Browsing by Author "Vuruşkan, Hakan"

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Angiomyofibroblastoma-like tumor of the scrotum: A case report and review of literature
(De Gruyter Poland Sp Zoo, 2012-01-01) AYTAÇ VURUŞKAN, BERNA; YALÇINKAYA, ÜLVİYE; Yalçinkaya, Ulviye; Vuruşkan, Hakan; VURUŞKAN, HAKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; AAH-8924-2021; AAH-9746-2021
Angiomyofibroblastoma-like tumor is a rare mesenchymal tumor of men. It commonly occurs during the fifth to eighth decades of life and mainly involves the inguinoscrotal region. It is derived from perivascular stem cells and has capacity of lipoid and myofibroblastic differentiation. Histopathologically this tumor in the male genitalia mimics female angiomyofibroblastoma but there are morphological and immunohistochemical differences between these lesions. We report a case of an angiomyofibroblastoma- like tumor that arose in the scrotal region in a 40-year-old man.
Association of urokinase gene 3 '-UTR T/C polymorphism with calcium oxalate urolithiasis in children
(Springer, 2008-12) Öztürk, Murat; Kordan, Yakup; Cangül, Hakan; Doğan, Hasan Serkan; Kılıçarslan, Hakan; Vuruşkan, Hakan; Oktay, Bülent; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.; ABH-5513-2020; 56781010900; 9633365800; 8911611600; 7005856022; 56007473800; 6507328150; 6602172127
Introduction and objectives: Urokinase is synthesized by various cells such as kidney, pneumocytes, and phagocytes. It cleaves plasminogen to plasmin and hence stimulates fibrinolysis. Urokinase breaks down the matrix protein within the stone and thus prevents stone formation and growth. Urokinase concentrations are lower and urokinase gene 3′-UTR T/C polymorphism is higher in patients with recurrent stones. Our aim was to investigate the role of urokinase gene 3′-UTR T/C polymorphism in childhood recurrent stone disease. Material and methods: A control group of 40 healthy children having no history of stone formation (group 1) (mean age 10.5 ± 4.2 years), 40 children (mean age 10.5 ± 4.33 years) who had calcium oxalate stones for the first time (group 2), and 40 patients (mean age 11.2 ± 3.8 years) with recurrent calcium oxalate stone disease (group 3) were included in the study. The groups were compared with respect to age, gender and urokinase gene 3′-UTR T/C polymorphism. Polymerase chain reaction-based restriction analysis was used to identify C/T polymorphism of the urokinase gene. Results: No significant difference was observed between the three groups with respect to age and gender, while urokinase gene 3′-UTR T/C gene polymorphism was observed in four patients (10%) from group 3. In groups 1 and 2 there was no patient with T/C polymorphism. Conclusions: Urokinase 3′-UTR T/C gene polymorphism seems to appear more commonly in children with recurrent calcium oxalate stone disease than in healthy children and in those with stones for the first time. These results suggest that the urokinase gene might play a role in childhood recurrent calcium oxalate stone disease.
Association of urokinase gene 3'-UTR T/C polymorphism with recurrent urolithiasis in children
(Elsevier, 2007-03) Öztürk, Murat; Kordan, Yakup; Yavaşçaoglu, İsmet; Doǧan, Hasan Serkan; Kılıçarslan, Hakan; Vuruşkan, Hakan; Oktay, Bülent; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.; 56781010900; 9633365800; 8911611600; 7005856022; 56007473800; 6507328150; 6602172127
CDX2 immunostaining in primary and metastatic germ cell tumours of the testis
(Sage Publications, 2016-08-01) Atalay, Fatma Öz; Vuruşkan, Berna Aytaç; Vuruşkan, Hakan; Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; AAH-9746-2021; 15623010600; 57053559100; 6507328150
Objective: To evaluate the immunohistochemical staining pattern of caudal type homeobox 2 (CDX2) protein in germ cell tumours (GCTs) of the testis. Methods: This study reassessed archival tissue samples collected from patients diagnosed with primary and metastatic testicular GCTs for CDX2 immunoreactivity using standard immunohistochemical techniques. Positive nuclear immunostaining was evaluated with regard to both the staining intensity and the extent of the staining. Results: Tissue sections from primary and metastatic testicular GCTs (n = 104), germ cell neoplasia in situ (GCNis) (n = 5) and benign testicles (n = 15) were analysed. The GCNis and benign testicular tissues showed no immunoreactivity for CDX2. Strong and diffuse staining of CDX2 was demonstrated only in the mature colonic epithelium of teratomas in both primary and metastatic GCTs. CDX2 positivity in other tumours (one pure yolk sac tumour, one yolk sac component of a mixed GCT and one pure seminoma) was infrequent, and was only weak and focal. Conclusions: CDX2 immunostaining should be interpreted based on both the staining intensity and the extent of staining so as not to cause misdiagnosis. Teratomas with colonic-type epithelium should be considered in the differential diagnosis if a metastatic tumour with an unknown primary shows prominent CDX2 immunostaining.
