1995 Cilt 14 Sayı 1-2-3

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    AIDS çalışmaları için önemli bir model: FIV(feline immunodeficiency virus)
    (Uludağ Üniversitesi, 1995) Minbay, Ahmet; Çetin, Cengiz; Uludağ Üniversitesi/Veteriner Fakültesi.
    Recently, FIV which appears to be species specific to the cat has been discovered and it has been considered to be an important model for studies on AIDS because of its many similarities to HIV (Human Immunodeficiency Virus) that causes AIDS in man. FIV is a T-lymphotropic retrovirus with single-stranded RNA and Mg2+ - dependent RT (reverse transcriptase). It belongs to the same lentivirus subfamily of retroviruses as the HIV. FIV infection is widely distributed throught the world.The most common route of transmission seems to be via infected saliva inoculated by bites during cat fights. Infection is found mainly in older, male, free roaming cats. It gives rise to a wide range of symptoms similar to those seen in human patients immunosuppressed by HIV infection. FIV injection is usually diagnosed using an ELISA (Enzyme Linked lmmunosorbent Assay) test for detecting antibodies to the virus. Results of ELISA are confirmed by IFA (Immunofluorescence Antibody) testing or by WB (Westem Blot). lnvestigatians on the therapy and the development of effective vaccine against FIV infection have been continued imensively. Hopefully, the knowledges acquired from these researches will explain to unknown points in respect to FIV and HIV. The aim of this review article is to inform about importance and characteristics of FIV which is an important model for studies on AIDS.