Person: ERTÜRK, ERDİNÇ
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ERTÜRK
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ERDİNÇ
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Publication Risk factors and outcomes of the post-liver transplantation diabetes mellitus(Aves, 2022-09-01) Ünsal, Yasemin Aydoğan; Gül, Özen Öz; Göktuğ, Mehmet Refik; Cander, Soner; Ersoy, Canan Özyardımcı; Aydemir, Ensar; Ateş, Coşkun; Ünsal, Oktay; Kıyıcı, Murat; Ertürk, Erdinç; ÖZ GÜL, ÖZEN; GÖKTUĞ, MEHMET REFİK; CANDER, SONER; Ersoy, Canan Özyardımcı; AYDEMİR, ENSAR; ATEŞ, COŞKUN; KIYICI, MURAT; ERTÜRK, ERDİNÇ; Tıp Fakültesi; Dahiliye Ana Bilim Dalı; 0000-0001-8519-784X ; GBT-4320-2022; CSJ-5407-2022; CJH-1319-2022; JMT-8992-2023; AAB-6671-2022; CDO-0747-2022; FHW-0015-2022; AAJ-6536-2021Objective: We aimed to identify the risk factors for the development of diabetes mellitus after transplantation in liver recipients.Methods: Two hundred twenty-seven patients with a follow-up period >8 months after liver transplantation were included in the study. The clinical and laboratory data of patients with post-liver transplantation diabetes mellitus and without post-liver transplantation diabetes mellitus were compared.Results: Of the 227 patients, 61 patients were diagnosed with diabetes mellitus in the pretransplantation period. Twelve percent of the patients (20 patients) were diagnosed with post-liver transplantation diabetes mellitus and 146 patients were not diagnosed with diabetes mellitus. We found that post-liver transplantation diabetes mellitus was associated with advanced age (95% CI: 1.002-1.142). Male liver recipients were diagnosed with a higher rate of post-liver transplantation diabetes mellitus than female recipients (15.5% and 5.4%, respectively; P =.045). Pretransplantation fasting plasma glucose levels were higher in patients with post-liver transplantation diabetes mellitus than without post-liver transplantation diabetes mellitus, which was not statistically significant (P =.097). While 22.2% of patients with post-liver transplantation diabetes mellitus had complications after transplantation, 14.2% of the patients without post-liver transplantation diabetes mellitus had complications after transplantation (P =.370).Conclusion: As post-liver transplantation diabetes mellitus is associated with graft failure and increased mortality and morbididy, candidates for liver transplantation should be screened for risk factors of diabetes, and blood work for diabetes mellitus should be done regularly in these patients. Since patients with advanced age, male gender, and higher fasting plasma glucose levels in the pretransplantation period have higher risk for the development of post-liver transplantation diabetes mellitus, these cases should be screened more carefully.Publication Answer regarding comment on: Risk factors and outcomes of the post-liver transplantation diabetes mellitus(Aves, 2023-01-01) Ünsal, Yasemin Aydoğan; Gül, Özen Öz; Göktuğ, Mehmet Refik; Cander, Soner; Ersoy, Canan Özyardımcı; Aydemir, Ensar; Ateş, Coşkun; Ünsal, Oktay; Kıyıcı, Murat; Ertürk, Erdinç; ÖZ GÜL, ÖZEN; GÖKTUĞ, MEHMET REFİK; CANDER, SONER; ERSOY, CANAN; AYDEMİR, ENSAR; ATEŞ, COŞKUN; KIYICI, MURAT; ERTÜRK, ERDİNÇ; Tıp Fakültesi; Endokrinoloji ve Metabolizma Hastalıklar Ana Bilim Dalı; 0000-0001-8519-784X ; GBT-4320-2022; CSJ-5407-2022; CJH-1319-2022; JMT-8992-2023; AAB-6671-2022; CDO-0747-2022; FHW-0015-2022; AAJ-6536-2021Publication A close look at our cases with parathyroidectomy: 11 years of experience(Edizioni Minerva Medica, 2022-06-01) Saraydaroğlu, Özlem; SARAYDAROĞLU, ÖZLEM; ÖZŞEN, MİNE; Kirdak, Turkay; Narter, Selin; NARTER, SELİN; Ertürk, Erdinç; ERTÜRK, ERDİNÇ; Tıp Fakültesi; Patoloji Ana Bilim Dalı; 0000-0002-5771-7649; AAJ-6536-2021BACKGROUND: Hyperparathyroidism is caused by parathyroid adenoma, hyperplasia or