Challenging risk factors for right and left laparoscopic adrenalectomy: A single centre experience with 272 cases
(Brazilian Soc Urol, 2019-07-01) Kordan, Yakup; Günseren, Kadir Ömür; GÜNSEREN, KADİR ÖMÜR; Çiçek, Mehmet Cağatay; ÇİÇEK, MEHMET ÇAĞATAY; Vuruşkan, Hakan; VURUŞKAN, HAKAN; Yavaşçaoğlu, İsmet; YAVAŞCAOĞLU, İSMET; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0001-8673-3093; 0000-0002-0471-5404; 0000-0002-9947-848X; ABC-9924-2020
Purpose: This study aimed to compare perioperative and postoperative results of right and left laparoscopic adrenalectomy (LA), and to evaluate the impact of challenging factors on these outcomes.Materials and Methods: A total of 272 patient's medical records that underwent single side LA between October 2006 and September 2017 were retrospectively reviewed. The patients were divided into 2 groups according to operation side. Moreover, pheochromocytoma, metastatic masses and adrenal lesions >5cm in size were considered to be difficult adrenalectomy cases and the outcomes of these cases were compared between two groups.Results: 135 patients (49.6%) underwent right LA and 137 patients (50.4%) underwent left LA. Operation time, estimated blood loss (EBL) and hospitalization time were similar between the groups (p=0.415, p=0.242, p=0.741, respectively). Although EBL was higher on the right side than the left (p=0.038) in the first 20 cases, after this learning period has been completed, there was no significant difference between the groups. In patients with pheochromocytoma, metastatic mass and a mass >5cm in size, despite bleeding complications were clinically higher on the right side, this difference was not statistically significant.Conclusions: During the learning period of LA, EBL is higher on the right side. Due to the greater risk of bleeding complications on the right side even on the hands of experienced surgeons, extra care and preoperative planning are required in patients with pheochromocytoma, metastatic masses and masses >5cm in size.
Characteristics of deceased donors used for kidney transplantation: Single-center experience
(Frontiers Media Sa, 2019-10-01) Ersoy, Alparslan; Elgin, Ersin; Akgür, Suat; Yıldız, Abdülmecit; Kaygısız, Onur; Oflaz, Rafet; Selimoğlu, Kerem; Oruç, Ayşegül; Ünsal, Oktay; Coşkun, Burhan; Aydın, Mehmet Fethullah; Keskin, Sahriye; Kordan, Yakup; Vuruşkan, Hakan; ERSOY, ALPARSLAN; Elgin, Ersin; AKGÜR, SUAT; YILDIZ, ABDULMECİT; KAYGISIZ, ONUR; Oflaz, Rafet; Selimoğlu, Kerem; ORUÇ, AYŞEGÜL; Ünsal, Oktay; COŞKUN, BURHAN; Aydın, Mehmet Fethullah; Keskin, Sahriye; Kordan, Yakup; VURUŞKAN, HAKAN; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Nefroloji Bilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Organ ve Doku Nakli Merkezi.; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0002-9790-7295 ; 0000-0002-0710-0923 ; 0000-0002-0342-9692; 0000-0002-5665-7402; AAH-5054-2021; DXA-2790-2022; EJA-1761-2022; HIG-9032-2022; AAM-9726-2020; DJU-5362-2022; CDS-3299-2022; AAH-4002-2021; JJY-8484-2023; AAH-9704-2021; AAJ-8220-2020; CZH-6714-2022; GAF-0095-2022; EFH-9523-2022
Clinical course of angiomyolipom in our cases
(Aves, 2006-03-01) VURUŞKAN, HAKAN; Çalışkan, Zülküf; Vuruşkan, Hakan; Kordan, Yakup; Sökmen, Ali; Yavaşcaoğlu, İsmet; YAVAŞCAOĞLU, İSMET; Oktay, Bülent; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0002-9947-848X
