoms which were observed 37 times among all patients. The most common symptom, abdominal and flank pain, was observed in 54.1 % (13 patients) of patients. In patients with lesions <4 cm the prevalence of these symptoms were 16.2% (6), 2.7% (1), 5.4% (2) and in patients with lesions >4 cm were 8.1% (3), 37.8% ( 14), 29.7% (11) in group1, 2 and 3 respectively. Considering the growth of the lesions; in group 1with lesions <4 cm only 1 patient out of 13 showed 0.6 cm (18.1%) growth during follow-up. Similarly 1 patient of group1 with lesion >4 cm showed no increase in size of the lesion. In group 2 all patients showed an increase in size of the lesions, which was 1 cm (33.3%) in the group with the lesion <4 cm (1 patient) and 4.6 +/- 3.4 cm (41.8%) in the group with the lesion >4 cm (2 patients). Among group 3 patients with the lesions <4 cm, 3 of 4 showed a mean increase in the diameter of previous lesion of 0.9 +/- 4.2 cm (28.1%), while in 1 patient the lesion remained unchanged. Similarly in group 3 patients with the lesions >4 cm, 2 out of 3 showed a mean increase of 1.8 +/- 5.3 cm (33.3%), while 1 remained unchanged.Conclusion: In AML patients the most important factors which determine the lesion to grow and be symptomatic are the size, the number (multiplicity) of the lesions and the presence of tuberous sclerosis.
Comparison of ureteroscopic laser lithotripsy with laparoscopic ureterolithotomy for large proximal and mid-ureter stones
(Karger, 2015-01-01) Kaygısız, Onur; Coşkun, Burhan; Kılıçarslan, Hakan; Kordan, Yakup; Vuruşkan, Hakan; Özmerdiven, Gökhun; Yavacaoğlu, İsmet; KAYGISIZ, ONUR; COŞKUN, BURHAN; KILIÇARSLAN, HAKAN; Kordan, Yakup; VURUŞKAN, HAKAN; Özmerdiven, Gökhun; Yavacaoğlu, İsmet; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Bölümü; 0000-0002-9790-7295; 0000-0002-8242-9921; 0000-0002-9947-848X; AAH-9704-2021; L-9439-2019; JCO-5169-2023; AAM-9726-2020; JIT-9412-2023; GAF-0095-2022; EFH-9523-2022; JIF-9579-2023; EIN-0828-2022
Objectives: To compare the effectiveness and complications of ureteroscopic laser lithotripsy with laparoscopic ureter laparoscopic ureterolithotomy in mid- or proximal portion of large ureteral stones. Material and Methods: We reviewed patients with large (>15 mm) ureteral stone and those who underwent ureteroscopic laser lithotripsy CURS group) or laparoscopic ureterolithotomy (LU group). The first attempt was considered successful in patients who had residual fragments smaller than 2 mm and no conversion of the primary procedure to another. Results: Sixty patients (URS group 29, LU group 31) met inclusion criteria. FURS was used as an adjunctive procedure in one patient for URS group and in two patients for LU group in the same season. LU had a higher success rate and the first-day stone-free rate when compared with URS. Number of procedures was also significantly higher in URS group. There was no difference in stone-free rates at the first and third months, and length of hospitalization and operation were higher in the LU group. Only two patients in the LU group and one patient in the URS group had major complications. Conclusions: Laparoscopy is an effective option of large proximal and mid-ureter stone treatment; however, URS provides similar stone-free rates at three months as a minimal invasive procedure.
