PubMed

Permanent URI for this collectionhttps://hdl.handle.net/11452/24864

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Aspergillosis osteomyelitis and joint infection in a renal transplant recipient
(Elsevier Science, 2007-06-16) Ersoy, Alparslan; Akdağ, İbrahim; Akalın, Halis; Sarısözen, Bartu; Ener, Beyza; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; 0000-0002-4803-8206; 0000-0002-0710-0923; AAU-8952-2020; AAG-8523-2021; ABI-7283-2020; AAH-5054-2021; 35612977100; 8342488100; 57207553671; 55890736200; 15053025300
Invasive Aspergillosis occurs in almost every human organ, most commonly in the lungs. Bone involvement classically has been considered exceedingly rare for both immunocompromised and immunocompetent hosts, however, there are limited data in transplant recipients. We report an unusual case of osteomyelitis and joint infection of the ankle caused by Aspergillus fumigatus in a renal transplant recipient.
Effect of fluvastatin on serum prohepcidin levels in patients with end-stage renal disease
(Pergamon-Elsevier Science, 2008-09) Arabul, Mahmut; Güllülü, Mustafa; Yılmaz, Yusuf; Akdağ, İbrahim; Kahvecioğlu, Serdar; Eren, Mehmet Ali; Dilek, Kamil; Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji ve Romatoloji Anabilim Dalı.; 0000-0003-4518-5283; ABH-7279-2020; 15925230900; 6602684544; 22936014300; 8342488100; 55956719500; 7006788432; 56005080200
Objectives: Anemia, low-grade inflammation and/or alterations in lipid metabolism are common findings in individuals with end-stage renal disease (ESRD) despite advances in dialysis treatment. Hepcidin, a key regulator of iron metabolism, may play an important role in the interdependence of inflammation and anemia in ESRD patients. Statins may reduce cardiovascular events in dialysis patients and have pleiotropic effects in addition to lowering total and low-density lipoprotein (LDL)-cholesterol. Design and methods: Because there is a paucity of data on the effect of statins on serum prohepcidin levels in dialysis patients, this 8-week study was conducted to test the effect of fluvastatin (80 mg/day, n = 22) compared with placebo (n = 18) on circulating scruin prohepcidin, a prohormone of hepcidin, and high-sensitive C-reactive protein (hs-CRP) in dyslipidemic ESRD patients with renal anemia. Results: Fluvastatin treatment decreased total cholesterol (P < 0.05), LDL-cholesterol (P < 0.01), hs-CRP (P < 0.05) and serum prohepcidin levels (P < 0.05) significantly. Conclusion: Our pilot data suggest that short-term statin treatment may exert a beneficial effect on serum prohepcidin levels in ESRD patients. The potential clinical benefits of statins on renal anemia need to be confirmed and expanded with an appropriately powered long-term study.
Paraoxonase activity in glomerulonephritic patients
(Taylor & Francis, 2007) Güllülü, Mustafa; Kahvecioğlu, Serdar; Dirican, Melahat; Akdağ, İbrahim; Ocak, Nihal; Demircan, Celalettin; Dilek, Kamil; Ersoy, Alpaslan; Yavuz, Mahmut; Yurtkuran, Mustafa; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Dahiliye Anabilim Dalı.; 0000-0002-0710-0923; AAG-6985-2021; AAH-5054-2021; 6602684544; 55956719500; 6601919847; 8342488100; 23989248600; 6507741676; 56005080200; 35612977100; 7006244754; 7003389525
Background. Cardiovascular disease is the most common cause of morbidity and mortality in patients with chronic renal failure. Glomerulonephritic patients have an increased risk for cardiovascular disease, but its etiology is unclear. It is known that an increase in oxidizability of apolipoprotein B-containing lipoproteins has a key role in the initiation of atherosclerosis, and paraoxonase enzyme activity particularly has a preventive role against atherosclerosis. The aim of the present study was to evaluate the oxidizability of apolipoprotein B-containing lipoproteins, serum, and urinary paraoxonase/arylesterase activities in g] omerulonephritis patients who had normal lipid parameters and creatinine levels. Methods. Thirty-two patients with glomerulonephritis and 22 healthy controls were included in this study. A total of 32 patients (including nine with membranous GN, eight with immunoglobulin A nephropathy, eight with mesangial prolifferative GN, five with focal-segmental glomerulosclerosis, one with diffuse proliferative GN, and one with minimal chance disease having biopsy proven GN) were enrolled into the study. We compared serum and urinary paraoxonase, arylesterase, serum lipids, urea, creatinine, hemoglobin, total protein and albumin values between groups. Results. Serum urea, creatinine, total protein, albumin, uric acid, hemoglobin, and lipid parameters were similar in the glomerulonephritis and control groups (p > 0.05). PON1 activity was significantly lower in GN group nan controls, but there was no statistically significant difference on arylesterase activity between groups. Oxidizability of apolipoprotein B-containing lipoproteins was significantly higher in GN group than controls. Conclusion. Our study shows that the findings of normal serum levels of creatinine, lipids, and protieins increased the oxidizability of apolipoprotein B-containing lipo-proteins, and any decrease in PON1 activity in patients diagnosed with GN should be considered important. Hence, the immediate commencement of preventive as well as curative treatment in other to avoid the risk of cardiovascular and renal problems would be a correct approach.
Tumour lysis syndrome with acute renal failure during imatinib therapy
(Pergamon-Elsevier Science, 2007-04) Ali, Rıdvan; Özkalemkaş, Fahir; Özkan, Atilla; Özçelik, Tülay; Özkocaman, Vildan; Akdağ, İbrahim; Ozan, Ülkü; Uludağ Üniversitesi/Tıp Fakültesi/Hematoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Nefroloji Anabilim Dalı.; AAG-8495-2021; AAH-1854-2021; 7201813027; 6601912387; 9250698600; 7005424333; 6603145040; 8342488100; 6507254632; 6602797853

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Browsing by BUU Author "Akdağ, İbrahim"