Introduction: The aim of the study is to determine the factors that affect the clinical course of angiomyolipomas (AML)Materials and Methods: Between January 1992 and November 2003, 24 patients were diagnosed clinically and radiologically to have angiomyolipoma. They were followed prospectively for a mean of 4.6 years (range: 2-11 years). Patients were divided into 3 groups; Group 1: Patients with a solitary lesion, Group2: Patients with multiple lesions associated with tuberous sclerosis and Group 3: Patients with multiple lesions having no tuberous sclerosis. According to the size of the lesion (lesions <4 cm and lesions >4cm) patients were also subdivided into 2 groups. The lesions were followed regularly every 6 month with ultrasonography. These 3 groups were compared in terms of symptoms, size and the percentage of the growth of the lesion.Results: The median age of the patients was 43 (31-59). 13 patients in group 1, 1 patient in group 2 and 4 patients in group 3 had lesions <4 cm and 1 patient in group 1, 2 patients in group 2 and 3 patients in group 3 had lesions >4 cm. In 3 patients from group 2 and 2 patients from group 3 the lesions were bilateral. 7 cases out of 24 (29.1%) were diagnosed incidentally. Patients were found to have 8 different symptoms which were observed 37 times among all patients. The most common symptom, abdominal and flank pain, was observed in 54.1 % (13 patients) of patients. In patients with lesions <4 cm the prevalence of these symptoms were 16.2% (6), 2.7% (1), 5.4% (2) and in patients with lesions >4 cm were 8.1% (3), 37.8% ( 14), 29.7% (11) in group1, 2 and 3 respectively. Considering the growth of the lesions; in group 1with lesions <4 cm only 1 patient out of 13 showed 0.6 cm (18.1%) growth during follow-up. Similarly 1 patient of group1 with lesion >4 cm showed no increase in size of the lesion. In group 2 all patients showed an increase in size of the lesions, which was 1 cm (33.3%) in the group with the lesion <4 cm (1 patient) and 4.6 +/- 3.4 cm (41.8%) in the group with the lesion >4 cm (2 patients). Among group 3 patients with the lesions <4 cm, 3 of 4 showed a mean increase in the diameter of previous lesion of 0.9 +/- 4.2 cm (28.1%), while in 1 patient the lesion remained unchanged. Similarly in group 3 patients with the lesions >4 cm, 2 out of 3 showed a mean increase of 1.8 +/- 5.3 cm (33.3%), while 1 remained unchanged.Conclusion: In AML patients the most important factors which determine the lesion to grow and be symptomatic are the size, the number (multiplicity) of the lesions and the presence of tuberous sclerosis.
Clinicopathologic features of incidental prostatic adenocarcinoma in radical cystoprostatectomy specimens
(Bmc, 2011-07-20) Aytaç, Berna; Vuruşkan, Hakan; Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; AAH-9746-2021; 56527372000; 6507328150
Background: The aim of this study is to review all features of incidentally discovered prostate adenocarcinoma in patients undergoing radical cystoprostatectomy for bladder cancer. Methods: The medical charts of 300 male patients who underwent radical cystoprostatectomy for bladder cancer between 1997 and 2005 were retrospectively reviewed. The mean age of the patients was 62 (range 51-75) years. Results: Prostate adenocarcinoma was present in 60 (20%) of 300 specimens. All were acinar adenocarcinoma. Of these, 40 (66.7%) were located in peripheral zone, 20 (33.3%) had pT2a tumor, 12 (20%) had pT2b tumor, 22(36.7%) had pT2c and, 6 (10%) had pT3a tumor. Gleason score was 6 or less in 48 (80%) patients. Surgical margins were negative in 54 (90%) patients, and tumor volume was less than 0.5 cc in 23 (38.3%) patients. Of the 60 incidentally detected cases of prostate adenocarcinoma 40 (66.7%) were considered clinically significant. Conclusion: Incidentally detected prostate adenocarcinoma is frequently observed in radical cystoprostatectomy specimens. The majority are clinically significant.