carcinoma. Parathyroid ade-nomas are the most common cause of parathyroid disease (85-88%) while atypical parathyroid adenomas and carcinomas are the least frequently seen parathyroid neoplasms which cause diagnostic difficulty. This series aims to identifiy lesions of parathyroidectomy specimens in our center and draw attention to borderline cases in between parathyroid adenoma and carcinoma.METHODS: The study included 638 parathyroidectomy materials diagnosed in our center between the years 2005 and 2016 and examined retrospectively, and all were included in the study.RESULTS: In all the 638 parathyroidectomy cases evaluated, 427 were diagnosed with adenoma, 117 with hyperplasia, 54 with normal parathyroid tissue, 32 with parathyroid neoplasm with uncertain malignant potential, 7 with parathyroid carcinoma and 1 with normal thyroid tissue.CONCLUSIONS: Parathyroid neoplasm with uncertain malignant potential defines cases with suspicious histopathological features of carcinoma but doesn't meet the criteria for parathyroid carcinoma. In our series, these cases are identified as atypical parathyroid adenoma. We present clinical and morphological features of our parathyroidectomy cases in an 11-year period and aim to raise concern about borderline cases in between adenoma and carcinoma. We think that such tumors, similar to the thyroid neoplasm classification, should be defined as parathyroid neoplasms with uncertain malignant potential and should be followed closely.Publication Differences between atypical parathyroid tumors and parathyroid adenomas in patients with primary hyperparathyroidism(Springer India, 2023-09-29) Aydemir, Ensar; AYDOĞAN ÜNSAL, YASEMİN; ÖZ GÜL, ÖZEN; AYDEMİR, ENSAR; ATEŞ, COŞKUN; Ateş, Coşkun; CANDER, SONER; Cander, Soner; Saraydaroğlu, Özlem; SARAYDAROĞLU, ÖZLEM; Ersoy, Canan; ERSOY, CANAN; Ertürk, Erdinc; ERTÜRK, ERDİNÇ; Tıp Fakültesi; İç Hastalıkları Ana Bilim Dalı; 0000-0003-4300-2965; 0000-0003-4565-9848; 0000-0002-1332-4165; AAJ-6536-2021; AAB-6671-2022; AAA-7171-2022Atypical parathyroid tumor is a rare disease that can be challenging to distinguish from parathyroid adenoma. Atypical parathyroid tumor shows some laboratory and histopathological features with parathyroid cancer. This study attempts to compare clinical, laboratory, radiologic, and histopathological characteristics in atypical parathyroid tumor and parathyroid adenoma. This was a retrospective study based on the database of eighty-two subjects who underwent surgery for primary hyperparathyroidism at a tertiary referral center between 2010 and 2021. Forty-one patients with atypical parathyroid tumor were matched by age and gender to controls with parathyroid adenoma. Clinical, laboratory, radiologic, and characteristics were obtained from the hospital database. Forty-five (54.8%) of primary hyperparathyroidism patients were symptomatic, 36 (90%) had nephrolithiasis, 6 (15%) had fracture, and 3 (7.5%) had hypercalcemic crisis. Atypical parathyroid tumor patients present with significantly increased serum calcium, parathormone, and alkaline phosphatase levels (P < .001, all). No significant difference was observed in the results of bone mineral density, T-scores, and Z-scores. The size of adenoma was significantly greater in the atypical parathyroid tumor group (24 (8.8-70) mm vs. 12 (3.8-32) mm, P = 0.005). Our study revealed that increased preoperative serum calcium, parathormone, alkaline phosphatase concentrations, and parathyroid adenoma size on ultrasound may have predicted the atypical parathyroid tumor.Publication Adrenocortical carcinoma: Single center experience(Aves, 2017-12-01) Şişman, Pınar; Şahin, Ahmet Bilgehan; Peynirci, Hande; Cander, Soner; Gül, Özen Öz; Ertürk, Erdinç; Ersoy, Canan; ŞAHİN, AHMET BİLGEHAN; CANDER, SONER; ÖZ GÜL, ÖZEN; ERTÜRK, ERDİNÇ; ERSOY, CANAN; Tıp Fakültesi; Endokrinoloji ve Metabolizma Ana Bilim Dalı; 