Detection of vesico-ureteric reflux in renal transplant recipients by colour doppler urosonograpy
(Aves, 2005-09-01) Vuruskan, Hakan; VURUŞKAN, HAKAN; Çift, Ali; Oktay, Bülent; Bolca, Naile; BOLCA TOPAL, NAİLE; Kordan, Yakup; Yavasçaoğlu, İsmet; YAVAŞCAOĞLU, İSMET; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.; 0000-0002-9947-848X; AAH-7103-2019
Introduction: In this study, we evaluated the vesico-ureteric reflux (VUR) in renal transplant recipients by using color Doppler urosonography (CDU).Materials and Methods: Among 149 renal transplant recipients, 42 (27 men, 15 women) who accepted to take part were included to the study. The mean age and duration of post-transplant follow-up of the patients were 35.1+/-1.39 years (15-55) and 63.6+/-7.2 months (7-170), respectively. In all patients, ureterovesical anastomosis and antireflux submucosal tunnel were performed with Lich-Gregoir technique without using ureteral stent. Urinary system was assessed in all patients with CDU without any contrast enhancing agent by the same radiologist. During CDU, patients were asked to make Valsalva maneuver when their bladders were full with urine and were evaluated for reflux. The patients' ureteric jets were first investigated in transverse and then in longitudinal plane by observing distal ureteric segment and ureteral orifice. The flows coming towards the transducer were coded red in color while those moving away from the transducer were coded blue in color. During observation of the distal ureteric segment; detection of red color was regarded as reflux. The patients, in whom reflux was detected by CDU, were reassessed by voiding cystouretrography (VCUG).Results: Among 42 patients who underwent CDU, 7 patients (16.7%) were diagnosed to have VUR. In all patients, the diagnosis of CDU detected VUR was confirmed by VCUG. In 4 patients (57.2%) low grade and in 3 patients (42.9%) intermediate grade reflux was found by using CDU. None of the patients had high grade reflux. In 3 patients (42.9%) grade 2, in 3 patients (42.9%) grade 3, in 1 patient (14.2%) grade 4 reflux were observed during evaluation of these patients by VCUG. Since VCUG is an invasive procedure and the patients who were determined not to have VUR by CDU had no urinary tract infection history in the follow-up they did not undergo VCUG.Conclusion: CDU is a non-invasive and effective method for the diagnosis and follow-up of VUR in renal transplant recipients.
Diode laser in the treatment of benign prostatic enlargement: A preliminary study
(Aves, 2011-03-01) Oktay, Bülent; Kılıçarslan, Hakan; Doğan, Hasan Serkan; Kordan, Yakup; Yavaşcaoğlu, İsmet; Vuruşkan, Hakan; Oktay, Bülent; KILIÇARSLAN, HAKAN; Doğan, Hasan Serkan; Kordan, Yakup; YAVAŞCAOĞLU, İSMET; VURUŞKAN, HAKAN; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0002-9947-848X; ABH-5513-2020; DKK-2716-2022; JIT-9412-2023; GAF-0095-2022; EIN-0828-2022; EFH-9523-2022
Objective: To evaluate the efficacy of a novel treatment diode laser, in treatment of benign prostatic enlargement.Materials and methods: We evaluated the surgical and functional outcomes of 85 patients who underwent diode laser treatment for benign prostatic enlargement between September 2007 and April 2009. Preoperative and postoperative the International Prostate Symptom Score (IPSS), the International Index of Erectile Function (IIEF), maximum flow rate, postvoiding residual urine, and prostate volumes were analyzed.Results: All the patients were considered clinically as having benign prostatic enlargement. Mean age was 70.8 +/- 8.6 years and follow-up period was 12.6 +/- 6 months. In all patients, the power used was 120 W, the mean applied energy was 190 +/- 70 kJ and the total laser time was 21.9 +/- 7.2 min. Improvement in functional outcomes began in the third postoperative month and was sustained through 12 months postoperatively. Compared to preoperative data, at postoperative 12 months, we detected a significant decrease in prostate volumes (55.5 +/- 27.6 mL vs. 42.8 +/- 21.7 mL), IPSS (21.6 +/- 4.75 vs. 4.6 +/- 3.3) and residual urine volume (89.5 +/- 85.6 mL vs. 30.4 +/- 22.4 mL), and a significant increase in maximum flow rates (18.7 +/- 6.9 mL/sec vs. 9.6 +/- 5.6 mL/sec). No difference was detected in IIEF scores (36.8 +/- 21.2 vs. 37.8 +/- 23.7). Re-treatment was required in 5.8% of patients, and retrograde ejaculation was reported in 17% of patients.Conclusion: The early results of diode laser treatment for benign prostatic enlargement were equivalent to other endoscopic and minimally invasive treatments.