Comparison of the effect of anastomosis type on early graft functions and complications in kidney transplant patients with multiple arteries
(Oxford University, 2017-05) Sönmez, Aykut; Kordan, Yakup; Kaygısız, Onur; Coşkun, Burhan; Vuruşkan, Hakan; Yıldız, Abdülmecit; Oruç, Ayşegül; Ayar, Yavuz; Aydın, Mehmet Fethullah; Ersoy, Alparslan; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0003-4607-9220; 0000-0002-0710-0923; 0000-0002-9790-7295; 0000-0002-5665-7402; O-9948-2015; AGF-0767-2022; AAH-9704-2021; GSE-0029-2022; AAH-4002-2021; AAH-5054-2021; AAM-9726-2020; AAJ-8220-2020
Comparison of two different suture techniques in laparoscopic partial nephrectomy
(Brazilian Social Urology, 2017-01-24) Çelen, Sinan; Kaygısız, Onur; Vuruşkan, Berna Aytaç; Vuruşkan, Hakan; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Patoloji Anabilim Dalı.; 0000-0002-9790-7295; L-9439-2019; AAM-9726-2020; AAH-9746-2021; 16637252400; 56527372000; 6507328150
Objective: To comparatively evaluate the traditional interrupted knot-tying and running suture renorrhaphy with Monocryl (R) in laparoscopic partial nephrectomy (LPN). Materials and Methods: A retrospective analysis of 62 consecutive patients undergoing LPN using traditional interrupted knot-tying suture renorrhaphy (Group 1; n= 31) or running suture technique renorrhaphy with 2-0 monofilament polyglecaprone (Monocryl (R), Ethicon) (Group 2; n= 31) from December 2011 to October 2015 at the University. All patients underwent LPN performed by an experienced laparoscopic surgeon. The demographic, perioperative and postoperative parameters were compared between the groups, and the effect of both suture techniques on the warm ischemic time (WIT) and trifecta were evaluated. Results: The running suture renorrhaphy with Monocryl (R) reduced WIT, estimated blood lost and length of hospitalization stay significantly without increasing postoperative complication rate during LPN in comparison with interrupted knot-tying suture. Conclusion: The renorrhaphy using the running suture with Monocryl (R) is an effective and safe technique with the advantage of shortening WIT even in more challenging and larger tumors during LPN.
Comparison of ureteroscopic laser lithotripsy with laparoscopic ureterolithotomy for large proximal and mid-ureter stones
(Karger, 2015-01-01) Kaygısız, Onur; Coşkun, Burhan; Kılıçarslan, Hakan; Kordan, Yakup; Vuruşkan, Hakan; Özmerdiven, Gökhun; Yavacaoğlu, İsmet; KAYGISIZ, ONUR; COŞKUN, BURHAN; KILIÇARSLAN, HAKAN; Kordan, Yakup; VURUŞKAN, HAKAN; Özmerdiven, Gökhun; Yavacaoğlu, İsmet; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Bölümü; 0000-0002-9790-7295; 0000-0002-8242-9921; 0000-0002-9947-848X; AAH-9704-2021; L-9439-2019; JCO-5169-2023; AAM-9726-2020; JIT-9412-2023; GAF-0095-2022; EFH-9523-2022; JIF-9579-2023; EIN-0828-2022
Objectives: To compare the effectiveness and complications of ureteroscopic laser lithotripsy with laparoscopic ureter laparoscopic ureterolithotomy in mid- or proximal portion of large ureteral stones. Material and Methods: We reviewed patients with large (>15 mm) ureteral stone and those who underwent ureteroscopic laser lithotripsy CURS group) or laparoscopic ureterolithotomy (LU group). The first attempt was considered successful in patients who had residual fragments smaller than 2 mm and no conversion of the primary procedure to another. Results: Sixty patients (URS group 29, LU group 31) met inclusion criteria. FURS was used as an adjunctive procedure in one patient for URS group and in two patients for LU group in the same season. LU had a higher success rate and the first-day stone-free rate when compared with URS. Number of procedures was also significantly higher in URS group. There was no difference in stone-free rates at the first and third months, and length of hospitalization and operation were higher in the LU group. Only two patients in the LU group and one patient in the URS group had major complications. Conclusions: Laparoscopy is an effective option of large proximal and mid-ureter stone treatment; however, URS provides similar stone-free rates at three months as a minimal invasive procedure.