0000-0002-7846-0870; AAI-1005-2021; AAH-8861-2021; AAJ-6536-2021; HUR-0563-2023; AAM-4927-2020Objective: Adrenocortical carcinoma is an aggressive endocrine malignancy with an annual incidence of 0.5-2 cases per million. The most important factors that determine prognosis are tumor stage at the time of diagnosis and the success of surgery. However, advanced age, large tumor size, hormone secretion, high Ki-67 index (>10%), tumor necrosis and high mitotic activity are other factors associated with poor prognosis. In the present study, we aimed to evaluate the contribution of the patient and treatment-related factors to the prognosis in adrenocortical carcinoma.Material and methods: We included 15 adrenocortical carcinoma patients who were followed in our center between 2005 and 2015. The effects of age, gender, tumor size, type of operation, postoperative resection status and adjuvant treatment on disease-free survival and overall survival were analyzed.Results: Disease-free survival was 23.32+/-3.69 months and overall survival was 36.60+/-10.78 months. Gender, tumor size, tumor stage, type of operation, hormonal activity, presence of necrosis, recurrence and development of metastasis were not found to be associated with disease-free survival and overall survival (p>0.05). Postoperatively applied adjuvant treatments including mitotane, chemotherapy and radiotherapy did not significantly affect disease-free survival in our study, but statistically significant increase in overall survival was observed in patients getting adjuvant treatments (p=0.006).Conclusion: Adrenocortical carcinoma has poor prognosis and short overall survival, and in its clinical course, recurrence and development of metastasis can be commonly observed even after complete resection of the tumor. Therefore, the patients should be evaluated carefully while determining the surgical procedure during the preoperative period, and the operation and post-operative follow-up should be performed in experienced centers. However, due to the positive effects of adjuvant treatments on survival, all patients should be evaluated postoperatively for the necessity of adjuvant treatments, especially mitotane.Publication A rare cause of hypopituitarism: Pituitary tuberculosis(Aves, 2012-01-01) Gül, Özen Öz; Ertürk, Erdinç; Cander, Soner; Ünal, Oğuz Kaan; Hakyemez, Bahattin; İmamoğlu, Şazi; ÖZ GÜL, ÖZEN; ERTÜRK, ERDİNÇ; CANDER, SONER; Ünal, Oğuz Kaan; HAKYEMEZ, BAHATTİN; İmamoğlu, Şazi; Tıp Fakültesi; Radyoloji Ana Bilim Dalı; AAI-1005-2021; AAI-2318-2021; AAJ-6536-2021; HUR-0563-2023; GGN-5983-2022; FCO-4676-2022Pituitary tuberculosis is a rare condition that can present with hypopituitarism even without any evidence of systemic tuberculosis and is easily confused with pituitary adenomas. Headache and hypopituitarism are the most common presenting symptoms. We report the case of pituitary tuberculosis in a 39-year-old male patient who presented with panhypopituitarism. Although it is rare and difficult to diagnose, pituitary tuberculosis should be considered in every nonfunctional sellar masses, especially in fairly small ones with unexpected hypopituitarism.Publication Central venous sampling and magnetic resonance imaging in the diagnosis of acth-dependent cushing's syndrome(Sage Publications Inc, 2022-09-08) Ünsal, Yasemin Aydoğan; Gül, Zen Z.; Aydemir, Ensar; AYDEMİR, ENSAR; Ate, Co Kun; Ertürk, Erdinç; ERTÜRK, ERDİNÇ; Cander, Soner; CANDER, SONER; Ersoy, Canan; ERSOY, CANAN; Özpar, Rıfat; ÖZPAR, RİFAT; HAKYEMEZ, BAHATTİN; Tıp Fakültesi; Endokrinoloji ve Metabolizma Ana Bilim Dalı; 0000-0003-4300-2965; AAB-6671-2022; AAA-7171-2022; AAJ-6536-2021; HCI-4522-2022Objectives: Central venous sampling (CVS) with corticotropin-releasing hormone (CRH) stimulation is a crucial technique in evaluating adrenocorticotropic hormone (ACTH)-dependent Cushing's syndrome (CS). We