Effect of operation timeline on frequency of surgical complication in deceased donor kidney transplantation
(Frontiers Media SA, 2019-10-01) Ersoy, Alparslan; Düger, Hakan; Dizdar, Oğuzhan Sıtkı; Yıldız, Abdülmecit; Akgür, Suat; Kaygısız, Onur; Oruç, Ayşegul; Ünsal, Oktay; Coşkun, Burhan; Kordan, Yakup; Türker, Gürkan; Vuruşkan, Hakan; ERSOY, ALPARSLAN; Düger, Hakan; Dizdar, Oğuzhan Sıtkı; YILDIZ, ABDULMECİT; AKGÜR, SUAT; KAYGISIZ, ONUR; ORUÇ, AYŞEGÜL; Ünsal, Oktay; COŞKUN, BURHAN; Kordan, Yakup; TÜRKER, YUNUS GÜRKAN; VURUŞKAN, HAKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı/Nefroloji Bilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Anestezi ve Reanimasyon Anabilim Dalı.; 0000-0001-5478-3192; 0000-0002-9790-7295; 0000-0002-0342-9692; 0000-0002-8242-9921; 0000-0002-9947-848X; 0000-0002-3019-581X; AAM-9726-2020; AAH-5054-2021; AAI-6642-2021; AAH-4002-2021; IZP-9361-2023; AAH-9704-2021; BBE-2157-2022; HIG-9032-2022; EJA-1761-2022; JJY-8484-2023; AAH-9704-2021; GAF-0095-2022; EFH-9523-2022
Emphysematous pyelonephritis: Case report
(Aves, 2005-09-01) VURUŞKAN, HAKAN; Vuruşkan, Hakan; Çalışkan, Zülküf; Çift, Ali; Kordan, Yakup; Yavaşçaoğlu, İsmet; YAVAŞCAOĞLU, İSMET; Oktay, Bülent; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0002-9947-848X; AAH-7103-2019
Introduction: Emphysematous pyelonephritis (EP) is a lethal infection which is rarely seen and is characterized by gas in intrarenal or perirenal region. The traditional treatment of EP is open surgical flowing and parenteral antibiotherapy or nephrectomy. In this study a 74 years old male patient with EP treated with percutaneous drainage catheter and comprehensive antibiotherapy because of no clinical response to antibiotherapy is presented.
Evaluation of 1 year old graft status of right and left kidneys from the same donor used between 2007 and 2017: Single center experience.
(Lippincott Williams & Wilkins, 2019-11-01) Elgin, Ersin; Yıldız, Abdülmecid; Oruç, Ayşegül; Akgür, Suat; Ünsal, Oktay; Keskin, Sahriye; Selimoğlu, Kerem; Oflaz, Rafet; Karan, Elif; Arslan, İlknur; Çiçek, Mehmet Çağatay; Günseren, Kadir Ömür; Vuruşkan, Hakan; Ersoy, Alparslan; Elgin, Ersin; Yıldız, Abdülmecid; ORUÇ, AYŞEGÜL; AKGÜR, SUAT; Ünsal, Oktay; Keskin, Sahriye; Selimoğlu, Kerem; Oflaz, Rafet; Karan, Elif; Arslan, İlknur; ÇİÇEK, MEHMET ÇAĞATAY; GÜNSEREN, KADİR ÖMÜR; VURUŞKAN, HAKAN; ERSOY, ALPARSLAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Organ Nakli Merkezi.; 0000-0002-9509-5799; 0000-0002-0342-9692; 0000-0003-3635-7282; 0000-0002-3454-8483; 0000-0002-0471-5404; AAH-4002-2021; AAH-5054-2021; DXA-2790-2022; EIF-8983-2022; EJA-1761-2022; JJY-8484-2023; CZH-6714-2022; CDS-3299-2022; DJU-5362-2022; FDB-4488-2022; CCH-8947-2022; HGM-5995-2022; JKA-8956-2023; EFH-9523-2022
Factors influencing lymphocel development after kidney transplantation: Single center experience