Cytokine gene polymorphisms as potential risk and protective factors in renal cell carcinoma
(Academic Press Ltd, 2005-04-07) Baştürk, Bilkay; Yavaşçaoğlu, İsmet; Vuruşkan, Hakan; Göral, Güher; Oktay, Bülent; Oral, H. Barbaros; Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji ve Enfeksiyon Hastalıkları Anabilim Dalı/İmmünoloji Birimi.; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0002-8784-1974; 0000-0003-0463-6818; AAD-6918-2021; K-7285-2012
The major aim of this study was to investigate the association of the cytokine gene polymorphisms with the development of renal cell carcinoma (RCC). The study included 29 patients with RCC and 50 healthy controls. All genotyping (TNF-alpha, TGF-beta, IL-10, IL-6, IFN-gamma) experiments were performed using sequence-specific primers PCR (PCR-SSP). It was found that TNF-alpha -308 G/G and TGF-beta codon 10-25 T/T-G/C genotypes were significantly higher in frequency in the patients with RCC group compared with the healthy control group. Additionally, the frequency of TNF-alpha -308 G allele was significantly higher in the patients when compared to controls. On the other hand, the frequencies of TNF-alpha -308 G/A, IL-6 C/C and TGF-beta 1 codon 10-25 C/C-G/G genotypes were significantly lower in the cancer group compared with the healthy control group. However, after correction for multiple comparisons (Bonferroni), these results did not remain significant. Nevertheless, these findings suggest that the TNF-alpha -308 G/G and TGF-beta codon 10-25 T/T-G/C genotypes may be potential risk factors for RCC, whereas TNF-alpha -308 G/A, IL-6 C/ C and TGF-beta 1 codon 10-25 C/C-G/G genotypes may be possible protective factors. The number of the cases has to be increased to investigate the independency of these polymorphisms involved in the oncogenesis of RCC.
Diode laser in the treatment of benign prostatic enlargement: A preliminary study
(Aves, 2011-03-01) Oktay, Bülent; Kılıçarslan, Hakan; Doğan, Hasan Serkan; Kordan, Yakup; Yavaşcaoğlu, İsmet; Vuruşkan, Hakan; Oktay, Bülent; KILIÇARSLAN, HAKAN; Doğan, Hasan Serkan; Kordan, Yakup; YAVAŞCAOĞLU, İSMET; VURUŞKAN, HAKAN; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0002-9947-848X; ABH-5513-2020; DKK-2716-2022; JIT-9412-2023; GAF-0095-2022; EIN-0828-2022; EFH-9523-2022
Objective: To evaluate the efficacy of a novel treatment diode laser, in treatment of benign prostatic enlargement.Materials and methods: We evaluated the surgical and functional outcomes of 85 patients who underwent diode laser treatment for benign prostatic enlargement between September 2007 and April 2009. Preoperative and postoperative the International Prostate Symptom Score (IPSS), the International Index of Erectile Function (IIEF), maximum flow rate, postvoiding residual urine, and prostate volumes were analyzed.Results: All the patients were considered clinically as having benign prostatic enlargement. Mean age was 70.8 +/- 8.6 years and follow-up period was 12.6 +/- 6 months. In all patients, the power used was 120 W, the mean applied energy was 190 +/- 70 kJ and the total laser time was 21.9 +/- 7.2 min. Improvement in functional outcomes began in the third postoperative month and was sustained through 12 months postoperatively. Compared to preoperative data, at postoperative 12 months, we detected a significant decrease in prostate volumes (55.5 +/- 27.6 mL vs. 42.8 +/- 21.7 mL), IPSS (21.6 +/- 4.75 vs. 4.6 +/- 3.3) and residual urine volume (89.5 +/- 85.6 mL vs. 30.4 +/- 22.4 mL), and a significant increase in maximum flow rates (18.7 +/- 6.9 mL/sec vs. 9.6 +/- 5.6 mL/sec). No difference was detected in IIEF scores (36.8 +/- 21.2 vs. 37.8 +/- 23.7). Re-treatment was required in 5.8% of patients, and retrograde ejaculation was reported in 17% of patients.Conclusion: The early results of diode laser treatment for benign prostatic enlargement were equivalent to other endoscopic and minimally invasive treatments.
