Person: BİÇER, MURAT
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BİÇER
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MURAT
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Publication Raising the bar to ultradisciplinary collaborations in management of chronic thromboembolic pulmonary hypertension(Baycinar Medical Publ-baycinar Tibbi Yayincilik, 2021-07-01) Akay, Tankut; Kaymaz, Cihangir; Akar, Ahmet Ruchan; Orhan, Gokcen; Yanartas, Mehmed; Gultekin, Bahadir; Sirlak, Mustafa; Kervan, Umit; Tas, Serpil Gezer; Yagdi, Tahir; Ispir, Selim; Dogan, Riza; Bicer, Murat; BİÇER, MURAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kardiyovasküler Cerrahi.Chronic thromboembolic pulmonary hypertension is an underdiagnosed and potentially fatal subgroup of pulmonary hypertension, if left untreated. Clinical signs include exertional dyspnea and non-specific symptoms. Diagnosis requires multimodality imaging and heart catheterization. Pulmonary endarterectomy, an open heart surgery, is the gold standard treatment of choice in selected patients in specialized centers. Targeted medical therapy and balloon pulmonary angioplasty can be effective in high-risk patients with significant comorbidities, distal pulmonary vascular obstructions, or recurrent/persistent pulmonary hypertension after pulmonary endarterectomy. Currently, there is a limited number of data regarding novel coronavirus-2019 infection in patients with chronic thromboembolic pulmonary hypertension and the changing spectrum of the disease during the pandemic. Challenging times during this outbreak due to healthcare crisis and relatively higher case-fatality rates require convergence; that is an ultradisciplinary collaboration, which crosses disciplinary and sectorial boundaries to develop integrated knowledge and new paradigms. Management strategies for the "new normal" such as virtual care, preparedness for further threats, redesigned standards and working conditions, reevaluation of specific recommendations, and online collaborations for optimal decisions for chronic thromboembolic pulmonary hypertension patients may change the poor outcomes.Publication Comparison of the effects of on-pump and off-pump techniques on the quality of life in coronary artery bypass surgery(Yerkure Tanitim & Yayincilik Hizmetleri A S, 2020-01-01) Binicier, Nofel Ahmet; Yolgosteren, Atif; YOLGÖSTEREN, ATIF; Bicer, Murat; BİÇER, MURAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi; AAG-2372-2021Objective: In this study, we aimed to compare the effects between on-pump and off-pump coronary artery bypass surgery on the effect of quality of life.Methods: Fifty patients who underwent isolated coronary artery bypass (CABG) between 01.08.2012 - 31.01.2013 were divided into two equal groups (group 1: off-pump CABG; group 2: on-pump CABG). The quality of life of all patients was evaluated using the SF-36 questionnaire in the postoperative first week and first month (8 basic parameters in SF-36 questionnaire form: Physical function, pain, physical role, mental health, emotional role, social function, fitness / fatigue, general health)Results: One week after CABG surgery, physical function, physical role, social function and emotional role were significantly better in group 1 than group 2 (p <0.05). There was no statistically significant difference between the two groups in terms of quality of life, one month after CABG surgery (p> 0.05). Physical function was significantly better in female gender one week after CABG (p <0.05). There was no difference between the two genders in terms of quality of life after one month (p> 0.05).Conclusion: We think that CABG performed off-pump in order to avoid from negative effects of cardiopulmonary bypass has no significant effect on the quality of life of the patients in the postoperative period. Nevertheless, in order to get a clearer idea on this issue, we think that large series studies should be conducted with a higher number of patients.Publication Evaluation of polylactide film for prevention of pericardial adhesion in a rabbit model(Baycinar Medical Publ-Bayçınar Tıbbi