evaluated central venous sampling (CVS) and magnetic resonance imaging (MRI) findings in predicting the localization and lateralization of pituitary microadenomas.Methods: We analyzed 29 patients with CS who underwent CVS with CRH stimulation and examined with MRI retrospectively. Catheterization to central sinuses was successfully performed in 26 patients. Three patients with variant anatomy or inability to cannulate were diagnosed with CD after examination of pathology.Results: After CVS, among 26 patients, 23 patients were determined to have CD (88.4%) and 2 (7.7%) patients were diagnosed with ectopic ACTH syndrome. One patient was diagnosed with CD postoperatively. While the sensitivity of the CVS was 95.6%, sensitivity of the preoperative pituitary MRI was lower (69.5%). Also, the negative predictive value ratio was higher in CVS than in MRI (66% versus 22%). Diagnostic accuracy in the lateralization of the tumor was high as in CVS as in MRI (76.4% versus 73.9%).Conclusion: Central venous sampling with higher sensitivity in the localization of pituitary microadenoma, also has approximately similar diagnostic accuracy in lateralizing the tumor with MRI.Publication Evaluation of upper gastrointestinal system in acromegaly(Masson Editeur, 2019-09-01) Şişman, Pınar; Pekgöz, Murat; Bayrakçı, Ismail; Şişman, Mete; Cander, Soner; CANDER, SONER; Gül, Özen Öz; ÖZ GÜL, ÖZEN; Ertürk, Erdinç; ERTÜRK, ERDİNÇ; Ersoy, Canan; ERSOY, CANAN; Tıp Fakültesi; AAH-8861-2021; AAI-1005-2021; AAJ-6536-2021Purpose. - Acromegaly causes multiple comorbidities, including gastrointestinal disorders. The present study evaluated the frequency of hiatal hernia and other upper gastrointestinal pathologies in patients with acromegaly, given that visceromegaly and reduced nitric oxide levels in acromegaly may impact diaphragm and lower esophageal sphincter function and thus possibly the development of hiatal hernia.Methods. - Thirty-nine acromegaly patients followed our center for the previous 6 months were recruited. Upper gastrointestinal endoscopy was performed once in all patients to evaluate hiatal hernia, esophagitis, gastroduodenitis and ulcer.Results. - Twenty-three patients were male and 16 female. Upper gastrointestinal endoscopy found hiatal hernia, esophagitis and gastroduodenitis or gastric ulcer in 3 (7.6%), 2 (1.7%) and 31 (79.4%) patients, respectively. Pathologic examination of gastric antrum biopsy found intestinal metaplasia in 12 (30.7%) patients, and Helicobacter pylori was positive in 13 (33.3%). There were no significant correlations between age, gender, disease duration or preoperative adenoma size on the one hand and hiatal hernia or other endoscopic findings on the other. Similarly, neither surgical success nor recurrence was associated with endoscopic findings.Conclusions. - The study showed that prevalence of gastritis, duodenitis, peptic ulcer and intestinal metaplasia is higher and prevalence of hiatal hernia lower in acromegaly patients than in the healthy population. Various unknown disease-related pathophysiological conditions may play a role; there is a need for further studies.Publication Association between p16(cdkn2a) c540g polymorphism and tumor behavior in prolactinoma: A single-center study(Spandidos Publ Ltd, 2014-07-01) Karkucak, Mutlu; Gül, Özen Öz; ÖZ GÜL, ÖZEN; Yakut, Tahsin; Sağ, Şebnem Özemri; ÖZEMRİ SAĞ, ŞEBNEM; Ersoy, Canan; ERSOY, CANAN; Tuncel, Ercan; Ertürk, Erdinç; ERTÜRK, ERDİNÇ; Cander, Soner; Tıp Fakültesi; Genetik Ana Bilim Dalı; AAJ-6536-2021; AAH-8861-2021; AAI-1005-2021; ABI-5648-2022; AAH-8355-2021Pituitary tumors usually originate as benign sporadic adenomas and develop into invasive and aggressive tumors such as prolactinomas, which are common functioning pituitary adenomas. The aim of the present study was to examine the association between the tumor behavior in prolactinomas and the