Distal hipospadias olgularında ideal cerrahi tedavi
(Uludağ Üniversitesi, 2005-05-27) Çalışkan, Zülküf; Vuruşkan, Hakan; Küçük, Muaffak; Kordan, Yakup; Yavaşçaoğlu, İsmet; Oktay, Bülent; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.
Çalışmanın amacı distal hipospadiasta uygulanan TIPU (Snodgrass), Mathieu ve MAGPI cerrahi yöntemlerinin başarı ve komplikasyon oranlarını kıyaslayarak, ideal cerrahi yöntemi belirlemektir. 1994-2003 yılları arasında kliniğimizde TIPU, Mathieu ve MAGPI yöntemiyle primer hipospadias onarımı uygulanan distal yerleşimli 60 hipospadias olgusu retrospektif olarak incelendi. TIPU (GrupI) Mathieu (GrupII) ve MAGPI (GrupIII) cerrahi yöntemiyle hipospadias onarımı uygulanan grupların herbirine preop ve postoperatif ampisilinsulbaktam 50mg/kg dozunda uygulandı. Olguların hastanede yatış süreleri, erken ve geç postoperatif komplikasyonlar ile, üretral kateter kalış süreleri ve üriner enfeksiyon oranları retrospektif olarak karşılaştırıldı. 60 olgunun gruplara göre dağılımı, grup I’de 25, grup II’de 22 ve grup III’de 13 olarak belirlendi. Grup I, II ve III’deki hastaların ortalama yaşları sırasıyla; 5 yaş, 11yaş, 6 yaş olarak saptandı. Olguların hastanede ortalama kalış süresi sırasıyla 3 gün, 5gün, 4gün olarak saptandı. Kateter kalış süreleri 5 gün, 7 gün ve 8 gündü. Olgular ortalama 4.5yıl takip edildi. Grup I’deki olgularda 1 (%4) cilt altı hematomu, 1 (%4) üretrokutanöz fistül, 1 (%4) meatal stenoz, 1 (%4) üretral stenoz ve 1 (%4) üriner enfeksiyon saptandı. Grup II’deki olgularda; 1 (%4.5) yara enfeksiyonu, 1 (%4.5) cilt altı hematomu, 2 (%9) üretrokutanöz fistül, 1 (%4.5) üretral stenoz ve 2 (%9) üriner enfeksiyon saptandı. Grup III’de 1 (%7.6) yara enfeksiyonu, 1 (%7.6) meatal stenoz, 2 (%15.3) penil deformite ve 1 (%7.6) üriner enfeksiyon saptandı. Distal hipospadias olgularında, kozmetik ve genel komplikasyon oranları açısından bakıldığında en ideal tedavi seçeneği TIPU’dir.