(Oxford University Press, 2015-05-01) Sayılar, Emel Işıktaş; Ersoy, Alparslan; Ayar, Yavuz; Aydın, Mehmet Fethullah; Şahin, Ahmet Bilgehan; Coşkun, Burhan; Kaygısız, Onur; Yıldız, Abdulmecit; Kordan, Yakup; Vuruşkan, Hakan; SAYILAR, EMEL IŞIKTAŞ; ERSOY, ALPARSLAN; AYAR, YAVUZ; AYDIN, MEHMET FETHULLAH; ŞAHİN, AHMET BİLGEHAN; COŞKUN, BURHAN; KAYGISIZ, ONUR; YILDIZ, ABDULMECİT; KORDAN, YAKUP; VURUŞKAN, HAKAN; 0000-0003-4607-9220; 0000-0002-5665-7402; 0000-0002-7846-0870; 0000-0002-8242-9921; 0000-0002-9790-7295; 0000-0002-9947-848X; 0000-0002-0710-0923; AAH-5054-2021; O-9948-2015; L-9439-2019; JCO-5169-2023; AAH-9704-2021; AGF-0767-2022; AAJ-8220-2020; AAM-4927-2020; GSE-0029-2022; W-2575-2017; AAM-9726-2020; HIG-9032-2022; GAF-0095-2022; EFH-9523-2022
Factors influencing lymphocele development after kidney transplant: Single center experience
(Başkent Üniversitesi, 2023-03-01) Sayılar, Emel Işıktaş; Ersoy, Alparslan; Ayar, Yavuz; Aydın, Mehmet Fethullah; Şahin, Ahmet Bilgehan; Coşkun, Burhan; Kaygısız, Onur; Yıldız, Abdülmecit; Kordan, Yakup; Vuruşkan, Hakan; Sayılar, Emel Işıktaş; ERSOY, ALPARSLAN; Ayar, Yavuz; Aydın, Mehmet Fethullah; ŞAHİN, AHMET BİLGEHAN; COŞKUN, BURHAN; KAYGISIZ, ONUR; YILDIZ, ABDULMECİT; Kordan, Yakup; VURUŞKAN, HAKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0003-4607-9220; 0000-0002-5665-7402; 0000-0002-7846-0870; 0000-0002-8242-9921; 0000-0002-9790-7295; 0000-0002-9947-848X; AAJ-8220-2020; O-9948-2015; AAH-9704-2021; L-9439-2019; JCO-5169-2023; AAM-4927-2020; HYA-4372-2023; CPX-5894-2022; HIG-9032-2022; GAF-0095-2022; EFH-9523-2022
Objectives: Lymphocele is a well-known postoperative surgical complication after kidney transplant. In this study, our aim was to analyze incidence, risk factors, and outcomes of posttransplant lymphocele in a large cohort.Materials and Methods: This observational study included 395 consecutive patients (219 males and 176 females) who underwent kidney transplant procedures from 183 living and 212 deceased donors in our center between January 2007 and 2014. A lymphocele was diagnosed with ultrasonography.Results: The incidence of lymphoceles in our cohort was 31.9% (n = 126). There were no significant differences with regard to body mass indexes, age of donors, deceased donor ratios, acute rejection episodes, and history of abdominal surgery between those with and without lymphoceles. The pretransplant serum albumin levels (3.29 +/- 0.67 vs 3.48 +/- 0.69 g/dL; P = .009) in the lymphocele group and diabetes mellitus ratios (15.9% vs 4.5%; P < .001) in the nonlymphocele group were lower than levels shown in the other group. The lymphocele ratio in patients who received cyclosporine was higher than that shown in patients who did not received it (37.5% vs. 27.4%; P = .032). There was no difference in lymphocele incidence between patients who were taking and those who were not taking mammalian target of rapamycin inhibitors, mycophenolate mofetil, or mycophenolate sodium. In regression analysis, presence of diabetes mellitus, transplant from deceased donors, older age of donors, and lower albumin levels were independent risk factors for posttransplant lymphocele occurrence.Conclusions: Posttransplant lymphocele was a relatively common surgical complication in our cohort. We concluded that diabetes mellitus, use of kidneys from deceased donors, older donor age, and hypoalbuminemia were independent risk factors for lymphocele development.
Investigation of the tissue allele distribution of the deceased kidney donors between 2007 and 2017.