Yayıncılık, 2015-01-01) Gürbüz, Orçun; Ercan, Abdulkadir; Biçer, Murat; Kumtepe, Gencehan; Bayram, Sami; Şenkaya, Işık; Saba, Davit; BİÇER, MURAT; BAYRAM, AHMET SAMİ; ŞENKAYA SIĞNAK, IŞIK; Saba, Davit; Uludağ Üniversitesi/Tıp Fakültesi/Kalp Damar Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; ABC-2231-2020; ABB-7580-2020; DTC-2331-2022; DPS-9311-2022Background: This study aims to evaluate the efficacy of a bioabsorbable polylactide film, which was proven to be effective in preventing pelvic adhesions, in prevention of postoperative pericardial adhesions in an animal model.Methods: Forty New Zealand white rabbits were divided equally into control and treatment groups. Subjects were performed left anterior thoracotomy and partial pericardiectomy followed by epicardial abrasion. In control groups (group 1 and 2), the pericardium was left open to allow retrosternal adhesions. In treatment groups (group 3 and 4), the pericardial defect was closed with 0.02 mm bioabsorbable polylactide film. Postoperative macroscopic and microscopic evaluations were made by the same blinded observers at the end of the third week in group 1 and 3, and at the end of the sixth week in group 2 and 4.Results: Macroscopic and histopathologic examinations revealed no significant differences between control and treatment groups in terms of adhesion formation. However, polylactide film supported the growth of a mesothelium-like layer in the treatment groups.Conclusion: Although polylactide film assists in the regeneration of mesothelial cells layer, it does not prevent the development of pericardial adhesions.Publication The relationship between Cardiotrophin-1 and Troponin-I in coronary arterial bypass grafting on the beating heart: A prospective study(Forum Multimedia Publishing, 2015-08-01) Çalışkan, Serhat; Beşli, Feyzullah; Yıldırım, Ahmet; Güngören, Fatih; Alışır, Mehmet Fethi; Polat, Ufuk; Özdemir, Bülent; Biçer, Murat; Çalışkan, Serhat; Yıldırım, Ahmet; Güngören, Fatih; Polat, Ufuk; ÖZDEMİR, BÜLENT; BİÇER, MURAT; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kalp Damar Cerrahisi Anabilim Dalı.; 0000-0003-4411-8185; 0000-0002-0815-9505; AAA-3163-2021; ABC-2231-2020; AAC-9352-2021; ERK-8925-2022; JTI-0902-2023; DLY-6718-2022Objective: Cardiotrophin-1 (CT-1) is closely associated with many cardiovascular diseases, such as hypertension, myocardial infarction (MI), and heart failure, and exhibits a cardioprotective effect in ischemia-reperfusion injury. The aim of this study was to evaluate the relationship between CT-1 and Troponin-I (Tn-I) in off-pump coronary artery bypass (OPCAB) grafting on the beating heart.Methods: Seventy-eight patients (mean age 60.8 +/- 9.7 years, 79.5% male) undergoing elective OPCAB surgery were included in this study undertaken between July 1, 2012 and July 1, 2013 in the Department of Cardiology and Cardiac Surgery, University School of Medicine Hospital. Venous blood samples were collected 5 minutes before OPCAB surgery and 6 hours after surgery. Plasma CT-1 levels were measured using the ELISA method.Results: Compared to the preoperative period, Tn-I and CT-1 values were higher in the postoperative period [0.255 ng/mL (0.030-0.430) versus 0.045 ng/mL (0.005-0.090), P < .001; and 33.7 pg/mL (15.8-98.5) versus 8.7 pg/mL (0.68-25.4), P <. 001]. There was also an elevation in white blood cells, aspartate aminotransferase, creatine kinase (CK), and creatine kinase MB (CK-MB) values, as well as a decrease in hemoglobin values (P < .001). When a correlation analysis for postoperative CT-1 was performed, there was a significant positive correlation between postoperative CK, CK-MB, and Tn-I levels (r = 0.250, P < .027; r = 0.270, P =.017; and r = 0.241, P < .034).Conclusion: CT-1 was found to be associated with Tn-I, which is used to detect myocardial damage after OPCAB surgery. CT-1 may also be used to detect myocardial damage.Publication Association of aortic diameters with coronary artery disease severity and albumin excretion(Hindawi, 2015-04-08) Özdemir, Bülent; Emul, Ali; Özdemir, Levent; Sağ, Saim; Biçer, Murat; Aydınlar, Ali; ÖZDEMİR, BÜLENT; Sağ, Saim; BİÇER, MURAT; AYDINLAR, ALİ; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Anabilim