Effect of operation timeline on frequency of surgical complication in deceased donor kidney transplantation
(Frontiers Media SA, 2019-10-01) Ersoy, Alparslan; Düger, Hakan; Dizdar, Oğuzhan Sıtkı; Yıldız, Abdülmecit; Akgür, Suat; Kaygısız, Onur; Oruç, Ayşegul; Ünsal, Oktay; Coşkun, Burhan; Kordan, Yakup; Türker, Gürkan; Vuruşkan, Hakan; ERSOY, ALPARSLAN; Düger, Hakan; Dizdar, Oğuzhan Sıtkı; YILDIZ, ABDULMECİT; AKGÜR, SUAT; KAYGISIZ, ONUR; ORUÇ, AYŞEGÜL; Ünsal, Oktay; COŞKUN, BURHAN; Kordan, Yakup; TÜRKER, YUNUS GÜRKAN; VURUŞKAN, HAKAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı/Nefroloji Bilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Anestezi ve Reanimasyon Anabilim Dalı.; 0000-0001-5478-3192; 0000-0002-9790-7295; 0000-0002-0342-9692; 0000-0002-8242-9921; 0000-0002-9947-848X; 0000-0002-3019-581X; AAM-9726-2020; AAH-5054-2021; AAI-6642-2021; AAH-4002-2021; IZP-9361-2023; AAH-9704-2021; BBE-2157-2022; HIG-9032-2022; EJA-1761-2022; JJY-8484-2023; AAH-9704-2021; GAF-0095-2022; EFH-9523-2022
The effect of renal arterial anastomosis techniques on the development of complications and graft dysfunction in recipients after kidney transplantation
(Oxford University, 2017-05) Kanat, Fevzi Mutlu; Kordan, Yakup; Kaygısız, Onur; Coşkun, Burhan; Vuruşkan, Hakan; Oruç, Ayşegül; Yıldız, Abdulmecit; Ayar, Yavuz; Ersoy, Alparslan; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0002-0710-0923; 0000-0003-4607-9220; 0000-0003-4607-9220; 0000-0003-4607-9220; 0000-0002-9790-7295; AAH-5054-2021; GSE-0029-2022; O-9948-2015; AAH-9704-2021; AGF-0767-2022; AAH-4002-2021; AAM-9726-2020
The effects of tadalafil on renal ischemia reperfusion injury: An experimental study
(Assoc Basic Meical Sci Federarion Bosbia & Herzegovina Sara, 2011-08) Gasanov, Feyzullah; Aytaç, Berna; Vuruşkan, Hakan; Uludağ Üniversitesi/Tıp Fakültesi/Cerrahi Patoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; AAH-9746-2021; 56629254000; 56527372000; 6507328150
Many pharmacological agents were investigated for the prevention of renal ischemic reperfusion (I/R) injury as well as the phosphodiesterase (PDE) inhibitors. The aim of the study was to examine the possible renoprotective effect of a member in this family, tadalafil (Td) on I/R injury. Thirty-six Sprague Dawley rats were allocated to six groups as; control, sham, ischemia (I), ischemia/reperfusion (I/R), Td pretreatment ischemia (Td/I) and Td pretreatment ischemia/reperfusion (Td/IR) groups. Right nephrectomy was performed in all groups. Td was dissolved in saline solution and given as a single dose (1mg/kg) through an orogastrictube 60 min before the operation in the Td pretreatment groups. In ischemia group the left renal pedicle was occluded for 45 minutes and after than underwent left nephrectomy. In I/R group left renal pedicle was occluded for 45 minutes, reperfused for I hour and after then underwent nephrectomy. The left kidneys were evaluated after standard laboratory procedures with regard to tubular morphology, and leukocyte infiltration. The data were analyzed by using Kruskal Wallis test to determine differences among the groups. A p value of < 0.05 was considered significant. Renal tubular damage was significant increased in the ischemia and I/R group (Groups III and IV) when compared to those in the sham group (Group II), (p = 0.004, 0.004, respectively). Tubular damage, in the Td pretreatment ischemia (Td/I) (Group V) and Td pretreatment ischemia/reperfusion (Td/IR) (Group VI) were less than that in the ischemia group (Group III) (p=0.0010, p=0.025, respectively). Td administration prior to the renal I/R injury attenuated these morphological disarrangements, which were observed in renal I/R. Tubular necrosis, which may be considered as an important issue of the developing renal injury, was also completely prevented with Td administration.