(Lippincott Williams & Wilkins, 2019-11-01) Oflaz, Rafet; Elgin, Ersin; Yıldız, Abdülmecid; Oruç, Ayşegül; Akgür, Suat; Ünsal, Oktay; Karaca, Mert; Ersoy, Sahriye; Selimoğlu, Kerem; Arslan, İlknur; Karan, Elif; Çiçek, Mehmet Çağatay; Günseren, Kadir Ömür; Güllülü, Sümmeyye; Vuruşkan, Hakan; Oflaz, Rafet; Elgin, Ersin; Yıldız, Abdülmecid; ORUÇ, AYŞEGÜL; AKGÜR, SUAT; Ünsal, Oktay; KARACA, MERT; Ersoy, Sahriye; Selimoğlu, Kerem; Arslan, İlknur; Karan, Elif; ÇİÇEK, MEHMET ÇAĞATAY; GÜNSEREN, KADİR ÖMÜR; GÜLLÜLÜ, NAZMİYE SÜMEYYE; VURUŞKAN, HAKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Organ Nakli Merkezi.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/İmmünoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; 0000-0002-9509-5799; 0000-0002-0342-9692; 0000-0003-3635-7282; 0000-0002-3454-8483; 0000-0002-0471-5404; 0000-0001-6711-676X; AAG-7406-2021; AAH-4002-2021; DJU-5362-2022; DXA-2790-2022; EIF-8983-2022; JIX-1144-2023; JJY-8484-2023; AAG-7406-2021; EVS-9805-2022; CDS-3299-2022; CCH-8947-2022; FDB-4488-2022; HGM-5995-2022; EFH-9523-2022; CST-9838-2022; ITO-9188-2023
Investigation of VHL gene associated with miR-223 in clear cell renal cell carcinoma
(Springer, 2021-11-26) Ünal, Ufuk; Çeçener, Gülşah; Ünlü, Havva Tezcan; Vuruşkan, Berna Aytaç; Erdem, Ecem Efendi; Egeli, Ünal; Nazlıoğlu, Hülya Öztürk; Kaygısız, Onur; Tunca, Berrin; Vuruşkan, Hakan; Ünal, Ufuk; ÇEÇENER, GÜLŞAH; Ünlü, Havva Tezcan; AYTAÇ VURUŞKAN, BERNA; Erdem, Ecem Efendi; EGELİ, ÜNAL; ÖZTÜRK NAZLIOĞLU, HÜLYA; KAYGISIZ, ONUR; TUNCA, BERRİN; VURUŞKAN, HAKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0003-4913-3616; 0000-0002-3820-424X; 0000-0002-0910-4258; 0000-0001-7904-883X; 0000-0002-9790-7295; 0000-0002-1619-6680; AAH-1420-2021; L-9439-2019; GYU-0252-2022; ABC-1357-2020; AAP-9988-2020; GYU-0252-2022; EEJ-1452-2022; ESY-2704-2022; FLN-9596-2022; ABI-6078-2020; EFH-9523-2022
Background Clear cell type renal cell carcinoma (ccRCC) is the most common renal cell carcinoma (RCC). In this study, we examined the expressions of VHL and miR-223 in ccRCC patients' tissues to investigate the possible role in the development of ccRCC.Methods and results This study collected five expression profiles (GSE36139, GSE3, GSE73731, GSE40435, and GSE26032) from Gene Omnibus Data. Expressions of VHL and miR-223 in paraffinized tumor and normal tissues of 100 Turkish patients' ccRCC tissues were determined by bioinformatic data mining and real-time quantitative polymerase chain reaction (qRT-PCR). The VHL gene was subjected to mutational analysis by DNA sequencing, and pVHL was analyzed using western blotting. Our study's t-test and Pearson correlation analysis showed that VHL gene expression in tumoral tissues with a - 0.39-fold decrease was not significantly lower than normal tissues (p = 0.441), and a 0.97-fold increase miR-223 (p = 0.045) was determined by real-time PCR. Also, as a result of DNA sequence analysis performed in the VHL gene, it was found that 26% of the patients have mutations. The mutations for (VHL):c.60C>A (p.Val20=) and (VHL):c.467delA (p.Tyr156Leu) was detected for the first time in Turkish patients.Conclusions The present study demonstrated that the differences in the expression levels of miR-223 have the potential to be biomarkers to determine the poor prognosis in ccRCC.
Is laparoscopic adrenalectomy for pheochromocytoma safe and effective in geriatric patients?