p16(CDKN2A) gene polymorphism occurring at the 3'-untranslated region of exon 3 (C540G). A total of 104 patients with prolactinoma were included and assigned to two groups based on invasive vs. non-invasive tumor behavior. Ki67 indices were recorded according to histopathology results. Genotypic analysis of the p16( CDKN2A) C540G polymorphism was carried out using a modified polymerase chain reaction-restriction fragment length polymorphism assay. The corresponding frequencies for CC, CG and GG genotypes in non-invasive vs. invasive tumors were 61.5, 30.8, 7.7 and 64.1, 28.2, 7.7%, respectively ( not significant). The observed CG genotype frequency was higher compared with previous studies. In addition, the patients with giant adenomas or a high Ki67 index had a higher frequency of the CG genotype as compared with the other subgroups, although the differences were not significant (46.2 and 42.9%, respectively). In conclusion, a higher frequency of the C540G CG genotype of the CDKN2A gene was found among patients with prolactinoma in comparison with previous studies. These frequencies were also higher in the subgroups with elevated Ki67 or giant adenomas. Further studies are required to improve the definition of the role of the CG genotype in the development and progression of tumors in prolactinomas.Publication Frequency of atopy and allergic disorders among adults with type 1 diabetes mellitus in the southern marmara region of turkey(Springer, 2008-03-01) Duran, C.; Ediger, D.; Ersoy, C.; Coşkun, N. F.; Selimoğlu, H.; Ercan, I.; Kıyıcı, S.; Güçlü, M.; Sağlam, D. A.; Ertürk, E.; Tuncel, E.; İmamoğlu, S.; EDİGER, DANE; ERSOY, CANAN; Coşkun, N. Funda; Selimoğlu, Hadi; ERCAN, İLKER; Kıyıcı, Sinem; Güçlü, Metin; SAĞLAM, DİLEK; ERTÜRK, ERDİNÇ; Tuncel, Ercan; İMAMOĞLU, SÜLEYMAN; Tıp Fakültesi; Göğüs Hastalıkları Ana Bilim Dalı; Göğüs Hastalıkları Bilim Dalı; 0000-0001-9560-180X; 0000-0002-2954-4293; 0000-0003-3604-8826; 0000-0002-2382-290X; 0000-0001-5082-9894; 0000-0003-3604-8826; AAJ-6536-2021; ABF-2367-2020; AAH-8861-2021; ABI-4847-2020; AAE-9142-2019; AAD-1271-2019; FWY-5938-2022; FGL-7924-2022; DNS-0810-2022; EBN-7188-2022; DEA-5443-2022Aim: Autoimmune disorders are considered to be associated with a Th1 immune response whereas allergic diseases with a Th2 response. Studies mainly per-Formed on children revealed conflicting results regarding the association of atopy/allergic disease and autoimmune disorders. Therefore, we aimed to investigate the prevalence of allergic diseases in adult Type 1 diabetic patients. Methods: Eighty-nine Type 1 diabetic patients and 64 controls were enrolled into the study. Skin-prick test and European Community Respiratory Health Survey questionnaire were performed on all cases. Patients who gave at least one positive answer to questions about asthma in the questionnaire underwent pulmonary function test and methacholine challenge test. Results: Patients' mean age were similar in diabetic patients and controls (28.2 +/- 8.9 and 28.1 +/- 5.2 yr; respectively). In skin-prick test, the rate Of Positive response to at least one allergen was not significantly different in diabetes (29.2%) and in the control group (31.3%). In European Community Respiratory Health Survey questionnaire, diabetic patients waked up by an attack of cough more than controls did. The rate of physician-diagnosed asthma was similar in both groups. There was no difference between the 2 groups based on the answers of other questions about asthma and other allergic diseases such as allergic rhinitis, eczema, and drug allergy. Conclusion: We found that atopy frequencies were similar in an adult population of Type 1 diabetic patients and controls. Although asthmatic symptom prevalence is increased in diabetic patients, the incidence of current asthma was similar in both groups.
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