Efficacy of artificial urinary sphincter implantation after failed bone-anchored male sling for postbrostatectomy incontinence
(Elsevier Science, 2007-11) Fisher, Mark B.; Aggarwal, Neelesh; Singla, Ajay K.; Vuruşkan, Hakan; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Bölümü.; 6507328150
OBJECTIVES To evaluate the feasibility and efficacy of artificial urinary sphincter placement after failed bone-anchored male sling for postprostatectomy stress urinary incontinence. METHODS Eleven patients with postprostatectomy stress urinary incontinence who failed bone-anchored male sling underwent artificial urinary sphincter placement. All patients were evaluated before and after artificial urinary sphincter placement with a history and physical examination, pad score, and the incontinence section of the University of California, Los Angeles (UCLA)/RAND prostate cancer index (total score possible = 26). Urodynamic evaluation was performed before sphincter placement. RESULTS The average age in our study population was 70 years (range, 51 to 80 years). The mean follow-up after artificial urinary sphincter placement was 14.2 months (range, 3 to 20 months). Incontinence was defined as mild (I to 2 pads), moderate (3 to 5 pads), or severe (more then 5 pads). After sling placement, cure was defined as no pad use, failure as same pad usage, and improvement as fewer pads used. The severity of incontinence before artificial urinary sphincter placement was mild, moderate, and severe in 3, 1, and 7 patients, respectively. After artificial urinary sphincter placement the severity of incontinence was cured, mild, and moderate in 8, 2, and 0, respectively. One patient required artificial urinary sphincter removal because of infection. Mean UCLA/RAND scores increased from 10.8 to 19.7. Patient satisfaction after artificial urinary sphincter placement was 74.5%. No intraoperative complications or urethral injuries occurred. CONCLUSIONS Artificial urinary sphincter placement after failed bone-anchored male sling is technically feasible and does not affect the short-term efficacy of the artificial sphincter.
Elevated plasma concentrations of transforming growth factor-beta 1 in patients with unilateral ureteral obstruction
(Springer, 2005-12) Vuruşkan, Hakan; Çalışkan, Zulüf; Özakın, Cüneyt; Yavasçaoğlu, İsmet; Oktay, Burçin; Kordan, Yakup; Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Bölümü.; Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji Bölümü.
We measured plasma concentrations of TGF-beta 1 in patients with obstructive ureteral calculi and compared them with the plasma concentrations of healthy volunteers. The present study was a prospective study containing a homogenous group of patients with unilateral ureteral obstruction (UUO). The study consisted of patients with ureteral stones less than 7 mm in diameter that caused mild to moderate obstruction. All patients were referred by the emergency department of our hospital and examined between April 2003 and April 2004. The presence and characteristics of both stone and obstruction were determined by plain abdominal x-ray and gray-scale ultrasonography (US). Blood samples were collected from both patients and control individuals on admission and 1 week after conservative follow-up. The plasma TGF-beta 1 concentration was determined using a quantitative sandwich enzyme immunoassay specific for TGF-beta 1. There were 35 patients with 20 women and 15 men (average age 26.8 +/- 5.9 years), and 15 volunteers in the control group, with nine women and six men (average age 24.2 +/- 4.5 years). Average stone size was 5.6 mm +/- 1.2 mm (range 3.5-7) for the patient group. US showed the presence of mild hydronephrosis in 24 and moderate hydronephrosis in 11 patients. Plasma concentrations of TGF-beta 1 in patients with ureteral obstruction (1,117 +/- 5.8 ng/ml, range 36-2,442 ng/ml) were significantly higher than those in the healthy control group (32 +/- 4 ng/ml) on admission (P < 0.001). There was a significant increase in TGF-beta 1 plasma concentrations in the patient group (33,525 +/- 6.8 ng/ml, range 1,107-73,288 ng/ml) after 1 week follow-up (P < 0.001). Ureteral obstruction increases plasma TGF-beta 1 concentrations in patients with ureteral stones as in UUO models in animal studies. A concomitant treatment with an anti-fibrotic agent may reduce the incidence of renal injury during obstruction.
Emphysematous pyelonephritis: Case report
(Aves, 2005-09-01) VURUŞKAN, HAKAN; Vuruşkan, Hakan; Çalışkan, Zülküf; Çift, Ali; Kordan, Yakup; Yavaşçaoğlu, İsmet; YAVAŞCAOĞLU, İSMET; Oktay, Bülent; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Üroloji Anabilim Dalı.; 0000-0002-9947-848X; AAH-7103-2019
Introduction: Emphysematous pyelonephritis (EP) is a lethal infection which is rarely seen and is characterized by gas in intrarenal or perirenal region. The traditional treatment of EP is open surgical flowing and parenteral antibiotherapy or nephrectomy. In this study a 74 years old male patient with EP treated with percutaneous drainage catheter and comprehensive antibiotherapy because of no clinical response to antibiotherapy is presented.