(Wiley, 2021-06-12) Günseren, Kadir Ömur; Çiçek, Mehmet Çağatay; Bolat, Deniz; Yeni, Sezgin; Vuruşkan, Hakan; Gül, Özen Öz; Yavaşcaoğlu, İsmet; GÜNSEREN, KADİR ÖMÜR; ÇİÇEK, MEHMET ÇAĞATAY; VURUŞKAN, HAKAN; ÖZ GÜL, ÖZEN; YAVAŞCAOĞLU, İSMET; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Anabilim Dalı.; 0000-0001-8673-3093; 0000-0002-0471-5404; 0000-0002-1332-4165; ABC-9924-2020; HGM-5995-2022 ; GFT-1275-2022; EFH-9523-2022; GBT-4320-2022; EIN-0828-2022
Objectives The study aimed to assess the haemodynamic changes of laparoscopic adrenalectomy (LA) in geriatric patients with pheochromocytoma (PHEO). To the best of our knowledge, this is the first study to evaluate the haemodynamic outcomes of LA in this patient population.Methods Data of 350 patients who underwent single-side transperitoneal LA between 2000 and 2020 were reviewed retrospectively. Patients with a histopathological diagnosis of PHEO were included in the study and classified into two groups according to their ages at the date of surgery. Patients older than 65 years were accepted as elderly according to the World Health Organisation (WHO) recommendations.Results A total of 54 patients underwent LA for PHEO. Fifteen patients were enrolled in the elderly and 39 in the young groups. There were no significant differences in terms of the operation site (0.564), tumour size (0.878), perioperative results such as mean anaesthesia; operation times, blood loss and haemodynamic changes. There were no significant differences in mean hospitalisation and intensive care unit times. One patient in both groups had grade 1 complication according to Clavien Dindo classification (prolonged ileus, managed with medical treatment and transfusion during surgery, respectively).Conclusion Young and elderly patients had similar outcomes in terms of haemodynamic changes that occurred with LA. LA in elderly patients with PHEO is as safe and effective as in younger patients.
Laparoscopic extraperitoneal radical prostatectomy: Our first experiences
(Aves, 2005-09-01) Oktay, Bülent; Vuruskan, Hakan; VURUŞKAN, HAKAN; Yavasçaoğlu, İsmet; YAVAŞCAOĞLU, İSMET; Kordan, Yakup; Çalışkan, Zülküf; Öztürk, Murat; ÖZTÜRK, MURAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0002-9947-848X; 0000-0002-0668-8075
Introduction: Laparoscopic radical prostatectomy is a relatively new and contemporary approach in the surgical management of localized prostate cancer. We report our preliminary results after 6 procedures.Materials and Methods: We performed laparoscopic extraperitoneal radical prostatectomy (LERP) in 6 patients between January and June in 2004. Clinical stage, serum PSA, Gleason score, operating time, surgical and medical complications, estimated blood loss, transfusion rate, hospital stay and catheterization times were recorded. The pathologic stage (1997 TNM classification), status of surgical margins and continence were noted.Results: There was no conversion and reintervention. The mean operation time was 320 minutes. The mean blood loss was 178.3 ml. The mean hospital stay was 4.5 days. There were no major complications. Subileus occurred in one patient and resolved spontaneously. The mean catheterization time was 13.3 days. 2 of 6 patients had positive surgical margins at the urethra. 4 of 6 patients were continent after a median followup period of 3 months.Conclusion: LERP as a minimally invasive procedure seems to offer the same early oncological and surgical results as conventional open radical prostatectomy. Long and gradual learning curve of this procedure is its main disadvantage.