Dalı.; Uludağ Üniversitesi/Tıp Fakültesi/Kalp, Damar Cerrahisi Anabilim Dalı.; 0000-0002-8974-8837; 0000-0001-8404-8252; AAW-9185-2020; ABC-2231-2020; AAI-6632-2021; JHE-3353-2023Introduction. Aortic diameters, aortic distensibility, microalbuminuria, coronary artery disease which are all together related to vascular aging are investigated in this paper. Methods. Eighty consecutive nondiabetic patients undergoing elective coronary angiography were enrolled into the study. Systolic and diastolic aortic diameters, aortic distensibility, CAD severity by angiogram with the use of Gensini scoring, and albumin excretion rates were determined. Results. Cases with CAD had significantly larger systolic (30,72 +/- 3,21mm versus 34,19 +/- 4,03 mm for cases without and with CAD, resp.) and diastolic aortic diameters measured 3 cm above aortic valve compared to patients without CAD (33,56 +/- 4,07 mm versus 29,75 +/- 3,12 mm). The systolic and diastolic diameters were significantly higher in albuminuria positive patients compared to albuminuria negative patients (p = 0.017 and 0.008, resp., for systolic and diastolic diameters). Conclusion. In conclusion aortic diameters are increased in patients with coronary artery disease and in patients with microalbuminuria. In CAD patients, systolic blood pressure, pulse pressure, aortic systolic and diastolic pressure, and albumin excretion rate were higher and aortic distensibility was lower.Publication Attitudes to genetically modified organisms and food among university students(Scibulcom, 2016-01-01) Utkualp, Nevin; Özdemir, Aysel; Biçer, Murat; Özdemir, Burhan; UTKUALP, NEVİN; ÖZDEMİR, AYSEL; BİÇER, MURAT; Özdemir, Burhan; Uludağ Üniversitesi/Tıp Fakültesi/Kalp ve Damar Cerrahisi Kliniği; Uludağ Üniversitesi/Tıp Fakültesi/Kardiyoloji Bölümü; 0000-0002-0815-9505; ABC-2231-2020; AAC-9352-2021; AAJ-1202-2021; FRF-3343-2022Genetically modified organisms and food have serious concerns due to their unpredicted nature. The beneficial effects include cost-effectiveness, economical benefits and endurance of the related product to certain obstacles including infections, and drought. Many diseases are attributed to genetically modified foods as with environmental hazards. Some of these have not been validated via scientific committees.In this study we aimed to investigate the attitudes of 85 students of the Institute of Health Sciences in Uludag University. The study was a descriptive study. We gathered data via questionnaire focusing on the attitudes, believes, knowledge levels and socioeconomical characteristics. The mean age of the study group was 21.77 +/- 1.21 (range 20-26). Among the group 67 (78.8%) were female. Majority of them mostly lived in cities. More than half of the students think that genetics of food is changed to make national governments dependent to foreign countries. Majority of students think that GMF and GMOs are detrimental for human health. A negative perception is present of GMOs. The socioeconomic characteristics did not affect the attitudes of students towards GMOs. 100% of the students think food labels should contain data related to presence of GMOs.Publication Extrapulmonary sequestration mimicking mediastinal cyst: Report of two identical cases(Turkish Assoc Tuberculosis & Thorax, 2007-01-01) BAYRAM, AHMET SAMİ; GEBİTEKİN, CENGİZ; Gebitekin, Cengiz; Biçer, Murat; BİÇER, MURAT; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Kalp ve Damar Cerrahisi Anabilim Dalı.; 0000-0003-0684-0900; ABC-2231-2020; JCE-0097-2023; AAE-1069-2022; ABB-7580-2020Extrapulmonary sequestration (EPS) is a rare congenital anomaly usually diagnosed during the first six months of life. It is mostly found between the left lower lobe of the lung and the diaphragm. Mediastinal presentation is extremely rare. We describe two identical cases of extrapulmonary sequestration mimicking mediastinal cystic mass in two boys. These emphasize the need to keep this diagnosis in mind when dealing with children presenting with anterior mediastinal mass.