Laparoscopic radical cystectomy: Uludag University experience
(Aves, 2009-09-01) Yavaşcaoğlu, İsmet; Gökcen, Kaan; Doğan, Hasan Serkan; Kordan, Yakup; Aytaç, Berna; Vuruşkan, Hakan; Oktay, Bülent; YAVAŞCAOĞLU, İSMET; Gökcen, Kaan; Doğan, Hasan Serkan; Kordan, Yakup; AYTAÇ VURUŞKAN, BERNA; VURUŞKAN, HAKAN; Oktay, Bülent; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-9947-848X; ABH-5513-2020; AAH-9746-2021; EIN-0828-2022; JMX-6994-2023; GAF-0095-2022; EFH-9523-2022; DKK-2716-2022
Objective: To present the experience of our clinic on laparoscopic radical cystectomy (LRC).Materials and methods: Twenty-three patients who underwent laparoscopic radical cystectomy, lymphadenectomy and urinary diversion between May 2006 and April 2009 were included. Twenty-two patients were male and one was female. Mean age of patients was 61.5 (40-75) years.Results: Mean total operative time was 388 (270-510) minutes, whereas mean time for laparoscopic cystectomy and lymph node dissection was 225 (180-310) minutes. Simultaneous nephroureterectomy was performed in two patients. Ileal conduit was performed in 20 patients as urinary diversion and orthotopic neobladder was constructed in 3. Mean blood loss was 130 mL (40-300) and intraoperative blood transfusion was not necessary in any of the patients. Mean postoperative hospitalization was 11.1 (7-24) days. No intraoperative complication was experienced and conversion to open surgery has never happened. Superficial wound infection and dehiscence have happened in 2 patients and prolonged ileus was encountered in 1 patient. Histological examination revealed organ confined (pT0/pT1/pT2/pT3a) disease in 21 (91.3%), extravesical (pT3b/pT4) disease in 2 (8.7%), and lymph node involvement in 4 (17%) patients. Four patients with lymph node involvement, 1 patient with squamous cell cancer, and 1 patient with neuroendocrin carcinoma received adjuvant chemotherapy. Within a mean time period of 13.1 (1-26) months, 95.6% (22/23) of patients, including patients who were given adjuvant chemotherapy, were alive. No port site metastasis has been reported during the follow-up period.Conclusion: Our clinical experience confirms that LRS can be performed safely without compromising the oncological principles.
Multicystic dysplastic kidney: Four-year evaluation
(Türk Patoloji Derneği, 2011-01-01) Aytaç, Berna; Şehitoğlu, İbrahim; Vuruşkan, Hakan; AYTAÇ VURUŞKAN, BERNA; Şehitoğlu, İbrahim; VURUŞKAN, HAKAN; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı; AAH-9746-2021; ABF-8955-2021; EFH-9523-2022
Objective: Multicystic dysplastic kidney is a relatively common developmental abnormality in infants and children. Additional abnormalities like vesicoureteral reflux, ureteropelvic junction obstruction, and ureterovesical junction obstruction may accompany multicystic dysplastic kidney. In this article, we reviewed the pathogenesis, diagnosis, associated urinary tract anomalies and results of management of multicystic dysplastic kidney in the light of the literature.Material and Method: We retrospectively assessed 20 children with unilateral multicystic dysplastic kidney between January 2005 and December 2009. Mean duration of follow-up was 35 +/- 8.7 months. All children with multicystic dysplastic kidney underwent nephrectomy. Patient characteristics, the pathology findings, associated urinary tract anomalies and results of management were reviewed.Results: Abdominal ultrasound, voiding cystourethrography and renal scintigraphy revealed vesicoureteral reflux in 3 (15%) children, ureteropelvic junction obstruction in 3 (15%) children, and a duplex system in the contralateral kidney in 1 (5%) child. Blood pressure values, serum urea, creatinine and urinalysis were within normal range in all children during follow-up.Conclusion: A conservative approach to children with multicystic dysplastic kidney has been advocated, but surgical removal is also another management modality on the basis of risk of hypertension, mass effect, potential for malignant change, and cost of repeated ultrasound examination.
Myxoid liposarcoma of the spermatic cord: A case report
(Aves, 2007-12-01) Kılıçarslan, Hakan; Yalçınkaya, Ulviye; Vuruşkan, Hakan; Doğan, Hasan Serkan; Kordan, Yakup; KILIÇARSLAN, HAKAN; YALÇINKAYA, ÜLVİYE; VURUŞKAN, HAKAN; Doğan, Hasan Serkan; Kordan, Yakup; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-9947-848X; ABH-5513-2020; AAH-8924-2021; FGY-3115-2022; EFH-9523-2022; GAF-0095-2022
Introduction: Myxoid liposarcoma is a rare condition and a very little number of cases have been described in the spermatic cord to date. It presents as painless scrotal or inguinal masses that are often confused with hydroceles or inguinal hernias. These lesions tend to recur locally, whereas metastasis is less common than with round cell, pleomorphic, and dedifferentiated liposarcomas. For this reason, high inguinal orchiectomy is the treatment of choice in myxoid liposarcoma of the spermatic cord. Prognostically favorable factors in liposarcomas of the spermatic cord are low tumor grade, small tumor size and superficial depth of invasion, complete resection with negative margins, and the absence of metastases. We present a case of myxoid liposarcoma of spermatic cord which has all these favorable prognostic factors with a brief review of this rare entity.
Perioperative outcomes of robotic and laparoscopic simple prostatectomy: A European-American multi-institutional analysis
(Elsevier, 2015-07-01) Autorino, Riccardo; Zargar, Homayoun; Mariano, Mirandolino B.; Sanchez-Salas, Rafael; Sotelo, Rene J.; Chlosta, Piotr L.; Castillo, Octavio; Matei, Deliu V.; Celia, Antonio; Koç, Gökhan; Vora, Anup; Aron, Monish; Parsons, J. Kellogg; Pini, Giovannalberto; Jensen, James C.; Sutherland, Douglas; Cathelineau, Xavier; Nunez Bragayrac, Luciano A.; Varkarakis, Ioannis M.; Amparore, Daniele; Ferro, Matteo; Gallo, Gaetano; Volpe, Alessandro; Vuruşkan, Hakan; Bandi, Gaurav; Hwang, Jonathan; Nething, Josh; Muruve, Nic; Chopra, Sameer; Patel, Nishant D.; Derweesh, Ithaar; Weeks, David Champ; Spier, Ryan; Kowalczyk, Keith; Lynch, John; Harbin, Andrew; Verghese, Mohan; Samavedi, Srinivas; Molina, Wilson R.; Dias, Emanuel; Ahallal, Youness; Laydner, Humberto; Cherullo, Edward; De Cobelli, Ottavio; Thiel, David D.; Lagerkvist, Mikael; Haber, Georges-Pascal; Kaouk, Jihad; Kim, Fernando J.; Lima, Estevao; Patel, Vipul; White, Wesley; Mottrie, Alexander; Porpiglia, Francesco; VURUŞKAN, HAKAN; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; EFH-9523-2022
Background: Laparoscopic and robotic simple prostatectomy (SP) have been introduced with the aim of reducing the morbidity of the standard open technique. Objective: To report a large multi-institutional series of minimally invasive SP (MISP).Design, setting, and participants: Consecutive cases of MISP done for the treatment of bladder outlet obstruction (BOO) due to benign prostatic enlargement (BPE) between 2000 and 2014 at 23 participating institutions in the Americas and Europe were included in this retrospective analysis. Intervention: Laparoscopic or robotic SP.Outcome measurements and statistical analysis: Demographic data and main perioperative outcomes were gathered and analyzed. A multivariable analysis was conducted to identify factors associated with a favorable trifecta outcome, arbitrarily defined as a combination of the following postoperative events: International Prostate Symptom Score <8, maximum flow rate >15 ml/s, and no perioperative complications.Results and limitations: Overall, 1330 consecutive cases were analyzed, including 487 robotic (36.6%) and 843 laparoscopic (63.4%) SP cases. Median overall prostate volume was 100 ml (range: 89-128). Median estimated blood loss was 200 ml (range: 150-300). An intraoperative transfusion was required in 3.5% of cases, an intraoperative complication was recorded in 2.2% of cases, and the conversion rate was 3%. Median length of stay was 4 d (range: 3-5). On pathology, prostate cancer was found in 4% of cases. Overall postoperative complication rate was 10.6%, mostly of low grade. At a median follow-up of 12 mo, a significant improvement was observed for subjective and objective indicators of BOO. Trifecta outcome was not significantly influenced by the type of procedure (robotic vs laparoscopic; p = 0.136; odds ratio [OR]: 1.6; 95% confidence interval [CI], 0.8-2.9), whereas operative time (p = 0.01; OR: 0.9; 95% CI, 0.9-1.0) and estimated blood loss (p = 0.03; OR: 0.9; 95% CI, 0.9-1.0) were the only two significant factors. Retrospective study design, lack of a control arm, and limited follow-up represent major limitations of the present analysis.Conclusions: This study provides the largest outcome analysis reported for MISP for BOO/BPE. These findings confirm that SP can be safely and effectively performed in a minimally invasive fashion in a variety of healthcare settings in which specific surgical expertise and technology is available. MISP can be considered a viable surgical treatment in cases of large prostatic adenomas. The use of robotic technology for this indication can be considered in centers that have a robotic program in place for other urologic indications.Patient summary: Analysis of a large data set from multiple institutions shows that surgical removal of symptomatic large prostatic adenomas can be carried out with good outcomes by using robot-assisted laparoscopy.